-
1
المؤلفون: Keumhan Noh, Eung-Seok Lee, Sajita Shah, Tae Cheon Jeong, Mahesh Raj Nepal, Ganesh Bist
المصدر: Journal of Toxicology and Environmental Health, Part A. 82:502-513
مصطلحات موضوعية: Male, medicine.medical_specialty, Guanine, Health, Toxicology and Mutagenesis, Spleen, Toxicology, Adduct, Rats, Sprague-Dawley, DNA Adducts, Random Allocation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, DNA adduct, medicine, Animals, 030304 developmental biology, 0303 health sciences, Kidney, Glutathione, Hydrocarbons, Brominated, Rats, 1-Bromopropane, Endocrinology, medicine.anatomical_structure, Liver, chemistry, 030220 oncology & carcinogenesis, Toxicity, Solvents, Environmental Pollutants
-
2
المؤلفون: Eung-Seok Lee, Ganesh Bist, Seojeong Park, Pramila Katila, Tara Man Kadayat, Youngjoo Kwon, Aarajana Shrestha, Somin Shin
المصدر: Bioorganic Chemistry. 79:1-18
مصطلحات موضوعية: 0301 basic medicine, Pyridines, medicine.drug_class, DNA damage, Antineoplastic Agents, Apoptosis, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Phenols, Cell Line, Tumor, Drug Discovery, medicine, Humans, Topoisomerase II Inhibitors, Structure–activity relationship, Poly-ADP-Ribose Binding Proteins, Mode of action, Molecular Biology, Etoposide, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Topoisomerase, Organic Chemistry, G1 Phase Cell Cycle Checkpoints, DNA Topoisomerases, Type II, 030104 developmental biology, Enzyme, Drug Design, 030220 oncology & carcinogenesis, biology.protein, Drug Screening Assays, Antitumor, Topoisomerase inhibitor, DNA, DNA Damage, medicine.drug
-
3
المؤلفون: Eung-Seok Lee, Seojeong Park, Seojeong Kim, Naeun Sheen, Soo-Yeon Hwang, Haejin Jang, Tara Man Kadayat, Minjung Seo, Kyung-Hwa Jeon, Surendra Kunwar, Ganesh Bist, Aarajana Shrestha, Youngjoo Kwon
المصدر: European Journal of Medicinal Chemistry. 227:113916
مصطلحات موضوعية: Cell Survival, Pyridones, Topoisomerase Inhibitors, Stereochemistry, medicine.drug_class, Mice, Nude, Antineoplastic Agents, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Halogens, Drug Discovery, Gene expression level, Tumor Cells, Cultured, medicine, Animals, Humans, Poly-ADP-Ribose Binding Proteins, Inhibitory effect, Cell Proliferation, Pharmacology, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, biology, Topoisomerase, Organic Chemistry, DNA, Neoplasms, Experimental, General Medicine, DNA Topoisomerases, Type II, DNA Topoisomerases, Type I, Indenes, chemistry, Cancer cell, Halogen, biology.protein, Female, Drug Screening Assays, Antitumor, Derivative (chemistry), Topoisomerase inhibitor
-
4
المؤلفون: Suhrid Banskota, Til Bahadur Thapa Magar, Ganesh Bist, Pallavi Gurung, Eung-Seok Lee, Jung-Ae Kim, Aarajana Shrestha, Tara Man Kadayat
المصدر: European Journal of Medicinal Chemistry. 137:575-597
مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharide, Pharmacology, Inflammatory bowel disease, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, Structure–activity relationship, Colitis, Benzofuran, Benzofurans, Dose-Response Relationship, Drug, Molecular Structure, U937 cell, Tumor Necrosis Factor-alpha, Chemistry, Organic Chemistry, U937 Cells, General Medicine, Inflammatory Bowel Diseases, medicine.disease, Rats, Transcription Factor AP-1, Disease Models, Animal, 030104 developmental biology, Indenes, Trinitrobenzenesulfonic Acid, 030220 oncology & carcinogenesis, Female, Tumor necrosis factor alpha, HT29 Cells
-
5
المؤلفون: Jeong Ahn Kim, Ganesh Bist, Surendra Kunwar, Youngjoo Kwon, Til Bahadur Thapa Magar, Eung-Seok Lee, Aarajana Shrestha, Seung Hee Seo
المصدر: Bioorganic Chemistry. 111:104884
مصطلحات موضوعية: Halogenation, Pyridines, Stereochemistry, Antineoplastic Agents, Hydroxylation, 01 natural sciences, Biochemistry, Catalysis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyridine, Tumor Cells, Cultured, Humans, Topoisomerase II Inhibitors, Structure–activity relationship, Moiety, Poly-ADP-Ribose Binding Proteins, Molecular Biology, Benzofurans, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Topoisomerase, Organic Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, DNA Topoisomerases, Type II, chemistry, Cell culture, biology.protein, Drug Screening Assays, Antitumor, Selectivity, Tricyclic
-
6
المؤلفون: Aarajana Shrestha, Tara Man Kadayat, Ganesh Bist, Seojeong Park, Eung-Seok Lee, Til Bahadur Thapa Magar, Hwa Jong Lee, Youngjoo Kwon
