المؤلفون: Dos Santos Ferreira D; From the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School., Arora G; Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA., Gieseck RL 3rd; Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Rotile NJ; From the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School., Waghorn PA; From the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School., Tanabe KK; Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA., Wynn TA; Laboratory of Parasitic Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Caravan P, Fuchs BC; Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA.

المصدر: Investigative radiology [Invest Radiol] 2021 Apr 01; Vol. 56 (4), pp. 244-251.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0045377 Publication Model: Print Cited Medium: Internet ISSN: 1536-0210 (Electronic) Linking ISSN: 00209996 NLM ISO Abbreviation: Invest Radiol Subsets: MEDLINE

مواضيع طبية MeSH: Schistosomiasis mansoni*/diagnostic imaging , Schistosomiasis mansoni*/pathology, Animals ; Inflammation/diagnostic imaging ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/diagnostic imaging ; Magnetic Resonance Imaging ; Mice ; Schistosoma mansoni

المؤلفون: Rimland CA; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.; Medical Scientist Training Program, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC., Tilson SG; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.; Welcome Trust Sanger Institute, Hinxton, United Kingdom.; Liver Diseases Branch, NIDDK, NIH, Bethesda, MD., Morell CM; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Tomaz RA; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Lu WY; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, The University of Birmingham, Birmingham, United Kingdom., Adams SE; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD.; Department of Biological Sciences, North Carolina State University, Raleigh, NC., Georgakopoulos N; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Otaizo-Carrasquero F; Genomic Technologies Section, Research Technologies Branch, NIAID, NIH, Bethesda, MD., Myers TG; Genomic Technologies Section, Research Technologies Branch, NIAID, NIH, Bethesda, MD., Ferdinand JR; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Gieseck RL 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD., Sampaziotis F; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Tysoe OC; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Ross A; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Kraiczy JM; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Wesley B; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Muraro D; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.; Welcome Trust Sanger Institute, Hinxton, United Kingdom., Zilbauer M; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Oniscu GC; Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, United Kingdom., Hannan NRF; Division of Cancer and Stem Cells, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom.; National Institute for Health Research Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom., Forbes SJ; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom., Saeb-Parsy K; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Wynn TA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD., Vallier L; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2021 Jan; Vol. 73 (1), pp. 247-267.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Bile Ducts, Extrahepatic/*cytology , Bile Ducts, Intrahepatic/*cytology , Epithelial Cells/*cytology , Organoids/*physiology, Animals ; Bile ; Bile Ducts, Extrahepatic/physiology ; Bile Ducts, Intrahepatic/physiology ; Cell Differentiation ; Common Bile Duct/cytology ; Epithelial Cells/physiology ; Gallbladder/cytology ; Gene Expression Regulation ; Humans ; Keratin-19/analysis ; Liver/physiology ; Mice ; RNA-Seq ; Tissue and Organ Procurement

المؤلفون: Karmele EP; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Institute for Biomedical Sciences, The George Washington University, Washington, DC, USA., Pasricha TS; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Ramalingam TR; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Thompson RW; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Gieseck RL 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Inflammation and Immunology Research Unit, Pfizer Inc., Cambridge, MA, USA., Knilans KJ; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Hegen M; Inflammation and Immunology Research Unit, Pfizer Inc., Cambridge, MA, USA., Farmer M; Biomedicine Design, Pfizer Inc., Cambridge, MA, USA., Jin F; Biomedicine Design, Pfizer Inc., Cambridge, MA, USA., Kleinman A; 23andMe, Mountain View, CA, USA., Hinds DA; 23andMe, Mountain View, CA, USA., Almeida Pereira T; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., de Queiroz Prado R; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Inflammation and Immunology Research Unit, Pfizer Inc., Cambridge, MA, USA., Bing N; Human Genetics, Pfizer Inc., Cambridge, MA, USA., Tchistiakova L; Biomedicine Design, Pfizer Inc., Cambridge, MA, USA., Kasaian MT; Inflammation and Immunology Research Unit, Pfizer Inc., Cambridge, MA, USA., Wynn TA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Inflammation and Immunology Research Unit, Pfizer Inc., Cambridge, MA, USA., Vannella KM; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. kevin.vannella@nih.gov.

مؤلفون مشاركون: 23andMe Research Team

المصدر: Mucosal immunology [Mucosal Immunol] 2019 Sep; Vol. 12 (5), pp. 1174-1186. Date of Electronic Publication: 2019 Jul 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101299742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-3456 (Electronic) Linking ISSN: 19330219 NLM ISO Abbreviation: Mucosal Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents/*pharmacology , Antibodies, Monoclonal/*pharmacology , Inflammatory Bowel Diseases/*metabolism , Interleukin-13 Receptor alpha2 Subunit/*antagonists & inhibitors , Interleukin-13 Receptor alpha2 Subunit/*metabolism, Animals ; Crohn Disease/etiology ; Crohn Disease/metabolism ; Crohn Disease/pathology ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Disease Susceptibility ; Eosinophils/immunology ; Eosinophils/metabolism ; Gain of Function Mutation ; Genetic Variation ; Humans ; Immunity ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/pathology ; Interleukin-13 Receptor alpha2 Subunit/genetics ; Mice ; Odds Ratio

المؤلفون: Gieseck RL 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20852, USA., Wilson MS; Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA., Wynn TA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20852, USA.

