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المؤلفون: G. J. Bijloo, Martens Bj, de Groot Mj, Nico P. E. Vermeulen, van Acker Fa
المساهمون: Medicinal chemistry, Molecular and Computational Toxicology
المصدر: de Groot, M J, Bijlo, G J, Martens, B J, Goeptar, A R & Vermeulen, N P E 1997, ' A refined substrate model for human cytochrome P450 2D6. ', SON Discussiegroep Farmacochemie, Lunteren, 14/04/97-15/04/97 .
SON Discussiegroep Farmacochemie, Lunteren
Chemical Research in Toxicology, 10, 41-48. American Chemical Society
de Groot, M J, Bijlo, G J, Martens, B J, van Acker, F A A & Vermeulen, N P E 1997, ' A refined substrate model for human cytochrome P450 2D6. ', Chemical Research in Toxicology, vol. 10, pp. 41-48 . https://doi.org/10.1021/tx960129f
Vrije Universiteit Amsterdamمصطلحات موضوعية: Models, Molecular, Steric effects, Aspartic Acid, Binding Sites, Protein Conformation, Stereochemistry, Mutagenesis, Substrate (chemistry), Heme, General Medicine, Gene mutation, Toxicology, Substrate Specificity, chemistry.chemical_compound, Cytochrome P-450 CYP2D6, chemistry, Aspartic acid, Humans, Moiety, Homology modeling, Oxidation-Reduction
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2
المساهمون: Medicinal chemistry, Molecular and Computational Toxicology
المصدر: van der Aar, E M, de Groot, M J, Bijloo, G J, van der Goot, H & Vermeulen, N P E 1996, ' Structure-activity relationships for the glutathione conjugation of 2-substituted 1-chloro-4-nitrobenzenes by rat glutathione S-transferase 4-4. ', Chemical Research in Toxicology, vol. 9, pp. 527-534 . https://doi.org/10.1021/tx9501391
Chemical Research in Toxicology, 9, 527-534. American Chemical Societyمصطلحات موضوعية: Steric effects, Chemistry, Stereochemistry, Substituent, General Medicine, Glutathione, Toxicology, Kinetic energy, Transition state, Rats, chemistry.chemical_compound, Structure-Activity Relationship, Reaction rate constant, Nucleophile, SDG 3 - Good Health and Well-being, Physical chemistry, Animals, Kappa, Nitrobenzenes, Software, Glutathione Transferase, Protein Binding
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3
المؤلفون: G. J. Bijloo, H. Van Der Goot, H. Timmerman, Aalt Bast
المصدر: Journal of Inorganic Biochemistry. 40:237-244
مصطلحات موضوعية: Steric effects, Xanthine Oxidase, Free Radicals, Stereochemistry, Phenanthroline, chemistry.chemical_element, Cytochrome c Group, Xanthine, Biochemistry, Redox, Inorganic Chemistry, chemistry.chemical_compound, Superoxides, Organometallic Compounds, Superoxide dismutase mimetics, biology, Superoxide Dismutase, Chemistry, Superoxide, Cytochrome c, Hydrogen Peroxide, Copper, Xanthines, biology.protein, Dismutase, Oxidation-Reduction, Phenanthrolines
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المؤلفون: S W Ellis, J. Mahling, G. M. Blackburn, F. E. Blaney, Martin S. Lennard, M. J. De Groot, N. P. E. Vermeulen, Tracy Lightfoot, M. J. Ackland, G. J. Bijloo, Geoffrey T. Tucker
المساهمون: Molecular and Computational Toxicology, Medicinal chemistry
المصدر: Xenobiotica, 30, 219-233. Informa Healthcare
