المؤلفون: Craig S. Harris, Isabelle Cardinaud, Feriel Hacini-Rachinel, Nicolas Rodeville, Audrey Beillard, Arnaud Reitz, Marilyne Bourotte, Benoit Deprez, Laetitia Bonnary, Catherine Comino, Corinne Millois, Delphine Spiesse, Claire Bouix-Peter, Denis Duvert, Jean-Guy Boiteau, Jean-Marie Arlabosse, Yushma Bhurruth-Alcor, Anne-Pascale Luzy, Laurent F. Hennequin, Gaëlle Polge, Emmanuel Vial, Loïc Tomas, Samuel Tabet, Kevin Reverse, Arnaud Mathieu, Artur Pinto, Angélique Feret, Karine Bouquet, Gilles Ouvry, Stéphanie Astri, Nicolas Orsini, Jonathan Pascau, Nathalie Taquet, David Piwnica, Patricia Rossio

المصدر: Bioorganic & Medicinal Chemistry. 26:945-956

مصطلحات موضوعية: 0301 basic medicine, Process development, Administration, Topical, Clinical Biochemistry, Druggability, Pharmaceutical Science, Topical treatment, ADAM17 Protein, Pharmacology, Hydroxamic Acids, Skin Diseases, 01 natural sciences, Biochemistry, Mice, 03 medical and health sciences, In vivo, Psoriasis, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Mice, Hairless, Sulfonamides, Tumor Necrosis Factor-alpha, 010405 organic chemistry, Chemistry, Organic Chemistry, Oxazolone, medicine.disease, Tace inhibitor, 0104 chemical sciences, 030104 developmental biology, Solubility, Drug Design, Microsomes, Liver, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4758b7574647be3dbf23c8335599b665
https://doi.org/10.1016/j.bmc.2017.07.054

المؤلفون: Arnaud Reitz, Corinne Millois, Marilyne Bourotte, Feriel Hacini-Rachinel, Carine Rosignoli, Arnaud Mathieu, Sandrine Chambon, Denis Duvert, Anne-Pascale Luzy, Laetitia Bonnary, Gwenaëlle Duvert, Gilles Ouvry, Jonathan Pascau, Craig S. Harris, Benoit Deprez, Laurent F. Hennequin, Catherine Comino, Yushma Bhurruth-Alcor, Yaël Berton, Nathalie Taquet, Claire Bouix-Peter, Gaëlle Polge, Kevin Reverse, Artur Pinto, Karine Bouquet

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1848-1853

مصطلحات موضوعية: 0301 basic medicine, Cellular activity, Side effect, Administration, Topical, Clinical Biochemistry, Pharmaceutical Science, Context (language use), ADAM17 Protein, Pharmacology, Hydroxamic Acids, 01 natural sciences, Biochemistry, 03 medical and health sciences, Psoriasis, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Molecular Biology, Tumor necrosis factor α, ADME, chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, medicine.disease, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6d576b781466f2d73bb18129c36d97
https://doi.org/10.1016/j.bmcl.2017.02.035

المؤلفون: Romain Pierre, Etienne Thoreau, Catherine Raffin, Claire Bouix-Peter, Laurent Chantalat, Gaëlle Polge, Jonathan Pascau, Gilles Ouvry, Nathalie Taquet, Catherine Comino, Denis Duvert, Danielle Orfila, Agnès Perrin, Yves Rival, Laurent Francois Andre Hennequin, Laurent Lamy, Christophe Feret, Branislav Musicki, Veronique Parnet, Anne-Pascale Luzy, Olivier Christin, Fabrice Ciesielski, Craig S. Harris

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:5802-5808

مصطلحات موضوعية: 0301 basic medicine, Indazoles, Drug Inverse Agonism, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Topical treatment, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Humans, Inverse agonist, Molecular Biology, Organic Chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, Molecular Docking Simulation, 030104 developmental biology, Nuclear receptor, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af63284f22f668869fc68a5936ba38ec
https://doi.org/10.1016/j.bmcl.2016.10.023