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1
المؤلفون: Matthew D. Hill, Haiquan Fang, Derek Norris, George V. Delucca, Hong Huang, Mikkel DeBenedetto, Claude Quesnelle, William D. Schmitz, John S. Tokarski, Steven Sheriff, Chunhong Yan, Caroline Fanslau, Zuzana Haarhoff, Christine Huang, Melissa Kramer, Shilpa Madari, Krista Menard, Laura Monereau, John Morrison, Nirmala Raghavan, Eric E. Shields, Jean Simmermacher-Mayer, Michael Sinz, Ching Kim Tye, Richard Westhouse, Chunshan Xie, Haiying Zhang, Lisa Zhang, Tatyana Zvyaga, Francis Lee, Ashvinikumar V. Gavai, Andrew P. Degnan
المصدر: ACS Medicinal Chemistry Letters. 13:1165-1171
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
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2
المؤلفون: Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
المصدر: Journal of Medicinal Chemistry. 64:14247-14265
مصطلحات موضوعية: Drug, Proline, Phenylalanine, media_common.quotation_subject, Carbazoles, Administration, Oral, Antineoplastic Agents, Cell Cycle Proteins, Computational biology, BET inhibitor, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Transcriptional regulation, Humans, Potency, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Tryptophan, Signal transducing adaptor protein, Bromodomain, Molecular Medicine, Transcription Factors
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3
المؤلفون: Mary-Ellen Cvijic, Percy H. Carter, Douglas G. Batt, Qing Shi, George V. Delucca, Rui-Qin Liu, Qihong Zhao, Gregory D. Brown, Feng Qiu, Joel C. Barrish, Michael Galella
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:662-666
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, CCR2, Receptors, CCR2, Stereochemistry, animal diseases, Clinical Biochemistry, Cyclohexene, Pharmaceutical Science, Ring (chemistry), 01 natural sciences, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cyclohexenes, parasitic diseases, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, IC50, G protein-coupled receptor, Drug discovery, Chemistry, Organic Chemistry, hemic and immune systems, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine, CC chemokine receptors
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المؤلفون: Andrew J. Tebben, Wenqing Yao, Prabhakar Reddy, Carl P. Decicco, John V. Duncia, Eric A. Wadman, Kimberly A. Solomon, Percy H. Carter, Patricia K. Welch, Paul Davies, Sandhya Mandlekar, George V. Delucca, Soo S. Ko, Paul S. Watson, Ilona Kariv, Chongsheng Shi, Gardner Daniel S, Dean A. Wacker, Swamy Yeleswaram, Dani M. Graden, Joseph B. Santella
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:576-585
مصطلحات موضوعية: Cyclohexane, Stereochemistry, Receptors, CCR3, Clinical Biochemistry, Molecular Conformation, Ab initio, Administration, Oral, Pharmaceutical Science, Plasma protein binding, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Piperidines, Drug Discovery, Animals, Cytochrome P-450 Enzyme Inhibitors, Urea, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Hydrogen Bonding, Chemotaxis, Rats, Eosinophils, Chemotaxis, Leukocyte, Eosinophil chemotaxis, Molecular Medicine, Linker