Lightfoot, T, ellis, S W, Mahling, J, Acklands, M J, Blaney, F E, Bijloo, G J, de Groot, M J, Vermeulen, N P E, Blackburn, G M, Lennard, M S & Tucker, G T 2000, ' Regioselective hydroxylation of debrisoquine by cytochrome P450 2D6: implications for active site modelling ', Xenobiotica, vol. 30, pp. 219-233 . https://doi.org/10.1080/004982500237622مصطلحات موضوعية: CYP2D6, DNA, Complementary, Cytochrome, Stereochemistry, Health, Toxicology and Mutagenesis, Toxicology, Hydroxylation, digestive system, Biochemistry, chemistry.chemical_compound, Yeasts, Humans, skin and connective tissue diseases, Chromatography, High Pressure Liquid, Pharmacology, Binding Sites, biology, Active site, Cytochrome P450, Hydrogen Bonding, General Medicine, Debrisoquin, Kinetics, Debrisoquine, chemistry, Cytochrome P-450 CYP2D6, Models, Chemical, biology.protein, Microsome, Microsomes, Liver, Pharmacophore
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المؤلفون: I, Andreadou, E A, Rekka, V J, Demopoulos, G J, Bijloo, P N, Kourounakis
المصدر: Arzneimittel-Forschung. 47(5)
مصطلحات موضوعية: Male, Free Radicals, Anti-Inflammatory Agents, Non-Steroidal, In Vitro Techniques, Carrageenan, Ethylenediamines, Antioxidants, Rats, Inbred F344, Rats, Structure-Activity Relationship, Ethanolamines, Microsomes, Liver, Animals, Edema, Dimethyl Sulfoxide, Chromatography, Thin Layer, Lipid Peroxidation
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3bdf1780c8cb4792266b56b2664e84c5
https://pubmed.ncbi.nlm.nih.gov/9205779 -
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المؤلفون: F.A.A. van Acker, G. J. Bijloo, M.J. de Groot, C. Fonseca Guerra, J.G. Snijders, Nico P. E. Vermeulen
المساهمون: Rijksuniversiteit Groningen, Medicinal chemistry, Theoretical Chemistry, Molecular and Computational Toxicology
المصدر: de Groot, M J, Bijlo, G J, van Acker, F A A, Fonseca Guerra, C, Vermeulen, N P E & Snijders, J G 1997, ' Extension of a predictive substrate model for human cytochrome P450 2D6. ', Xenobiotica, vol. 27, pp. 357-368 . https://doi.org/10.1080/004982597240514
Xenobiotica, 27(4), 357-368
Xenobiotica, 27, 357-368. Informa Healthcareمصطلحات موضوعية: Models, Molecular, Cytochrome, Molecular model, Stereochemistry, Protein Conformation, Health, Toxicology and Mutagenesis, Toxicology, Biochemistry, Substrate Specificity, Hydroxylation, chemistry.chemical_compound, Cytochrome P-450 CYP2D6 Inhibitors, Humans, Enzyme Inhibitors, Pharmacology, biology, Cytochrome P450, Substrate (chemistry), Stereoisomerism, General Medicine, Small molecule, chemistry, Cytochrome P-450 CYP2D6, Pharmaceutical Preparations, biology.protein, Enantiomer, Human cytochrome
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المؤلفون: M J, de Groot, G J, Bijloo, K T, Hansen, N P, Vermeulen
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 23(6)
مصطلحات موضوعية: Structure-Activity Relationship, Cytochrome P-450 CYP2D6, Cytochrome P-450 Enzyme System, Dopamine Uptake Inhibitors, Predictive Value of Tests, Reproducibility of Results, Computer Simulation, Oxidation-Reduction, Piperazines, Mixed Function Oxygenases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1007073ef093591947aeca5536f4191c
https://pubmed.ncbi.nlm.nih.gov/7587951 -
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المؤلفون: J. F. Rodrigues de Miranda, J. van der Weide, P. C. Tepper, J. B. de Vries, A. S. Horn, A. P. Ijzerman, T. Bultsma, H. Timmerman, M. Th. M. Tulp, L. H. M. Janssen, D. de Kaste, K. J. H. van Buuren, W. Soudijn, H. J. Kloosterboer, E. W. Bergink, Joop C. van Oene, John W. Kebabian, B. Rademnker, A. Bast, K. Kramer, B. Rademaker, A. Bakri, G. M. J. BeijersberRen van Henegouwen, H. de Vries, J. Wilting, W. J. M. Underberg, R. W. Busker, G. M. J. Beijersbergen van Henesouwen, G. M. J. Beijersbergen van Henegouwen, M. de Zwart, H. van der Goot, G. M. Donne-Op den Kelder, G. J. Bijloo, E. E. J. Haaksma, J. Ch. Eriks, Y. Severne, V. Nerme, G. Vauquelin, R. Leurs, M. M. Mennen, J. F. Plantjé, J. C. Stoof, B. J. 't Hart, J. J. de Gier, R. v. d. Straat, T. Kulkons, A. J. J. Debets, J. de Vries, H. P. E. Verneulen, J. F. van der Werf, A. C. van der Kuyl, J. M. S. van Maanen, C. de Ruiter, P. R. Kootstra, J. Broersen, M. V. M. Lafleur, J. Retèl, H. M. Pinedo, K. Wezel, E. I. Bakker, M. Wolf, A. J. Beld, E. Mutschler