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3279-3283
مصطلحات موضوعية: Halogenation, Pyridines, Topoisomerase Inhibitors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, chemistry.chemical_element, Antineoplastic Agents, 010402 general chemistry, Inhibitory postsynaptic potential, 01 natural sciences, Biochemistry, Cell Line, Tumor, Neoplasms, Drug Discovery, Chlorine, Humans, Chlorine substituent, Molecular Biology, Benzofurans, Cell Proliferation, biology, 010405 organic chemistry, Chemistry, Topoisomerase, Organic Chemistry, 0104 chemical sciences, DNA Topoisomerases, Type II, DNA Topoisomerases, Type I, biology.protein, Molecular Medicine
-
7
المؤلفون: Tara Man Kadayat, Eung-Seok Lee, Ganesh Bist, Aarajana Shrestha, Youngjoo Kwon, Til Bahadur Thapa Magar, Kyu Yeon Jun, Seojeong Park
المصدر: European Journal of Medicinal Chemistry. 125:14-28
مصطلحات موضوعية: Pyridines, Stereochemistry, Antineoplastic Agents, 01 natural sciences, HeLa, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, DU145, Antigens, Neoplasm, Cell Line, Tumor, Drug Discovery, medicine, Humans, Topoisomerase II Inhibitors, Moiety, Etoposide, Cell Proliferation, Pharmacology, biology, 010405 organic chemistry, Aryl, Topoisomerase, Organic Chemistry, DNA, General Medicine, biology.organism_classification, 0104 chemical sciences, DNA-Binding Proteins, Molecular Docking Simulation, DNA Topoisomerases, Type II, chemistry, Mechanism of action, 030220 oncology & carcinogenesis, biology.protein, medicine.symptom, medicine.drug
-
8
المؤلفون: Somin Shin, Kyu Yeon Jun, Youngjoo Kwon, Ganesh Bist, Tara Man Kadayat, Aarajana Shrestha, Til Bahadur Thapa Magar, Eung-Seok Lee, Radha Karki, Younghwa Na
المصدر: European Journal of Medicinal Chemistry. 113:228-245
مصطلحات موضوعية: 0301 basic medicine, Pyridines, Stereochemistry, Quantitative Structure-Activity Relationship, Antineoplastic Agents, HeLa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, Humans, Topoisomerase II Inhibitors, Moiety, Cytotoxicity, Cell Proliferation, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Topoisomerase, Aryl, Organic Chemistry, Rational design, General Medicine, biology.organism_classification, DNA Topoisomerases, Type II, 030104 developmental biology, DNA Topoisomerases, Type I, 030220 oncology & carcinogenesis, biology.protein, Drug Screening Assays, Antitumor, Topoisomerase I Inhibitors, Topoisomerase-II Inhibitor, Terpyridine
-
9
المؤلفون: Ganesh Bist, Eung-Seok Lee, Seojeong Park, Aarajana Shrestha, Tara Man Kadayat, Kyu Yeon Jun, Youngjoo Kwon, Younghwa Na, Til Bahadur Thapa Magar
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:1726-1731
مصطلحات موضوعية: 0301 basic medicine, Halogenation, Cell Survival, Pyridines, Topoisomerase Inhibitors, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Breast Neoplasms, 01 natural sciences, Biochemistry, HeLa, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Pyridine, polycyclic compounds, medicine, Humans, Structure–activity relationship, Breast, Cytotoxicity, Molecular Biology, biology, 010405 organic chemistry, Chemistry, Topoisomerase, Biphenyl Compounds, Organic Chemistry, biology.organism_classification, 0104 chemical sciences, Biphenyl compound, 030104 developmental biology, Indenes, Drug Design, biology.protein, Molecular Medicine, Female, Topoisomerase inhibitor, HeLa Cells
-
10
المؤلفون: Suhrid Banskota, Pallavi Gurung, Ganesh Bist, Aarajana Shrestha, Tara Man Kadayat, Til Bahadur Thapa Magar, Jung-Ae Kim, Eung-Seok Lee
المصدر: Bioorganicmedicinal chemistry letters. 28(14)
مصطلحات موضوعية: 0301 basic medicine, Monocyte adhesion, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Inhibitory postsynaptic potential, Biochemistry, Inflammatory bowel disease, Monocytes, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Oral administration, Drug Discovery, Pyridine, medicine, Cell Adhesion, Animals, Humans, Colitis, Molecular Biology, Biological evaluation, Dose-Response Relationship, Drug, Molecular Structure, Tumor Necrosis Factor-alpha, Organic Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Epithelial Cells, medicine.disease, Inflammatory Bowel Diseases, Small molecule, digestive system diseases, Rats, Disease Models, Animal, 030104 developmental biology, chemistry, Trinitrobenzenesulfonic Acid, Indans, Molecular Medicine, HT29 Cells