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1دورية أكاديمية
المؤلفون: Bharathi Balasubramanian, Vaclav Belak, Isha Verma, Yeva Prysiazhniuk, Frederick Sannajust, Elena S. Trepakova
المصدر: Toxicology Reports, Vol 6, Iss , Pp 305-320 (2019)
مصطلحات موضوعية: Toxicology. Poisons, RA1190-1270
وصف الملف: electronic resource
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المؤلفون: Xi Yang, Brian R. Berridge, Joseph C. Wu, Frederick Sannajust, Hong Shi, Philip T. Sager, Mathew Brock, Norman Stockbridge, Beverly Lyn-Cook, Najah Abi-Gerges, Li Pang
المصدر: Circulation Research. 125:855-867
مصطلحات موضوعية: Cardiotoxicity, Government, Cardiovascular safety, Physiology, business.industry, Pre-clinical development, White paper, Drug development, Risk analysis (engineering), Cardiotoxicities, Medicine, Cardiology and Cardiovascular Medicine, Risk assessment, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::41f220c1310ca8890788ecff775ced03
https://doi.org/10.1161/circresaha.119.315378 -
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المؤلفون: Frederick Sannajust, Bharathi Balasubramanian, Yeva Prysiazhniuk, Isha Verma, Elena Trepakova, Vaclav Belak
المصدر: Toxicology Reports, Vol 6, Iss, Pp 305-320 (2019)
Toxicology Reportsمصطلحات موضوعية: Drug, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Cell, 010501 environmental sciences, Toxicology, 01 natural sciences, Article, 03 medical and health sciences, 0302 clinical medicine, lcsh:RA1190-1270, Human induced pluripotent stem cell-derived cardiomyocytes, medicine, Staurosporine, Induced pluripotent stem cell, High content imaging, 0105 earth and related environmental sciences, media_common, lcsh:Toxicology. Poisons, biology, hiPSC-CMs, Chemistry, Fluorescence, Fibronectin, medicine.anatomical_structure, Cell culture, biology.protein, Biophysics, 030217 neurology & neurosurgery, medicine.drug
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المؤلفون: Jixin Wang, Armando Lagrutta, Frederick Sannajust, Holly Clouse, Haoyu Zeng
المصدر: Toxicological Sciences. 167:573-580
مصطلحات موضوعية: 0301 basic medicine, Induced Pluripotent Stem Cells, hERG, Drug Evaluation, Preclinical, Action Potentials, Tetrodotoxin, Pharmacology, Toxicology, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, medicine, Humans, Myocytes, Cardiac, Channel blocker, Calcium Signaling, Diltiazem, Cells, Cultured, Calcium channel opener, Voltage-dependent calcium channel, biology, Chemistry, Calcium channel, Calcium Channel Inhibition, Calcium Channel Blockers, Culture Media, 030104 developmental biology, Potassium, biology.protein, Verapamil, Calcium Channels, 030217 neurology & neurosurgery, Sodium Channel Blockers, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a0496ec1502cec63d4631efbab6d92
https://doi.org/10.1093/toxsci/kfy264 -
5
المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez
المصدر: Toxicology and Applied Pharmacology
مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization
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6
المؤلفون: Joseph J. DeGeorge, Hillary K. Regan, David B. Gilberto, Theodore J. Detwiler, Frederick Sannajust, Li Chen, Christopher P. Regan, Gary L. Stump
المصدر: Journal of Pharmacological and Toxicological Methods. 81:107-114
مصطلحات موضوعية: Male, Cardiac function curve, medicine.medical_specialty, Cardiotonic Agents, Drug-Related Side Effects and Adverse Reactions, Drug Evaluation, Preclinical, Hemodynamics, Blood Pressure, 030204 cardiovascular system & hematology, Toxicology, Models, Biological, Risk Assessment, 030226 pharmacology & pharmacy, Ventricular Function, Left, Electrocardiography, 03 medical and health sciences, Dogs, 0302 clinical medicine, Internal medicine, medicine, Animals, Telemetry, Pharmacology, Ejection fraction, medicine.diagnostic_test, business.industry, Safety pharmacology, Cardiac Pacing, Artificial, medicine.disease, Myocardial Contraction, Electrodes, Implanted, Pyridazines, Preload, Pimobendan, Anesthesia, Heart failure, Heart Function Tests, Cardiology, Safety, business, medicine.drug
