يعرض 1 - 10 نتائج من 338 نتيجة بحث عن '"Florence I. Raynaud"', وقت الاستعلام: 1.50s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

    المؤلفون: Olivier A. Pierrat, Manjuan Liu, Gavin W. Collie, Kartika Shetty, Matthew J. Rodrigues, Yann-Vaï Le Bihan, Emma A. Gunnell, P. Craig McAndrew, Mark Stubbs, Martin G. Rowlands, Norhakim Yahya, Erald Shehu, Rachel Talbot, Lisa Pickard, Benjamin R. Bellenie, Kwai-Ming J. Cheung, Ludovic Drouin, Paolo Innocenti, Hannah Woodward, Owen A. Davis, Matthew G. Lloyd, Ana Varela, Rosemary Huckvale, Fabio Broccatelli, Michael Carter, David Galiwango, Angela Hayes, Florence I. Raynaud, Christopher Bryant, Steven Whittaker, Olivia W. Rossanese, Swen Hoelder, Rosemary Burke, Rob L. M. van Montfort

    المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2045-2322

    URL الوصول: https://doaj.org/article/0430233ed30549f9969eadd4d689eff3

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  2. 2
    دورية أكاديمية
    FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas

    المؤلفون: Christopher I. Milton, Joanna Selfe, Ewa Aladowicz, Stella Y. K. Man, Carolina Bernauer, Edoardo Missiaglia, Zoë S. Walters, Susanne A. Gatz, Anna Kelsey, Melanie Generali, Gary Box, Melanie Valenti, Alexis deHaven‐Brandon, David Galiwango, Angela Hayes, Matthew Clarke, Elisa Izquierdo, David Gonzalez De Castro, Florence I. Raynaud, Vladimir Kirkin, Janet M. Shipley

    المصدر: Molecular Oncology, Vol 16, Iss 6, Pp 1272-1289 (2022)

    مصطلحات موضوعية: autocrine loop, FGF7, FGFR2, fibroblast growth factor receptor, NVP‐BGJ398, rhabdomyosarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

    URL الوصول: https://doaj.org/article/5b496d1e847c44f09cabb855a8b74715

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  3. 3
    دورية أكاديمية
    Presence of human breast cancer xenograft changes the diurnal profile of amino acids in mice

    المؤلفون: Rubens Paula Junior, Nathália Martins Sonehara, Bruna Victorasso Jardim-Perassi, Akos Pal, Yasmin Asad, Luiz Gustavo Almeida Chuffa, Roger Chammas, Florence I. Raynaud, Debora A. P. C. Zuccari

    المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2045-2322

    URL الوصول: https://doaj.org/article/e275906a0033490cb068fb904e90c331

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  4. 4
    دورية أكاديمية
    A Phase I/II Study of a 72-h Continuous Infusion of Etoposide in Advanced Soft Tissue Sarcoma

    المؤلفون: Charles R. Crawley, Ian R. Judson, Mark Verrill, Catherine Hill, Florence I. Raynaud

    المصدر: Sarcoma, Vol 1, Iss 3-4, Pp 149-154 (1997)

    مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1357-714X; https://doaj.org/toc/1369-1643

    URL الوصول: https://doaj.org/article/0ef2cd0f6ead41d8bf46653e7af92f3f

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  5. 5
    Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones

    المؤلفون: Alice C. Harnden, Owen A. Davis, Gary M. Box, Angela Hayes, Louise D. Johnson, Alan T. Henley, Alexis K. de Haven Brandon, Melanie Valenti, Kwai-Ming J. Cheung, Alfie Brennan, Rosemary Huckvale, Olivier A. Pierrat, Rachel Talbot, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Selby de Klerk, Peter Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder

    المصدر: Journal of Medicinal Chemistry. 66:5892-5906

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c9094aa8cbb7b8cceb3273b677e3d3d9
    https://doi.org/10.1021/acs.jmedchem.3c00155

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  6. 6
    HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

    المؤلفون: A. Elisa Pasqua, Swee Y. Sharp, Nicola E. A. Chessum, Angela Hayes, Loredana Pellegrino, Michael J. Tucker, Asadh Miah, Birgit Wilding, Lindsay E. Evans, Carl S. Rye, N. Yi Mok, Manjuan Liu, Alan T. Henley, Sharon Gowan, Emmanuel De Billy, Robert te Poele, Marissa Powers, Suzanne A. Eccles, Paul A. Clarke, Florence I. Raynaud, Paul Workman, Keith Jones, Matthew D. Cheeseman

