المؤلفون: da Costa Rodrigues K; Research Laboratory in Biochemical Pharmacology (LaFarBio), Neurobiotechnology Research Group (GPN), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), Campus Capão do Leão, Pelotas, RS, CEP 96010-900, Brazil., da Conceição Oliveira M; Research Laboratory in Biochemical Pharmacology (LaFarBio), Neurobiotechnology Research Group (GPN), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), Campus Capão do Leão, Pelotas, RS, CEP 96010-900, Brazil., Dos Santos BF; Laboratory of Organic Catalysis and Biocatalysis, Federal University of Grande Dourados, Dourados, MS, Brazil., de Campos Domingues NL; Laboratory of Organic Catalysis and Biocatalysis, Federal University of Grande Dourados, Dourados, MS, Brazil., Fronza MG; Graduate Program in Biotechnology (GPN), Technological Development Center, Federal University of Pelotas (UFPel), Pelotas, RS, CEP 96010-900, Brazil., Savegnago L; Graduate Program in Biotechnology (GPN), Technological Development Center, Federal University of Pelotas (UFPel), Pelotas, RS, CEP 96010-900, Brazil., Wilhelm EA; Research Laboratory in Biochemical Pharmacology (LaFarBio), Neurobiotechnology Research Group (GPN), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), Campus Capão do Leão, Pelotas, RS, CEP 96010-900, Brazil., Luchese C; Research Laboratory in Biochemical Pharmacology (LaFarBio), Neurobiotechnology Research Group (GPN), Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), Campus Capão do Leão, Pelotas, RS, CEP 96010-900, Brazil. cristiane_luchese@yahoo.com.br.

المصدر: Psychopharmacology [Psychopharmacology (Berl)] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE

المؤلفون: Fronza MG; Pharmacology Departament, Ribeirão Preto Medical School, University of São Paulo, São Paulo 14049-900, Brazil., Ferreira BF; Pharmacology Departament, Ribeirão Preto Medical School, University of São Paulo, São Paulo 14049-900, Brazil., Pavan-Silva I; Pharmacology Departament, Ribeirão Preto Medical School, University of São Paulo, São Paulo 14049-900, Brazil., Guimarães FS; Pharmacology Departament, Ribeirão Preto Medical School, University of São Paulo, São Paulo 14049-900, Brazil., Lisboa SF; Pharmacology Departament, Ribeirão Preto Medical School, University of São Paulo, São Paulo 14049-900, Brazil.; Biomolecular Sciences Department, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo 14040-903, Brazil.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 22; Vol. 29 (1). Date of Electronic Publication: 2023 Dec 22.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Nitric Oxide* , Stress Disorders, Post-Traumatic*, Humans ; Fear ; Glutamic Acid ; Neurotransmitter Agents ; Adaptor Proteins, Signal Transducing

المؤلفون: Fronza MG; Neurobiotechnology Research Group (GPN) - Centre for Technology Development CDTec, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil., Alves D; Laboratory of Clean Organic Synthesis (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), UFPel, RS, Brazil., Praticò D; Alzheimer's Center at Temple - ACT, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, United States., Savegnago L; Neurobiotechnology Research Group (GPN) - Centre for Technology Development CDTec, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil. Electronic address: luciellisavegnago@yahoo.com.br.

المصدر: Ageing research reviews [Ageing Res Rev] 2023 Sep; Vol. 90, pp. 102033. Date of Electronic Publication: 2023 Aug 16.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE

مواضيع طبية MeSH: Acetylcholinesterase* , Alzheimer Disease*, Humans ; Glycogen Synthase Kinase 3 beta ; Amyloid beta-Peptides ; Amyloid Precursor Protein Secretases ; Neurobiology ; Neuroinflammatory Diseases ; Aspartic Acid Endopeptidases

المؤلفون: Fronza MG; Neurobiotechnology Research Group (GPN) - Postgraduate Program of Biotechnology, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil., Sacramento M; Laboratory of Clean Organic Synthesis (LASOL), Postgraduate Program of Chemistry, UFPel, Pelotas, RS, Brazil., Alves D; Laboratory of Clean Organic Synthesis (LASOL), Postgraduate Program of Chemistry, UFPel, Pelotas, RS, Brazil., Praticò D; Alzheimer's Center at Temple - ACT, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA., Savegnago L; Neurobiotechnology Research Group (GPN) - Postgraduate Program of Biotechnology, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil. luciellisavegnago@yahoo.com.br.