المصدر: Nature reviews. Immunology [Nat Rev Immunol] 2018 Jan; Vol. 18 (1), pp. 62-76. Date of Electronic Publication: 2017 Aug 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1741 (Electronic) Linking ISSN: 14741733 NLM ISO Abbreviation: Nat Rev Immunol

مواضيع طبية MeSH: Cytokines/*immunology , Fibrosis/*immunology , Regeneration/*immunology , Th2 Cells/*immunology, Alarmins/immunology ; Basophils/immunology ; Eosinophils/immunology ; Epithelial Cells ; Humans ; Hypersensitivity/immunology ; Immunity, Innate/immunology ; Interleukin-13/immunology ; Interleukin-4/immunology ; Interleukin-5/immunology ; Interleukin-9/immunology ; Liver Cirrhosis/immunology ; Liver Diseases, Parasitic/immunology ; Lymphocytes/immunology ; Macrophages/immunology ; Mast Cells/immunology ; Parasitic Diseases/immunology ; Pulmonary Fibrosis/immunology ; Schistosomiasis/immunology

المؤلفون: Sampaziotis F; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Justin AW; Department of Engineering, University of Cambridge, Cambridge, UK., Tysoe OC; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Sawiak S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Godfrey EM; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Gieseck RL 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA., de Brito MC; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Berntsen NL; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Gómez-Vázquez MJ; Cambridge Genomic Services, Department of Pathology, University of Cambridge, Cambridge, UK., Ortmann D; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Yiangou L; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Ross A; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; University Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Bargehr J; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Bertero A; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Zonneveld MCF; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK., Pedersen MT; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark., Pawlowski M; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK., Valestrand L; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Madrigal P; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Georgakopoulos N; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Pirmadjid N; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Skeldon GM; School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK.; Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK., Casey J; Department of Surgery, University of Edinburgh, Edinburgh Royal Infirmary, Edinburgh, UK., Shu W; School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK.; Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK., Materek PM; NIHR Cambridge Biomedical Centre (BRC) hIPSCs Core Facility, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Snijders KE; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK., Brown SE; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Rimland CA; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA.; University of North Carolina, Chapel Hill, School of Medicine, Chapel Hill, North Carolina, USA., Simonic I; Medical Genetics Laboratories, Cambridge University Hospitals NHS Trust, Cambridge, UK., Davies SE; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Jensen KB; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Zilbauer M; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Gelson WTH; Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Alexander GJ; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Sinha S; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; University Department of Paediatrics, University of Cambridge, Cambridge, UK., Hannan NRF; Center for Biomolecular Sciences, University of Nottingham, Nottingham, UK.; Nottingham Digestive Diseases Centre, NIHR Nottingham Biomedical Research Centre at the Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK., Wynn TA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA., Karlsen TH; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Melum E; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Markaki AE; Department of Engineering, University of Cambridge, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Vallier L; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.

المصدر: Nature medicine [Nat Med] 2017 Aug; Vol. 23 (8), pp. 954-963. Date of Electronic Publication: 2017 Jul 03.

نوع المنشور: Journal Article; Video-Audio Media

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Bile Ducts, Extrahepatic/*physiology , Epithelial Cells/*cytology , Gallbladder/*physiology , Organoids/*physiology , Regeneration/*physiology , Tissue Engineering/*methods, Animals ; Bile Ducts, Extrahepatic/cytology ; Bile Ducts, Extrahepatic/injuries ; Biliary Tract/cytology ; Biliary Tract/injuries ; Biliary Tract/physiology ; Cell Transplantation ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Gallbladder/injuries ; Humans ; In Vitro Techniques ; Keratin-19/metabolism ; Keratin-7/metabolism ; Mice ; Organoids/cytology ; Organoids/drug effects ; Organoids/metabolism ; Secretin/pharmacology ; Somatostatin/pharmacology ; Tissue Scaffolds ; gamma-Glutamyltransferase/metabolism

المؤلفون: Hart KM; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Fabre T; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Québec, Canada., Sciurba JC; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Gieseck RL 3rd; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Borthwick LA; Tissue Fibrosis and Repair Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Vannella KM; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Acciani TH; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., de Queiroz Prado R; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Thompson RW; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., White S; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Soucy G; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Département de pathologie et biologie cellulaire, Université de Montréal, Montréal, Québec, Canada., Bilodeau M; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Département de médecine, Université de Montréal, Montréal, Québec, Canada., Ramalingam TR; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Arron JR; Genentech Inc., South San Francisco, CA 94080, USA., Shoukry NH; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Département de médecine, Université de Montréal, Montréal, Québec, Canada., Wynn TA; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. twynn@niaid.nih.gov.

