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1دورية أكاديمية
المؤلفون: Viktor Martyanov, Grace-Hyun J Kim, Wendy Hayes, Shuyan Du, Bishu J Ganguly, Oumar Sy, Sun Ku Lee, Galina S Bogatkevich, Gary L Schieven, Elena Schiopu, Roberta Gonçalves Marangoni, Jonathan Goldin, Michael L Whitfield, John Varga
المصدر: PLoS ONE, Vol 12, Iss 11, p e0187580 (2017)
وصف الملف: electronic resource
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المؤلفون: Emily C. Cherney, Liping Zhang, Julian Lo, Tram Huynh, Donna Wei, Vijay Ahuja, Claude Quesnelle, Gary L. Schieven, Alan Futran, Gregory A. Locke, Zeyu Lin, Laura Monereau, Charu Chaudhry, Jordan Blum, Sha Li, Mark Fereshteh, Bifang Li-Wang, Sanjeev Gangwar, Chin Pan, Colin Chong, Xiao Zhu, Shana L. Posy, John S. Sack, Ping Zhang, Max Ruzanov, Mary Harner, Fahad Akhtar, Gretchen M. Schroeder, Gregory Vite, Brian Fink
المصدر: Journal of Medicinal Chemistry. 65:3518-3538
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Shana L. Posy, David A Critton, Stefan Ruepp, Ratna Kumar Sreekantha, Laxman Pasunoori, Dharmpal S. Dodd, Murali Subramanian, Andrew Watson, Percy H. Carter, Honghe Wan, Debarati Mazumder Tagore, Paul Davies, Shailesh Dudhgaonkar, Gary L. Schieven, Ratika Srivastava, Luisa Salter-Cid, Michael A. Poss, Alaric J. Dyckman, Mussari Christopher P
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Autoimmune disease, Toll-like receptor, Innate immune system, 010405 organic chemistry, Organic Chemistry, virus diseases, Context (language use), TLR7, Pharmacology, TLR8, Biology, medicine.disease_cause, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Autoimmunity, 010404 medicinal & biomolecular chemistry, Drug Discovery, medicine, Receptor
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المؤلفون: Rachael Siegel, Venu Bommireddy, Paget Steven, Albert J. Uveges, Rukiye-Nazan Eraslan, Lee Pellegrino, Krista Saufler, Chia-yu Huang, Eli Mordechai, Haihua Zheng, Gary L. Schieven, Jason Trama, Michael McQueney, Miglena Prabagar, Ku Lu, Axel Metzger, Martin E. Adelson, David Diller, Grant Gallagher, Brian F. Mcguinness, Stanley P. Nawoschik, James R. Beasley
المصدر: Cancer Research. 81:524-524
مصطلحات موضوعية: Agonist, Cancer Research, Sting, Immune system, Bladder cancer, Oncology, business.industry, medicine.drug_class, Cancer research, Medicine, business, Non muscle invasive, medicine.disease
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f9b856e7848effdfb38bf1a76408541e
https://doi.org/10.1158/1538-7445.am2021-524 -
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المؤلفون: Sidney Pitt, John S. Sack, Vicky Tang, William J. Pitts, Steven H. Spergel, Jonathan Lippy, Junqing Guo, Michael Galella, Mertzman Michael E, Sylwia Stachura, Steven G. Nadler, Aberra Fura, Percy H. Carter, Gary L. Schieven, Luisa Salter-Cid, Kim W. McIntyre, James Kempson, Javed Khan, Lauren Haque, Rosemary Zhang, John S. Tokarski, Guoxiang Shen, Kathleen M. Gillooly, Stephen T. Wrobleski, Joel C. Barrish
مصطلحات موضوعية: Tofacitinib, Kinase, business.industry, Organic Chemistry, Prodrug, Pharmacology, medicine.disease, Biochemistry, Immune system, Tyrosine kinase 2, Rheumatoid arthritis, Drug Discovery, Functional selectivity, Medicine, business, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1a959ab8edd802fd477e946d59e0fb
https://europepmc.org/articles/PMC6421541/ -
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المؤلفون: Hong Wu, Gary L. Schieven, Joel C. Barrish, Bei Wang, Bang Chi Chen, Sam T. Chao, Gerry Everlof, Jung Hui Sun, Chunjian Liu, John H. Dodd, Murray McKinnon, Kathleen M. Gillooly, Katerina Leftheris, John Hynes, Tracy L. Taylor, Vivekananda M. Vrudhula, T. G. Murali Dhar, Stephen T. Wrobleski, Hongjian Zhang, David J. Shuster, Shuqun Lin, Kim W. McIntyre, Rulin Zhao, Christoph Gesenberg, James Lin, Punit Marathe
المصدر: Journal of Medicinal Chemistry. 58:7775-7784
مصطلحات موضوعية: Male, Phenylacetates, Stereochemistry, Phenyl acetate, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Chemistry Techniques, Synthetic, Mitogen-Activated Protein Kinase 14, Rats, Sprague-Dawley, Structure-Activity Relationship, Acetic acid, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Structure–activity relationship, Prodrugs, Protein Kinase Inhibitors, Triazine, Dose-Response Relationship, Drug, Molecular Structure, Prodrug, Arthritis, Experimental, Organophosphates, Macaca fascicularis, Solubility, chemistry, Rats, Inbred Lew, Molecular Medicine, Alkaline phosphatase
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المؤلفون: Joel C. Barrish, Aberra Fura, Guoxiang Shen, Jingwu Duan, David S. Nirschl, Jonathan Lippy, Stephen T. Wrobleski, Rosemary Zhang, Lidia M. Doweyko, Bingwei V. Yang, Lauren Haque, Murray McKinnon, Shuqun Lin, Luisa Salter-Cid, Sidney Pitt, William J. Pitts, Percy H. Carter, John S. Sack, Gary L. Schieven, Bin Jiang, John Hynes, Gregory D. Brown, John S. Tokarski, Zhonghui Lu, Javed Khan, Steven G. Nadler