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المؤلفون: Frederick Sannajust, Jeffery J. Travis, Pierre Morissette, Christopher P. Regan, Patrick Fanelli, Kevin Fitzgerald, S. Wang, Pamela Gerenser
المصدر: Journal of Pharmacological and Toxicological Methods. 81:171-182
مصطلحات موضوعية: Male, Xylazine, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Guinea Pigs, hERG, Drug Evaluation, Preclinical, Torsades de pointes, In Vitro Techniques, 030204 cardiovascular system & hematology, Toxicology, 030226 pharmacology & pharmacy, QT interval, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Torsades de Pointes, Internal medicine, medicine, Animals, Anesthesia, Ketamine, cardiovascular diseases, Pharmacology, Proarrhythmia, Anesthetics, Dissociative, biology, business.industry, Safety pharmacology, Arrhythmias, Cardiac, Heart, medicine.disease, Long QT Syndrome, Concomitant, cardiovascular system, biology.protein, Cardiology, business, Adrenergic alpha-Agonists, circulatory and respiratory physiology, medicine.drug
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8
المؤلفون: Armando Lagrutta, Maria I. Roman, Haoyu Zeng, E V Lis, Frederick Sannajust
المصدر: Journal of Pharmacological and Toxicological Methods. 81:217-222
مصطلحات موضوعية: 0301 basic medicine, Induced Pluripotent Stem Cells, hERG, Drug Evaluation, Preclinical, Dofetilide, 030204 cardiovascular system & hematology, Pharmacology, Toxicology, Ion Channels, Membrane Potentials, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Torsades de Pointes, medicine, Humans, Myocytes, Cardiac, Induced pluripotent stem cell, Ion channel, Membrane potential, biology, business.industry, Cardiac electrophysiology, Sotalol, Cardiovascular Agents, Heart, Cardiac action potential, Electrophysiological Phenomena, 030104 developmental biology, biology.protein, Calcium Channels, Safety, business, Central Nervous System Agents, medicine.drug
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المؤلفون: Haoyu Zeng, Holly Clouse, Jixin Wang, Frederick Sannajust, Armando Lagrutta
المصدر: JRSM Cardiovascular Disease, Vol 8 (2019)
مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, lcsh:Diseases of the circulatory (Cardiovascular) system, 030104 developmental biology, 0302 clinical medicine, lcsh:RC666-701, Stem cell, Repolarization reserve, Biology, Induced pluripotent stem cell, 030226 pharmacology & pharmacy, Cell biology
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المؤلفون: Jennifer B. Pierson, Armando Lagrutta, Holly Clouse, Michael Furniss, Ivan Kopljar, Frederick Sannajust, Ralf Kettenhofen, Haoyu Zeng, Hua Rong Lu, Karel Van Ammel, Fetene Tekle, Ard Teisman, Jin Zhai, Liang Guo, David J. Gallacher
المصدر: Toxicol Sci
مصطلحات موضوعية: 0301 basic medicine, Drug, Risk, media_common.quotation_subject, Torsades de pointes, 030204 cardiovascular system & hematology, Pharmacology, Toxicology, QT interval, Afterdepolarization, 03 medical and health sciences, 0302 clinical medicine, Emerging Technologies, Methods, and Models, Medicine, Myocyte, Humans, Myocytes, Cardiac, Cells, Cultured, media_common, Proarrhythmia, Dose-Response Relationship, Drug, business.industry, Stem Cells, Arrhythmias, Cardiac, medicine.disease, In vitro, Long QT Syndrome, 030104 developmental biology, Calcium, business, Plate reader
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4418e4a66a243ef3d4307d9ae9b7ee7
https://pubmed.ncbi.nlm.nih.gov/31020317
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