المؤلفون: Mark E. Warchol, Finley Je, Lamber Pr, Rende Gu, Linda D. Saffer, Jeffrey T. Corwin

المصدر: Ciba Foundation Symposium 196-Growth Factors as Drugs for Neurological and Sensory Disorders

مصطلحات موضوعية: Specific growth, Sensory epithelia, Programmed cell death, Future studies, Embryogenesis, Extracellular, Sensory system, Biology, Cell survival, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f3841c6d63f88123cafd213b42dd60a0
https://doi.org/10.1002/9780470514863.ch12

المؤلفون: Harney J; Drug Safety Research and Development, Pfizer, Groton, CT, USA. Electronic address: Julie.Harney@pfizer.com., Bajaj P; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Finley JE; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Kopec AK; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Koza-Taylor PH; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Boucher GG; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Lanz TA; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Doshna CM; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Somps CJ; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Adkins K; Drug Safety Research and Development, Pfizer, Groton, CT, USA., Houle C; Drug Safety Research and Development, Pfizer, Groton, CT, USA.

المصدر: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2021 Feb; Vol. 70, pp. 105012. Date of Electronic Publication: 2020 Oct 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 8712158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3177 (Electronic) Linking ISSN: 08872333 NLM ISO Abbreviation: Toxicol In Vitro Subsets: MEDLINE

مواضيع طبية MeSH: Models, Biological*, Alveolar Epithelial Cells/*pathology , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*antagonists & inhibitors, ATP-Binding Cassette Transporters/metabolism ; Adenocarcinoma of Lung/metabolism ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/ultrastructure ; Cells, Cultured ; Drug Evaluation, Preclinical ; Gene Expression ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Lung Neoplasms/metabolism ; Pulmonary Surfactant-Associated Protein C/metabolism

المؤلفون: Kopec AK; Drug Safety Research & Development, Pfizer, Inc., CT, USA., Yokokawa R; Department of Micro Engineering, Kyoto University, Japan., Khan N; Drug Safety Research & Development, Pfizer, Inc., CT, USA., Horii I; Drug Safety Research & Development, Pfizer, Inc., Japan., Finley JE; Drug Safety Research & Development, Pfizer, Inc., CT, USA., Bono CP; Drug Safety Research & Development, Pfizer, Inc., CT, USA., Donovan C; Drug Safety Research & Development, Pfizer, Inc., CT, USA., Roy J; Drug Safety Research & Development, Pfizer, Inc., CT, USA., Harney J; Drug Safety Research & Development, Pfizer, Inc., CT, USA., Burdick AD; Drug Safety Research & Development, Pfizer, Inc., MA, USA., Jessen B; Drug Safety Research & Development, Pfizer, Inc., CA, USA., Lu S; Drug Safety Research & Development, Pfizer, Inc., CA, USA., Collinge M; Drug Safety Research & Development, Pfizer, Inc., CT, USA., Sadeghian RB; Department of Micro Engineering, Kyoto University, Japan., Derzi M; Drug Safety Research & Development, Pfizer, Inc., MA, USA., Tomlinson L; Drug Safety Research & Development, Pfizer, Inc., MA, USA., Burkhardt JE; Drug Safety Research & Development, Pfizer, Inc., CT, USA.

المصدر: The Journal of toxicological sciences [J Toxicol Sci] 2021; Vol. 46 (3), pp. 99-114.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Doku Sayō Kenkyūkai Country of Publication: Japan NLM ID: 7805798 Publication Model: Print Cited Medium: Internet ISSN: 1880-3989 (Electronic) Linking ISSN: 03881350 NLM ISO Abbreviation: J Toxicol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Microfluidic Analytical Techniques* , Models, Biological*, Drug Development/*methods , Drug Development/*trends, Animals ; Biological Products ; Drug Industry ; Forecasting ; Humans ; Lab-On-A-Chip Devices

المؤلفون: Rouet R, Thuma BA; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Roy MD; Pfizer Drug Safety R&D , Groton , Connecticut 06340 , United States., Lintner NG; Pfizer Medicine Design , Cambridge , Massachusetts 02139 , United States., Rubitski DM; Pfizer Drug Safety R&D , Groton , Connecticut 06340 , United States., Finley JE; Pfizer Drug Safety R&D , Groton , Connecticut 06340 , United States., Wisniewska HM; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Mendonsa R, Hirsh A, de Oñate L, Compte Barrón J, McLellan TJ; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Bellenger J; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Feng X; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Varghese A; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Chrunyk BA; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Borzilleri K; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Hesp KD; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Zhou K, Ma N, Tu M; Pfizer Medicine Design , Cambridge , Massachusetts 02139 , United States., Dullea R; Pfizer CVMET Biology , Cambridge , Massachusetts 02139 , United States., McClure KF; Pfizer Medicine Design , Cambridge , Massachusetts 02139 , United States., Wilson RC, Liras S; Pfizer Medicine Design , Cambridge , Massachusetts 02139 , United States., Mascitti V; Pfizer Medicine Design , Groton , Connecticut 06340 , United States., Doudna JA; MBIB Division , Lawrence Berkeley National Laboratory , Berkeley , California 94720 , United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2018 May 30; Vol. 140 (21), pp. 6596-6603. Date of Electronic Publication: 2018 May 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Gene Editing*, Endonucleases/*metabolism, Cell Line, Tumor ; Endonucleases/genetics ; Hep G2 Cells ; Humans ; Molecular Structure ; Protein Engineering

