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1
المؤلفون: Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud
المصدر: Journal of Medicinal Chemistry. 63:512-528
مصطلحات موضوعية: 0303 health sciences, biology, Fulvestrant, Chemistry, Estrogen receptor, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Breast cancer, Hormone receptor, Drug Discovery, biology.protein, medicine, Cancer research, Molecular Medicine, Aromatase, Receptor, Estrogen receptor alpha, Tamoxifen, 030304 developmental biology, medicine.drug
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2
المؤلفون: Jean Christophe Carry, Youssef El-Ahmad, Bruno Filoche-Romme, Frank Halley, Loic Vincent, Andreas Karlsson, Thomas Bertrand, Christoph Lengauer, Tsiala Benard, Pierre Yves Abecassis, Peter Below, Alexey Rak, Jean Paul Nicolas, Gilles Lebourg, Audrey Louboutin, Victor Certal, Laurent Schio, Cécile Delorme, Nadine Michot, Fabienne Pilorge, Fabienne Chatreaux, Pascale Lejeune, Fabienne Thompson, Angela Virone-Oddos, Isabelle Vade, Hélène Bonnevaux, Jean Pierre Marquette, Odile Angouillant-Boniface
المصدر: Journal of Medicinal Chemistry. 55:4788-4805
مصطلحات موضوعية: Models, Molecular, Gene isoform, Benzimidazole, Class I Phosphatidylinositol 3-Kinases, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Pharmacology, Crystallography, X-Ray, medicine.disease_cause, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, PTEN, Tensin, Pyrimidone, Phosphorylation, PI3K/AKT/mTOR pathway, Benzoxazoles, Molecular Structure, biology, Kinase, Chemistry, Macrophages, PTEN Phosphohydrolase, Neoplasms, Experimental, Fibroblasts, Xenograft Model Antitumor Assays, Isoenzymes, biology.protein, Molecular Medicine, Benzimidazoles, Carcinogenesis, Proto-Oncogene Proteins c-akt, Protein Binding