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المؤلفون: Altincekic N; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany., Jores N; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany., Löhr F; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.; Institute of Biophysical Chemistry, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany., Richter C; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany., Ehrhardt C; Department of Biochemistry, University of Zurich, 8093 Zurich, Switzerland., Blommers MJJ; SavernaTherapeutics, 4105 Biel-Benken, Switzerland., Berg H; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany., Öztürk S; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany., Gande SL; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany., Linhard V; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany., Orts J; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria., Abi Saad MJ; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria., Bütikofer M; Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, ETH Zurich, 8093 Zürich, Switzerland., Kaderli J; Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, ETH Zurich, 8093 Zürich, Switzerland., Karlsson BG; Swedish NMR Centre, Department of Chemistry and Molecular Biology, University of Gothenburg, SE40530 Göteborg, Sweden.; SciLifeLab, University of Gothenburg, SE40530 Göteborg, Sweden., Brath U; Swedish NMR Centre, Department of Chemistry and Molecular Biology, University of Gothenburg, SE40530 Göteborg, Sweden., Hedenström M; Swedish NMR Centre, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden., Gröbner G; Swedish NMR Centre, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden., Sauer UH; Protein Production Sweden, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden., Perrakis A; Oncode Institute and Division of Biochemistry, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands., Langer J; Max Planck Institute of Biophysics, D-60438 Frankfurt am Main, Germany., Banci L; Magnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.; Consorzio Interuniversitario Risonanze Magnetiche Metalloproteine, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy., Cantini F; Magnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.; Consorzio Interuniversitario Risonanze Magnetiche Metalloproteine, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy., Fragai M; Magnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.; Consorzio Interuniversitario Risonanze Magnetiche Metalloproteine, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy., Grifagni D; Magnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy., Barthel T; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, D-12489 Berlin, Germany., Wollenhaupt J; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, D-12489 Berlin, Germany., Weiss MS; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, D-12489 Berlin, Germany., Robertson A; NIH, LCP NIDDK, Bethesda, Maryland 20892, United States., Bax A; NIH, LCP NIDDK, Bethesda, Maryland 20892, United States., Sreeramulu S; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany., Schwalbe H; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.

المصدر: ACS chemical biology [ACS Chem Biol] 2024 Feb 16; Vol. 19 (2), pp. 563-574. Date of Electronic Publication: 2024 Jan 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*/methods , SARS-CoV-2*/metabolism, Catalytic Domain ; Magnetic Resonance Spectroscopy ; Peptide Hydrolases/metabolism ; Protease Inhibitors/metabolism ; Antiviral Agents/pharmacology ; Molecular Docking Simulation

المؤلفون: Tröster A; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., DiPrima M; Laboratory of Cellular Oncology Center for Cancer Research (CCR), National Cancer Institute (NCI), 37 Convent Drive, NIH Bethesda Campus Building 37, Room 4124, Bethesda, MD 20892, USA., Jores N; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Kudlinzki D; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Sreeramulu S; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Gande SL; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Linhard V; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Ludig D; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Schug A; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Saxena K; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Reinecke M; Chair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354, Freising, Germany.; German Cancer Consortium (DKTK), Partner-Site Munich and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Heinzlmeir S; Chair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354, Freising, Germany., Leisegang MS; Institute for Cardiovascular Physiology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Wollenhaupt J; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489, Berlin, Germany., Lennartz F; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489, Berlin, Germany., Weiss MS; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489, Berlin, Germany., Kuster B; Chair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354, Freising, Germany.; German Cancer Consortium (DKTK), Partner-Site Munich and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354, Freising, Germany., Tosato G; Laboratory of Cellular Oncology Center for Cancer Research (CCR), National Cancer Institute (NCI), 37 Convent Drive, NIH Bethesda Campus Building 37, Room 4124, Bethesda, MD 20892, USA., Schwalbe H; Center for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

المصدر: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Apr 21; Vol. 29 (23), pp. e202203967. Date of Electronic Publication: 2023 Mar 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE

مواضيع طبية MeSH: Pyrazoles*/chemistry , Colorectal Neoplasms*/drug therapy, Humans ; Pyrimidines/pharmacology ; Pyrimidines/chemistry ; Cell Line ; Cell Line, Tumor

