المؤلفون: Haiyan Zhao, Natalie Young, Jens Kalchschmidt, Jenna Lieberman, Laila El Khattabi, Rafael Casellas, Francisco J. Asturias

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/7934c13067644d569a269ff83cc26d9e

المؤلفون: Patrick R. Griffin, Nikoloz Shkriabai, Valentine V. Courouble, Arun S. Annamalai, Daniel Adu-Ampratwum, Parmit K. Singh, Ashwanth C. Francis, Naseer Iqbal, Guochao Wei, Peter Van Blerkom, James H. Morrison, Mamuka Kvaratskhelia, Eric M. Poeschla, Francisco J. Asturias, Gregory B. Melikyan, Alan Engelman, Haiyan Zhao, James R. Fuchs, S.M. Bester

المصدر: Science

مصطلحات موضوعية: Anti-HIV Agents, viruses, Protein domain, Human immunodeficiency virus (HIV), Crystallography, X-Ray, medicine.disease_cause, Article, Cofactor, 03 medical and health sciences, Capsid, Protein Domains, medicine, Humans, 030304 developmental biology, mRNA Cleavage and Polyadenylation Factors, 0303 health sciences, Multidisciplinary, biology, 030306 microbiology, Chemistry, Cryoelectron Microscopy, HEK 293 cells, Deuterium Exchange Measurement, Antiretroviral therapy, Cell biology, Chromatin, Nuclear Pore Complex Proteins, HEK293 Cells, HIV-1, biology.protein, Nuclear transport, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abba43ae87faf2e0bbf0e44fc51e8d1a
https://doi.org/10.1126/science.abb4808

المؤلفون: Rafael Casellas, Francisco J. Asturias, Laila El Khattabi, Natalie Young, Haiyan Zhao, Jens Kalchschmidt, Jenna Ariel Lieberman

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Saccharomyces cerevisiae Proteins, Molecular model, Science, General Physics and Astronomy, Repressor, RNA polymerase II, Saccharomyces cerevisiae, Protein Structure, Secondary, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Mediator, Cryoelectron microscopy, Transcription (biology), Cell Line, Tumor, Animals, Disease, Conserved Sequence, Mammals, Mediator Complex, Multidisciplinary, biology, Chemistry, Extramural, General Chemistry, Yeast, Cell biology, 030104 developmental biology, Mutation, biology.protein, Gene expression, Transcription, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafb245163184a84981e8e43bad748d5
https://doi.org/10.1038/s41467-021-21601-w

المؤلفون: Robert G. Roeder, Sai J. Ganesan, Miki Jishage, Xiaodi Yu, Andrej Sali, Yi Shi, Brian T. Chait, Wei Yi Chen, Francisco J. Asturias

المصدر: Nature structural & molecular biology
Nature structural & molecular biology, vol 25, iss 9
Nature Structural and Molecular Biology, vol 25, iss 9

مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, 1.1 Normal biological development and functioning, viruses, Biophysics, RNA polymerase II, Medical and Health Sciences, Article, Transcription Factors, TFII, 03 medical and health sciences, Mediator, Genetic, Underpinning research, Structural Biology, Transcription (biology), Genetics, Transcriptional regulation, Animals, Humans, Molecular Biology, Psychological repression, TFII, Binding Sites, biology, Chemistry, Cryoelectron Microscopy, Biological Sciences, Cell biology, Drosophila melanogaster, 030104 developmental biology, Gene Expression Regulation, Hela Cells, Chemical Sciences, biology.protein, Maternal to zygotic transition, Transcription factor II F, Generic health relevance, RNA Polymerase II, Transcription, Transcription factor II B, Transcription Factors, Developmental Biology, HeLa Cells

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1861467b409dbe786053fc2b400a085d
https://doi.org/10.1038/s41594-018-0118-5

المؤلفون: Rafael Casellas, Natalie Young, Jenna Ariel Lieberman, Francisco J. Asturias, Laila El Khattabi, Jens Kalchschmidt, Haiyan Zhao

مصطلحات موضوعية: Mediator, biology, Molecular model, Chemistry, Transcription (biology), biology.protein, Repressor, RNA polymerase II, Angstrom, Yeast, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::63ad0f5c6a1a81ffdf47f61489e3c381
https://doi.org/10.1101/2020.10.05.326918

المؤلفون: Natacha Opalka, Jesse Brown, William J Lane, Kelly-Anne F Twist, Robert Landick, Francisco J Asturias, Seth A Darst

المصدر: PLoS Biology, Vol 8, Iss 9, p e1000483 (2010)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20856905/pdf/?tool=EBI; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

