المؤلفون: Qilong Wang, Yanze Yang, Mei Du, Jinna Wei, Xianxian Zheng, Zhang Han, Erwei Liu, Xiumei Gao, Yuefei Wang, Patrick Kwabena Oduro

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 50-75 (2022)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: HFD, high-fat diet, Cys, cysteine, cGAS, cyclic GMP–AMP synthase, Review, Poly: I.C, polyinosinic-polycytidylic acid, SAVI, STING-associated vasculopathy with onset in infancy, Bioinformatics, PPI, protein–protein interface, TRAF6, tumor necrosis factor receptor-associated factor 6, TREX1, three prime repair exonuclease 1, STIM1, stromal interaction molecule 1, 0302 clinical medicine, AA, amino acids, GTP, guanosine triphosphate, MLKL, mixed lineage kinase domain-like protein, ICAM-1, intracellular adhesion molecule 1, Medicine, PDE3B/4, phosphodiesterase-3B/4, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, NF-κB, nuclear factor-kappa B, cGAMP, 2′,3′-cyclic GMP–AMP, NLRP3, NOD-, LRR- and pyrin domain-containing protein 3, 0303 health sciences, dsDNA, double-stranded DNA, TFAM, mitochondrial transcription factor A, Fatty liver, Damage-associated molecular patterns, IFNIC, interferon-inducible cells, CTD, C-terminal domain, Mitochondria, Crosstalk (biology), Cardiovascular diseases, SNPs, single nucleotide polymorphisms, 030220 oncology & carcinogenesis, Stimulator of interferon genes, AAD, aortic aneurysm and dissection, MI, myocardial infarction, IFNAR, interferon receptors, ER stress, CVDs, cardiovascular diseases, NASH, nonalcoholic steatohepatitis, Intracellular, CDG, c-di-GMP, NTase, nucleotidyltransferase, ATP, adenosine triphosphate, Ser, serine, mTOR, mammalian target of rapamycin, RM1-950, STING, stimulator of interferon genes, hSTING, human stimulator of interferon genes, AKT, protein kinase B, CDNs, cyclic dinucleotides, TLR, Toll-like receptors, ER, endoplasmic reticulum, 03 medical and health sciences, LBD, ligand-binding pocket, ROS, reactive oxygen species, YAP1, Yes-associated protein 1, IFN, interferon, ISGs, IRF-3-dependent interferon-stimulated genes, DAMPs, danger-associated molecular patterns, IFN-I, type 1 interferon, 030304 developmental biology, Inflammation, Ang II, angiotensin II, TNFα, tumor necrosis factor-alpha, business.industry, IRF3, interferon regulatory factor 3, CTT, C-terminal tail, Autophagy, TAK1, transforming growth factor β-activated kinase 1, Metabolic diseases, medicine.disease, HAQ, R71H-G230A-R293Q, IL, interleukin, mtDNA, mitochondrial DNA, AMPK, AMP-activated protein kinase, Sting, Apoptosis, TBK1, TANK-binding kinase 1, CBD, C-binding domain, LPS, lipopolysaccharides, NO2-FA, nitro-fatty acids, PKA, protein kinase A, NAFLD, nonalcoholic fatty liver disease, Therapeutics. Pharmacology, DsbA-L, disulfide-bond A oxidoreductase-like protein, business, Homeostasis, MST1, mammalian Ste20-like kinases 1, TM, transmembrane, STING, cGAS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf60046ceb32698b7a7ea7c3674b44
http://www.sciencedirect.com/science/article/pii/S2211383521001775

المؤلفون: Alice M. Banks, Colette J. Whitfield, Steven R. Brown, David A. Fulton, Sarah A. Goodchild, Christopher Grant, John Love, Dennis W. Lendrem, Jonathan E. Fieldsend, Thomas P. Howard

المصدر: Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 218-229 (2022)
Computational and Structural Biotechnology Journal