المؤلفون: Tannenberg R; Federal Institute for Materials Research and Testing (BAM), Richard-Willstätter-Strasse 11, 12489 Berlin, Germany., Paul M; Federal Institute for Materials Research and Testing (BAM), Richard-Willstätter-Strasse 11, 12489 Berlin, Germany., Röder B; Federal Institute for Materials Research and Testing (BAM), Richard-Willstätter-Strasse 11, 12489 Berlin, Germany., Gande SL; Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Sreeramulu S; Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Saxena K; Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Richter C; Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Schwalbe H; Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Swart C; National Metrology Institute (PTB), Bundesallee 100, 38116 Braunschweig, Germany., Weller MG; Federal Institute for Materials Research and Testing (BAM), Richard-Willstätter-Strasse 11, 12489 Berlin, Germany.

المصدر: Biosensors [Biosensors (Basel)] 2023 Apr 03; Vol. 13 (4). Date of Electronic Publication: 2023 Apr 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Pub Country of Publication: Switzerland NLM ID: 101609191 Publication Model: Electronic Cited Medium: Internet ISSN: 2079-6374 (Electronic) Linking ISSN: 20796374 NLM ISO Abbreviation: Biosensors (Basel) Subsets: MEDLINE

مواضيع طبية MeSH: Biosensing Techniques* , Myocardial Infarction*/diagnosis, Humans ; Troponin I ; Luminescence ; Immunoassay ; Biomarkers

المؤلفون: Heering J; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, 60596Frankfurt, Germany., Jores N; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany., Kilu W; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438Frankfurt, Germany., Schallmayer E; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438Frankfurt, Germany., Peelen E; Immunic AG, 82166Gräfelfing, Germany., Muehler A; Immunic AG, 82166Gräfelfing, Germany., Kohlhof H; Immunic AG, 82166Gräfelfing, Germany., Vitt D; Immunic AG, 82166Gräfelfing, Germany., Linhard V; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany., Gande SL; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany., Chaikuad A; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438Frankfurt, Germany., Sreeramulu S; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany., Schwalbe H; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany., Merk D; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438Frankfurt, Germany.; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377Munich, Germany.

المصدر: ACS chemical biology [ACS Chem Biol] 2022 Nov 18; Vol. 17 (11), pp. 3159-3168. Date of Electronic Publication: 2022 Nov 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Cytoplasmic and Nuclear* , Bile Acids and Salts*, Ligands ; Protein Domains ; Cell Nucleus

