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المؤلفون: Tricia Protack, Michael A. Walker, Guo Li, David R. Langley, B. Narasimhulu Naidu, Nicholas A. Meanwell, George L. Trainor, Alicia Ng, Susan Jenkins, Mark Krystal, Zeyu Lin, Samuel Gerritz, Christopher Cianci, Hal A. Lewis, Kevin Kish, Javed Khan, Prasanna Sivaprakasam, Annapurna Pendri, Ira B. Dicker, Linda Discotto
المصدر: Journal of Medicinal Chemistry. 63:2620-2637
مصطلحات موضوعية: Male, Pyridines, Allosteric regulation, Administration, Oral, HIV Infections, HIV Integrase, Pharmacology, 01 natural sciences, Pyrazolopyrimidine, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, Animals, Humans, Transferase, HIV Integrase Inhibitors, Vector (molecular biology), 030304 developmental biology, 0303 health sciences, biology, Chemistry, Drug discovery, virus diseases, Active site, 0104 chemical sciences, Bioavailability, Integrase, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, HIV-1, biology.protein, Pyrazoles, Molecular Medicine
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المؤلفون: Chris Roberts, George L. Trainor, Matt Lucas, Luca Arista, Nigel J. Waters, Iwona Wrona, Elizabeth Buck, Tai-An Lin, Darlene Romashko, Deborah Chen, Matthew O'Connor, Alexander Flohr, David R. Raleigh, Giorgio Ottaviani, Raffaele Fiorenza, Theodore Nicolaides, Tomoko Ozawa, Sara Rasmussen
المصدر: Cancer Research. 81:LB140-LB140
مصطلحات موضوعية: Cancer Research, business.industry, Allosteric regulation, Mutant, Brain tumor, Cancer, medicine.disease, Blood–brain barrier, chemistry.chemical_compound, medicine.anatomical_structure, Oncology, chemistry, medicine, Cancer research, In patient, Penetrant (biochemical), business, EGFR inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::911562fa874222b1ecfca796f985896b
https://doi.org/10.1158/1538-7445.am2021-lb140 -
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المؤلفون: Chris Roberts, David R. Raleigh, Giorgio Ottaviani, Tomoko Ozawa, Matthew O'Connor, Raffaele Fiorenza, Elizabeth Buck, Luca Arista, Nigel J. Waters, Theodore Nicolaides, Alexander Flohr, George L. Trainor, Sara Rasmussen, Tai-An Lin, Darlene Romashko, Matt Lucas
المصدر: Neuro Oncol
مصطلحات موضوعية: Cancer Research, Mutation, Mutant, Preclinical Experimental Therapeutics, medicine.disease_cause, Blood–brain barrier, EGFR Gene Mutation, chemistry.chemical_compound, medicine.anatomical_structure, Oncology, chemistry, Extracellular, medicine, Cancer research, Neurology (clinical), Signal transduction, Penetrant (biochemical), Tumor xenograft
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd85c889bdb9e39960cfeae85a85f45
https://doi.org/10.1093/neuonc/noaa215.413 -
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المؤلفون: Robert F. Kaltenbach, Simon P. Robinson, George L. Trainor
المصدر: Asian Spine Journal
Selective Estrogen Receptor Modulators
Asian Spine Journal, Vol 10, Iss 4, Pp 787-791 (2016)مصطلحات موضوعية: medicine.medical_specialty, medicine.drug_class, Colorectal cancer, Osteoporosis, lcsh:Medicine, Estrogen receptor, Review Article, Breast cancer, Internal medicine, medicine, Orthopedics and Sports Medicine, Estrogen receptor beta, business.industry, lcsh:R, medicine.disease, Endocrinology, Estrogen, Selective estrogen receptor modulator, Cancer research, Surgery, business, Selective estrogen receptor modulators, Tamoxifen, hormones, hormone substitutes, and hormone antagonists, medicine.drug
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المؤلفون: Gregory D. Vite, Paul A. Elzinga, David L. Gold, Cheryl A. Rizzo, Thomas E. Spires, Sophie Beyer, Vanessa M. Spires, Marco M. Gottardis, George L. Trainor, Aberra Fura, Audris Huang, Gordon Todderud, John A. Newitt, Lata Jayaraman, Aaron Balog, Andrew J. Tebben, Yongxin Zhu, Mary T. Obermeier, Goodenough Angela, Bethanne M. Warrack, Arthur M. Doweyko, Yi Fan
المصدر: ACS Medicinal Chemistry Letters. 7:40-45
مصطلحات موضوعية: 0301 basic medicine, Benzimidazole, education, Organic Chemistry, Pharmacology, medicine.disease, Lyase, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Prostate cancer, 030104 developmental biology, chemistry, In vivo, CYP17A1, Lyase inhibitor, Drug Discovery, medicine, Steroid 11-beta-hydroxylase, Glucocorticoid, medicine.drug
