المؤلفون: Guckelberger P, Doughty BR, Munson G, Rao SSP, Tan Y, Cai XS, Fulco CP, Nasser J, Mualim KS, Bergman DT, Ray J, Jagoda E, Munger CJ, Gschwind AR, Sheth MU, Tan AS, Steinmetz LM, Lander ES, Meissner A, Aiden EL, Engreitz JM

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 12. Date of Electronic Publication: 2024 Jul 12.

نوع المنشور: Journal Article; Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Martyn GE; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA., Montgomery MT; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA., Jones H; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA., Guo K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA., Doughty BR; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Linder J; Calico Life Sciences, South San Francisco, CA, USA., Chen Z; Department of Computer Science, Stanford University, Stanford, CA, USA., Cochran K; Department of Computer Science, Stanford University, Stanford, CA, USA., Lawrence KA; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Munson G; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pampari A; Department of Computer Science, Stanford University, Stanford, CA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Present Address: Sanofi, Cambridge, MA, USA., Kelley DR; Calico Life Sciences, South San Francisco, CA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Kundaje A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Engreitz JM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Science and Engineering Initiative, Stanford Children's Health, Betty Irene Moore Children's Heart Center, Stanford, CA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 21. Date of Electronic Publication: 2023 Dec 21.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Weeks EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. eweeks@broadinstitute.org., Ulirsch JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.; Artificial Intelligence Laboratory, Illumina, Inc., San Diego, CA, USA., Cheng NY; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Trippe BL; Program in Computational & Systems Biology, MIT, Cambridge, MA, USA.; Computer Science & Artificial Intelligence Lab, MIT, Cambridge, MA, USA., Fine RS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Vertex Pharmaceuticals Incorporated, Boston, MA, USA., Miao J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA., Patwardhan TA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Statistics, Harvard University, Cambridge, MA, USA., Kanai M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, MGH, Boston, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Tashman KC; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aguet F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Li T; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; MD-PhD Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ordovas-Montanes J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Program in Immunology, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Smillie CS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Computational & Systems Biology, MIT, Cambridge, MA, USA., Biton M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, MGH, Boston, MA, USA.; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Department of Chemistry, MIT, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MMIT, Cambridge, MA, USA., Ananthakrishnan AN; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, MGH, Boston, MA, USA.; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Howard Hughes Medical Institute, MIT, Cambridge, MA, USA.; Genentech, San Francisco, CA, USA., Gupta RM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Cardiovascular Medicine and Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Lage K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Surgery, MGH, Boston, MA, USA., Ardlie KG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Hirschhorn JN; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA., Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA. finucane@broadinstitute.org.; Analytic and Translational Genetics Unit, MGH, Boston, MA, USA. finucane@broadinstitute.org.

المصدر: Nature genetics [Nat Genet] 2023 Aug; Vol. 55 (8), pp. 1267-1276. Date of Electronic Publication: 2023 Jul 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Multifactorial Inheritance*/genetics , Quantitative Trait Loci*/genetics, Humans ; Genome-Wide Association Study/methods ; Genetic Predisposition to Disease/genetics ; Phenotype ; Polymorphism, Single Nucleotide/genetics

المؤلفون: Iyer AR, Gurumurthy A, Kodgule R, Aguilar AR, Saari T, Ramzan A, Rausch D, Gupta J, Hall CN, Runge JS, Weiss M, Rahmat M, Anyoha R, Fulco CP, Ghobrial IM, Engreitz J, Cieslik MP, Ryan RJH

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 03. Date of Electronic Publication: 2023 May 03.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Bergman DT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Jones TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Liu V; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Ray J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jagoda E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Siraj L; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Biophysics Graduate Program, Harvard University, Cambridge, MA, USA., Kang HY; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA., Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kane M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rios A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Nguyen TH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Grossman SR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.

المصدر: Nature [Nature] 2022 Jul; Vol. 607 (7917), pp. 176-184. Date of Electronic Publication: 2022 May 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Enhancer Elements, Genetic*/genetics , Promoter Regions, Genetic*/genetics, Humans ; RNA/biosynthesis ; RNA/genetics ; Transcription Factors/metabolism

المؤلفون: Dahlqvist J; Center for Cell Circuits, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.; Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden., Fulco CP; Center for Cell Circuits, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.; Bristol Myers Squibb, Cambridge, MA 02142, USA., Ray JP; Center for Cell Circuits, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.; Systems Immunology, Benaroya Research Institute, Seattle, WA 98101, USA., Liechti T; ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20814, USA., de Boer CG; Klarman Cell Observatory, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Lieb DJ; Center for Cell Circuits, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Eisenhaure TM; Center for Cell Circuits, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Engreitz JM; Center for Cell Circuits, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA., Roederer M; ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20814, USA., Hacohen N; Center for Cell Circuits, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.

