المؤلفون: Corcoran RB; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Do KT; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Kim JE; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Cleary JM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Parikh AR; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Yeku OO; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Xiong N; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Weekes CD; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Veneris J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Ahronian LG; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Mauri G; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, and Department of Hematology Oncology, and Molecular Medicine, Grande Ospedale Metropolitano Niguarda, Milan, Italy., Tian J; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Norden BL; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Michel AG; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Van Seventer EE; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Siravegna G; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Camphausen K; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Chi G; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Fetter IJ; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Brugge JS; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts., Chen H; National Institute of Health, National Cancer Institute, Division of Cancer Treatment and Diagnosis, Cancer Therapy Evaluation Program, Bethesda, Maryland., Takebe N; National Institute of Health, National Cancer Institute, Division of Cancer Treatment and Diagnosis, Cancer Therapy Evaluation Program, Bethesda, Maryland., Penson RT; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Juric D; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Flaherty KT; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Sullivan RJ; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Clark JW; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Heist RS; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Matulonis UA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Liu JF; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Shapiro GI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 May 01; Vol. 30 (9), pp. 1739-1749.

نوع المنشور: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Pyridones*/administration & dosage , Pyridones*/adverse effects , Pyridones*/therapeutic use , Aniline Compounds*/administration & dosage , Aniline Compounds*/adverse effects , Aniline Compounds*/therapeutic use , Pyrimidinones*/administration & dosage , Pyrimidinones*/adverse effects , Proto-Oncogene Proteins p21(ras)*/genetics , Mutation* , Neoplasms*/drug therapy , Neoplasms*/genetics , Neoplasms*/pathology , bcl-X Protein*/antagonists & inhibitors , bcl-X Protein*/genetics , Sulfonamides*/administration & dosage , Sulfonamides*/adverse effects, Humans ; Female ; Male ; Middle Aged ; Aged ; Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Aged, 80 and over ; GTP Phosphohydrolases/genetics ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Treatment Outcome

المؤلفون: Tian J; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Chen JH; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA.; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Chao SX; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Pelka K; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Gladstone-UCSF Institute of Genomic Immunology, Gladstone Institutes Department of Microbiology and Immunology, UCSF, San Francisco, CA, USA., Giannakis M; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Hess J; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Burke K; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Jorgji V; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Sindurakar P; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Braverman J; The Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Mehta A; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA.; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Oka T; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Huang M; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Lieb D; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Spurrell M; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Allen JN; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Abrams TA; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Clark JW; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Enzinger AC; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Enzinger PC; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Klempner SJ; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., McCleary NJ; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Meyerhardt JA; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Ryan DP; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Yurgelun MB; Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Kanter K; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Van Seventer EE; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Baiev I; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Chi G; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Jarnagin J; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Bradford WB; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Wong E; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Michel AG; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Fetter IJ; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Siravegna G; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Gemma AJ; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Sharpe A; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Demehri S; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Leary R; Novartis Institute for Biomedical Research, Cambridge, MA, USA., Campbell CD; Novartis Institute for Biomedical Research, Cambridge, MA, USA., Yilmaz O; The Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Getz GA; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Parikh AR; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA., Hacohen N; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA. NHACOHEN@mgh.harvard.edu.; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. NHACOHEN@mgh.harvard.edu., Corcoran RB; Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA. rbcorcoran@partners.org.

المصدر: Nature medicine [Nat Med] 2023 Feb; Vol. 29 (2), pp. 458-466. Date of Electronic Publication: 2023 Jan 26.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Melanoma*/pathology , Colorectal Neoplasms*/genetics, Humans ; Proto-Oncogene Proteins B-raf/genetics ; Programmed Cell Death 1 Receptor/genetics ; Mitogen-Activated Protein Kinase Kinases/genetics ; Mutation ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Pyridones/therapeutic use ; Pyrimidinones/therapeutic use ; Protein Kinase Inhibitors/pharmacology

المؤلفون: Wo JY; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. jwo@mgh.harvard.edu., Clark JW; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Eyler CE; Department of Radiation Oncology, Duke Cancer Center, Duke School of Medicine, Durham, North Carolina., Mino-Kenudson M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Klempner SJ; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Allen JN; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Keane FK; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Parikh AR; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Roeland E; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Drapek LC; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ryan DP; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Corcoran RB; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Van Seventer E; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Fetter IJ; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Shahzade HA; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Khandekar MJ; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Lanuti M; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Morse CR; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Heist RS; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ulysse CA; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Christopher B; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Baglini C; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Yeap BY; Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Mullen JT; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Hong TS; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Dec 01; Vol. 27 (23), pp. 6343-6353. Date of Electronic Publication: 2021 Jul 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma*/drug therapy , Adenocarcinoma*/therapy , Pancreatic Neoplasms*/pathology, Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Fluorouracil ; Humans ; Irinotecan ; Leucovorin ; Neoadjuvant Therapy/methods ; Neoplasm Recurrence, Local ; Oxaliplatin ; Pilot Projects ; Prospective Studies ; Treatment Outcome