المصدر: Science translational medicine [Sci Transl Med] 2017 Jun 28; Vol. 9 (396).

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Disease Progression* , Immunity*, Metabolic Diseases/*immunology , Metabolic Diseases/*prevention & control , Non-alcoholic Fatty Liver Disease/*immunology , Non-alcoholic Fatty Liver Disease/*prevention & control , Transforming Growth Factor beta/*metabolism, Adipose Tissue/pathology ; Animals ; Diet, High-Fat ; Eosinophils/pathology ; Humans ; Inflammation/pathology ; Interferon-gamma/deficiency ; Interferon-gamma/metabolism ; Liver Cirrhosis/pathology ; Male ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity/pathology

المؤلفون: Gieseck RL 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge CB2 0SZ, UK., Ramalingam TR; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA., Hart KM; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA., Vannella KM; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA., Cantu DA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA., Lu WY; Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Ferreira-González S; Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Forbes SJ; Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Vallier L; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge CB2 0SZ, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK., Wynn TA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA. Electronic address: twynn@niaid.nih.gov.

المصدر: Immunity [Immunity] 2016 Jul 19; Vol. 45 (1), pp. 145-58. Date of Electronic Publication: 2016 Jul 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

مواضيع طبية MeSH: Fatty Liver/*immunology , Fibroblasts/*immunology , Interleukin-13/*metabolism , Liver/*pathology , Liver Cirrhosis, Biliary/*immunology , Schistosoma mansoni/*immunology , Schistosomiasis mansoni/*immunology, Animals ; Bile Acids and Salts/biosynthesis ; Cell Proliferation ; Cells, Cultured ; Fibrosis ; Humans ; Interleukin-13/genetics ; Interleukin-13/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction ; Th2 Cells/immunology

المؤلفون: Gieseck RL 3rd; Department of Surgery, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Forvie Building, Robinson Way, Cambridge, UK; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA., Colquhoun J; Department of Surgery, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Forvie Building, Robinson Way, Cambridge, UK., Hannan NR; Department of Surgery, Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Forvie Building, Robinson Way, Cambridge, UK. Electronic address: nrfh2@cam.ac.uk.

المصدر: Biochimica et biophysica acta [Biochim Biophys Acta] 2015 Jan; Vol. 1851 (1), pp. 76-89. Date of Electronic Publication: 2014 Jun 02.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Pub. Co Country of Publication: Netherlands NLM ID: 0217513 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-3002 (Print) Linking ISSN: 00063002 NLM ISO Abbreviation: Biochim Biophys Acta Subsets: MEDLINE

مواضيع طبية MeSH: Induced Pluripotent Stem Cells/*physiology , Liver/*physiology, Animals ; Cell Differentiation/physiology ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/physiology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Liver/cytology ; Models, Biological

المؤلفون: Gieseck RL 3rd; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, Department of Surgery, University of Cambridge, Robinson Way, Cambridge, CB2 0SZ, UK., Vallier L, Hannan NR

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2015; Vol. 1250, pp. 123-42.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Evaluation, Preclinical*, Cell Differentiation/*drug effects , Cell Differentiation/*physiology , Hepatocytes/*cytology , Hepatocytes/*drug effects , Pluripotent Stem Cells/*cytology , Pluripotent Stem Cells/*drug effects, Cell Culture Techniques ; Endoderm/cytology ; Endoderm/embryology ; Humans

المؤلفون: Gieseck RL 3rd; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, Department of Surgery, University of Cambridge, Cambridge, United Kingdom ; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Hannan NR; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, Department of Surgery, University of Cambridge, Cambridge, United Kingdom., Bort R; Unidad de Hepatología Experimental, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Hanley NA; Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom., Drake RA; TAP Biosystems, Royston, United Kingdom., Cameron GW; TAP Biosystems, Royston, United Kingdom., Wynn TA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Vallier L; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, Department of Surgery, University of Cambridge, Cambridge, United Kingdom ; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.

المصدر: PloS one [PLoS One] 2014 Jan 22; Vol. 9 (1), pp. e86372. Date of Electronic Publication: 2014 Jan 22 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Cell Culture Techniques* , Cell Differentiation*, Hepatocytes/*cytology , Induced Pluripotent Stem Cells/*cytology, Aged ; Aged, 80 and over ; Cell Line ; Cluster Analysis ; Gene Expression Profiling ; Hepatocytes/metabolism ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Intercellular Junctions ; Male ; Middle Aged ; Phenotype