المؤلفون: Riccardo Ronchetti, Luigi Alfonso Pannone, Bruno Cerra, Emidio Camaioni, Gianfranco Lopopolo, Emanuele Attolino, Antimo Gioiello

المصدر: Molecules, Vol 28, Iss 23, p 7859 (2023)

مصطلحات موضوعية: mometasone furoate, mometasone furoate EP impurity C, synthesis of APIs impurities, steroid, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/23/7859; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/d976aa964adf42c7a81b6b6ca039c861

المؤلفون: Magda Monari, Emanuele Attolino, Gianfranco Lopopolo, Fabrizio Bosco, Massimo Gazzano

المصدر: Crystals, Vol 13, Iss 8, p 1211 (2023)

مصطلحات موضوعية: estetrol, polymorphism, crystal structure, thermal stability, Crystallography, QD901-999

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4352/13/8/1211; https://doaj.org/toc/2073-4352

URL الوصول: https://doaj.org/article/d9860dea6fce4209b172f29210d48d14

المؤلفون: Flavio De Maio, Mariagrazia Rullo, Modesto de Candia, Rosa Purgatorio, Gianfranco Lopopolo, Giulia Santarelli, Valentina Palmieri, Massimiliano Papi, Gabriella Elia, Erica De Candia, Maurizio Sanguinetti, Cosimo Damiano Altomare

المصدر: Viruses, Vol 14, Iss 8, p 1730 (2022)

مصطلحات موضوعية: factor Xa, thrombin, anticoagulants, SARS-CoV-2, COVID-19, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/8/1730; https://doaj.org/toc/1999-4915

URL الوصول: https://doaj.org/article/37a09714cf044919b8b60db65bfe2bb4

المؤلفون: Rosa Purgatorio, Nicola Gambacorta, Francesco Samarelli, Gianfranco Lopopolo, Modesto de Candia, Marco Catto, Orazio Nicolotti, Cosimo D. Altomare

المصدر: Molecules, Vol 27, Iss 13, p 4269 (2022)

مصطلحات موضوعية: antithrombotic agents, N,N′-malonamides, fXa inhibitors, thrombin inhibitors, acetylcholinesterase, butyrylcholinesterase, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/13/4269; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/ce80e619bc244730a8c2370c8db82558

المؤلفون: Modesto de Candia, Cosimo Altomare, Gianfranco Lopopolo, Francesca Incampo, Mario Colucci, Giorgia Zaetta, Rocco Caliandro, Benny Danilo Belviso

المصدر: Journal of medicinal chemistry 57 (2014): 8563–8575. doi:10.1021/jm5010754
info:cnr-pdr/source/autori:Belviso, Benny D.; Caliandro, Rocco; de Candia, Modesto; Zaetta, Giorgia; Lopopolo, Gianfranco; Incampo, Francesca; Colucci, Mario; Altomare, Cosimo D./titolo:How a beta-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study, and Evaluation of Antithrombotic Properties/doi:10.1021%2Fjm5010754/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:8563/pagina_a:8575/intervallo_pagine:8563–8575/volume:57

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Cooperativity, Chemistry Techniques, Synthetic, Thiophenes, Crystal structure, Crystallography, X-Ray, Antithrombins, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, Glucosides, Glucoside, Drug Discovery, Antithrombotic, medicine, Side chain, Humans, Moiety, Potency, Fibrin, Binding Sites, Dose-Response Relationship, Drug, Chemistry, Fibrinolysis, Anticoagulants, Hydrogen Bonding, Molecular Medicine, Factor Xa Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef594adb70b266c2a81cc672b046fdc9
https://doi.org/10.1021/jm5010754

المؤلفون: Gianfranco Lopopolo, Luigi Panza, Modesto de Candia, Maria Rosaria Romano, Marcello D. Lograno, Francesco Campagna, Cosimo Altomare