مصطلحات موضوعية: CoA, coenzyme A, RFU, relative fluorescence units, ATP, adenosine triphosphate, Mg, magnesium glutamate, Biophysics, CTP, cytidine triphosphate, Biochemistry, CFE, cell-free extract, OFAT, one-factor-at-a-time, Statistical engineering, Automation, GTP, guanosine triphosphate, NAD, nicotinamide adenine dinucleotide, Structural Biology, X-gal, 5-bromo-4-chloro-3-indolyl-β-D-galactopyranoside, Genetics, tRNA, transfer ribonucleic acid, RSM, Response Surface Model, Robustness, K-glutamate, potassium glutamate, 0802 Computation Theory and Mathematics, ComputingMethodologies_COMPUTERGRAPHICS, CFPS, cell-free protein synthesis, 0103 Numerical and Computational Mathematics, LB, lysogeny broth, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, PEP, phosphoenolpyruvate, Design of Experiments (DoE), PEG-8000, polyethylene glycol 8000, FEU, fluorescein equivalent units, Computer Science Applications, cAMP, cyclic adenosine monophosphate, NTP, nucleoside triphosphate, eGFP, enhanced green fluorescent protein, DTT, dithiothreitol, G-6-P, glucose-6-phosphate, 3-PGA, 3-phosphoglyceric acid, DSD, Definitive Screening Design, Cell-free protein synthesis (CFPS), UTP, uridine triphosphate, DoE, Design of Experiments, TP248.13-248.65, Research Article, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d8a1b131f6dc02f2654a6fd7aef7a7
http://www.sciencedirect.com/science/article/pii/S2001037021005213

المؤلفون: Kasper Hoebe, Shrinivas Bishu, John Y. Kao, Varsha Ganesan, Ankit Sharma, Yanfen Yang, Chang Zeng, Rodney D. Newberry, Sahiti Marella, Simon P. Hogan, Philip D. King, Ariel Munitz, Jazib Uddin, Taeko K. Noah, Lee A. Denson, Andrew R. Patterson, Simone Vanoni, Lisa Waggoner, Senad Divanovic, Paul S. Foster, Michael J. Rosen, S. M. S. Tomar

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)

مصطلحات موضوعية: CD4+ T Cells, mLN, mesenteric lymph node, Th, T-helper cell, Cell, RC799-869, mTORC1, Paired Immunoglobulin Receptor, PIR-B, paired immunoglobulin-like receptor B, GAP, GTPase-activating protein, Mice, PCR, polymerase chain reaction, ERK, extracellular signal-regulated kinase, GTP, guanosine triphosphate, RAR-related orphan receptor gamma, T-Lymphocyte Subsets, Interleukin 17, DEG, differentially expressed gene, LP, lamina propria, Intestinal Mucosa, Receptors, Immunologic, Receptor, Original Research, GFP, green fluorescent protein, Mice, Knockout, TNF, tumor necrosis factor, IBD, inflammatory bowel disease, Interleukin-17, Gastroenterology, DU, deep ulcer, ILC, innate lymphoid cell, mTORC1, mammalian target of rapamycin complex 1, Diseases of the digestive system. Gastroenterology, Colitis, Immunohistochemistry, mRNA, messenger RNA, Interleukin-10, iCD, ileal involvement Crohn’s disease, medicine.anatomical_structure, LILRB3, leukocyte immunoglobulin-like receptor subfamily B member 3, Disease Susceptibility, SHP, Src-homology region 2 domain-containing phosphatase, Signal Transduction, TSC, tuberous sclerosis, Cell Survival, T cell, Biology, Proinflammatory cytokine, Immunophenotyping, Immunomodulation, p-ERK, phosphorylated extracellular signal-regulated kinase, cCD, colonic-only involvement Crohn’s disease, medicine, CD, Crohn’s disease, Animals, IFN, interferon, Interleukin-7 receptor, RPKM, reads per kb of transcript, per million mapped reads, Hepatology, Gene Expression Profiling, Inflammatory Bowel Disease, ITIM, immunoreceptor tyrosine-based inhibitory motif, Inflammatory Bowel Diseases, Molecular biology, WT, wild-type, IL, interleukin, Disease Models, Animal, Gene Expression Regulation, TRM, tissue resident memory, Immunologic Memory, Biomarkers, Q, quartile

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bc9234d68120dd2171e099da6a99f4
http://europepmc.org/articles/PMC8531983

المؤلفون: Iulia Oancea, Andy Wu, Michael A. McGuckin, Sumaira Z. Hasnain, Rabina Giri, John D. Hooper, Veronika Schreiber, Brett C McWhinney, Julie M. Davies, Jakob Begun, Yonghua Sheng, David P. Fairlie, Saleh Y. Alabbas, Gregor Kijanka, Yaowu He, Ramya Movva, Andrew J. Lucke, Timothy H. Florin