المصدر: Molecular neurobiology [Mol Neurobiol] 2023 Mar; Vol. 60 (3), pp. 1733-1745. Date of Electronic Publication: 2022 Dec 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

مواضيع طبية MeSH: Depressive Disorder, Major*/pathology , Alzheimer Disease*/complications , Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism, Mice ; Animals ; Amyloid beta-Peptides/metabolism ; tau Proteins/metabolism ; Mice, Transgenic ; Neuroinflammatory Diseases ; Acetylcholinesterase/metabolism ; Triazoles/pharmacology ; Memory Disorders/complications ; Memory Disorders/drug therapy ; Memory Disorders/metabolism ; Hippocampus/metabolism ; Disease Models, Animal ; Amyloid beta-Protein Precursor/metabolism

المؤلفون: Fronza MG; Neurobiotechnology Research Group (GPN)-Centre for Technology Development CDTec, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil., Sacramento M; Laboratory of Clean Organic Synthesis (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), UFPel, RS, Brazil., Alves D; Laboratory of Clean Organic Synthesis (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), UFPel, RS, Brazil., Praticò D; Alzheimer's Center at Temple-ACT, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, USA. praticod@temple.edu., Savegnago L; Neurobiotechnology Research Group (GPN)-Centre for Technology Development CDTec, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil. lucielli@ufpel.edu.br.

المصدر: Neurochemical research [Neurochem Res] 2022 Apr; Vol. 47 (4), pp. 1110-1122. Date of Electronic Publication: 2022 Feb 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , tau Proteins*/metabolism, Acetylcholinesterase/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Phosphorylation ; Quinolines ; Triazoles/therapeutic use

المؤلفون: da Costa Rodrigues K; Postgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Research Group in Neurobiotechnology (GPN), Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), CEP 96010- 900, Pelotas, RS, Brazil., Leivas de Oliveira R; Postgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Research Group in Neurobiotechnology (GPN), Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), CEP 96010- 900, Pelotas, RS, Brazil., da Silva Chaves J; Postgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Research Group in Neurobiotechnology (GPN), Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), CEP 96010- 900, Pelotas, RS, Brazil., Esteves da Rocha VM; Postgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Research Group in Neurobiotechnology (GPN), Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), CEP 96010- 900, Pelotas, RS, Brazil., Fuzinato Dos Santos B; Laboratory of Organic Catalysis and Biocatalysis, Federal University of Grande Dourados (UFGD), 79825-070, Dourados, MS, Brazil., Fronza MG; Postgraduate Program in Biotechnology, GPN, Technological Development Center, UFPel, CEP, 96010-900, Pelotas, RS, Brazil., Luís de Campos Domingues N; Laboratory of Organic Catalysis and Biocatalysis, Federal University of Grande Dourados (UFGD), 79825-070, Dourados, MS, Brazil., Savegnago L; Postgraduate Program in Biotechnology, GPN, Technological Development Center, UFPel, CEP, 96010-900, Pelotas, RS, Brazil., Wilhelm EA; Postgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Research Group in Neurobiotechnology (GPN), Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), CEP 96010- 900, Pelotas, RS, Brazil. Electronic address: ethel.wilhelm@ufpel.edu.br., Luchese C; Postgraduate Program in Biochemistry and Bioprospecting, Research Laboratory in Biochemical Pharmacology (LaFarBio), Research Group in Neurobiotechnology (GPN), Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas (UFPel), CEP 96010- 900, Pelotas, RS, Brazil. Electronic address: cristiane.luchese@ufpel.edu.br.

المصدر: Chemico-biological interactions [Chem Biol Interact] 2022 Jan 05; Vol. 351, pp. 109736. Date of Electronic Publication: 2021 Nov 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

مواضيع طبية MeSH: Acetylcholinesterase/*metabolism , Amnesia/*drug therapy , Cholinesterase Inhibitors/*therapeutic use , Nootropic Agents/*therapeutic use , Sulfides/*therapeutic use , Thiadiazoles/*therapeutic use, Amnesia/chemically induced ; Animals ; Avoidance Learning/drug effects ; Cholinesterase Inhibitors/metabolism ; Male ; Maze Learning/drug effects ; Mice ; Molecular Docking Simulation ; Nootropic Agents/metabolism ; Protein Binding ; Scopolamine ; Sulfides/metabolism ; Thiadiazoles/metabolism