المصدر: Pharmaceutisch Weekblad. 7:293-300
مصطلحات موضوعية: Pharmacology, Pharmacology (medical)
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المؤلفون: H. Rollema, C. J. Grol, M. G. P. Feenstra, Joop C. van Oene, Hendrik A. Houwing, Alan S. Horn, A. P. Ijzerman, T. Bultsma, H. Timmerman, J. Zaagsma, M. van der Graaff, N. P. E. Vermeulen, R. P. Joeres, D. D. Breimer, A. Tsantili-Kakoulidou, F. van der Valk, R. F. Rekker, G. J. Bijloo, C. E. M. Zoetemelk, W. van Hoven, B. van Meeteren-Wālchli, A. van der Gen, G. R. Mohn, W. Buijs, W. Onkenhout, H. J. de Jong, A. A. Rog, C. A. M. van Ginneken, E. G. W. M. Lentjes, A. Bast, E. M. Savenije-Chapel, J. Noordhoek, A. J. Beld, J. F. Rodrigues de Miranda, W. F. van der Giesen, J. H. M. Dröge, J. Wilting, L. H. M. Janssen, J. G. C. van Amsterdam, K. J. H. van Buuren, H. J. A. Wijnne, M. R. A. Nolet, J. M. H. Kremer, G. Bakker, P. J. C. M. van der Heijden, M. W. G. van der Schaar, C. M. C. Bank, J. Ch. Eriks, H. -D. Gaisser, H. van der Goot, G. J. Sterk, F. M. Lock, J. de Vries, H. Mullink, L. van Bree, F. A. M. Redegeld, C. W. J. Grolleman, A. C. de Visser, J. G. C. Wolke, P. Buchan, J. W. Burns
المصدر: Pharmaceutisch Weekblad. 4:205-212
مصطلحات موضوعية: Pharmacology, Pharmacology (medical)
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المؤلفون: H. Timmerman, J. Wilting, M. Th. M. Tulp, J. Kelder, Pramod R. Saxena, J. M. van Nueten, W. J. Janssens, A. Bast, E. J. Freyne, A. H. M. Raeymaekers, J. van Gelder, M. G. Venet, V. K. Sipido, F. de Clerck, Guy van Lommen, Marcel de Bruvn, Marc Schroven, W. Wouters, B. Rademaker, Hans Rollema, Ray Booth, Neal Castagnoli, W. Timmerman, B. H. C. Westerink, J. B. de Vries, P. G. Tepper, A. S. Horn, I. M. Pirovano, P. J. M. van Galen, A. P. Ijzerman, W. Soudijn, A. H. Voorschuur, Anja Garritsen, Adriaan f. Ijzerman, G. J. Bijloo, H. van der Goot, A. J. van der Vlies, E. E. J. Haaksma, G. M. Donné-Op den Kelder, H. -P. Voss, W. Ravenek, P. Vernooijs, S. Ciere, C. J. Klaver, Luc Koymans, Joop H. van Lenthe, Ronald van de Straat, Nico P. E. Vermeulen, H. M. M. Bastiaans, K. Kramer, H. Dijkstra, C. G. W. C. Smink, G. R. M. M. Haenen, B. M. de Rooij, A. Convents, G. Vauquelin, J. F. Rodrigues de Miranda, R. Feifel, A. Aasen, C. Strohmann, R. Tacke, M. Waelbroeck, J. Christophe, G. Lambrecht, E. Mutschler, C. M. van Rijn, T. vd Velden, M. G. P. Feenstra, O. R. Hommes, W. Vleeming, R. Pijnenburg, H. H. van Rooij, J. Wemer, A. J. Porsius, S. P. van Helden, A. J. Claessens, M. J. van Drooge, A. C. A. Jansen, L. H. M. Janssen, P. P. Kelder, N. J. de Mol, K. J. Lusthot, W. Richter, D. de Kaste, H. J. A. Wynne, W. M. Blankesteijn, P. Grasveld, C. J. de Vos, J. S. de Graaf, C. J. Witmans, C. J. Grol, R. K. Wierenga, W. G. J. Hol, F. R. Opperdoes, A. van der Vliet, T. J. R. Tuinstra
المصدر: Pharmaceutisch Weekblad. 10:300-308
مصطلحات موضوعية: Pharmacology, Pharmacology (medical)
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