نتائج البحث - "Fusion/*metabolism"

المصدر: Nature communications, vol. 12, no. 1, pp. 3705
Nature communications, Vol. 12, no.1, p. 3705 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Oncogene Proteins, Fusion, General Physics and Astronomy, Kaplan-Meier Estimate, Proto-Oncogene Proteins c-fyn, Cohort Studies, Mice, 0302 clinical medicine, RNA-Seq, Receptor, Cancer genetics, Multidisciplinary, Forkhead Box Protein O1, Intracellular Signaling Peptides and Proteins, NF-kappa B, RNA-Binding Proteins, hemic and immune systems, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Sin3 Histone Deacetylase and Corepressor Complex, medicine.anatomical_structure, 030220 oncology & carcinogenesis, T-cell lymphoma, Adaptor Proteins, Signal Transducing/genetics, Adaptor Proteins, Signal Transducing/metabolism, Animals, Cell Line, Tumor, Cell Membrane/metabolism, DNA-Binding Proteins/genetics, DNA-Binding Proteins/metabolism, Forkhead Box Protein O1/genetics, Forkhead Box Protein O1/metabolism, Gene Expression Regulation, Neoplastic/genetics, Humans, Intracellular Signaling Peptides and Proteins/metabolism, Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics, Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism, Lymphoma, T-Cell, Peripheral/genetics, Lymphoma, T-Cell, Peripheral/metabolism, Lymphoma, T-Cell, Peripheral/pathology, Mice, Inbred C57BL, NF-kappa B/metabolism, Oncogene Proteins, Fusion/genetics, Oncogene Proteins, Fusion/metabolism, Proto-Oncogene Proteins c-fyn/genetics, Proto-Oncogene Proteins c-fyn/metabolism, RNA-Binding Proteins/genetics, RNA-Binding Proteins/metabolism, Receptors, Antigen, T-Cell/metabolism, Signal Transduction/genetics, Sin3 Histone Deacetylase and Corepressor Complex/genetics, Sin3 Histone Deacetylase and Corepressor Complex/metabolism, bcl-X Protein/antagonists & inhibitors, bcl-X Protein/metabolism, Signal transduction, Signal Transduction, Science, T cell, Receptors, Antigen, T-Cell, bcl-X Protein, Peripheral T-cell lymphoma not otherwise specified, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, FYN, medicine, Adaptor Proteins, Signal Transducing, Cell Membrane, T-cell receptor, Lymphoma, T-Cell, Peripheral, General Chemistry, medicine.disease, Lymphoma, 030104 developmental biology, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Cancer research, Ex vivo

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133ce4ef8eab96b32fc1be9ac3896731
https://doi.org/10.1038/s41467-021-24037-4

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6

TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases

المؤلفون: Rachel Deplus, Martine Duterque-Coquillaud, Anne Flourens, Edith Bonnelye, Nathalie Vanpouille, Tian V. Tian, Philippe Clézardin, Anais Fradet, Carine Delliaux, Xavier Leroy, Yvan de Launoit, Mathilde Bouchet, Arnauld Villers

المساهمون: Mécanismes de tumorigenèse et thérapies ciblées, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal (UdeM), Universitat Pompeu Fabra [Barcelona] (UPF), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Pôle de Biologie Pathologie Génétique [CHU Lille], This work was in part supported by the Centre national de la recherche scientifique (CNRS), Ligue nationale contre le Cancer (Comité du Pas-de-Calais), Institut national du cancer (INCa_4419), Institut Pasteur de Lille, Conseil Régional du Nord-Pas-de-Calais and Fondation pour la Recherche Médicale (FRM), Conseil Régional du Nord-Pas-de-Calais, Association pour la Recherche sur le Cancer (ARC), MINECO (Juan de la Cierva Postdoctoral Fellowship FJCI-2014-22946), ARTP (Association de Recherche sur les tumeurs de prostate)., Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161 (M3T), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Center for Genomic Regulation (CRG-UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Service d'urologie, Hôpital Huriez-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), We would like to thank M. Tardivel, A. Bongiovanni and E. Werkmeister from the BioImaging Center Lille Nord de France (BICeL) for their technical assistance, M. Canouil for his statistics advice, and M. Vernier for his bioinformatic advice and stimulating discussions. We would also like to thank the local Tumor Tissue Bank (Tumorothèque), Regional Reference Oncology Center (CRRC) (Head, Pr. M.C. Copin) in Lille, France.

المصدر: Cancer Letters
Cancer Letters, Elsevier, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
Cancer Letters, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Oncogene Proteins, Fusion, [SDV]Life Sciences [q-bio], MESH: Gene Expression Regulation, Neoplastic, Mice, SCID, urologic and male genital diseases, Fusion gene, MESH: Oncogene Proteins, Fusion/metabolism, Metastasis, Prostate cancer, 0302 clinical medicine, MESH: Animals, MESH: Mice, SCID, MESH: Osteoblasts/pathology, ComputingMilieux_MISCELLANEOUS, MESH: Prostatic Neoplasms/genetics, Endothelin-1, Bone metastasis, MESH: Prostatic Neoplasms/pathology, Tumor Burden, 3. Good health, Gene Expression Regulation, Neoplastic, Phenotype, Osteoblastic lesions, Oncology, 030220 oncology & carcinogenesis, PC-3 Cells, MESH: Bone Neoplasms/metabolism, MESH: Bone Neoplasms/secondary, MESH: PC-3 Cells, MESH: Endothelin-1/metabolism, Erg, MESH: Alkaline Phosphatase/metabolism, MESH: Cell Line, Tumor, Transplantation, Heterologous, MESH: Biomarkers, Tumor/genetics, MESH: Tumor Burden/genetics, Bone Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, MESH: Phenotype, TMPRSS2, MESH: Oncogene Proteins, Fusion/genetics, 03 medical and health sciences, Transcriptional regulation, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, MESH: Transplantation, Heterologous, MESH: Biomarkers, Tumor/metabolism, Osteoblasts, MESH: Alkaline Phosphatase/genetics, MESH: Humans, MESH: Prostatic Neoplasms/metabolism, Prostatic Neoplasms, Gene rearrangement, Alkaline Phosphatase, MESH: Bone Neoplasms/genetics, MESH: Osteoblasts/metabolism, medicine.disease, MESH: Male, Collagen Type I, alpha 1 Chain, TMPRSS2:ERG, 030104 developmental biology, MESH: Endothelin-1/genetics, Cancer research, Ectopic expression