المؤلفون: Fronza MG; Neurobiotechnology Research Group (GPN) - Centre for Technology Development CDTec, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil., Baldinotti R; Neurobiotechnology Research Group (GPN) - Centre for Technology Development CDTec, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil., Fetter J; Neurobiotechnology Research Group (GPN) - Centre for Technology Development CDTec, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil., Rosa SG; Laboratory of Synthesis, Reactivity and Pharmacological and Toxicological Evaluation of Organocalcogens, Center for Natural and Exact Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil., Sacramento M; Laboratory of Clean Organic Synthesis (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), UFPel, RS, Brazil., Nogueira CW; Laboratory of Synthesis, Reactivity and Pharmacological and Toxicological Evaluation of Organocalcogens, Center for Natural and Exact Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil., Alves D; Laboratory of Clean Organic Synthesis (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), UFPel, RS, Brazil., Praticò D; Alzheimer's Center at Temple - ACT, Temple University, Lewis Katz School of Medicine, Philadelphia, PA, United States., Savegnago L; Neurobiotechnology Research Group (GPN) - Centre for Technology Development CDTec, Federal University of Pelotas (UFPel), Pelotas, RS, Brazil. Electronic address: luciellisavegnago@yahoo.com.br.

المصدر: Brain, behavior, and immunity [Brain Behav Immun] 2022 Jan; Vol. 99, pp. 177-191. Date of Electronic Publication: 2021 Oct 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

مواضيع طبية MeSH: Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/metabolism , Lipopolysaccharides*/metabolism , Lipopolysaccharides*/pharmacology, Acetylcholinesterase/metabolism ; Acetylcholinesterase/pharmacology ; Animals ; Blood-Brain Barrier/metabolism ; Depression/drug therapy ; Mice ; Microglia/metabolism ; NF-kappa B/metabolism ; Permeability ; Quinolines ; Triazoles

المؤلفون: Krüger R; Clean Organic Synthesis Laboratory - LASOL - CCQFA - Federal University of Pelotas - UFPel, CEP, 96010-900 Pelotas, RS, Brazil., Larroza A; Clean Organic Synthesis Laboratory - LASOL - CCQFA - Federal University of Pelotas - UFPel, CEP, 96010-900 Pelotas, RS, Brazil., Fronza MG; Neurobiotechnology Research Group - GPN, CDTec, Federal University of Pelotas, UFPel, CEP, 96010-900 Pelotas, RS, Brazil., Tisoco I; Chemistry Department, Bioinorganics and Porphyrinic Materials Laboratory, Federal University of Santa Maria, UFSM, CEP, 97105-900 Santa Maria, RS, Brazil., Savegnago L; Neurobiotechnology Research Group - GPN, CDTec, Federal University of Pelotas, UFPel, CEP, 96010-900 Pelotas, RS, Brazil., Reis JS; Institute of Chemistry, Fluminense Federal University, UFF, CEP, 24020-141 Niteroi, RJ, Brazil., Back DF; Chemistry Department, Inorganic Materials Laboratory, Federal University of Santa Maria, UFSM, CEP, 97105-900 Santa Maria, RS, Brazil., Iglesias BA; Chemistry Department, Bioinorganics and Porphyrinic Materials Laboratory, Federal University of Santa Maria, UFSM, CEP, 97105-900 Santa Maria, RS, Brazil., Alves D; Clean Organic Synthesis Laboratory - LASOL - CCQFA - Federal University of Pelotas - UFPel, CEP, 96010-900 Pelotas, RS, Brazil.

المصدر: The Journal of organic chemistry [J Org Chem] 2021 Dec 17; Vol. 86 (24), pp. 17866-17883. Date of Electronic Publication: 2021 Nov 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

مواضيع طبية MeSH: Serum Albumin, Bovine* , Thiadiazoles*, DNA ; Molecular Docking Simulation

