نتائج البحث - "Genomic Instability/genetics"

1

Genetic predisposition to mosaic Y chromosome loss in blood

المؤلفون: Ragnar P. Kristjansson, Steven A. McCarroll, Florian Zink, Malcolm G. Dunlop, Nicholas J. Wareham, Yoichiro Kamatani, Daniel F. Gudbjartsson, Giulio Genovese, Rong Li, Stephen J. Chanock, Unnur Thorsteinsdottir, Ben Kinnersley, Kari Stefansson, Philip J. Law, Martin Ingelsson, Lars Forsberg, Joe Dennis, Richard S. Houlston, Jonatan Halvardson, Nicola D. Kerrison, Chikashi Terao, Douglas F. Easton, Anna Murray, Yunxuan Jiang, Jan P. Dumanski, Chey Loveday, Steve P Jackson, Robert A. Scott, Edyta Rychlicka-Buniowska, Ian Tomlinson, Daniel J Wright, Deborah J. Thompson, Victoria A Fisher, Yoshinori Murakami, John R. B. Perry, Paweł Olszewski, Felix R. Day, Eva Hoffmann, Hanna Davies, Po-Ru Loh, Adam Auton, Siddhartha Kar, Behrooz Torabi Moghadam, Clare Turnbull, Ken K. Ong, Marcus Danielsson, Jacob C. Ulirsch, Jonas Mattisson, Patrick Sulem, Olafur B. Davidsson, Mitchell J. Machiela

المساهمون: Internal Medicine, APH - Methodology, APH - Mental Health, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases

المصدر: Thompson, D J, Genovese, G, Kar, S, Perry, J RB & et al. 2019, ' Genetic predisposition to mosaic Y chromosome loss in blood ', Nature, vol. 575, pp. 652–657 . https://doi.org/10.1038/s41586-019-1765-3
Nature, 575(7784), 652-657. Nature Publishing Group
Thompson, D J, Genovese, G, Forsberg, L A, Perry, J R B, International Lung Cancer Consortium (INTEGRAL-ILCCO), Boomsma, D, Nivard, M, van Dongen, J, Pool, R & Hottenga, J J 2019, ' Genetic predisposition to mosaic Y chromosome loss in blood ', Nature, vol. 575, no. 7784, pp. 652-657 . https://doi.org/10.1038/s41586-019-1765-3
Nature
2019, ' Genetic predisposition to mosaic Y chromosome loss in blood ', Nature, vol. 575, no. 7784, pp. 652-657 . https://doi.org/10.1038/s41586-019-1765-3
Thompson, D J, Genovese, G, Halvardson, J, Ulirsch, J C, Wright, D J, Terao, C, Davidsson, O B, Day, F R, Sulem, P, Jiang, Y, Danielsson, M, Davies, H, Dennis, J, Dunlop, M G, Easton, D F, Fisher, V A, Zink, F, Houlston, R S, Ingelsson, M, Kar, S, Kerrison, N D, Kinnersley, B, Kristjansson, R P, Law, P J, Li, R, Loveday, C, Mattisson, J, McCarroll, S A, Murakami, Y, Murray, A, Olszewski, P, Rychlicka-Buniowska, E, Scott, R A, Thorsteinsdottir, U, Tomlinson, I, Moghadam, B T, Turnbull, C, Wareham, N J, Gudbjartsson, D F, Kamatani, Y, Hoffmann, E R, Jackson, S P, Stefansson, K, Auton, A, Ong, K K, Machiela, M J, Loh, P-R, Dumanski, J P, Chanock, S J, Forsberg, L A, International Lung Cancer Consortium (INTEGRAL-ILCCO) & The PRACTICAL Consortium 2019, ' Genetic predisposition to mosaic Y chromosome loss in blood ', Nature, vol. 575, no. 7784, pp. 652-657 . https://doi.org/10.1038/s41586-019-1765-3

مصطلحات موضوعية: Male, 0301 basic medicine, Haematopoietic system, Genome-wide association study, Chromosomes, Human, Y/genetics, Genome-wide association studies, 0302 clinical medicine, Y Chromosome, Neoplasms, Databases, Genetic, Leukocytes, Cancer genomics, Genetics, Multidisciplinary, Mosaicism, Genetic Predisposition to Disease/genetics, Leukocytes/pathology, Middle Aged, Neoplasms/genetics, 3. Good health, 030220 oncology & carcinogenesis, Medical genetics, Female, Chromosome Deletion, Human, Genetic Markers, Adult, Genomic instability, medicine.medical_specialty, Cell division, Y/genetics, Biology, Y chromosome, Article, Genomic Instability, Chromosomes, Databases, 03 medical and health sciences, Genetic, medicine, Genetic predisposition, Humans, Genetic Predisposition to Disease, Gene, Aged, Genetic Markers/genetics, Chromosomes, Human, Y, Computational Biology, Cancer, Chromosome, medicine.disease, United Kingdom, 030104 developmental biology, Genetic marker, Genomic Instability/genetics

