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المؤلفون: Johnson ZL; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Ammirati M; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Wasilko DJ; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Chang JS; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Noell S; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Foley TL; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Yoon H; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, USA., Smith K; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, USA., Asano S; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, USA., Hales K; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, USA., Wan M; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, USA., Yang Q; Internal Medicine, Medicine Design, Pfizer Inc., Cambridge, MA, USA., Piotrowski MA; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Farley KA; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Gilbert T; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, USA., Aschenbrenner LM; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Fennell KF; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Dutra JK; Internal Medicine, Medicine Design, Pfizer Inc., Groton, CT, USA., Xu M; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Guo C; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Varghese AE; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Bellenger J; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Quinn A; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Am Ende CW; Internal Medicine, Medicine Design, Pfizer Inc., Groton, CT, USA., West GM; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Griffor MC; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Bennett D; Biostatistics, Early Clinical Development, Pfizer Inc., Cambridge, MA, USA., Calabrese M; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Steppan CM; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Han S; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA., Wu H; Discovery Sciences, Medicine Design, Pfizer Inc., Groton, CT, USA. huixian.wu@pfizer.com.

المصدر: Nature structural & molecular biology [Nat Struct Mol Biol] 2023 Jan; Vol. 30 (1), pp. 22-30. Date of Electronic Publication: 2022 Dec 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Liver*/metabolism , Mitochondrial Membranes*/metabolism, Humans ; Glycerol-3-Phosphate O-Acyltransferase/chemistry ; Glycerol-3-Phosphate O-Acyltransferase/metabolism ; Amino Acid Sequence

المؤلفون: Zhu H; Simulation and Modelling Sciences, Pfizer Inc., Groton, Connecticut 06340, United States., Foley TL; Discovery Sciences, Pfizer Inc., Groton, Connecticut 06340, United States., Montgomery JI; Discovery Sciences, Pfizer Inc., Groton, Connecticut 06340, United States., Stanton RV; Simulation and Modelling Sciences, Pfizer Inc., Cambridge, Massachusetts 02139, United States.

المصدر: Journal of chemical information and modeling [J Chem Inf Model] 2022 May 09; Vol. 62 (9), pp. 2239-2247. Date of Electronic Publication: 2021 Dec 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

مواضيع طبية MeSH: DNA* , Small Molecule Libraries*, Data Analysis ; Uncertainty

المؤلفون: Ratnayake AS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: anokha.ratnayake@pfizer.com., Flanagan ME; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: mark.e.flanagan@pfizer.com., Foley TL; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Timothy.Foley@pfizer.com., Hultgren SL; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Scott.Hultgren@pfizer.com., Bellenger J; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Justin.Bellenger@pfizer.com., Montgomery JI; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Justin.Montgomery@pfizer.com., Lall MS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Manjinder.Lall@pfizer.com., Liu B; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Bo.Liu2@pfizer.com., Ryder T; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: tim.ryder@pfizer.com., Kölmel DK; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Dominik.Koelmel@pfizer.com., Shavnya A; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: andre.shavnya@pfizer.com., Feng X; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Xidong.Feng@pfizer.com., Lefker B; Lefker Biopharma Consulting LLC, Arlington, MA 02474 United States. Electronic address: bruce@lefkerbiopharmaconsulting.com., Byrnes LJ; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Laura.Byrnes@pfizer.com., Sahasrabudhe PV; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Parag.Sahasrabudhe@Pfizer.com., Farley KA; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: kathleen.a.farley@pfizer.com., Chen S; HitGen Inc., Shuangliu District, Chengdu, China. Electronic address: shi.chen@hitgen.com., Wan J; HitGen Inc., Shuangliu District, Chengdu, China. Electronic address: jq.wan@hitgen.com.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jul 01; Vol. 41, pp. 116205. Date of Electronic Publication: 2021 May 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , Gene Library*, DNA/*chemistry , Mass Spectrometry/*methods, Combinatorial Chemistry Techniques ; Ligands ; Molecular Structure ; Small Molecule Libraries/chemistry

المؤلفون: Dutra JK; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA., Foley TL; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA., Huang Z; Pfizer Worldwide Research and Development, 1 Portland St, Cambridge, MA 02139, USA., Fisher EL; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA., Lachapelle EA; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA., Mahapatra S; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA., Ogilvie K; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA., Butler TW; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA., Bellenger J; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA., Devraj Majmudar J; Pfizer Worldwide Research and Development, 1 Portland St, Cambridge, MA 02139, USA., Am Ende CW; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA.