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: rac1 GTP-Binding Protein, 0301 basic medicine, TGTP, thioguanine nucleotide triphosphate, TCF/LEF, T-cell factor/lymphoid enhancer factor, Colorectal cancer, MP, mercaptopurine, TGN, thioguanine nucleotides, medicine.disease_cause, Autophagy-Related Protein 7, Inflammatory bowel disease, BrdU, bromodeoxyuridine, Mice, chemistry.chemical_compound, AOM, azoxymethane, 0302 clinical medicine, GTP, guanosine triphosphate, GTPase, guanosine triphosphatase, DSS, dextran sodium sulfate, Intestinal Mucosa, Wnt Signaling Pathway, beta Catenin, Original Research, GDP, guanosine diphosphate, IBD, inflammatory bowel disease, Colon Cancer, Mercaptopurine, Dextran Sulfate, Gastroenterology, Wnt signaling pathway, Colitis, Atg7ΔIEC, intestinal epithelial cell–specific deletion of autophagy related 7 gene, Editorial, Gene Knockdown Techniques, CRC, colorectal cancer, 030211 gastroenterology & hepatology, Colon, β-Catenin, CAC, colitis-associated cancer, Azoxymethane, Mice, Transgenic, DAI, disease activity index scores, IMPDH, inosine-5′-monophosphate dehydrogenase, 03 medical and health sciences, Administration, Rectal, Anseriformes, medicine, Autophagy, Animals, Humans, lcsh:RC799-869, Thioguanine, IC50, inhibitory concentration of 50%, Hepatology, business.industry, Neuropeptides, Cancer, DMEM, Dulbecco modified Eagle medium, PBS-T, phosphate-buffered saline with 0.1% Tween-20, HCT116 Cells, medicine.disease, WT, wild-type, TG, thioguanine, 030104 developmental biology, chemistry, siRNA, small interfering RNA, Cancer research, BSA, bovine serum albumin, lcsh:Diseases of the digestive system. Gastroenterology, Caco-2 Cells, Colitis-Associated Neoplasms, business, Carcinogenesis, HPRT, hypoxanthine phosphoribosyltransferase gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f601ccce23a182b6171ce5a7c5598ec
http://www.sciencedirect.com/science/article/pii/S2352345X20300886

المؤلفون: Tingting Chen, Ancheng Shen, Ao Zhang, Chunyong Ding, Zilan Song

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PD-L1, programmed death ligand 1, TBK1, medicine.medical_treatment, ICI, immune checkpoint inhibitor, DC50, concentration for 50% degradation, Review, ACMA, 9-amino-6-chloro-2-methoxyacridine, PD-1, programmed death receptor 1, ULD, ubiquitin-like domain, Anti-tumor, ABZI, amidobenzimidazole, 0302 clinical medicine, GMP, guanosine monophosphate, LBD, ligand-binding domain, GTP, guanosine triphosphate, PRRs, pattern recognition receptors, Interferon, cAIMP, cyclic adenosine-inosine monophosphate, Medicine, CMA, 10-carboxymethyl-9-acridanone, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, ISG, interferon stimulated gene, MinEC5×, minimum effective concentration for inducing 5-fold luciferase activity, 0303 health sciences, KD, kinase domain, dsDNA, double-stranded DNA, MG, Mangostin, ITC, isothermal titration calorimetry, Immunogenicity, PBMCs, peripheral-blood mononuclear cells, MDCK, Madin–Darby canine kidney, PROTACs, proteolysis targeting chimeras, FAA, flavone-8-acetic acid, CTD, C-terminal domain, DMXAA, 5,6-dimethylxanthenone-4-acetic acid, DSDP, dispiro diketopiperzine, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, 030220 oncology & carcinogenesis, CDN, cyclic dinucleotide, QC, quinacrine, FP, fluorescence polarization, PDK1, 3-phosphoinositide-dependent protein kinase 1, Immunotherapy, Signal transduction, DCs, dendritic cells, CDA, cyclic diadenosine monophosphate (c-di-AMP), medicine.drug, Ntase, nucleotidyl transferase, ATP, adenosine triphosphate, CDG, cyclic diguanosine monophosphate (c-di-GMP), T cell, SDD, scaffold and dimerization domain, NF-κB, nuclear factor-κB, STING, stimulator of interferon genes, TNFRSF, tumor necrosis factor receptor superfamily, EM, cryo-electron microscopy, ER, endoplasmic reticulum, 03 medical and health sciences, MLK, mixed lineage kinase, Immune system, CBD, cyclic dinucleotide-binding domain, THIQCs, tetrahydroisoquinolone acetic acids, SAR, structure–activity relationship, HCQ, hydrochloroquine, ENPP1, ecto-nucleotide pyrophosphatase/phosphodiesterase, HTS, high throughput screening, 030304 developmental biology, MI, maximum induction, CXCL, chemokine (C-X-C motif) ligand, Innate immune system, PDE, phosphodiesterases, IO, immune-oncology, business.industry, IRF3, interferon regulatory factor 3, i.t., intratumoral, CTT, C-terminal tail, lcsh:RM1-950, BNBC, 6-bromo-N-(naphthalen-1-yl)benzo[d][1,3]dioxole-5-carboxamide, Chimeric antigen receptor, PPi, pyrophosphoric acid, Small molecule modulators, FDA, U.S. Food and Drug Administration, VHL, von Hippel–Lindau, lcsh:Therapeutics. Pharmacology, AMP, adenosine monophosphate, TBK1, TANK-binding kinase 1, Cancer research, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, business, cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase, CTLA-4, cytotoxic T lymphocyte associated protein 4, cGAS, STING