URL الوصول: https://doaj.org/article/c02ae16cbc07446e81ced5aaa6ec2ae6

المؤلفون: Kuang-Lei Tsai, Francisco J. Asturias, Ying Zhang, Joan W. Conaway, Laurence Florens, Ronald C. Conaway, Sneha Gopalan, Kenji Murakami, Michael P. Washburn, Xiaodi Yu, Ti-Chun Chao

المصدر: Nature. 544:196-201

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Protein subunit, RNA polymerase II, Bioinformatics, Article, Structure-Activity Relationship, 03 medical and health sciences, Protein structure, Mediator, Transcription (biology), Schizosaccharomyces, Binding Sites, Mediator Complex, Multidisciplinary, General transcription factor, biology, Chemistry, Cryoelectron Microscopy, biology.organism_classification, Cell biology, Protein Subunits, 030104 developmental biology, Schizosaccharomyces pombe, biology.protein, RNA Polymerase II, Schizosaccharomyces pombe Proteins, Holoenzymes, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3bd1c6ac32af333bb8ad060f01014a
https://doi.org/10.1038/nature21393

المؤلفون: Anita Saraf, Chieri Tomomori-Sato, Francisco J. Asturias, Kuang-Lei Tsai, Shigeo Sato, Laurence Florens, Xiaodi Yu, Joan W. Conaway, Michael P. Washburn, Mihaela E. Sardiu, Ronald C. Conaway

المصدر: Journal of Biological Chemistry. 291:26886-26898

مصطلحات موضوعية: 0301 basic medicine, Saccharomyces cerevisiae Proteins, Transcription, Genetic, Protein Conformation, viruses, RNA polymerase II, Saccharomyces cerevisiae, Transcription coregulator, Biology, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, Mediator, Transcription (biology), Transcriptional regulation, Humans, Gene Regulation, Amino Acid Sequence, Binding site, Molecular Biology, RNA polymerase II holoenzyme, Binding Sites, Mediator Complex, Sequence Homology, Amino Acid, Cell Biology, Molecular biology, Cell biology, 030104 developmental biology, biology.protein, RNA Polymerase II, Transcription factor II D, Holoenzymes, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a319f82332bcaf97c33b30f8c5755dd0
https://doi.org/10.1074/jbc.m116.756098

المؤلفون: Solji Park, Kyong-Rim Kieffer-Kwon, Su-Chen Huang, Laila El Khattabi, Francisco J. Asturias, Erez Lieberman Aiden, Suhas S.P. Rao, Haiyan Zhao, Peter Van Blerkom, Jordan Krebs, Xiang Wang, Daniel Chauss, Nathanael Pruett, Subhash K. Tripathi, Marcelo A. Nobrega, Seolkyoung Jung, Philippe Kieffer-Kwon, Erica Sadler, Andrea Lopez, Noboru J. Sakabe, Rafael Casellas, Jens Kalchschmidt, Débora R. Sobreira, Natalie Young

المصدر: Cell. 178(5)

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, Saccharomyces cerevisiae Proteins, Chromosomal Proteins, Non-Histone, RNA polymerase II, Cell Cycle Proteins, Saccharomyces cerevisiae, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, 0302 clinical medicine, Mediator, Protein structure, Animals, Humans, Enhancer, Promoter Regions, Genetic, Protein Structure, Quaternary, Transcription factor, Cells, Cultured, 030304 developmental biology, Gene Editing, 0303 health sciences, Mediator Complex, biology, Eukaryotic transcription, Cryoelectron Microscopy, Promoter, Mouse Embryonic Stem Cells, Cell biology, Mice, Inbred C57BL, Enhancer Elements, Genetic, biology.protein, RNA Polymerase II, Degron, CRISPR-Cas Systems, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b089073935df12db018b793661a158
https://pubmed.ncbi.nlm.nih.gov/31442397

المؤلفون: Samuel Thompson, Haoran Li, Julia E. Page, Catherine L. Drennan, Edward J. Brignole, Nozomi Ando, Francisco J. Asturias, JoAnne Stubbe, Martin I. McLaughlin

المصدر: Biochemistry

مصطلحات موضوعية: 0301 basic medicine, Ribonucleotide, Stereochemistry, Protein subunit, Allosteric regulation, Random hexamer, Biology, Crystallography, X-Ray, Biochemistry, Deoxyribonucleotides, Protein Structure, Secondary, Article, 03 medical and health sciences, chemistry.chemical_compound, Deoxyadenine Nucleotides, Allosteric Regulation, X-Ray Diffraction, Oxidoreductase, Ribonucleotide Reductases, Scattering, Small Angle, Humans, chemistry.chemical_classification, Protein Structure, Tertiary, 3. Good health, 030104 developmental biology, Ribonucleotide reductase, chemistry, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d0597eeafca386478bf9c2261691c4
https://doi.org/10.1021/acs.biochem.5b01207