المصدر: Chembiochem : a European journal of chemical biology [Chembiochem] 2021 May 14; Vol. 22 (10), pp. 1769-1774. Date of Electronic Publication: 2021 Mar 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

مواضيع طبية MeSH: Fluorine/*chemistry , Organophosphonates/*metabolism, Adipocytes/cytology ; Adipocytes/metabolism ; Humans ; Organophosphonates/chemical synthesis ; Organophosphonates/chemistry ; Polymers/chemistry ; Serine Endopeptidases/metabolism ; Solid-Phase Synthesis Techniques

المؤلفون: Foley TL; Discovery Sciences, Pfizer Inc., Groton, CT, USA., Burchett W; Early Clinical Development, Pfizer Inc., Groton, CT, USA., Chen Q; Lead Generation Unit, HitGen Inc., Chengdu, Shuangliu District, China., Flanagan ME; Discovery Sciences, Pfizer Inc., Groton, CT, USA., Kapinos B; Discovery Sciences, Pfizer Inc., Groton, CT, USA., Li X; Lead Generation Unit, HitGen Inc., Chengdu, Shuangliu District, China., Montgomery JI; Discovery Sciences, Pfizer Inc., Groton, CT, USA., Ratnayake AS; Discovery Sciences, Pfizer Inc., Groton, CT, USA., Zhu H; Simulation and Modelling Sciences, Pfizer Inc., Groton, CT, USA., Peakman MC; Discovery Sciences, Pfizer Inc., Groton, CT, USA.

المصدر: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Feb; Vol. 26 (2), pp. 263-280. Date of Electronic Publication: 2021 Jan 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

مواضيع طبية MeSH: Gene Library* , Small Molecule Libraries*, Drug Discovery/*methods, Drug Discovery/standards ; Humans

المؤلفون: Chen Q; HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Hall J; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Rd, Groton, CT, 06340, USA., Foley TL; Worldwide Medicinal Chemistry, Pfizer, Eastern Point Rd, Groton, CT, 06340, USA., Wan J; HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Li Y; HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Israel DI; HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China. Electronic address: david.israel@hitgen.com.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 03; Vol. 533 (2), pp. 249-255. Date of Electronic Publication: 2020 May 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, DNA/*chemistry , Small Molecule Libraries/*chemistry , Small Molecule Libraries/*pharmacology, Binding Sites ; Combinatorial Chemistry Techniques ; DNA/chemical synthesis ; Humans ; Ligands ; Phosphotransferases/metabolism ; Protein Binding ; Small Molecule Libraries/chemical synthesis

المؤلفون: Hall J; Structural Biology, Pfizer, 3200 Walnut Rd, Boulder, CO, 80301, USA. Electronic address: justin.hall@pfizer.com., Foley TL; Discovery Sciences, Pfizer, Eastern Point Rd, Groton, CT, 06340, USA., Chen Q; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Israel DI; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Xu Y; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Ford KK; Discovery Sciences, Pfizer, Eastern Point Rd, Groton, CT, 06340, USA., Xie P; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Fan J; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China., Wan J; Lead Generation Unit, HitGen Inc, Building 6, Tianfu International Bio-Town, No. 8, Huigu 1st East Road, Shuangliu District, Chengdu, Sichuan, 610000, China.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 18; Vol. 527 (1), pp. 250-256. Date of Electronic Publication: 2020 May 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Combinatorial Chemistry Techniques* , Gene Library*, Cell Cycle Proteins/*chemistry , DNA/*chemistry , Transcription Factors/*chemistry , rho-Associated Kinases/*chemistry, Humans

المؤلفون: Ratnayake AS; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Flanagan ME; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Foley TL; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Smith JD; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Johnson JG; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Bellenger J; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Montgomery JI; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Paegel BM; Department of Chemistry , The Scripps Research Institute , 130 Scripps Way , Jupiter , Florida 33458 , United States.

