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المؤلفون: Jeffrey W. Johannes, Fiona Pachl, Amber Balazs, Tieguang Yao, C. Larner, Lisa McWilliams, Marianne Schimpl, Scott W. Martin, Kevin J. Embrey, Tom D. Heightman, Paul Hemsley, Jonathan P. Orme, Derek Barratt, Giuditta Illuzzi, Andrew Madin, Paolo Di Fruscia, Avipsa Ghosh, Martin J. Packer, Scott D. Edmondson, Elisabetta Leo, Xiaolan Zheng, Matthew D. Chuba, Xiaohui Pei, Mark J. O'Connor, Verity Talbot, Ke Zhang, Stephen Fawell, Elizabeth Underwood, Anna Staniszewska, Lina Liu, Lin Xue, Sonja J. Gill, Anders Gunnarsson, Andrew Pike, Susan E. Critchlow, Jeffrey G. Varnes, Andrew X. Zhang, Sébastien L. Degorce, J. Lane, Sudhir M. Hande, Hongyao She, Sabina Cosulich, Michal Bista
المصدر: Journal of Medicinal Chemistry. 64:14498-14512
مصطلحات موضوعية: chemistry.chemical_compound, PARP1, Chemistry, In vivo, Poly ADP ribose polymerase, Drug Discovery, Mutant, Cancer research, Molecular Medicine, Progenitor cell, Homologous recombination, DNA, In vitro
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المؤلفون: Göran Dahl, Katelyn Cassidy, Kevin Moreau, Andrew X. Zhang, Fiona Pachl, Andrea M. Zuhl
المصدر: SLAS Discovery. 26:518-523
مصطلحات موضوعية: Proteomics, 0301 basic medicine, Proteasome Endopeptidase Complex, Computer science, Ubiquitin-Protein Ligases, Computational biology, Protein degradation, Ligands, Biochemistry, Mass Spectrometry, Analytical Chemistry, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Humans, Molecular Targeted Therapy, Novel protein, Mechanism (biology), Ubiquitination, Protein turnover, High-Throughput Screening Assays, Targeted proteomics, Eukaryotic Cells, 030104 developmental biology, 030220 oncology & carcinogenesis, Proteolysis, Molecular Medicine, Protein Processing, Post-Translational, Protein Binding, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5251b9012618b03cdc776a059f0ee1
https://doi.org/10.1177/2472555220985776 -
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المؤلفون: Pieter Giesbertz, Hannelore Daniel, Theresa Schöttl, Martin Klingenspor, Bernhard Kuster, Tobias Fromme, Fiona Pachl
المصدر: Obesity. 28:590-600
مصطلحات موضوعية: Male, Proteomics, Endocrinology, Diabetes and Metabolism, Mice, Obese, Medicine (miscellaneous), Adipose tissue, 030209 endocrinology & metabolism, Oxidative phosphorylation, Mitochondrion, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Downregulation and upregulation, Adipocyte, Adipocytes, Animals, Humans, Inner membrane, Obesity, 030212 general & internal medicine, Nutrition and Dietetics, Mitochondria, ddc, Cell biology, chemistry, Energy Metabolism, Bacterial outer membrane
وصف الملف: application/pdf
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المؤلفون: Jeffrey W, Johannes, Amber, Balazs, Derek, Barratt, Michal, Bista, Matthew D, Chuba, Sabina, Cosulich, Susan E, Critchlow, Sébastien L, Degorce, Paolo, Di Fruscia, Scott D, Edmondson, Kevin, Embrey, Stephen, Fawell, Avipsa, Ghosh, Sonja J, Gill, Anders, Gunnarsson, Sudhir M, Hande, Tom D, Heightman, Paul, Hemsley, Giuditta, Illuzzi, Jordan, Lane, Carrie, Larner, Elisabetta, Leo, Lina, Liu, Andrew, Madin, Scott, Martin, Lisa, McWilliams, Mark J, O'Connor, Jonathan P, Orme, Fiona, Pachl, Martin J, Packer, Xiaohui, Pei, Andrew, Pike, Marianne, Schimpl, Hongyao, She, Anna D, Staniszewska, Verity, Talbot, Elizabeth, Underwood, Jeffrey G, Varnes, Lin, Xue, Tieguang, Yao, Ke, Zhang, Andrew X, Zhang, Xiaolan, Zheng
المصدر: Journal of medicinal chemistry. 64(19)
مصطلحات موضوعية: Poly (ADP-Ribose) Polymerase-1, Humans, DNA, Poly(ADP-ribose) Polymerase Inhibitors, Poly(ADP-ribose) Polymerases, Crystallography, X-Ray, Substrate Specificity
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المؤلفون: Avipsa Ghosh, Sudhir M. Hande, Amber Balazs, Derek Barratt, Sabina Cosulich, Barry Davies, Sébastien Degorce, Kevin Embrey, Sonja Gill, Anders Gunnarsson, Giuditta Illuzzi, Peter Johnström, Jordan Lane, Carrie Larner, Rachel Lawrence, Elisabetta Leo, Andrew Madin, Elizabeth Martin, Lisa McWilliams, Lenka O’Connor, Mark O’Connor, Jonathan Orme, Fiona Pachl, Martin Packer, Andy Pike, Philip Rawlins, Marianne Schimpl, Magnus Schou, Anna Staniszewska, Wenzhan Yang, James Yates, Andrew Zhang, XiaoLa Zheng, Stephen Fawell, Petra Hamerlik, Jeffrey Johannes
المصدر: Cancer Research. 82:6302-6302
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::288251eb61b3a0254c30186cb54c9b42
https://doi.org/10.1158/1538-7445.am2022-6302 -
6Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase
المؤلفون: Claire Crafter, Erica Banks, Yumeng Mao, Omid Tavana, Bin Yang, David Kouvchinov, Viia Valge-Archer, Fiona Pachl, Sébastien L. Degorce, Anisha Solanki, Lakshmaiah Gingipalli, Scott D. Edmondson
المصدر: Journal of medicinal chemistry. 63(18)
مصطلحات موضوعية: 0303 health sciences, Chemistry, THP-1 Cells, Triazines, Ubiquitin-Protein Ligases, Proteolysis targeting chimera, Signal transducing adaptor protein, Phthalimides, Ligands, 01 natural sciences, In vitro, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Chimera (genetics), Interleukin-1 Receptor-Associated Kinases, Drug Discovery, Proteolysis, Molecular Medicine, Humans, Pyrroles, 030304 developmental biology, Adaptor Proteins, Signal Transducing
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المؤلفون: Pete Newham, Helen Boyd, M. Paola Castaldi, Fiona Pachl, Clay W Scott, Andrew X. Zhang, Kevin Moreau, Göran Dahl, Muireann Coen
المصدر: Br J Pharmacol
مصطلحات موضوعية: 0301 basic medicine, Drug, Proteasome Endopeptidase Complex, media_common.quotation_subject, Proteolysis, Ubiquitin-Protein Ligases, INDISULAM, Computational biology, KNOCKDOWN, 03 medical and health sciences, Chimera (genetics), 0302 clinical medicine, Ubiquitinated Proteins, DESIGN, SELECTIVE DEGRADATION, medicine, Pharmacology & Pharmacy, PROTEIN-DEGRADATION, Review Articles, media_common, LIGASE, Pharmacology, Science & Technology, medicine.diagnostic_test, business.industry, Chimera, GSPT1, A protein, CONCISE GUIDE, MODEL, 030104 developmental biology, Proteasome, Drug development, Pharmaceutical Preparations, PROTACS, 1115 Pharmacology and Pharmaceutical Sciences, business, Life Sciences & Biomedicine, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd7a568c229ff314cd00bfa85807cce
http://hdl.handle.net/10044/1/77454 -
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المؤلفون: Mark J. O'Connor, Philip B. Rawlins, Kevin J. Embrey, Anders Gunnarsson, Sudhir M. Hande, Anna Staniszewska, Fiona Pachl, Andrew X. Zhang, Jonathan P. Orme, Giuditta Illuzzi, Lisa McWilliams, Sonja J. Gill, Jeffrey W. Johannes, J. Lane, Sébastien L. Degorce, Amber Balazs, Martin J. Packer, Andrew Madin, Marianne Schimpl, Andrew Pike, Elisabetta Leo, Xiaolan Zheng, Avipsa Ghosh, C. Larner
المصدر: Cancer Research. 81:296-296
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, Nicotinamide, biology, Poly ADP ribose polymerase, hERG, Olaparib, chemistry.chemical_compound, Enzyme, PARP1, Oncology, chemistry, PARP inhibitor, Cancer research, biology.protein, Binding site
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5541745268ca2c08d1cdc8f164ef2184
https://doi.org/10.1158/1538-7445.am2021-296 -
9
المؤلفون: Bernhard Kuster, Nancy L. Brackett, Dominic Helm, Fiona Pachl, Jürgen Schiller, Barbara Ferreira da Silva, Emad Ibrahim, Chen Meng, Charles M. Lynne, Ricardo Pimenta Bertolla
المصدر: Molecular & Cellular Proteomics. 15:1424-1434
مصطلحات موضوعية: Adult, Male, Proteomics, 0301 basic medicine, Infertility, Proteome, Quantitative proteomics, Semen, Biology, Bioinformatics, Biochemistry, Mass Spectrometry, Analytical Chemistry, Male infertility, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Gene Regulatory Networks, Molecular Biology, Infertility, Male, Spinal Cord Injuries, Sperm motility, Research, Middle Aged, medicine.disease, 030104 developmental biology, Gene Expression Regulation, 030220 oncology & carcinogenesis, Sperm Motility, Prostasomes
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2166e99756fc9e0ab16082e05374ca67
https://doi.org/10.1074/mcp.m115.052175 -
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المؤلفون: Sameer Kawatkar, Philip B. Rawlins, Ning Gao, S. Bagal, Ronald Tomlinson, David Matthew Wilson, Elisabetta Chiarparin, James Robinson, Jessie Hao-Ru Hsu, Erin Code, Emma Bednarski, Lisa Drew, Kelly Jacques, Stephen Fawell, Andrew Bloecher, Xiahui Zhu, M. Paola Castaldi, Timothy Rasmusson, Haley Woods, Jon Read, Argyrides Argyrou, Minhui Shen, Daniel H. O' Donovan, Fiona Pachl
المصدر: Cell Chemical Biology. 27:41-46.e17
مصطلحات موضوعية: Pharmacology, biology, 010405 organic chemistry, Clinical Biochemistry, EZH2, Druggability, macromolecular substances, 01 natural sciences, Biochemistry, 0104 chemical sciences, Cell biology, Ubiquitin ligase, chemistry.chemical_compound, chemistry, Drug Discovery, Cancer cell, biology.protein, SUZ12, Molecular Medicine, Growth inhibition, PRC2, Molecular Biology, Ternary complex
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6eff7ece91c5973a337e9c595e228677
https://doi.org/10.1016/j.chembiol.2019.11.004