المصدر: ChemMedChem. 7:1669-1677

مصطلحات موضوعية: Male, medicine.drug_mechanism_of_action, Stereochemistry, Factor Xa Inhibitor, Thiophenes, Biochemistry, Serine, Mice, Thrombin, Drug Discovery, medicine, Animals, Humans, Thromboplastin, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Blood coagulation test, Pharmacology, Prothrombin time, chemistry.chemical_classification, medicine.diagnostic_test, Chemistry, Organic Chemistry, Anticoagulants, Blood Coagulation Factors, Enzyme binding, Glucose, Enzyme, Factor Xa, Molecular Medicine, Blood Coagulation Tests, Factor Xa Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cc2cf3197c97f0b1e35d3114400d0a
https://doi.org/10.1002/cmdc.201200224

المؤلفون: Modesto de Candia, Gianfranco Lopopolo, Cosimo Altomare

المصدر: Expert Opinion on Therapeutic Patents. 19:1535-1580

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Stroke etiology, medicine.drug_mechanism_of_action, medicine.drug_class, Factor Xa Inhibitor, Hemorrhage, Patents as Topic, Thromboembolism, Internal medicine, Atrial Fibrillation, Drug Discovery, Antithrombotic, medicine, Animals, Humans, In patient, cardiovascular diseases, Pharmacology, business.industry, Anticoagulant, Anticoagulants, General Medicine, Surgery, Stroke, Drug Design, Stroke prevention, business, Venous thromboembolism, Factor Xa Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6997ab28791c18e62d8eb525ccaffd6
https://doi.org/10.1517/13543770903270532

المؤلفون: Maria Rosaria Romano, Gianfranco Lopopolo, Filomena Fiorella, Modesto de Candia, Andrea Carotti, Marcello D. Lograno, Sophie Martel, Cosimo Altomare, Pierre-Alain Carrupt, Benny Danilo Belviso, Rocco Caliandro

المصدر: Journal of medicinal chemistry 56 (2013): 8696–8711. doi:10.1021/jm401169a
info:cnr-pdr/source/autori:de Candia, Modesto; Fiorella, Filomena; Lopopolo, Gianfranco; Carotti, Andrea; Romano, Maria Rosaria; Lograno, Marcello Diego; Martel, Sophie; Carrupt, Pierre-Alain; Belviso, Benny D.; Caliandro, Rocco; Altomare, Cosimo/titolo:Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity/doi:10.1021%2Fjm401169a/rivista:Journal of medicinal chemistry/anno:2013/pagina_da:8696/pagina_a:8711/intervallo_pagine:8696–8711/volume:56

مصطلحات موضوعية: Male, Models, Molecular, Proteases, Pyrrolidines, Membrane permeability, Stereochemistry, Molecular Dynamics Simulation, Crystallography, X-Ray, Serine, Mice, Structure-Activity Relationship, Thrombin, Piperidines, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Blood Coagulation, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Anticoagulants, Trypsin, In vitro, Factor X, Molecular Medicine, Cattle, Blood Coagulation Tests, Serine Proteases, Ex vivo, Discovery and development of direct thrombin inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6737437b86d975ef8a8c7f9e21f5b5de
http://www.cnr.it/prodotto/i/305511

المؤلفون: Filomena Fiorella, Pierre-Alain Carrupt, Gianfranco Lopopolo, Cosimo Altomare, Sophie Martel, Orazio Nicolotti, Modesto de Candia

المصدر: European Journal of Pharmaceutical Sciences, Vol. 42 (2011) pp. 180-190

مصطلحات موضوعية: Proteases, Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Spectrophotometry, Infrared, Stereochemistry, Factor Xa Inhibitor, Pharmaceutical Science, Serine, Amidine, chemistry.chemical_compound, Structure-Activity Relationship, Thrombin, medicine, Humans, Anilides, chemistry.chemical_classification, ddc:615, Enzyme, Biochemistry, chemistry, Docking (molecular), Isopropyl, medicine.drug, Factor Xa Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d72f45b1fe7790e0decd97fa605e3b1
https://pubmed.ncbi.nlm.nih.gov/21112391