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:5721-5726
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Clinical Biochemistry, Substituent, Administration, Oral, Pharmaceutical Science, Enzyme-Linked Immunosorbent Assay, Biochemistry, Pyrrolopyridazine, Pyridazine, Interferon-gamma, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Functional selectivity, Animals, Humans, Pyrroles, Tissue Distribution, Protein Kinase Inhibitors, Molecular Biology, Whole blood, Mice, Inbred BALB C, Molecular Structure, Organic Chemistry, Janus Kinase 3, Janus Kinase 1, Janus Kinase 2, Pyridazines, chemistry, Tyrosine kinase 2, Molecular Medicine, Amine gas treating, Janus kinase
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المؤلفون: Dezhi Xing, Carolyn A. Weigelt, Luisa Salter-Cid, Pirama Nayagam Arunachalam, Rodney B.W. Smith, Ling Li, Melissa Yarde, Jodi K. Muckelbauer, Jonathan Lippy, Mary Ellen Cvijic, Sidney Pitt, John S. Sack, Thatipamula Rp, Michael A. Poss, Paul Levesque, Robert J. Cherney, Ipsit Kundu, David Marcoux, Gary L. Schieven, Arvind Mathur, Qingjie Liu, Zheming Ruan, Rosemary Zhang, R M Fancher, Shweta Padmanabhan, Scott H. Watterson, Qing Shi, Mary T. Obermeier, Anurag S. Srivastava, Anuradha Gupta, Douglas G. Batt, James Neels, Joseph A. Tino, Kevin Stefanski, Percy H. Carter, Macor John E, John Hynes, Myra Beaudoin-Bertrand, Hao Lu, Kim W. McIntyre, Stacey Skala, Aberra Fura, Lan-Ying Qin, Cornelius Lyndon A M, James Hennan, Richard Rampulla, Bogdan Sleczka, Jenny Xie, Kallem Rajareddy, Jie Pan, Christine B. Goldstine, Hua Gong, Qian Ruan, Kathleen M. Gillooly, Donna L. Pedicord, Jingsong Fan, Rajeev S. Bhide, Stefan Ruepp
المصدر: Journal of medicinal chemistry. 60(12)
مصطلحات موضوعية: 0301 basic medicine, Antigens, Differentiation, T-Lymphocyte, Male, ERG1 Potassium Channel, hERG, Drug Evaluation, Preclinical, Phosphatidylinositol 3-Kinases, Pharmacology, Pyrazole, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Antigens, CD, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, Lectins, C-Type, Phosphatidylinositol, Enzyme Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, Kinase, Arthritis, Experimental, Isoenzymes, 030104 developmental biology, chemistry, Immune System Diseases, biology.protein, Molecular Medicine, Pyrazoles, Female, Efflux, Rabbits, Caco-2 Cells
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المؤلفون: Jingwu Duan, Stephen T. Wrobleski, Joel C. Barrish, Jagabandhu Das, Gary L. Schieven, Steven H. Spergel, Charu Chaudhry, Percy H. Carter, John S. Tokarski, Damaso Ovalle, John S. Sack, Aberra Fura, Zhonghui Lu, James Kempson, Luisa Salter-Cid, William J. Pitts, Junqing Guo, Yuval Blatt, John Hynes, Shuqun Lin, Hong Wu, Bin Jiang, Bingwei V. Yang, Javed Khan
المصدر: Bioorganicmedicinal chemistry letters. 27(20)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Cell Survival, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystal structure, Biochemistry, Active site cysteine, Cell Line, 03 medical and health sciences, Residue (chemistry), Inhibitory Concentration 50, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, Molecule, Humans, Molecular Biology, Protein Kinase Inhibitors, Binding Sites, Chemistry, Organic Chemistry, Janus Kinase 3, Janus Kinase 1, Janus Kinase 2, Combinatorial chemistry, Molecular Docking Simulation, 030104 developmental biology, Covalent bond, Electrophile, Molecular Medicine
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المؤلفون: Sidney Pitt, Sylwia Stachura, Rosemary Zhang, Steven G. Nadler, Kim W. McIntyre, Hong Wu, James Kempson, Jonathan Lippy, John Hynes, Joel C. Barrish, Zhonghui Lu, Percy H. Carter, Gary L. Schieven, Bin Jiang, Kate Gillooly, William J. Pitts, Javed Khan, Stephen T. Wrobleski, Jingwu Duan, Aberra Fura, Guoxiang Shen, John S. Tokarski, John S. Sack, Luisa Salter-Cid
المصدر: Bioorganicmedicinal chemistry letters. 27(14)
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Catalytic Domain, Drug Discovery, Mice, Inbred BALB C, biology, Chemistry, Translation (biology), Pyridazines, Tyrosine kinase 2, Molecular Medicine, Half-Life, hERG, Molecular Dynamics Simulation, Pyrrolopyridazine, Cell Line, 03 medical and health sciences, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Potency, Animals, Humans, Pyrroles, Molecular Biology, Protein Kinase Inhibitors, Inflammation, TYK2 Kinase, Binding Sites, 010405 organic chemistry, Aryl, Organic Chemistry, Janus Kinase 3, Janus Kinase 1, Janus Kinase 2, 0104 chemical sciences, Rats, Disease Models, Animal, 030104 developmental biology, Murine model, biology.protein
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