المؤلفون: Bortolotto VC; Laboratório de Avaliações Farmacológicas e Toxicológicas aplicadas às Moléculas Bioativas - Unipampa, Universidade Federal do Pampa - Campus Itaqui, Itaqui, RS, Brazil. Electronic address: vandreza.bortolotto@gmail.com., Araujo SM; Laboratório de Avaliações Farmacológicas e Toxicológicas aplicadas às Moléculas Bioativas - Unipampa, Universidade Federal do Pampa - Campus Itaqui, Itaqui, RS, Brazil. Electronic address: araujofani@gmail.com., Pinheiro FC; Laboratório de Avaliações Farmacológicas e Toxicológicas aplicadas às Moléculas Bioativas - Unipampa, Universidade Federal do Pampa - Campus Itaqui, Itaqui, RS, Brazil. Electronic address: fcabralpinheiro@gmail.com., Poetini MR; Laboratório de Avaliações Farmacológicas e Toxicológicas aplicadas às Moléculas Bioativas - Unipampa, Universidade Federal do Pampa - Campus Itaqui, Itaqui, RS, Brazil. Electronic address: marciapoetini@gmail.com., Meichtry LB; Laboratório de Avaliações Farmacológicas e Toxicológicas aplicadas às Moléculas Bioativas - Unipampa, Universidade Federal do Pampa - Campus Itaqui, Itaqui, RS, Brazil. Electronic address: luanabm93@gmail.com., Fronza MG; Grupo de Pesquisa em Neurobiotecnologia - GPN, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil. Electronic address: nanaa.fronza@gmail.com., Boeira SP; Laboratório de Avaliações Farmacológicas e Toxicológicas aplicadas às Moléculas Bioativas - Unipampa, Universidade Federal do Pampa - Campus Itaqui, Itaqui, RS, Brazil. Electronic address: silvespeter@yahoo.com., Savegnago L; Grupo de Pesquisa em Neurobiotecnologia - GPN, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil. Electronic address: luciellisavegnago@yahoo.com.br., Prigol M; Laboratório de Avaliações Farmacológicas e Toxicológicas aplicadas às Moléculas Bioativas - Unipampa, Universidade Federal do Pampa - Campus Itaqui, Itaqui, RS, Brazil. Electronic address: marinaprigol@unipampa.edu.br.

المصدر: Journal of psychiatric research [J Psychiatr Res] 2021 Dec; Vol. 144, pp. 225-233. Date of Electronic Publication: 2021 Oct 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE

مواضيع طبية MeSH: Hypothyroidism*/complications , Hypothyroidism*/drug therapy , Memory Disorders*/complications , Memory Disorders*/etiology, Animals ; Female ; Flavonoids/metabolism ; Hippocampus ; Maze Learning ; Mice ; Molecular Docking Simulation

المؤلفون: Baldinotti R; Neurobiotechnology Research Group, Postgraduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil., Fronza MG; Neurobiotechnology Research Group, Postgraduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil., Fetter J; Neurobiotechnology Research Group, Postgraduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil., Silva L; Chemical Institute, Laboratory of Molecular Catalysis, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Bender CB; Technological Development Center, Division of Biotechnology, Molecular and Cellular Oncology Research Group and Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, Brazil., Lüdtke DS; Chemical Institute, Laboratory of Molecular Catalysis, Federal University of Rio Grande Do Sul, Porto Alegre, RS, Brazil., Seixas FK; Technological Development Center, Division of Biotechnology, Molecular and Cellular Oncology Research Group and Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, Brazil., Collares T; Technological Development Center, Division of Biotechnology, Molecular and Cellular Oncology Research Group and Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, Brazil., Alves D; Center for Chemical, Pharmaceutical and Food Sciences, Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, Brazil., Savegnago L; Neurobiotechnology Research Group, Postgraduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil. Electronic address: luciellisavegnago@yahoo.com.br.

المصدر: European journal of pharmacology [Eur J Pharmacol] 2021 Nov 05; Vol. 910, pp. 174499. Date of Electronic Publication: 2021 Sep 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*prevention & control , Glycosides/*pharmacology , Organoselenium Compounds/*pharmacology, Alzheimer Disease/chemically induced ; Alzheimer Disease/pathology ; Animals ; Cerebral Cortex/drug effects ; Cerebral Cortex/pathology ; Disease Models, Animal ; Glycosides/therapeutic use ; Hippocampus/drug effects ; Hippocampus/pathology ; Humans ; Infusions, Intraventricular ; Lipid Peroxidation/drug effects ; Male ; Mice ; Organoselenium Compounds/therapeutic use ; Oxidative Stress/drug effects ; Streptozocin/administration & dosage ; Streptozocin/toxicity