المؤلفون: Parikh AR; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Van Seventer EE; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Siravegna G; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Hartwig AV; Guardant Health, Inc, Redwood City, California., Jaimovich A; Guardant Health, Inc, Redwood City, California., He Y; Guardant Health, Inc, Redwood City, California., Kanter K; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Fish MG; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Fosbenner KD; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Miao B; Department of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts., Phillips S; Department of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts., Carmichael JH; Department of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts., Sharma N; Department of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts., Jarnagin J; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Baiev I; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Shah YS; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Fetter IJ; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Shahzade HA; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Allen JN; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Blaszkowsky LS; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Clark JW; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Dubois JS; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Franses JW; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Giantonio BJ; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Goyal L; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Klempner SJ; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Nipp RD; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Roeland EJ; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Ryan DP; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Weekes CD; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Wo JY; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Hong TS; Department of Radiation Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts., Bordeianou L; Department of General and Gastrointestinal Surgery, Massachusetts General Hospital, Boston, Massachusetts., Ferrone CR; Department of General and Gastrointestinal Surgery, Massachusetts General Hospital, Boston, Massachusetts., Qadan M; Department of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts., Kunitake H; Department of General and Gastrointestinal Surgery, Massachusetts General Hospital, Boston, Massachusetts., Berger D; Department of General and Gastrointestinal Surgery, Massachusetts General Hospital, Boston, Massachusetts., Ricciardi R; Department of General and Gastrointestinal Surgery, Massachusetts General Hospital, Boston, Massachusetts., Cusack JC; Department of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts., Raymond VM; Guardant Health, Inc, Redwood City, California., Talasaz A; Guardant Health, Inc, Redwood City, California., Boland GM; Department of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts., Corcoran RB; Department of Medicine, Division of Hematology and Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts. rbcorcoran@partners.org.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Oct 15; Vol. 27 (20), pp. 5586-5594. Date of Electronic Publication: 2021 Apr 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Circulating Tumor DNA/*blood , Colorectal Neoplasms/*blood , Colorectal Neoplasms/*surgery , Neoplasm, Residual/*blood, Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/pathology ; Female ; Hematologic Tests ; Humans ; Male ; Middle Aged ; Prospective Studies

المؤلفون: Cleary JM; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Raghavan S; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Wu Q; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Li YY; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Spurr LF; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.; Eli and Edythe L Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Gupta HV; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Rubinson DA; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Fetter IJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Hornick JL; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Nowak JA; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Siravegna G; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Goyal L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Shi L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Brais LK; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Loftus M; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Shinagare AB; Dana-Farber Brigham and Women's Cancer Center, Department of Radiology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Abrams TA; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Clancy TE; Dana-Farber Brigham and Women's Cancer Center, Department of Surgical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Wang J; Dana-Farber Brigham and Women's Cancer Center, Department of Surgical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Patel AK; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Brichory F; Debiopharm International SA, Lausanne, Switzerland., Vaslin Chessex A; Debiopharm International SA, Lausanne, Switzerland., Sullivan RJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Keller RB; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Denning S; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Hill ER; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Shapiro GI; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Pokorska-Bocci A; Debiopharm International SA, Lausanne, Switzerland., Zanna C; Debiopharm International SA, Lausanne, Switzerland., Ng K; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Schrag D; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Jänne PA; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Hahn WC; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Cherniack AD; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Corcoran RB; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Meyerson M; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Daina A; SIB Swiss Institute of Bioinformatics, Molecular Modeling Group, Lausanne, Switzerland., Zoete V; SIB Swiss Institute of Bioinformatics, Molecular Modeling Group, Lausanne, Switzerland.; University of Lausanne, Department of Fundamental Oncology, Ludwig Lausanne Branch, Lausanne, Switzerland., Bardeesy N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. Brian_Wolpin@dfci.harvard.edu Bardeesy.Nabeel@mgh.harvard.edu., Wolpin BM; Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts. Brian_Wolpin@dfci.harvard.edu Bardeesy.Nabeel@mgh.harvard.edu.

