-
1
المؤلفون: Frank J. Hsu, Patrick J. Stiff, Ivana N. Micallef, Gary Bridger, Richard T. Maziarz, Auayporn Nademanee, Edward A. Stadtmauer, John F. DiPersio, Brian J. Bolwell
المصدر: Biology of Blood and Marrow Transplantation. 18(10):1564-1572
مصطلحات موضوعية: Oncology, Adult, Male, medicine.medical_specialty, Benzylamines, Receptors, CXCR4, Adolescent, medicine.medical_treatment, Antigens, CD34, Hematopoietic stem cell transplantation, Cyclams, Transplantation, Autologous, Placebos, Double-Blind Method, Heterocyclic Compounds, Poor mobilzer, Internal medicine, Granulocyte Colony-Stimulating Factor, Medicine, Humans, Immunologic Factors, Lymphocyte Count, Hematopoietic Stem Cell Mobilization, Multiple myeloma, Aged, Transplantation, business.industry, Plerixafor, Hematopoietic Stem Cell Transplantation, Hematopoietic stem cell, Hematology, Middle Aged, medicine.disease, AMD 3100, Granulocyte colony-stimulating factor, Haematopoiesis, Drug Combinations, medicine.anatomical_structure, Stem cell mobilization, Immunology, Blood Component Removal, Female, Stem cell, business, Multiple Myeloma, Biomarkers, medicine.drug
-
2
المؤلفون: Dana Huskens, Marilyn C. Darkes, Gary Bridger, Jennifer H. Cox, Simon P. Fricker, Zefferino Santucci, Renee Mosi, Jean Labrecque, Kim L. Nelson, Renato Skerlj, Stefan R. Idzan, Virginia Anastassova, Dominique Schols, Ketan Patel, Rebecca S.Y. Wong, Gloria Lau
المصدر: Biochemical Pharmacology. 83:472-479
مصطلحات موضوعية: CCR1, Receptors, CXCR4, Anti-HIV Agents, Allosteric regulation, Administration, Oral, Biological Availability, C-C chemokine receptor type 7, Pharmacology, Biology, Butylamines, Virus Replication, CXCR3, Biochemistry, Cell Line, Heterocyclic Compounds, 1-Ring, Dogs, Calcium flux, medicine, Animals, Humans, Receptor, Molecular Structure, Ligand binding assay, Virus Internalization, Chemokine CXCL12, Entry inhibitor, Gene Expression Regulation, Aminoquinolines, HIV-1, Benzimidazoles, Protein Binding, Signal Transduction, medicine.drug
-
3
المؤلفون: Renato Skerlj, Tuya Ba, Ernest J. McEachern, Elyse Bourque, Ian Baird, Dominique Schols, Wilson Trevor R, Renee Mosi, Jonathan Langille, Yuanxi Zhou, Bryon Carpenter, Michael Bey, Simon P. Fricker, Dana Huskens, Duane Veale, Rebecca S.Y. Wong, Gary Bridger, Curtis Harwig, Veronique Bodart, Ron MacFarland, Markus Metz, Sanjay Danthi
المصدر: ACS Medicinal Chemistry Letters. 3:216-221
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, biology, business.industry, Purkinje fibers, Organic Chemistry, hERG, Human immunodeficiency virus (HIV), Pharmacology, medicine.disease_cause, Biochemistry, Bioavailability, Chemokine receptor, medicine.anatomical_structure, Drug Discovery, Lipophilicity, biology.protein, Medicine, Action potential duration, cardiovascular diseases, business, Ion channel
-
4
المؤلفون: Renato Skerlj, Gary Bridger, Yuanxi Zhou, Elyse Bourque, Ernest McEachern, Jonathan Langille, Curtis Harwig, Duane Veale, Wen Yang, Tongshong Li, Yongbao Zhu, Michael Bey, Ian Baird, Michael Sartori, Markus Metz, Renee Mosi, Kim Nelson, Veronique Bodart, Rebecca Wong, Simon Fricker, Ron Mac Farland, Dana Huskens, Dominique Schols
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6950-6954
مصطلحات موضوعية: Tertiary amine, Anti-HIV Agents, Pyridines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, CCR5 receptor antagonist, Pharmacology, Virus Replication, Biochemistry, Peripheral blood mononuclear cell, Chemical synthesis, Inhibitory Concentration 50, Dogs, Piperidines, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, virus diseases, Amides, In vitro, Rats, Viral replication, Drug Design, CCR5 Receptor Antagonists, HIV-1, Leukocytes, Mononuclear, Molecular Medicine
-
5
المؤلفون: Renato T. Skerlj, Jason B. Crawford, Gary Bridger, Wilson Trevor R, Jenny Ji, Bryon Carpenter, Gang Chen
المصدر: Organic Process Research & Development. 16:109-116
مصطلحات موضوعية: Stereochemistry, Longest linear sequence, Chemistry, Organic Chemistry, CCR5 receptor antagonist, Physical and Theoretical Chemistry, Laboratory scale, Combinatorial chemistry
-
6
المؤلفون: Zefferino Santucci, Gary Bridger, Gloria Lau, Dominique Schols, Elyse Bourque, Wen Yang, Simon P. Fricker, Markus Metz, Curtis Harwig, Marilyn C. Darkes, Renato T. Skerlj, Jonathan Langille, Jean Labrecque, Sanjay Danthi