المؤلفون: Berg H; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Wirtz Martin MA; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Altincekic N; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Alshamleh I; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Kaur Bains J; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Blechar J; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany., Ceylan B; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., de Jesus V; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Dhamotharan K; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany.; Institute for Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue Strasse 7+9, 60438, Frankfurt am Main, Germany., Fuks C; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany., Gande SL; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Hargittay B; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Hohmann KF; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Hutchison MT; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Marianne Korn S; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany.; Institute for Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue Strasse 7+9, 60438, Frankfurt am Main, Germany., Krishnathas R; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Kutz F; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Linhard V; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Matzel T; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Meiser N; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany., Niesteruk A; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Pyper DJ; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Schulte L; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Trucks S; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany., Azzaoui K; Saverna Therapeutics, Pumpmattenweg 3, 4105, Biel-Benken, Switzerland., Blommers MJJ; Saverna Therapeutics, Pumpmattenweg 3, 4105, Biel-Benken, Switzerland., Gadiya Y; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Screening Port, Schnackenburgallee 114, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Karki R; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Screening Port, Schnackenburgallee 114, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Zaliani A; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Screening Port, Schnackenburgallee 114, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Gribbon P; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Screening Port, Schnackenburgallee 114, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., da Silva Almeida M; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil.; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Dinis Anobom C; National Center of Nuclear Magnetic Resonance (CNRMN), CENABIO, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil.; Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil., Bula AL; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia., Bütikofer M; ETH, Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, HCI F217, Vladimir-Prelog-Weg 2, 8093, Zürich, Switzerland., Putinhon Caruso Í; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil.; Multiuser Center for Biomolecular Innovation (CMIB), Department of Physics, São Paulo State University (UNESP), 01049-010, São José do Rio Preto, Brazil., Caterina Felli I; Magnetic Resonance Center (CERM), University of Florence, Via Luigi Sacconi 6, Sesto Fiorentino, 50019, Florence, Italy.; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Florence, Italy., Da Poian AT; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil., Cardoso de Amorim G; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil.; Multidisciplinary Center for Research in Biology (NUMPEX), Campus Duque de Caxias Federal University of Rio de Janeiro, 25.250-470, Duque de Caxias, Brazil., Fourkiotis NK; Department of Pharmacy, University of Patras, 26504, Patras, Greece., Gallo A; Department of Pharmacy, University of Patras, 26504, Patras, Greece.; Department of Chemistry, University of Torino, IT-10126, Torino, Italy., Ghosh D; ETH, Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, HCI F217, Vladimir-Prelog-Weg 2, 8093, Zürich, Switzerland., Gomes-Neto F; National Center of Nuclear Magnetic Resonance (CNRMN), CENABIO, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil.; Laboratory of Toxinology, Oswaldo Cruz Foundation (FIOCRUZ), 21040-900, Rio de Janeiro, Brazil., Gorbatyuk O; Department of Molecular Biology and Biophysics, UConn Health, 263 Farmington Ave., Farmington, CT 06030-3305, USA., Hao B; Department of Molecular Biology and Biophysics, UConn Health, 263 Farmington Ave., Farmington, CT 06030-3305, USA., Kurauskas V; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., Lecoq L; Molecular Microbiology and Structural Biochemistry, UMR5086 CNRS/Université Lyon 1, 7, passage du Vercors, 69367, Lyon, France., Li Y; Department of Molecular Biology and Biophysics, UConn Health, 263 Farmington Ave., Farmington, CT 06030-3305, USA., Cunha Mebus-Antunes N; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil., Mompeán M; 'Rocasolano' Institute for Physical Chemistry, CSIC, 28006, Madrid, Spain., Cristtina Neves-Martins T; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil., Ninot-Pedrosa M; Molecular Microbiology and Structural Biochemistry, UMR5086 CNRS/Université Lyon 1, 7, passage du Vercors, 69367, Lyon, France., Pinheiro AS; Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil., Pontoriero L; Magnetic Resonance Center (CERM), University of Florence, Via Luigi Sacconi 6, Sesto Fiorentino, 50019, Florence, Italy.; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Florence, Italy., Pustovalova Y; Department of Molecular Biology and Biophysics, UConn Health, 263 Farmington Ave., Farmington, CT 06030-3305, USA., Riek R; ETH, Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, HCI F217, Vladimir-Prelog-Weg 2, 8093, Zürich, Switzerland., Robertson AJ; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney, 20892-0520, Bethesda, USA., Jose Abi Saad M; University of Vienna, Department of Pharmaceutical Sciences, Josef-Holaubek-Platz 2, A-1090, Vienna, Austria., Treviño MÁ; 'Rocasolano' Institute for Physical Chemistry, CSIC, 28006, Madrid, Spain., Tsika AC; Department of Pharmacy, University of Patras, 26504, Patras, Greece., Almeida FCL; Institute of Medical Biochemistry, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil.; National Center of Nuclear Magnetic Resonance (CNRMN), CENABIO, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil., Bax A; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney, 20892-0520, Bethesda, USA., Henzler-Wildman K; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA., Hoch JC; Department of Molecular Biology and Biophysics, UConn Health, 263 Farmington Ave., Farmington, CT 06030-3305, USA., Jaudzems K; Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia., Laurents DV; 'Rocasolano' Institute for Physical Chemistry, CSIC, 28006, Madrid, Spain., Orts J; University of Vienna, Department of Pharmaceutical Sciences, Josef-Holaubek-Platz 2, A-1090, Vienna, Austria., Pierattelli R; Magnetic Resonance Center (CERM), University of Florence, Via Luigi Sacconi 6, Sesto Fiorentino, 50019, Florence, Italy.; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019, Florence, Italy., Spyroulias GA; Department of Pharmacy, University of Patras, 26504, Patras, Greece., Duchardt-Ferner E; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany.; Institute for Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue Strasse 7+9, 60438, Frankfurt am Main, Germany., Ferner J; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Fürtig B; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Hengesbach M; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany., Löhr F; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany.; Institute for Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue Strasse 7+9, 60438, Frankfurt am Main, Germany., Qureshi N; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Richter C; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Saxena K; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Schlundt A; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany.; Institute for Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue Strasse 7+9, 60438, Frankfurt am Main, Germany., Sreeramulu S; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Wacker A; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Weigand JE; Department of Biology, Technical University of Darmstadt, 64289, Darmstadt, Germany., Wirmer-Bartoschek J; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany., Wöhnert J; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany.; Institute for Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue Strasse 7+9, 60438, Frankfurt am Main, Germany., Schwalbe H; Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.; Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Frankfurt am Main (Germany), Max-von-LaueStrasse 7+9, 60438, Frankfurt am Main, Germany.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Nov 14; Vol. 61 (46), pp. e202205858. Date of Electronic Publication: 2022 Oct 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: SARS-CoV-2* , COVID-19 Drug Treatment*, Humans ; Proteome ; Ligands ; Drug Design

