-
1
المؤلفون: Gemma Victoria White, Duncan S. Holmes, Monika Rella, James H. Thorpe, Robert J. Young, Ann Louise Walker, Kathrine J. Smith, Emma V. Edgar, Alain Hovnanian, Oxana Polyakova, Ryan P. Bingham, Yichen Wang, Alan R. Ferrie, John Liddle
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1454-1458
مصطلحات موضوعية: Drug, Proteases, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Inflammation, Pharmacology, 01 natural sciences, Biochemistry, Drug Discovery, medicine, Humans, Netherton syndrome, Molecular Biology, media_common, integumentary system, 010405 organic chemistry, Chemistry, Organic Chemistry, KLK5, Kallikrein, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, LEKTI, Netherton Syndrome, Drug Design, Molecular Medicine, Itching, Kallikreins, medicine.symptom
-
2
المؤلفون: Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
المصدر: Journal of Medicinal Chemistry. 62:5096-5110
مصطلحات موضوعية: Models, Molecular, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Necroptosis, Biological Availability, Inflammation, Pharmacology, 01 natural sciences, Cell Line, Mice, Structure-Activity Relationship, 03 medical and health sciences, In vivo, Psoriasis, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, Kinase, Chemistry, RNA-Binding Proteins, Haplorhini, medicine.disease, Ulcerative colitis, High-Throughput Screening Assays, Rats, 0104 chemical sciences, Mice, Inbred C57BL, Nuclear Pore Complex Proteins, 010404 medicinal & biomolecular chemistry, Drug Design, Rheumatoid arthritis, Chronic Disease, Pyrazoles, Molecular Medicine, medicine.symptom, Retinitis Pigmentosa
-
3
المؤلفون: Alain Hovnanian, Gemma Victoria White, Andrew C. Pearce, Duncan S. Holmes, Ann Louise Walker, James H. Thorpe, Oxana Polyakova, Monika Rella, Emma V. Edgar, Xiao Qing Lewell, Yichen Wang, Kathrine J. Smith, John Liddle, Pamela Nassau
المصدر: Acta Crystallogr F Struct Biol Commun
مصطلحات موضوعية: Models, Molecular, Genetic Vectors, Static Electricity, Biophysics, Gene Expression, Spodoptera, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Research Communications, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Drug Discovery, Genetics, medicine, Sf9 Cells, Animals, Humans, Netherton syndrome, Protease Inhibitors, Amino Acid Sequence, Cloning, Molecular, 030304 developmental biology, 0303 health sciences, Binding Sites, Chemistry, KLK5, Robustness (evolution), Kallikrein, Condensed Matter Physics, medicine.disease, Recombinant Proteins, Benzamidines, Crystallography, Kinetics, Netherton Syndrome, 030220 oncology & carcinogenesis, Mutation, Kallikreins, Baculoviridae, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b904d6e32f37f3f2060eb5adea3aacfd
https://europepmc.org/articles/PMC6497096/ -
4
المؤلفون: Gemma Victoria White, Emma V. Edgar, Ann Louise Walker, Xiao Qing Lewell, Robert J. Young, Alain Hovnanian, John Liddle, Kathrine J. Smith, Duncan S. Holmes, James H. Thorpe, Yichen Wang, Oxana Polyakova
المصدر: Bioorganicmedicinal chemistry letters. 29(6)
مصطلحات موضوعية: Drug, Benzimidazole, Serine Proteinase Inhibitors, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Spodoptera, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, KLK7, Salicylamides, medicine, Animals, Netherton syndrome, Molecular Biology, media_common, Serine protease, biology, 010405 organic chemistry, Organic Chemistry, KLK5, Kallikrein, medicine.disease, 0104 chemical sciences, Benzamidines, 010404 medicinal & biomolecular chemistry, chemistry, LEKTI, Netherton Syndrome, Drug Design, biology.protein, Molecular Medicine, Kallikreins, Protein Binding
-
5
المؤلفون: Zhi-Jie Ni, Qun Li, Martin John Slater, Wuxin Zou, Linos Lazarides, Yang Liu, Lois L. Wright, Paul Rowland, Liang Liao, Charles Z. Ding, Tadeusz Skarzynski, Jacob J. Plattner, Jackie E. Mordaunt, Don O. Somers, Xianfeng Li, Colin M. Edge, Yong-Kang Zhang, Gemma Victoria White, Malcolm Ellis, Jon Wright, Stephen J. Baker, Dazhong Fan, Wieslaw M. Kazmierski, Gary K. Smith, Pia Thommes, Lewis E. Pennicott, Julia A. Hubbard, Richard L. Jarvest, Bill McDowell, Yasheen Zhou, Xuelei Qian, Pamela Nassau, Richard Martin Grimes
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3550-3556
مصطلحات موضوعية: Stereochemistry, viruses, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Peptide, Hepacivirus, Viral Nonstructural Proteins, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, Serine, medicine, Molecular Biology, chemistry.chemical_classification, Serine protease, NS3, Protease, Molecular Structure, biology, Organic Chemistry, virus diseases, Active site, Boronic Acids, digestive system diseases, Protease inhibitor (biology), chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, medicine.drug
-
6
المؤلفون: Gemma Victoria White, Helen E. Connor, Elizabeth Pickup, David Matthew Wilson, Clarissa J. Watts, Christopher Browning, Sanjeet Singh Sehmi, Karen M. L. Morriss, Mark James Bamford, Christopher A. Parr, Susannah Davies, Brian Edgar Looker, Panayiotis A. Procopiou, Simon Teanby Hodgson, Fogden Yvonne C, Rachael A. Ancliff, Woodrow Michael David, Duncan S. Holmes
المصدر: Journal of medicinal chemistry. 50(26)
مصطلحات موضوعية: Male, ERG1 Potassium Channel, Stereochemistry, Guinea Pigs, Administration, Oral, CHO Cells, In Vitro Techniques, Chemical synthesis, Piperazines, Rats, Sprague-Dawley, chemistry.chemical_compound, Radioligand Assay, Structure-Activity Relationship, Cricetulus, Dogs, Cytochrome P-450 Enzyme System, Ileum, Cricetinae, Isometric Contraction, Drug Discovery, Animals, Humans, Receptor, Cerebral Cortex, Chemistry, Brain, Muscle, Smooth, Penetration (firestop), Ether-A-Go-Go Potassium Channels, Bioavailability, Rats, Isoenzymes, Blood-Brain Barrier, Molecular Medicine, Amine gas treating, Histamine H3 receptor, Selectivity, Histamine, Histamine H3 Antagonists
Find this issue from the American Chemical Society