المؤلفون: Kulkarni C, Finley JE, Bessire AJ, Zhong X; Global Biotherapeutics Technologies, Pfizer Worldwide R&D , Cambridge, Massachusetts 02139, United States., Musto S; Oncology Research Unit, Pfizer Worldwide R&D , Pearl River, New York 10965, United States., Graziani EI

المصدر: Bioconjugate chemistry [Bioconjug Chem] 2017 Apr 19; Vol. 28 (4), pp. 1041-1047. Date of Electronic Publication: 2017 Mar 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

مواضيع طبية MeSH: Transcytosis*, Fluorescent Dyes/*chemistry , Immunoconjugates/*chemistry , Pyrans/*chemistry, Antibodies, Monoclonal, Humanized/metabolism ; Azides ; Biological Transport ; Cell Line, Tumor ; Click Chemistry ; Humans ; Immunoconjugates/pharmacokinetics ; Immunoconjugates/therapeutic use ; Microscopy, Confocal ; Pharmaceutical Preparations/metabolism

المؤلفون: Sanhueza CA; School of Chemistry & Biochemistry, Georgia Institute of Technology , 901 Atlantic Avenue, Atlanta, Georgia 30332, United States.; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 N. Torrey Pines Road, La Jolla, California 92037, United States., Baksh MM; School of Chemistry & Biochemistry, Georgia Institute of Technology , 901 Atlantic Avenue, Atlanta, Georgia 30332, United States.; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 N. Torrey Pines Road, La Jolla, California 92037, United States., Thuma B; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Roy MD; Pfizer Drug Safety R&D , Eastern Point Road, Groton, Connecticut 06340, United States., Dutta S; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 N. Torrey Pines Road, La Jolla, California 92037, United States., Préville C; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Chrunyk BA; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Beaumont K; Pfizer Medicine Design , Main Street, Cambridge, Massachusetts 02139, United States., Dullea R; Pfizer CVMET Biology , Main Street, Cambridge, Massachusetts 02139, United States., Ammirati M; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Liu S; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Gebhard D; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Finley JE; Pfizer Drug Safety R&D , Eastern Point Road, Groton, Connecticut 06340, United States., Salatto CT; Pfizer CVMET Biology , Main Street, Cambridge, Massachusetts 02139, United States., King-Ahmad A; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Stock I; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Atkinson K; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Reidich B; Pfizer CVMET Biology , Main Street, Cambridge, Massachusetts 02139, United States., Lin W; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States., Kumar R; Pfizer Medicinal Sciences , Eastern Point Road, Groton, Connecticut 06340, United States., Tu M; Pfizer Medicine Design , Main Street, Cambridge, Massachusetts 02139, United States., Menhaji-Klotz E; Pfizer Medicine Design , Main Street, Cambridge, Massachusetts 02139, United States., Price DA; Pfizer Medicine Design , Main Street, Cambridge, Massachusetts 02139, United States., Liras S; Pfizer Medicine Design , Main Street, Cambridge, Massachusetts 02139, United States., Finn MG; School of Chemistry & Biochemistry, Georgia Institute of Technology , 901 Atlantic Avenue, Atlanta, Georgia 30332, United States.; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 N. Torrey Pines Road, La Jolla, California 92037, United States., Mascitti V; Pfizer Medicine Design , Eastern Point Road, Groton, Connecticut 06340, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2017 Mar 08; Vol. 139 (9), pp. 3528-3536. Date of Electronic Publication: 2017 Feb 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Asialoglycoprotein Receptor/*metabolism , Bridged Bicyclo Compounds/*chemistry , Hepatocytes/*metabolism , Ketones/*chemistry , Liver/*metabolism , Polymers/*chemistry, Bridged Bicyclo Compounds/metabolism ; Crystallography, X-Ray ; Drug Carriers/chemistry ; Humans ; Ketones/metabolism ; Liver/cytology ; Models, Molecular ; Molecular Structure ; Polymers/metabolism

المؤلفون: Sukoff Rizzo SJ; Neuroscience Research Unit, Pfizer Research & Development, Cambridge, MA, USA., Lotarski SM, Stolyar P, McNally T, Arturi C, Roos M, Finley JE, Reinhart V, Lanz TA

المصدر: Genes, brain, and behavior [Genes Brain Behav] 2014 Sep; Vol. 13 (7), pp. 643-52. Date of Electronic Publication: 2014 Aug 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Munksgaard Country of Publication: England NLM ID: 101129617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-183X (Electronic) Linking ISSN: 1601183X NLM ISO Abbreviation: Genes Brain Behav Subsets: MEDLINE