المؤلفون: Tsika AC; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece. Electronic address: https://twitter.com/@katerina_tsika., Gallo A; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece. Electronic address: https://twitter.com/@AngeloGallo83., Fourkiotis NK; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece., Argyriou AI; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece., Sreeramulu S; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Löhr F; Institute for Biophysical Chemistry, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany., Rogov VV; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany; Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany., Richter C; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Linhard V; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Gande SL; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Altincekic N; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Krishnathas R; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Elamri I; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany., Schwalbe H; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany. Electronic address: schwalbe@nmr.uni-frankfurt.de., Wollenhaupt J; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Straße 15, D-12489 Berlin, Germany. Electronic address: https://twitter.com/@Jan_Wollenhaupt., Weiss MS; Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Straße 15, D-12489 Berlin, Germany. Electronic address: https://twitter.com/@ManfredSWeiss., Spyroulias GA; Department of Pharmacy, University of Patras, GR-26504 Patras, Greece. Electronic address: G.A.Spyroulias@upatras.gr.

المصدر: Journal of molecular biology [J Mol Biol] 2022 Aug 30; Vol. 434 (16), pp. 167720. Date of Electronic Publication: 2022 Jul 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: ADP-Ribosylation*/drug effects , Coronavirus Protease Inhibitors*/chemistry , Coronavirus Protease Inhibitors*/pharmacology , Poly(ADP-ribose) Polymerases*/chemistry , SARS-CoV-2*/drug effects , SARS-CoV-2*/enzymology, Adenosine/*analogs & derivatives, Adenosine/chemistry ; Adenosine/pharmacology ; Adenosine Diphosphate Ribose/chemistry ; Humans ; Protein Binding ; Protein Domains

المؤلفون: Elamri I; Institute of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Frankfurt am Main 60438, Germany., Abdellaoui C; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Frankfurt am Main 60438, Germany., Bains JK; Institute of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Frankfurt am Main 60438, Germany., Hohmann KF; Institute of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Frankfurt am Main 60438, Germany., Gande SL; Institute of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Frankfurt am Main 60438, Germany., Stirnal E; Institute of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Frankfurt am Main 60438, Germany., Wachtveitl J; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Frankfurt am Main 60438, Germany., Schwalbe H; Institute of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Frankfurt am Main 60438, Germany.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2021 Jul 21; Vol. 143 (28), pp. 10596-10603. Date of Electronic Publication: 2021 Jul 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Nimbarte VD; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Wirmer-Bartoschek J; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Gande SL; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.; German Cancer Research Center and German Cancer Consortium, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Alshamleh I; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Seibert M; Department of Medicine 2, Hematology/Oncology, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Nasiri HR; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany., Schnütgen F; German Cancer Research Center and German Cancer Consortium, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Department of Medicine 2, Hematology/Oncology, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.; Frankfurt Cancer Institute (FCI), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Serve H; German Cancer Research Center and German Cancer Consortium, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Department of Medicine 2, Hematology/Oncology, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.; Frankfurt Cancer Institute (FCI), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany., Schwalbe H; Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.; German Cancer Research Center and German Cancer Consortium, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.

المصدر: ChemMedChem [ChemMedChem] 2021 May 18; Vol. 16 (10), pp. 1667-1679. Date of Electronic Publication: 2021 Mar 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , G-Quadruplexes/*drug effects , Genes, myc/*drug effects , Indoles/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HeLa Cells ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured