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1
المؤلفون: Kwai-Ming J. Cheung, Joanne E. Baxter, Andrew M. Fry, K. Boxall, Savade Solanki, Swen Hoelder, Tara Hardy, Paolo Innocenti, Lisa Pickard, Fiona C. Rowan, Corine Mas-Droux, G.W. Aherne, Maura Westlake, Richard Bayliss, Sharon Yeoh
المصدر: Journal of Medicinal Chemistry. 55:3228-3241
مصطلحات موضوعية: Protein-Serine-Threonine Kinases, Structural biology, Biochemistry, Chemistry, Drug Discovery, Molecular Medicine, Structure–activity relationship, Transferase, Phosphorylation, Stereoisomerism, NIMA-Related Kinases, Mitosis
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2
المؤلفون: John J. Caldwell, A. Donald, K. Taylor, Martin G. Rowlands, Garrett, T.G. Davies, T. McHardy, Ruth Ruddle, G.W. Aherne, Florence I. Raynaud, Ian Collins, Paul Workman, L.K. Hunter, Marcel L. Verdonk
المصدر: Journal of Medicinal Chemistry. 51:2147-2157
مصطلحات موضوعية: Models, Molecular, Purine, Magnetic Resonance Spectroscopy, Pyrimidine, Stereochemistry, Crystallography, X-Ray, Ligands, Chemical synthesis, Mass Spectrometry, Substrate Specificity, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Animals, Humans, Transferase, Pyrroles, Enzyme Inhibitors, Protein kinase B, chemistry.chemical_classification, Binding Sites, Molecular Structure, Kinase, Stereoisomerism, Cyclic AMP-Dependent Protein Kinases, In vitro, Pyrimidines, Enzyme, chemistry, Microsomes, Liver, Molecular Medicine, Proto-Oncogene Proteins c-akt, Chromatography, Liquid
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3
المؤلفون: S J Welsh, G.W. Aherne, Ann L. Jackman, S D Webley
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, Methyltransferase, Blotting, Western, Antineoplastic Agents, Transfection, Thymidylate synthase, Colony-Forming Units Assay, chemistry.chemical_compound, Tumor Cells, Cultured, Animals, Humans, Pyrophosphatases, chemistry.chemical_classification, Deoxyuridine Triphosphate, biology, Thymineless death, Reverse Transcriptase Polymerase Chain Reaction, Uracil, Regular Article, DNA, Thymidylate Synthase, Flow Cytometry, uracil misincorporation, dUTPase, ZD9331, Enzyme, Oncology, chemistry, Biochemistry, Enzyme inhibitor, dUTP, biology.protein, Quinazolines, Female, Growth inhibition, Deoxyuracil Nucleotides, Cell Division, DNA Damage
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4
المؤلفون: G.W. Aherne, Ann L. Jackman, Robert D. Ladner, Anthea Hardcastle, S D Webley
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, Lung Neoplasms, DNA Repair, Biological activity, Regular Article, Antineoplastic Agents, Apoptosis, Thymidylate Synthase, Biology, Thymidylate synthase, Deoxyuridine, chemistry.chemical_compound, Oncology, chemistry, Biochemistry, Enzyme inhibitor, DUTP pyrophosphatase, biology.protein, Quinazolines, Tumor Cells, Cultured, Humans, Triphosphatase, MTT assay, Pyrophosphatases, Intracellular
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5
المؤلفون: Sheela Rao, Timothy J. Price, David Cunningham, Paul Ross, Hugo Ford, L. Vernillet, G.W. Aherne, G. Gruia, A. Massey, T Benepal
المصدر: British Journal of Cancer
مصطلحات موضوعية: Adult, Male, Antimetabolites, Antineoplastic, Cancer Research, medicine.medical_specialty, Adolescent, medicine.medical_treatment, drug combination, Thiophenes, Adenocarcinoma, Neutropenia, Irinotecan, Gastroenterology, Lethargy, Pharmacokinetics, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Survival rate, Aged, Gastrointestinal Neoplasms, Chemotherapy, business.industry, raltitrexed, Regular Article, phase I, Middle Aged, medicine.disease, Antineoplastic Agents, Phytogenic, Surgery, Survival Rate, Treatment Outcome, Oncology, Quinazolines, Camptothecin, Female, business, pharmacokinetics, Raltitrexed, medicine.drug
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المؤلفون: CJ Medlow, Michael I. Walton, F Mitchell, Ann L. Jackman, G.W. Aherne, F. T. Boyle
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Renal function, Antineoplastic Agents, Pharmacology, Kidney, Mice, Route of administration, Bolus (medicine), Pharmacokinetics, Thymidylate synthase inhibitor, Internal medicine, medicine, Animals, Infusions, Intravenous, biology, Chemistry, Area under the curve, Thymidylate Synthase, Endocrinology, medicine.anatomical_structure, Oncology, Mice, Inbred DBA, Renal physiology, Quinazolines, biology.protein, Female, Injections, Intraperitoneal, Research Article, Glomerular Filtration Rate
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c41815301bd275e5e27d603ce7609a0
https://doi.org/10.1038/bjc.1998.707 -
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المؤلفون: S. Clinton, G.W. Aherne, M. Findlay, Anthea Hardcastle, David Cunningham, Gareth J. Morgan
المصدر: British Journal of Cancer
مصطلحات موضوعية: Male, Cancer Research, Pathology, medicine.medical_specialty, Antimetabolites, Antineoplastic, Methyltransferase, medicine.medical_treatment, Alpha interferon, Interferon alpha-2, Thymidylate synthase, In vivo, medicine, Biomarkers, Tumor, Humans, Aged, Randomized Controlled Trials as Topic, Chemotherapy, biology, Interferon-alpha, Thymidylate Synthase, Middle Aged, Prognosis, Recombinant Proteins, Neoplasm Proteins, Oncology, Fluorouracil, biology.protein, Immunohistochemistry, Female, Colorectal Neoplasms, Immunostaining, medicine.drug, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8947625bcb603af93d8cc020b263e07b
http://europepmc.org/articles/PMC2063401 -
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المؤلفون: G.W. Aherne, Florence I. Raynaud, Ann L. Jackman, Anthea Hardcastle
المصدر: Biochemical Pharmacology. 51:1293-1301
مصطلحات موضوعية: medicine.drug_class, Radioimmunoassay, Mice, Inbred Strains, Thiophenes, Pharmacology, Biochemistry, Antimetabolite, Thymidylate synthase, Mice, chemistry.chemical_compound, In vivo, Tumor Cells, Cultured, medicine, Animals, Thymine Nucleotides, IC50, Leukemia, Experimental, Dose-Response Relationship, Drug, biology, Dipeptides, Thymidylate Synthase, Deoxyuridine, chemistry, Antifolate, Quinazolines, biology.protein, Folic Acid Antagonists, L1210 cells, Growth inhibition, Deoxyuracil Nucleotides
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المؤلفون: Anthea Hardcastle, G.W. Aherne, M. Brown, Ann L. Jackman, W. Gibson, R. Kimbell, Lloyd R. Kelland, F. T. Boyle
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, Methyltransferase, Drug Resistance, Antineoplastic Agents, Receptors, Cell Surface, Thiophenes, Thymidylate synthase, Mice, Folic Acid, Thymidylate synthase inhibitor, Tumor Cells, Cultured, Animals, Humans, Thymine Nucleotides, Lymphocytes, Peptide Synthases, Leukemia L1210, Ovarian Neoplasms, chemistry.chemical_classification, biology, Lymphoblast, Folate Receptors, GPI-Anchored, Proteins, Thymidylate Synthase, Membrane transport, Molecular biology, Neoplasm Proteins, Kinetics, Methotrexate, Enzyme, Polyglutamic Acid, Oncology, chemistry, Biochemistry, Enzyme inhibitor, Cell culture, Quinazolines, biology.protein, Folic Acid Antagonists, Female, Carrier Proteins, Deoxyuracil Nucleotides, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7675553756c1543352f935dfa9cb33
https://doi.org/10.1038/bjc.1995.178 -
10
المؤلفون: G.W. Aherne, M J Cross, S.P. Joel, D J Chapman
المصدر: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 32:297-302
مصطلحات موضوعية: Morphine Derivatives, 030213 general clinical medicine, Chromatography, Chemistry, Metabolite, Clinical Biochemistry, Radioimmunoassay, 030209 endocrinology & metabolism, General Medicine, Morphine-6-glucuronide, Sensitivity and Specificity, 03 medical and health sciences, chemistry.chemical_compound, Specific radioimmunoassay, 0302 clinical medicine, Blood plasma, medicine, Humans, Hapten, Quantitative analysis (chemistry), Conjugate, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f141e1e65f4f2c1b4e46145d0c17696
https://doi.org/10.1177/000456329503200306