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المؤلفون: Hart Amy C, Javed Khan, Grebinski James W, James Kempson, Jonathan Lippy, Gretchen M. Schroeder, Theresa M. McDevitt, Ashok V. Purandare, Ragini Vuppugalla, John S. Tokarski, George L. Trainor, Junqing Guo, Jennifer Inghrim, Matthew V. Lorenzi, Dan You, Honghe Wan, John S. Sack, William J. Pitts, Yueping Zhang, Louis J. Lombardo
المصدر: ACS Medicinal Chemistry Letters. 6:845-849
مصطلحات موضوعية: Janus kinase 2, biology, Kinase, Organic Chemistry, Hit to lead, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Pyridine, biology.protein, Side chain, Structure based, Selectivity, Thiazole
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المؤلفون: Janet Dell-John, John D. Dimarco, Cheryl A. Rizzo, Mark E. Salvati, Steven H. Spergel, Gregory Scott Martin, Weifang Shan, Aaron Balog, Georgia Cornelius, Richard Rampulla, Marco M. Gottardis, Andrew Nation, Christian L. Holst, Liang Schweizer, Gregory D. Vite, Lana M. Rossiter, Ricardo M. Attar, David J. Fairfax, Thomas E. Spires, Stanley R. Krystek, George L. Trainor, Jack Z. Gougoutas
المصدر: ACS Medicinal Chemistry Letters. 6:908-912
مصطلحات موضوعية: Nonsteroidal, Bicalutamide, business.industry, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, Cancer, Pharmacology, medicine.disease, Biochemistry, In vitro, Androgen receptor, stomatognathic diseases, Prostate cancer, chemistry.chemical_compound, chemistry, Drug Discovery, Medicine, Androgen receptor antagonist, business, medicine.drug
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المؤلفون: George L. Trainor, Jun Dai, Arvind Mathur, Francis Y. Lee, Sunilkumar Mandal, Yingru Zhang, Richard Rampulla, Kiran Babu Gona, Patrice Gill, Raja Thiruvenkadam, Victor R. Guarino, Wen-Ching Han, Ding Ren Shen, Aaron Balog, Mary Ellen Cvijic, Dauh-Rurng Wu, Gregory D. Vite, Krista Menard, Anne Rose, Sathiah Kandula, Ashvinikumar V. Gavai, Weifang Shan, John T. Hunt, Asoka Ranasinghe, Kelly McGlinchey, Richard A. Westhouse, Claude A. Quesnelle, Derek J. Norris, Mei-Li Wen, Ronald E. White, Kamalraj Thiyagarajan
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:1905-1909
مصطلحات موضوعية: Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Receptor, Solid tumor, Molecular Biology, Cell Proliferation, Benzodiazepinones, Dose-Response Relationship, Drug, Molecular Structure, Receptors, Notch, Chemistry, Organic Chemistry, Biological activity, Neoplasms, Experimental, medicine.disease, Leukemia, Orally active, Microsomes, Liver, Molecular Medicine, Drug Screening Assays, Antitumor
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المؤلفون: Claude A. Quesnelle, Patrice Gill, Richard Rampulla, Ching Su, Gerry Everlof, George L. Trainor, Ke Chen, Vinod Arora, Richard A. Westhouse, Celia D’Arienzo, Andrew J. Tebben, Weifang Shan, John T. Hunt, Derek J. Norris, Louis J. Lombardo, Zheng Yang, Arvind Mathur, Mei-Li Wen, Yingru Zhang, Dauh-Rurng Wu, Wen-Ching Han, Krista Menard, Victor R. Guarino, Asoka Ranasinghe, Richard E. Olson, Ashvinikumar V. Gavai, Bruce S. Fischer, Phil S. Baran, Anne Rose, Lan Xiao, Ronald E. White, Mary Ellen Cvijic, Gregory D. Vite, Ding Ren Shen, Jere E. Meredith, Haiqing Wang, Francis Y. Lee, Aaron Balog
المصدر: ACS Medicinal Chemistry Letters. 6:523-527
مصطلحات موضوعية: business.industry, Organic Chemistry, Pharmacology, medicine.disease, Biochemistry, T Acute Lymphoblastic Leukemia, Leukemia, In vivo, Drug Discovery, medicine, Receptor, business, Solid tumor, Clinical evaluation, Triple-negative breast cancer
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المؤلفون: George L. Trainor, Andrew Nation, Ricardo M. Attar, Jun Dai, Xiao Zhu, Jing Chen, Mary T. Obermeier, Weifang Shan, Mary Ellen Cvijic, Gregory D. Vite, Cheryl A. Rizzo, Sarah C. Traeger, Michael Galella, Ashvinikumar V. Gavai, Thomas E. Spires, Aaron Balog, Yingru Zhang, Jieping Geng
المصدر: Bioorganicmedicinal chemistry letters. 26(23)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Biochemistry, 03 medical and health sciences, Bridged Bicyclo Compounds, Structure-Activity Relationship, 0302 clinical medicine, Pharmacokinetics, Naphthalenesulfonates, Cell Line, Tumor, Drug Discovery, Androgen Receptor Antagonists, Structure–activity relationship, Androgen receptor antagonist, Animals, Humans, Molecular Biology, Bicyclic molecule, Chemistry, Organic Chemistry, Biological activity, Rats, Androgen receptor, 030104 developmental biology, Nuclear receptor, Receptors, Androgen, 030220 oncology & carcinogenesis, Molecular Medicine