المصدر: Cancer discovery [Cancer Discov] 2021 Oct; Vol. 11 (10), pp. 2488-2505. Date of Electronic Publication: 2021 Apr 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Bile Duct Neoplasms/*drug therapy , Cholangiocarcinoma/*drug therapy , Protein Kinase Inhibitors/*therapeutic use , Receptor, Fibroblast Growth Factor, Type 2/*genetics, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/pathology ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/pathology ; Female ; Humans ; Male ; Middle Aged ; Molecular Targeted Therapy ; Receptor, Fibroblast Growth Factor, Type 2/antagonists & inhibitors ; Young Adult

المؤلفون: McDuff SGR; Department of Radiation Oncology, Duke Cancer Center, Duke University Medical Center, Duke Medicine Circle, Durham, NC.; Harvard Radiation Oncology Program, Boston, MA., Hardiman KM; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL., Ulintz PJ; Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI., Parikh AR; Department of Internal Medicine and Hematology/Oncology, Massachusetts General Hospital, Boston, MA., Zheng H; Biostatistics Center, Massachusetts General Hospital, Boston, MA., Kim DW; Harvard Radiation Oncology Program, Boston, MA., Lennerz JK; Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital, Boston, MA., Hazar-Rethinam M; Massachusetts General Hospital Cancer Center, Boston, MA., Van Seventer EE; Massachusetts General Hospital Cancer Center, Boston, MA., Fetter IJ; Massachusetts General Hospital Cancer Center, Boston, MA., Nadres B; Massachusetts General Hospital Cancer Center, Boston, MA., Eyler CE; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA., Ryan DP; Department of Internal Medicine and Hematology/Oncology, Massachusetts General Hospital, Boston, MA., Weekes CD; Department of Internal Medicine and Hematology/Oncology, Massachusetts General Hospital, Boston, MA., Clark JW; Department of Internal Medicine and Hematology/Oncology, Massachusetts General Hospital, Boston, MA., Cusack JC; The Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Boston, MA., Goyal L; Department of Internal Medicine and Hematology/Oncology, Massachusetts General Hospital, Boston, MA., Zhu AX; Department of Internal Medicine and Hematology/Oncology, Massachusetts General Hospital, Boston, MA.; Jiahui International Cancer Center, Jiahui Health, Shanghai, China., Wo JY; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA., Blaszkowsky LS; Department of Internal Medicine and Hematology/Oncology, Massachusetts General Hospital, Boston, MA., Allen J; Department of Internal Medicine and Hematology/Oncology, Massachusetts General Hospital, Boston, MA., Corcoran RB; Department of Internal Medicine and Hematology/Oncology, Massachusetts General Hospital, Boston, MA.; Massachusetts General Hospital Cancer Center, Boston, MA., Hong TS; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA.

المصدر: JCO precision oncology [JCO Precis Oncol] 2021 Jan 12; Vol. 5. Date of Electronic Publication: 2021 Jan 12 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101705370 Publication Model: eCollection Cited Medium: Internet ISSN: 2473-4284 (Electronic) Linking ISSN: 24734284 NLM ISO Abbreviation: JCO Precis Oncol

مواضيع طبية MeSH: Neoadjuvant Therapy*, Circulating Tumor DNA/*blood , Rectal Neoplasms/*blood , Rectal Neoplasms/*therapy, Aged ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Predictive Value of Tests ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome

المؤلفون: Lin JJ; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Langenbucher A; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Gupta P; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Yoda S; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Fetter IJ; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Rooney M; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Do A; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Kem M; Harvard Medical School, Boston, MA USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA USA., Chang KP; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Oh AY; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Chin E; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Juric D; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Corcoran RB; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Dagogo-Jack I; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Gainor JF; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Stone JR; Harvard Medical School, Boston, MA USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA USA., Lennerz JK; Harvard Medical School, Boston, MA USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA USA., Lawrence MS; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Hata AN; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA., Mino-Kenudson M; Harvard Medical School, Boston, MA USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA USA., Shaw AT; Department of Medicine, Massachusetts General Hospital, Boston, MA USA.; Harvard Medical School, Boston, MA USA.

المصدر: NPJ precision oncology [NPJ Precis Oncol] 2020 Aug 03; Vol. 4, pp. 21. Date of Electronic Publication: 2020 Aug 03 (Print Publication: 2020).

نوع المنشور: Case Reports

بيانات الدورية: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: eCollection Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE

المؤلفون: Parikh AR; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Mojtahed A; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Schneider JL; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Kanter K; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Van Seventer EE; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Fetter IJ; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Thabet A; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Fish MG; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Teshome B; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Fosbenner K; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Nadres B; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Shahzade HA; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Allen JN; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Blaszkowsky LS; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ryan DP; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Giantonio B; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Goyal L; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Nipp RD; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Roeland E; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Weekes CD; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Wo JY; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Zhu AX; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Dias-Santagata D; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Lennerz JK; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Hong TS; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Siravegna G; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Horick N; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Clark JW; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Corcoran RB; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. rbcorcoran@partners.org.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Apr 15; Vol. 26 (8), pp. 1877-1885. Date of Electronic Publication: 2020 Jan 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Antineoplastic Agents/*therapeutic use , Biomarkers, Tumor/*genetics , Circulating Tumor DNA/*blood , Gastrointestinal Neoplasms/*pathology , High-Throughput Nucleotide Sequencing/*methods, Adult ; Aged ; Aged, 80 and over ; Disease Progression ; Female ; Gastrointestinal Neoplasms/blood ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Neoplasms/genetics ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Neoplasm Metastasis ; Prospective Studies ; Survival Rate ; Treatment Outcome ; Young Adult

المؤلفون: Parikh AR; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Leshchiner I; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Elagina L; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Goyal L; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Levovitz C; IBM Research, Yorktown Heights, NY, USA., Siravegna G; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Turin, Italy., Livitz D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rhrissorrakrai K; IBM Research, Yorktown Heights, NY, USA., Martin EE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Van Seventer EE; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hanna M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Slowik K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Utro F; IBM Research, Yorktown Heights, NY, USA., Pinto CJ; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Wong A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Danysh BP; Broad Institute of MIT and Harvard, Cambridge, MA, USA., de la Cruz FF; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Fetter IJ; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Nadres B; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Shahzade HA; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Allen JN; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Blaszkowsky LS; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Clark JW; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Giantonio B; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Murphy JE; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Nipp RD; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Roeland E; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Ryan DP; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Weekes CD; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Kwak EL; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Faris JE; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Wo JY; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Aguet F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dey-Guha I; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hazar-Rethinam M; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Dias-Santagata D; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Ting DT; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Zhu AX; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hong TS; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Golub TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Iafrate AJ; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Adalsteinsson VA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bardelli A; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.; Department of Oncology, University of Torino, Turin, Italy., Parida L; IBM Research, Yorktown Heights, NY, USA., Juric D; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Getz G; Cancer Center, Massachusetts General Hospital, Boston, MA, USA. gadgetz@broadinstitute.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. gadgetz@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. gadgetz@broadinstitute.org.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. gadgetz@broadinstitute.org., Corcoran RB; Cancer Center, Massachusetts General Hospital, Boston, MA, USA. rbcorcoran@partners.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. rbcorcoran@partners.org.

المصدر: Nature medicine [Nat Med] 2019 Dec; Vol. 25 (12), pp. 1949.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Parikh AR; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Leshchiner I; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Elagina L; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Goyal L; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Levovitz C; IBM Research, Yorktown Heights, NY, USA., Siravegna G; Candiolo Cancer Institute, FPO-IRCCS, Turin, Italy.; Department of Oncology, University of Torino, Turin, Italy., Livitz D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rhrissorrakrai K; IBM Research, Yorktown Heights, NY, USA., Martin EE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Van Seventer EE; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hanna M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Slowik K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Utro F; IBM Research, Yorktown Heights, NY, USA., Pinto CJ; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Wong A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Danysh BP; Broad Institute of MIT and Harvard, Cambridge, MA, USA., de la Cruz FF; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Fetter IJ; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Nadres B; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Shahzade HA; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Allen JN; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Blaszkowsky LS; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Clark JW; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Giantonio B; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Murphy JE; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Nipp RD; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Roeland E; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Ryan DP; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Weekes CD; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Kwak EL; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Faris JE; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Wo JY; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Aguet F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dey-Guha I; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hazar-Rethinam M; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Dias-Santagata D; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Ting DT; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Zhu AX; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hong TS; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Golub TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Iafrate AJ; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Adalsteinsson VA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bardelli A; Candiolo Cancer Institute, FPO-IRCCS, Turin, Italy.; Department of Oncology, University of Torino, Turin, Italy., Parida L; IBM Research, Yorktown Heights, NY, USA., Juric D; Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Getz G; Cancer Center, Massachusetts General Hospital, Boston, MA, USA. gadgetz@broadinstitute.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. gadgetz@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. gadgetz@broadinstitute.org.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. gadgetz@broadinstitute.org., Corcoran RB; Cancer Center, Massachusetts General Hospital, Boston, MA, USA. rbcorcoran@partners.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. rbcorcoran@partners.org.

المصدر: Nature medicine [Nat Med] 2019 Sep; Vol. 25 (9), pp. 1415-1421. Date of Electronic Publication: 2019 Sep 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Liquid Biopsy*, Cell-Free Nucleic Acids/*blood , DNA, Neoplasm/*blood , Gastrointestinal Neoplasms/*blood, Autopsy ; Cell-Free Nucleic Acids/genetics ; Cohort Studies ; DNA, Neoplasm/genetics ; Drug Resistance, Neoplasm/genetics ; Female ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/pathology ; Genetic Heterogeneity ; Humans ; Male ; Middle Aged ; Mutation ; Proto-Oncogene Proteins B-raf/genetics ; Exome Sequencing