    المصدر: Journal of Medicinal Chemistry. 66:5907-5936

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::719374538241e3474602d329b097d75c
    https://doi.org/10.1021/acs.jmedchem.3c00156

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  7. 7
    Machine learning estimation of human body time using metabolomic profiling

    المؤلفون: Tom Woelders, Victoria L. Revell, Benita Middleton, Katrin Ackermann, Manfred Kayser, Florence I. Raynaud, Debra J. Skene, Roelof A. Hut

    المساهمون: Genetic Identification, Hut lab, University of St Andrews. School of Chemistry, University of St Andrews. Institute of Behavioural and Neural Sciences

    المصدر: Proceedings of the National Academy of Sciences of the United States of America, 120(18):e2212685120. National Academy of Sciences
    Proceedings of the National Academy of Sciences of the United States of America, 120(18):e2212685120. NATL ACAD SCIENCES

    مصطلحات موضوعية: MCC, Multidisciplinary, circadian phase, Human body time, 3rd-DAS, metabolomics, Circadian phase, machine learning, Dim light melatonin onset, Machine learning, RC0321, Metabolomics, human body time, dim light melatonin onset, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189f82d8dd95a0b14eb9d0aaec70c7fe
    https://research.rug.nl/en/publications/835fb993-2e36-4f13-a8cb-302fd7a931d8

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  8. 8
    Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors

    المؤلفون: Owen A. Davis, Kwai-Ming J. Cheung, Alfie Brennan, Matthew G. Lloyd, Matthew J. Rodrigues, Olivier A. Pierrat, Gavin W. Collie, Yann-Vaï Le Bihan, Rosemary Huckvale, Alice C. Harnden, Ana Varela, Michael D. Bright, Paul Eve, Angela Hayes, Alan T. Henley, Michael D. Carter, P. Craig McAndrew, Rachel Talbot, Rosemary Burke, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Mirco Meniconi, Benjamin R. Bellenie, Swen Hoelder

    المصدر: Journal of Medicinal Chemistry. 65:8169-8190

    مصطلحات موضوعية: BTB-POZ Domain, Drug Discovery, Proto-Oncogene Proteins c-bcl-6, Molecular Medicine, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f6c02b01eed5ce5ede7cf979780c4e
    https://doi.org/10.1021/acs.jmedchem.1c02174

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  9. 9
    Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo

    المؤلفون: Rosemary Huckvale, Alice C. Harnden, Kwai-Ming J. Cheung, Olivier A. Pierrat, Rachel Talbot, Gary M. Box, Alan T. Henley, Alexis K. de Haven Brandon, Albert E. Hallsworth, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Angela Hayes, Emma A. Gunnell, Alfie Brennan, Owen A. Davis, Louise D. Johnson, Selby de Klerk, Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder

    المصدر: Journal of Medicinal Chemistry. 65:8191-8207

    مصطلحات موضوعية: Gene Expression Regulation, Neoplastic, Mice, Carcinogenesis, Drug Discovery, Proto-Oncogene Proteins c-bcl-6, Animals, Humans, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69d8cef8cdf04211cefb44860e5b55b
    https://doi.org/10.1021/acs.jmedchem.1c02175

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  10. 10
    Data from Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non–BRCA1/2-Mutant Cancers

    المؤلفون: Johann S. de Bono, Yvette Drew, Juanita S. Lopez, Bristi Basu, Ruth Plummer, Udai Banerji, Christopher J. Lord, Andrew Foxley, Justin P.O. Lindemann, Paul Rugman, Emma Hall, Laura Finneran, Karen E. Swales, Shaun Decordova, Florence I. Raynaud, Ruth Ruddle, Nicholas C. Turner, Heidrun Gevensleben, Neha Chopra, Nina Tunariu, Alison Turner, Mona Parmar, Ruth Matthews, Sarah Ward, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Ruth Riisnaes, Rowan Miller, Desamparados Roda, Suzanne Carreira, Joline S.J. Lim, Stephen J. Pettitt, Vasiliki Michalarea, Rebecca Kristeleit, Timothy A. Yap

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::01e33adbfd1faf3496d00cefbd4e1d17
    https://doi.org/10.1158/2159-8290.c.6547955.v1

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