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c604607610f05b2d37da5b2cce00382
http://www.sciencedirect.com/science/article/pii/S2211383519316946

المؤلفون: Götte, Martin^Aff3, Lazar, Thomas^Aff3, Yoo, Jin-San^Aff3, Scheglmann, Dietrich^Aff3, Gallwitz, Dieter^Aff3

المساهمون: Hilderson, Herwig, editor^Aff1, Fuller, Stephen, editor^Aff2

المصدر: Fusion of Biological Membranes and Related Problems. 34:133-173

المؤلفون: Hossam M. Abdallah, Gamal A. Mohamed, Ali M. El-Halawany, Martin K. Safo, Noura A. Hassan, Hany M. El-Bassossy

المصدر: Journal of Advanced Research, Vol 24, Iss, Pp 273-279 (2020)
Journal of Advanced Research

مصطلحات موضوعية: 0301 basic medicine, MDL, cis-N-(2-Phenylcyclopentyl)azacyclotridec-1-en-2-amine.HCl (MDL-12, 330A), AC, adenylate cyclase, Vasodilation, Pharmacology, 0302 clinical medicine, GTP, guanosine triphosphate, Vasodilator, NOS, nitric oxide synthase, CaM, calmodulin, lcsh:R5-920, Multidisciplinary, biology, Chemistry, eNOS, endothelial nitric oxide synthase, Depolarization, Ca2+, calcium, L-NAME, Nω-nitro-L-arginine methyl ester, Endothelial nitric oxide, Nitric oxide synthase, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Hypertension, lcsh:Medicine (General), VSMCs, vascular smooth muscle cells, PI3K, phosphoinositide 3-kinase, medicine.drug, TEA, tetraethylammonium chloride, Endothelium, Adenylate kinase, Cyclase, PP, Psiadia punctulata, Article, 03 medical and health sciences, medicine, CaMKII, Ca2+/calmodulin-dependent protein kinase II, lcsh:Science (General), Phenylephrine, ComputingMethodologies_COMPUTERGRAPHICS, Psiadia punctulata, Flavonoids, NO, nitric oxide, PE, phenylephrine, ODQ, 1H-(1,2,4)-oxadiazolo(4,3-a)quinoxalin-1-one, Calcium channel, MAPP, methanol extract from aerial parts of Psiadia punctulata, 030104 developmental biology, biology.protein, cGMP, cyclic guanosine monophosphate, PKG, protein kinase G, lcsh:Q1-390

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e154d40b7f6c70738bd46a118a460f
http://www.sciencedirect.com/science/article/pii/S2090123220300023

المؤلفون: Christoph Wittich, Claus A. M. Seidel, Radovan Dvorsky, Soheila Rezaei Adariani, Farhad Bazgir, Ehsan Amin, Mohammad Reza Ahmadian, Neda S. Kazemein Jasemi