المصدر: Journal of the American Chemical Society. 133:16477-16485
مصطلحات موضوعية: Models, Molecular, Anti-HIV Agents, Stereochemistry, hERG, Allosteric regulation, Mutagenesis (molecular biology technique), Microbial Sensitivity Tests, Computational biology, CCR5 receptor antagonist, Biochemistry, Catalysis, Structure-Activity Relationship, Colloid and Surface Chemistry, medicine, Humans, Urea, Structure–activity relationship, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Stereoisomerism, General Chemistry, Small molecule, Ether-A-Go-Go Potassium Channels, Entry inhibitor, Molecular Weight, Mutagenesis, Drug Design, CCR5 Receptor Antagonists, HIV-1, Leukocytes, Mononuclear, biology.protein, Pharmacophore, medicine.drug
-
7
المؤلفون: Frank J. Hsu, Gary Bridger, Sachin Marulkar, Richard T. Maziarz, Patrick J. Stiff, Auayporn Nademanee, Edward A. Stadtmauer, Brian J. Bolwell, John F. DiPersio, Ivana N. Micallef
المصدر: Biology of Blood and Marrow Transplantation. 17(8):1146-1153
مصطلحات موضوعية: Blood Platelets, Male, Benzylamines, Pathology, medicine.medical_specialty, Platelet Engraftment, Cell dose, medicine.medical_treatment, Platelet recovery, CD34, Urology, Antigens, CD34, Hematopoietic stem cell transplantation, Cyclams, Transplantation, Autologous, Heterocyclic Compounds, Autologous peripheral blood stem cell transplantation, Granulocyte Colony-Stimulating Factor, medicine, Humans, Multiple myeloma, Peripheral Blood Stem Cell Transplantation, Transplantation, Platelet Count, business.industry, Lymphoma, Non-Hodgkin, Plerixafor, Hematology, Hematopoietic Stem Cells, medicine.disease, Survival Analysis, Hematopoietic Stem Cell Mobilization, Lymphoma, Haematopoiesis, Female, Multiple Myeloma, business, medicine.drug
-
8
المؤلفون: Tong-Shuang Li, Simon P. Fricker, Gang Chen, Renato Skerlj, David Bogucki, Markus Metz, Gary Bridger, Susan Nan, Rebecca S.Y. Wong, Dominique Schols, Jean Labrecque, Gloria Lau, Marilyn C. Darkes, Bryon Carpenter
المصدر: Virology. 413(2):231-243
مصطلحات موضوعية: Models, Molecular, Receptors, CCR5, Protein Conformation, Vicriviroc, viruses, Aplaviroc, Drug design, CCR5 receptor antagonist, Computational biology, Biology, Maraviroc, chemistry.chemical_compound, HIV Fusion Inhibitors, Virology, High-Throughput Screening Assays, medicine, Homology modeling, Binding site characterization, virus diseases, Reproducibility of Results, Stereoisomerism, Virus Internalization, Molecular biology, Small molecule, Small molecule antagonists, Antifusogenic assay, chemistry, Mutagenesis, CCR5 Receptor Antagonists, Mutation, HIV-1, Mutagenesis, Site-Directed, CCR5, medicine.drug
-
9
المؤلفون: Renato Skerlj, Gary Bridger, Yuanxi Zhou, Elyse Bourque, Jonathan Langille, Maria Di Fluri, David Bogucki, Wen Yang, Tongshuang Li, Letian Wang, Susan Nan, Ian Baird, Markus Metz, Marilyn Darkes, Jean Labrecque, Gloria Lau, Simon Fricker, Dana Huskens, Dominique Schols
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2450-2455
مصطلحات موضوعية: Receptors, CCR5, Pyridines, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Virus Replication, Amides, Biochemistry, Rats, Cyclic N-Oxides, Structure-Activity Relationship, Dogs, Piperidines, Drug Design, CCR5 Receptor Antagonists, Oximes, Drug Discovery, HIV-1, Animals, Humans, Molecular Medicine, Molecular Biology
-
10
المؤلفون: Curtis Harwig, Rossana Wauthy, Renato Skerlj, Fluri Maria Di, Yongbao Zhu, Duane Veale, Dominique Schols, Gary Bridger, Helen Yee, Wen Yang, Wilson Trevor R, David Bogucki, Christopher Ronald Smith, Erik De Clercq, Krystyna A. Skupinska, Jonathon Langille, Jason M. Crawford, Dana Huskens, Ernie Mceachern
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:262-266
مصطلحات موضوعية: Receptors, CXCR4, Anti-HIV Agents, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Pharmacology, Butylamines, Virus Replication, Biochemistry, Chemical synthesis, CXCR4, Heterocyclic Compounds, 1-Ring, Structure-Activity Relationship, Chemokine receptor, Dogs, Pharmacokinetics, Drug Discovery, Animals, Humans, Structure–activity relationship, Calcium Signaling, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Virology, Rats, Viral replication, Aminoquinolines, HIV-1, Molecular Medicine, Benzimidazoles