مواضيع طبية MeSH: Exploratory Behavior* , Locomotion* , Maze Learning*, Protein Tyrosine Phosphatases, Non-Receptor/*metabolism, Animals ; Brain/metabolism ; Brain/physiology ; Brain/physiopathology ; Mice ; Mice, Inbred C57BL ; Pentylenetetrazole/toxicity ; Protein Tyrosine Phosphatases, Non-Receptor/genetics ; Seizures/chemically induced ; Seizures/genetics ; Seizures/physiopathology

المؤلفون: Brodney MA; Neuroscience Medicinal Chemistry, Pfizer PharmaTherapeutics Research and Development, Eastern Point Road, Groton, CT 06340, USA. michael.a.brodney@pfizer.com, Auperin DD, Becker SL, Bronk BS, Brown TM, Coffman KJ, Finley JE, Hicks CD, Karmilowicz MJ, Lanz TA, Liston D, Liu X, Martin BA, Nelson RB, Nolan CE, Oborski CE, Parker CP, Richter KE, Pozdnyakov N, Sahagan BG, Schachter JB, Sokolowski SA, Tate B, Wood DE, Wood KM, Van Deusen JW, Zhang L

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 May 01; Vol. 21 (9), pp. 2637-40. Date of Electronic Publication: 2010 Dec 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid Precursor Protein Secretases/*antagonists & inhibitors , Enzyme Activation/*drug effects , Enzyme Inhibitors/*chemical synthesis , Enzyme Inhibitors/*pharmacology , Tetrahydronaphthalenes/*chemical synthesis , Tetrahydronaphthalenes/*pharmacology , Valine/*analogs & derivatives, Animals ; Biological Assay ; Drug Design ; Enzyme Inhibitors/chemistry ; Guinea Pigs ; Imidazoles/chemical synthesis ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Inhibitory Concentration 50 ; Molecular Structure ; Structure-Activity Relationship ; Tetrahydronaphthalenes/chemistry ; Valine/chemical synthesis ; Valine/chemistry ; Valine/pharmacology

المؤلفون: Brodney MA; Neuroscience Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. michael.a.brodney@pfizer.com, Auperin DD, Becker SL, Bronk BS, Brown TM, Coffman KJ, Finley JE, Hicks CD, Karmilowicz MJ, Lanz TA, Liston D, Liu X, Martin BA, Nelson RB, Nolan CE, Oborski CE, Parker CP, Richter KE, Pozdnyakov N, Sahagan BG, Schachter JB, Sokolowski SA, Tate B, Van Deusen JW, Wood DE, Wood KM

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 May 01; Vol. 21 (9), pp. 2631-6. Date of Electronic Publication: 2010 Dec 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*, Amyloid Precursor Protein Secretases/*antagonists & inhibitors , Enzyme Activation/*drug effects , Enzyme Inhibitors/*chemical synthesis , Enzyme Inhibitors/*pharmacology , Imidazoles/*chemical synthesis , Imidazoles/*pharmacology, Amination/drug effects ; Amyloid beta-Peptides/blood ; Amyloid beta-Peptides/metabolism ; Animals ; Biological Assay ; Diamide/chemical synthesis ; Diamide/chemistry ; Diamide/pharmacology ; Enzyme Inhibitors/chemistry ; Guinea Pigs ; HeLa Cells ; Humans ; Imidazoles/chemistry ; Inhibitory Concentration 50 ; Molecular Structure ; Structure-Activity Relationship

المؤلفون: Lanz TA; Neuroscience Research Unit, Pfizer, Inc., Groton, CT 06340, USA. thomas.a.lanz@pfizer.com, Wood KM, Richter KE, Nolan CE, Becker SL, Pozdnyakov N, Martin BA, Du P, Oborski CE, Wood DE, Brown TM, Finley JE, Sokolowski SA, Hicks CD, Coffman KJ, Geoghegan KF, Brodney MA, Liston D, Tate B

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2010 Jul; Vol. 334 (1), pp. 269-77. Date of Electronic Publication: 2010 Apr 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid Precursor Protein Secretases/*antagonists & inhibitors , Enzyme Inhibitors/*pharmacokinetics , Enzyme Inhibitors/*pharmacology , Tetrahydronaphthalenes/*pharmacokinetics , Tetrahydronaphthalenes/*pharmacology , Valine/*analogs & derivatives, Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/drug effects ; Brain/drug effects ; Brain/enzymology ; Cell Line ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/adverse effects ; Enzyme Inhibitors/chemistry ; Escherichia coli/genetics ; Female ; Guinea Pigs ; Humans ; Lymphocyte Count ; Male ; Mice ; Mice, Inbred Strains ; Molecular Structure ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Spleen/cytology ; Spleen/drug effects ; Tetrahydronaphthalenes/adverse effects ; Tetrahydronaphthalenes/chemistry ; Tissue Distribution ; Transfection ; Valine/adverse effects ; Valine/chemistry ; Valine/pharmacokinetics ; Valine/pharmacology