نتائج البحث - "Gemma L. Baillie"

المصدر: J Med Chem
Journal of medicinal chemistry 62 (2019): 5049–5062. doi:10.1021/acs.jmedchem.9b00252
info:cnr-pdr/source/autori:Tseng C.-C.; Baillie G.; Donvito G.; Mustafa M.A.; Juola S.E.; Zanato C.; Massarenti C.; Dall'Angelo S.; Harrison W.T.A.; Lichtman A.H.; Ross R.A.; Zanda M.; Greig I.R./titolo:The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators/doi:10.1021%2Facs.jmedchem.9b00252/rivista:Journal of medicinal chemistry/anno:2019/pagina_da:5049/pagina_a:5062/intervallo_pagine:5049–5062/volume:62

مصطلحات موضوعية: Male, Models, Molecular, Stereochemistry, medicine.medical_treatment, Allosteric regulation, Ligands, 01 natural sciences, Article, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, aliphatic nitro group recepetor allosteric, Allosteric Regulation, Isomerism, Receptor, Cannabinoid, CB1, In vivo, Drug Discovery, Cyclic AMP, medicine, Animals, Structure–activity relationship, Binding site, 030304 developmental biology, 0303 health sciences, Binding Sites, Trifluoromethyl, Behavior, Animal, Nitro Compounds, 0104 chemical sciences, 3. Good health, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, chemistry, Drug Design, Nitro, Neuralgia, Molecular Medicine, Cannabinoid, Bioisostere

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429df73de2b0a760a53541b1b6887b26
https://doi.org/10.1021/acs.jmedchem.9b00252

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5

Synthesis and structure-activity relationships of N-(4-Benzamidino)-oxazolidinones: potent and selective inhibitors of kallikrein-related peptidase 6

المؤلفون: Veronique Hamon, Helma van den Hurk, Philip H. Jones, Angus Morrison, Natalia A. Ignatenko, Gemma L. Baillie, Niels Smits, Nikolas Gunkel, Aubry K. Miller, Joanne Hewitt, Andrew Pannifer, Elena De Vita, Elizabeth M. Beck, Emily Russell, Stuart P. McElroy

المصدر: Chemmedchem

مصطلحات موضوعية: PATHOGENESIS, Chemistry, Medicinal, MELANOMA, 01 natural sciences, Biochemistry, 0305 Organic Chemistry, SERINE-PROTEASE NEUROSIN, Cytochrome P-450 Enzyme System, Cell Movement, Drug Discovery, Pharmacology & Pharmacy, General Pharmacology, Toxicology and Pharmaceutics, chemistry.chemical_classification, Full Paper, biology, Chemistry, Drug discovery, High-throughput screening, Stereoisomerism, Full Papers, SUBSTRATE-SPECIFICITY, ALZHEIMERS-DISEASE, Molecular Docking Simulation, Neuroprotective Agents, Molecular Medicine, Kallikreins, SPINAL-CORD, 1115 Pharmacology and Pharmaceutical Sciences, Life Sciences & Biomedicine, Half-Life, EXPRESSION, Medicinal & Biomolecular Chemistry, Inhibitory Concentration 50, Structure-Activity Relationship, TARGETS, Potency, Structure–activity relationship, Humans, Oxazolidinones, Pharmacology, Serine protease, Science & Technology, Binding Sites, 0304 Medicinal and Biomolecular Chemistry, 010405 organic chemistry, Organic Chemistry, Kallikrein, Protease inhibitors, HCT116 Cells, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Docking (molecular), biology.protein, Tissue Kallikreins, ACTIVATION PROFILES, Medicinal Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028f6971b3491f16f6a912a55eb2fbe7
http://hdl.handle.net/10044/1/93822

6

In Vitro Assay Development and HTS of Small-Molecule Human ABAD/17β-HSD10 Inhibitors as Therapeutics in Alzheimer’s Disease

المؤلفون: Terry K. Smith, Angus Morrison, Philip S. Jones, Andrew D. Pannifer, Stuart P. McElroy, Laura Aitken, Frank J. Gunn-Moore, Gemma L. Baillie

المساهمون: Rosetrees Trust, University of St Andrews. School of Biology, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. Institute of Behavioural and Neural Sciences

المصدر: SLAS Discovery. 22:676-685

مصطلحات موضوعية: 0301 basic medicine, RM, Chemical Phenomena, QH301 Biology, NDAS, Peptide, In Vitro Techniques, Biology, Pharmacology, Ligands, 01 natural sciences, Biochemistry, Analytical Chemistry, QH301, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Alzheimer Disease, Drug Discovery, Humans, Cytotoxic T cell, ligand binding [Pharmacology], Enzyme Inhibitors, Enzyme Assays, Alcohol dehydrogenase, chemistry.chemical_classification, Ultra-high throughput screening, Enzyme assays or enzyme kinetics, Neurodegenerative diseases, 3-Hydroxyacyl CoA Dehydrogenases, Reproducibility of Results, Metabolism, Small molecule, In vitro, RM Therapeutics. Pharmacology, High-Throughput Screening Assays, 0104 chemical sciences, Kinetics, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Enzyme, Drug development, chemistry, RC0321, biology.protein, Molecular Medicine, Receptor binding, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, Protein Binding, Biotechnology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fb33157ea39d89368f777833bd160e
https://doi.org/10.1177/2472555217697964

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A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives

المؤلفون: Nadine Jagerovic, Ilaria Manca, Ruth A. Ross, Paula Morales, Paolo Lazzari, Marilena Pira, Gérard Aimé Pinna, Gemma L. Baillie, Matteo Zanda, Gabriele Murineddu, Matteo Falzoi, Monica Sani, Rita Distinto

المصدر: European journal of medicinal chemistry 121 (2016): 194–208. doi:10.1016/j.ejmech.2016.05.011
info:cnr-pdr/source/autori:Lazzari P.; Distinto R.; Manca I.; Baillie G.; Murineddu G.; Pira M.; Falzoi M.; Sani M.; Morales P.; Ross R.; Zanda M.; Jagerovic N.; Pinna G.A./titolo:A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-Tetrahydrobenzo[6,7]cyclohepta[1,2-c ]pyrazole-3-carboxamide and analogue derivatives/doi:10.1016%2Fj.ejmech.2016.05.011/rivista:European journal of medicinal chemistry/anno:2016/pagina_da:194/pagina_a:208/intervallo_pagine:194–208/volume:121

مصطلحات موضوعية: Cannabinoid receptor binding assays, 0301 basic medicine, Cannabinoid receptor, Intrinsic activity, medicine.drug_class, Stereochemistry, cyclohepta[1, Carboxamide, 7], Pyrazole, 40-dichlorophenyl)-Npiperidin-1-yl-1, cannabinoids, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Receptor, Cannabinoid, CB1, Drug Discovery, medicine, 8-Chloro-1-(20, Structure–activity relationship, CB1 receptor ligands, 6-Tetrahydrobenzo[6, Receptor, Pharmacology, Drug discovery, Organic Chemistry, Antagonist, 2-c]pyrazole-3-carboxamide, General Medicine, 030104 developmental biology, chemistry, Pyrazoles, Endocannabinoid system (ECS), 030217 neurology & neurosurgery, Protein Binding