المصدر: Human molecular genetics [Hum Mol Genet] 2022 Jun 22; Vol. 31 (12), pp. 1946-1961.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Autoimmune Diseases*/genetics , Enhancer Elements, Genetic* , Receptors, IgG*/genetics, Binding Sites ; Genomics ; Genotype ; Humans

المؤلفون: Gazal S; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. gazal@usc.edu.; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. gazal@usc.edu.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. gazal@usc.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. gazal@usc.edu., Weissbrod O; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hormozdiari F; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dey KK; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jagadeesh KA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Weiner DJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shi H; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., O'Connor LJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pasaniuc B; Departments of Computational Medicine, Human Genetics, Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA., Price AL; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. aprice@hsph.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. aprice@hsph.harvard.edu.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. aprice@hsph.harvard.edu.

المصدر: Nature genetics [Nat Genet] 2022 Jun; Vol. 54 (6), pp. 827-836. Date of Electronic Publication: 2022 Jun 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genome-Wide Association Study*/methods , Polymorphism, Single Nucleotide*/genetics, Phenotype

المؤلفون: Oren Y; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Tsabar M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Cuoco MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Amir-Zilberstein L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cabanos HF; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Medicine, Harvard Medical School, Boston, MA, USA., Hütter JC; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hu B; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Tabaka M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Colgan W; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuevas BM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hurvitz SA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA., Slamon DJ; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA., Deik A; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Pierce KA; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Clish C; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Hata AN; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Medicine, Harvard Medical School, Boston, MA, USA., Zaganjor E; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Lahav G; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Politi K; Section of Medical Oncology, Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Yale Cancer Center, New Haven, CT, USA., Brugge JS; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. joan_brugge@hms.harvard.edu.; Ludwig Center at Harvard, Boston, MA, USA. joan_brugge@hms.harvard.edu., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com.

المصدر: Nature [Nature] 2021 Aug; Vol. 596 (7873), pp. 576-582. Date of Electronic Publication: 2021 Aug 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle*/drug effects , Cell Lineage*/drug effects, Neoplasm Recurrence, Local/*drug therapy , Neoplasm Recurrence, Local/*pathology , Neoplasms/*drug therapy , Neoplasms/*pathology, Antioxidants/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Clone Cells/drug effects ; Clone Cells/metabolism ; Clone Cells/pathology ; DNA Barcoding, Taxonomic ; Fatty Acids/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Lentivirus/genetics ; Neoplasm Recurrence, Local/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Oncogene Proteins/antagonists & inhibitors ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Transcription, Genetic/drug effects

المؤلفون: Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bergman DT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Guckelberger P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany., Doughty BR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Patwardhan TA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Statistics, Harvard University, Cambridge, MA, USA., Jones TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen TH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ulirsch JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA., Lekschas F; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Mualim K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Natri HM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Weeks EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Munson G; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kane M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kang HY; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA., Cui A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA., Ray JP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA., Eisenhaure TM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Collins RL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Dey K; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Pfister H; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Price AL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Epstein CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kundaje A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Daly MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Huang H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA. lander@broadinstitute.org.; Department of Biology, MIT, Cambridge, MA, USA. lander@broadinstitute.org.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. lander@broadinstitute.org.; Office of Science and Technology Policy, Executive Office of the President, White House, Washington, DC, USA. lander@broadinstitute.org., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.

المصدر: Nature [Nature] 2021 May; Vol. 593 (7858), pp. 238-243. Date of Electronic Publication: 2021 Apr 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease* , Genome-Wide Association Study*, Enhancer Elements, Genetic/*genetics , Genetic Variation/*genetics , Genome, Human/*genetics , Inflammatory Bowel Diseases/*genetics, Cell Line ; Chromosomes, Human, Pair 10/genetics ; Cyclophilins/genetics ; Dendritic Cells ; Female ; Humans ; Macrophages/metabolism ; Male ; Mitochondria/metabolism ; Organ Specificity/genetics ; Phenotype

المؤلفون: Bick AG; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Weinstock JS; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Nandakumar SK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Bao EL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA., Zekavat SM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Yale School of Medicine, New Haven, CT, USA., Szeto MD; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Liao X; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Leventhal MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chang K; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Laurie C; Department of Biostatistics, University of Washington, Seattle, WA, USA., Burugula BB; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Gibson CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Niroula A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lin AE; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Taub MA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Aguet F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ardlie K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Barnes KC; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; 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مؤلفون مشاركون: NHLBI Trans-Omics for Precision Medicine Consortium

المصدر: Nature [Nature] 2021 Mar; Vol. 591 (7851), pp. E27.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: PubMed not MEDLINE; MEDLINE