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https://doi.org/10.1038/s41586-019-1765-3

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2

Transcription-dependent regulation of replication dynamics modulates genome stability

المؤلفون: Marion Blin, Caroline Brossas, Gaël A. Millot, Mélanie Schmidt, Viola Nähse, Marie-Noëlle Prioleau, Michelle Debatisse, Benoît Le Tallec

المساهمون: Dynamique de l'information génétique : bases fondamentales et cancer (DIG CANCER), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Sorbonne Université (SU), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Institute for Cancer Research [Oslo], Oslo University Hospital [Oslo], Institute of Clinical Medicine [Oslo], Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Stabilité Génétique et Oncogenèse (UMR 8200), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), The M.D. team is supported by the Agence Nationale de la Recherche (grant ANR-13-BSV6-0008-01/FRA-Dom), the Association pour la Recherche sur le Cancer (grant Subvention Libre Sl220130607073), and the Institut National du Cancer (grants INCa subventions 2013-103 and PLBIO17-194). The M.N.P. team is supported by the Association pour la Recherche sur le Cancer (grant Labellisation PGA120150202272) and the Agence Nationale de la Recherche (grant ANR-15-CE12-0004-01). M.B. was supported by fellowships from the Ministère de l’Enseignement Supérieur et de la Recherche and the Ligue contre le cancer., We thank S. Lambert and O. Hyrien for critical reading of the manuscript. The authors would like to acknowledge the Cell and Tissue Imaging Platform – PICT-IBiSA (member of France-Bioimaging) of the Genetics and Developmental Biology Department (UMR3215/U934) of Institut Curie for help with light microscopy, the Flow Cytometry Platform Imagoseine of Institut Jacques Monod, Université Paris Diderot, and the Imaging and Cytometry Platform (PFIC) of Institut Gustave Roussy for assistance with cell sorting., ANR-13-BSV6-0008,FRA-Dom,Chorégraphie des domaines de la chromatine au cours de la différenciation: réorganisation des profils de réplication et des sites fragiles communs(2013), Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Curie-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Lorraine (UL), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Université Paris Descartes - Faculté de Chirurgie Dentaire (UPD5 Odontologie), Université Paris Descartes - Paris 5 (UPD5), Institut Curie

المصدر: Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
Nature Structural and Molecular Biology, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩

مصطلحات موضوعية: DNA Replication, MESH: Genomic Instability / physiology, Transcription, Genetic, [SDV]Life Sciences [q-bio], Mitosis, [SDV.CAN]Life Sciences [q-bio]/Cancer, Endogeny, Biology, Genomic Instability, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Transcription (biology), MESH: Transcription, Genetic / genetics, MESH: DNA Replication / genetics, Animals, Humans, MESH: Animals, MESH: Chromosome Fragile Sites / genetics, MESH: Genomic Instability / genetics, Molecular Biology, Gene, 030304 developmental biology, Genome stability, 0303 health sciences, Replication timing, MESH: Humans, MESH: Mitosis / physiology, Chromosome Fragile Sites, Chromosomal fragile site, Promoter, Cell biology, MESH: Mitosis / genetics, MESH: Chromosome Fragile Sites / physiology, Fragile sites, MESH: DNA Replication / physiology, Transcription, Origin selection, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43eeaf52d0908fdafd2f3542152ba98e
https://doi.org/10.1038/s41594-018-0170-1

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3

رسالة جامعية

The role of cyclin E in cell cycle regulation and genomic instability

المؤلفون: Ekholm-Reed, Susanna

مصطلحات موضوعية: Cell cycle -- physiology, Cyclin E -- metabolism, Genomic instability -- genetics, Gene expression regulation, neoplastic, G1 phase -- physiology, DNA replication -- physiology, Cyclins

URL الوصول: http://diss.kib.ki.se/2004/91-7349-894-7/

Degree: Diss. (sammanfattning) Stockholm : Karol. inst., 2004

4

Homologous Recombination and the Formation of Complex Genomic Rearrangements

المؤلفون: Wolf Dietrich Heyer, Aurèle Piazza

المساهمون: Génétique des Interactions macromoléculaires / Genetics of Macromolecular Interactions, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), University of California [Davis] (UC Davis), University of California (UC), A.P. was supported by fellowships from the Fondation ARC pour la Recherche sur le Cancer (PDF20171206726), the European Molecular Biology Organisation (ALTF-238-2013), the Framework Project 7 of the European Union (Marie Curie International Outgoing Fellowship 628355), and received financial support from the Philippe Foundation. Research in the laboratory of W.D.H. is supported by the National Institutes of Health (grants GM58015 and CA92276) and the France-Berkeley Fund., European Project: 628355,EC:FP7:PEOPLE,FP7-PEOPLE-2013-IOF,MULTIPLE SEARCH, Génétique des Interactions macromoléculaires, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], University of California

المصدر: Trends in cell biology, vol 29, iss 2
Trends in Cell Biology
Trends in Cell Biology, 2019, 29 (2), pp.135-149. ⟨10.1016/j.tcb.2018.10.006⟩
Trends in Cell Biology, Elsevier, 2019, 29 (2), pp.135-149. ⟨10.1016/j.tcb.2018.10.006⟩

مصطلحات موضوعية: DNA Repair, Genetic instability, Genome, Medical and Health Sciences, MESH: DNA Repair, copynumber variation, Double-Stranded, 0302 clinical medicine, Models, DNA Breaks, Double-Stranded, MESH: Models, Genetic, Copy-number variation, Homologous Recombination, Cancer, MESH: Chromothripsis, 0303 health sciences, Chromothripsis, copy number variation, Biological Sciences, multi-invasion, non-allelic homologous recombination, Recombination, Human, Biotechnology, MESH: Chromosomal Instability / genetics, Genome integrity, DNA damage, 1.1 Normal biological development and functioning, Non-allelic homologous recombination, Computational biology, MESH: DNA / genetics, Biology, Article, MESH: Genome, Human / genetics, Genomic Instability, 03 medical and health sciences, structural variant, Genetic, Underpinning research, Chromosomal Instability, structure-selective endonuclease, MESH: DNA Breaks, Double-Stranded, Genetics, MESH: DNA / metabolism, Humans, Homologous recombination, MESH: Genomic Instability / genetics, 030304 developmental biology, MESH: Homologous Recombination, MESH: Humans, Models, Genetic, Genome, Human, DNA Breaks, Human Genome, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Cell Biology, DNA, chromothripsis, Generic health relevance, 030217 neurology & neurosurgery, Developmental Biology

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https://escholarship.org/uc/item/61c9v3w5

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5

Genomic, Transcriptomic, Epigenetic, and Immune Profiling of Mucinous Breast Cancer

المؤلفون: Samira Majjaj, Christine Desmedt, Diether Lambrechts, Denis Larsimont, Bastien Nguyen, Bram Boeckx, Sophia Leduc, Yacine Bareche, Christos Sotiriou, Isabelle Veys, David N Brown

المصدر: Journal of the National Cancer Institute, 111 (7
Journal of the National Cancer Institute

مصطلحات موضوعية: Epigenomics, Cancer Research, Receptor, ErbB-2, Estrogen receptor, Transcriptome, 0302 clinical medicine, Carcinoma, Ductal, Breast -- genetics -- pathology, Genomics -- methods, Adenocarcinoma, Mucinous -- genetics -- pathology, Stromal tumor, skin and connective tissue diseases, Breast Neoplasms -- genetics -- pathology, 0303 health sciences, Mucin-2 -- genetics, Transcriptome -- genetics, Carcinoma, Ductal, Breast, Genomic Instability -- genetics, Genomics, Sciences bio-médicales et agricoles, Adenocarcinoma, Mucinous, Receptors, Estrogen -- genetics, Exact test, Oncology, Receptors, Estrogen, 030220 oncology & carcinogenesis, Lymphatic Metastasis, DNA methylation, Female, Receptors, Progesterone, Life Sciences & Biomedicine, Class I Phosphatidylinositol 3-Kinases, DNA Methylation -- genetics, DISTINCT, Breast Neoplasms, Genomic Instability, Epigenomics -- methods, 03 medical and health sciences, Breast cancer, Receptor, ErbB-2 -- genetics, medicine, Humans, Epigenetics, 030304 developmental biology, Mucin-2, Science & Technology, Tumor-infiltrating lymphocytes, business.industry, Médecine pathologie humaine, DNA Methylation, medicine.disease, Cancérologie, INVASIVE DUCTAL CARCINOMAS, Receptors, Progesterone -- genetics, Class I Phosphatidylinositol 3-Kinases -- genetics, Cancer research, business

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https://pubmed.ncbi.nlm.nih.gov/30789657

6

Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability

المؤلفون: Coutelier, Héloïse, Xu, Zhou, Morisse, Mony Chenda, Lhuillier-Akakpo, Maoussi, Pelet, Serge, Charvin, Gilles, Dubrana, Karine, Teixeira, Maria Teresa

المساهمون: Gestionnaire, Hal Sorbonne Université, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes (LBMCE), Institut de biologie physico-chimique (IBPC (FR_550)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Stabilité génétique, Cellules Souches et Radiations (SCSR (U_967)), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Department of Fundamental Microbiology [Lausanne], Université de Lausanne = University of Lausanne (UNIL), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA), Centre National de la Recherche Scientifique (CNRS)-Institut de biologie physico-chimique (IBPC (FR_550)), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université de Lausanne (UNIL), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), ANR-16-CE12-0026,InTelo,Comment la prolifération cellulaire est contrôlée par les télomères: une approche à l'échelle de lignée cellulaire individuelle(2016)

المصدر: Genes and Development
Genes and Development, 2018, 32 (23-24), pp.1499-1513. ⟨10.1101/gad.318485.118⟩
Genes and Development, Cold Spring Harbor Laboratory Press, 2018, 32 (23-24), pp.1499-1513. ⟨10.1101/gad.318485.118⟩
Genes & development, vol. 32, no. 23-24, pp. 1499-1513

مصطلحات موضوعية: telomere, senescence, DNA Repair, [SDV]Life Sciences [q-bio], Optical Imaging, Adaptation, Physiological/genetics, Cell Cycle Checkpoints/genetics, DNA Damage/genetics, Genome, Fungal/genetics, Genomic Instability/genetics, Microfluidic Analytical Techniques, Mutation, Saccharomyces cerevisiae/enzymology, Saccharomyces cerevisiae/genetics, Telomerase/genetics, Cdc5, DNA damage checkpoint, adaptation, genomic instability, Cell Cycle Checkpoints, Saccharomyces cerevisiae, Adaptation, Physiological, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Genome, Fungal, Corrigendum, Telomerase, DNA Damage, Research Paper

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https://hal.sorbonne-universite.fr/hal-01953114/document

7

Targeting DNA Damage in SCLC

المؤلفون: Fabio Gomes, Fiona H Blackhall, Kristopher K. Frese, Katie Baker, Martin Forster, Maximilian W Schenk, Alice Lallo, Victoria Foy, Caroline Dive

المصدر: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Foy, V, Schenk, M, Baker, K, Gomes, F, Lallo, A, Frese, K, Forster, M, Dive, C & Blackhall, F 2017, ' Targeting DNA damage in SCLC ', Lung Cancer, vol. 114, 11, pp. 12-22 . https://doi.org/10.1016/j.lungcan.2017.10.006

مصطلحات موضوعية: 0301 basic medicine, Genome instability, Cancer Research, Cell cycle checkpoint, Lung Neoplasms, DNA Repair, Protein Kinase Inhibitors/therapeutic use, Piperazines, Cell Proliferation/drug effects, Small Cell Lung Carcinoma/genetics, 0302 clinical medicine, Phthalazines/therapeutic use, Aurora Kinases, Molecular Targeted Therapy, Etoposide, Genetics, Rad51 Recombinase/antagonists & inhibitors, Manchester Cancer Research Centre, Cytotoxins, Azepines, Oncology, Cell Cycle Checkpoints/genetics, Heterocyclic Compounds, 4 or More Rings/therapeutic use, Rad51 Recombinase/therapeutic use, 030220 oncology & carcinogenesis, medicine.drug, Pulmonary and Respiratory Medicine, Benzimidazoles/therapeutic use, Lung Neoplasms/genetics, DNA damage, DNA repair, Context (language use), Poly(ADP-ribose) Polymerase Inhibitors, Heterocyclic Compounds, 4 or More Rings, Genomic Instability, 03 medical and health sciences, Cell Proliferation/genetics, medicine, Cytotoxins/therapeutic use, Humans, CHLC ONC, Lung cancer, Lung Neoplasms/drug therapy, Protein Kinase Inhibitors, Cell Proliferation, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Pyrimidines/therapeutic use, Small Cell Lung Carcinoma/drug therapy, Cell Cycle Checkpoints, Carbolines/therapeutic use, Cell Cycle Checkpoints/drug effects, Etoposide/therapeutic use, medicine.disease, Small Cell Lung Carcinoma, Piperazines/therapeutic use, respiratory tract diseases, 030104 developmental biology, Pyrimidines, DNA Damage/drug effects, Genomic Instability/drug effects, Cancer cell, Cancer research, Phthalazines, Benzimidazoles, Azepines/therapeutic use, Rad51 Recombinase, DNA Damage/genetics, Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use, business, Aurora Kinases/therapeutic use, Genomic Instability/genetics, Molecular Targeted Therapy/methods, Carbolines, DNA Damage