المصدر: ACS combinatorial science [ACS Comb Sci] 2019 Oct 14; Vol. 21 (10), pp. 650-655. Date of Electronic Publication: 2019 Sep 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101540531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2156-8944 (Electronic) Linking ISSN: 21568944 NLM ISO Abbreviation: ACS Comb Sci Subsets: MEDLINE

مواضيع طبية MeSH: DNA/*chemistry , Small Molecule Libraries/*chemical synthesis, Combinatorial Chemistry Techniques ; Molecular Structure ; Small Molecule Libraries/chemistry ; Solutions

المؤلفون: Coussens NP; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Sittampalam GS; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Guha R; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Brimacombe K; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Grossman A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Chung TDY; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States., Weidner JR; QualSci Consulting, LLC, Carmel, Indiana, United States., Riss T; Promega Corporation, Madison, Wisconsin, United States., Trask OJ; PerkinElmer, Inc., Waltham, Massachusetts, United States., Auld D; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States., Dahlin JL; Brigham and Women's Hospital, Boston, Massachusetts, United States., Devanaryan V; Charles River Laboratories, Souderton, Pennsylvania, United States., Foley TL; Pfizer Worldwide Research and Development, Groton, Connecticut, United States., McGee J; Eli Lilly and Company, Indianapolis, Indiana, United States., Kahl SD; Eli Lilly and Company, Indianapolis, Indiana, United States., Kales SC; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Arkin M; Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States., Baell J; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Bejcek B; Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan, United States., Gal-Edd N; MacroGenics, Inc., Rockville, Maryland, United States., Glicksman M; Orig3n, Boston, Massachusetts, United States., Haas JV; Eli Lilly and Company, Indianapolis, Indiana, United States., Iversen PW; Eli Lilly and Company, Indianapolis, Indiana, United States., Hoeppner M; National Library of Medicine, National Center for Biotechnology Information, Bethesda, Maryland, United States., Lathrop S; National Library of Medicine, National Center for Biotechnology Information, Bethesda, Maryland, United States., Sayers E; National Library of Medicine, National Center for Biotechnology Information, Bethesda, Maryland, United States., Liu H; National Library of Medicine, National Center for Biotechnology Information, Bethesda, Maryland, United States., Trawick B; National Library of Medicine, National Center for Biotechnology Information, Bethesda, Maryland, United States., McVey J; National Library of Medicine, National Center for Biotechnology Information, Bethesda, Maryland, United States., Lemmon VP; Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States., Li Z; Bristol-Myers Squibb, Lead Discovery and Optimization, Princeton, New Jersey, United States., McManus O; Q-State Biosciences, Cambridge, Massachusetts, United States., Minor L; In Vitro Strategies, LLC, Flemington, New Jersey, United States., Napper A; FLX Bio, Inc., San Francisco, California, United States., Wildey MJ; Merck Research Laboratories, Kenilworth, New Jersey, United States., Pacifici R; CHDI Management, Inc./CHDI Foundation, Inc., Los Angeles, California, United States., Chin WW; Harvard Medical School, Boston, Massachusetts, United States., Xia M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Xu X; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Lal-Nag M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Michael S; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Inglese J; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States., Austin CP; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, United States.

المصدر: Clinical and translational science [Clin Transl Sci] 2018 Sep; Vol. 11 (5), pp. 461-470. Date of Electronic Publication: 2018 Jul 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review

بيانات الدورية: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci

مواضيع طبية MeSH: Drug Discovery*, Biological Assay/*methods, Geography ; High-Throughput Screening Assays ; Humans ; Translational Research, Biomedical