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, RIT, RAS-like protein expressed in many tissues, GTPase-activating protein, HRAS, Harvey rat sarcoma, GTPase, RALA, RAS-like protein A, RASD, dexamethasone-induced RAS-related, Biochemistry, protein interactions, RA, RAS association domain, RB, RAS-binding domain, NORE-1, GAP, GTPase-activating protein, ERK, extracellular signal-regulated kinase, GTP, guanosine triphosphate, GTPase, guanosine triphosphatase, RASSF, RAS association domain family, RAF, rapidly accelerated fibrosarcoma, biology, PLCε, phospholipase C epsilon, RAS association domain, HK1, hexokinase-1, RIN, RAS and RAB interactor, CR domain, cysteine-rich domain, RALA, TIAM, T-lymphoma invasion and metastasis protein, RERGL, RAS-related and estrogen-regulated growth inhibitor-like protein, RHEB, RAS homologous enriched in brain, RAP, RAS proximate, Guanine nucleotide exchange factor, PI3K, phosphoinositide 3-kinase, RHEB, Research Article, effectors, Protein Binding, Signal Transduction, SHANK, SH3 and multiple ankyrin repeat domain, RHO, RAS homologous, RGS, regulator of G protein signaling, AF6, ALL1-fused gene from chromosome 6, Computational biology, PDZGEF, PDZ-domain-containing guanine nucleotide exchange factor, Protein–protein interaction, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, Regulator of G protein signaling, RRAS, RAS-related protein, NKIRAS, NF-kappa-B inhibitor-interacting RAS-like protein, NRAS, neuroblastoma RAS, PKC, protein kinase C, RAS, rat sarcoma, RERG, RAS-related and estrogen-regulated growth inhibitor, Humans, Protein Interaction Domains and Motifs, HRAS, SIN1, stress-activated protein kinase-interacting protein 1, Molecular Biology, RALGDS, RAL guanine nucleotide dissociation stimulator, KRAS, Kristen rat sarcoma, 030102 biochemistry & molecular biology, SARAH, Salvador–RASSF–Hippo domain, Tumor Suppressor Proteins, Computational Biology, Cell Biology, NORE1, novel RAS effector, RAS-binding domain, 030104 developmental biology, HEK293 Cells, MBP, maltose binding protein, RGL, RAL guanine nucleotide dissociation stimulator-like, MEK, MAPK/ERK kinase, biology.protein, ras Proteins, RASSF5, SNX17, sorting nexin-17, RASSF1, Apoptosis Regulatory Proteins, RASSF, MAPK, mitogen-activated protein kinase, RAS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c908bf66f01ab88e26b2531338812873
http://europepmc.org/articles/PMC8163975

المؤلفون: J.L. Gray, Christina Bitsina, Frank von Delft, Paul Brennan, Andrew P. Thompson

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, aPKC, atypical protein kinase, dedicator of cytokinesis (DOCK), GTPase, Biology, guanosine triphosphate (GTP), Ras homologous (RHO) small GTPases, AD, Alzheimer’s disease, Biochemistry, PAK, p21-activated kinase, drug discovery, GTP Phosphohydrolases, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, GTP, guanosine triphosphate, APP, amyloid precursor protein, DOCK, Catalytic Domain, MRCK, myotonic dystrophy kinase-related CDC42-binding kinase, guanine nucleotide exchange factor, cell signaling, structural biology, Cytoskeleton, Molecular Biology, GDP, guanosine diphosphate, 030102 biochemistry & molecular biology, Drug discovery, DHR2 domain, JBC Reviews, GDI, GDP dissociation inhibitor, Cell Biology, CDOCK, dedicator of cytokinesis, Cell biology, 030104 developmental biology, Structural biology, Guanine nucleotide exchange factor, Cytokinesis, Rho Guanine Nucleotide Exchange Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a6616905efc2a2ef77da8d684aca0b
http://europepmc.org/articles/PMC8063744

المؤلفون: Tessa R. Young, Evelyne Deery, Anastasia Cooke, Martin J. Warren, Deenah Osman, Nigel J. Robinson

المصدر: Biochimica et Biophysica Acta. Molecular Cell Research

مصطلحات موضوعية: Coenzymes, Cobamide, Review, sensors, Ligands, 01 natural sciences, chemistry.chemical_compound, GTP, guanosine triphosphate, polycyclic compounds, Homeostasis, OM, outer membrane, GDP, guanosine diphosphate, 0303 health sciences, RND, resistance nodulation division, biology, Chelation, ABC, ATP-binding cassette, Corrin, NiCoT, nickel/cobalt transporter, Cobalt, Cobalamin, MeCbl, methylcobalamin, Vitamin B 12, CoA, co-enzyme A, Biochemistry, Metals, Biosynthetic process, RBS, ribosome binding site, Corrinoids, ATP, Adenosine triphosphate, inorganic chemicals, Cobalamin biosynthesis, TCA, tricarboxylic acid, chemistry.chemical_element, 010402 general chemistry, Cofactor, AqCbl, aquacobalamin, 03 medical and health sciences, ROS, reactive oxygen species, Bacterial Proteins, AdoCbl, adenosylcobalamin, Animals, Humans, Vitamin B12, Symbiosis, Molecular Biology, 030304 developmental biology, SBP, substrate-binding protein, nutritional and metabolic diseases, MFS, major facilitator superfamily, Cell Biology, Tetrapyrrole, 0104 chemical sciences, ECF, Electron-coupled factor, MCM, methylmalonyl-CoA mutase, chemistry, Tetrapyrroles, biology.protein, GC–MS, gas chromatography–mass spectrometry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ace2dec5de2d9cde658800a4c92af8b
http://europepmc.org/articles/PMC7689651