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1
المؤلفون: Terry Roemer, James R. Tata, Charles G. Garlisi, Mihirbaran Mandal, Christina B. Madsen-Duggan, Ginny D. Ho, Todd Mayhood, Jin Wu, Marc A. Labroli, John P. Caldwell, Alexei V. Buevich, Emma R. Parmee, Hao Wang, Jing Su, Paul Tawa, Sandra Koseoglu, Xiujuan Wen, Sang Ho Lee, Kallol Basu, Payal R. Sheth, Shu-Wei Yang, David G. McLaren, Haifeng Tang, Zheng Tan, Reynalda deJesus, Jenny Liu, Erika Walsh, Sookhee Ha, Christopher M. Tan, Li Xiao, Diane Rindgen, Amy M. Flattery, Debra Mcguinness, Christine Yang, Charles Gill, Paul L. Walsh, Lianzhu Liang
المصدر: Journal of Medicinal Chemistry. 60:3851-3865
مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, 0301 basic medicine, 030106 microbiology, Microbial Sensitivity Tests, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Structure–activity relationship, Solubility, Mice, Inbred BALB C, Teichoic acid, Ligand efficiency, biology, Lipids, Small molecule, Enzyme assay, chemistry, Biochemistry, Lipophilicity, biology.protein, Molecular Medicine, Female
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2
المؤلفون: Zheng Tan, Steve Sorota, Deen Tulshian, R. Jason Herr, William G. Earley, Charles R. Heap, Stephanie Brumfield, Terry Bridal, Jennifer Hanisak, Xiaoping Zhou, Julius Matasi, Ana Bercovici, Ginny D. Ho, Diane Rindgen, Brandy Courneya, Shu-Wei Yang
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:4110-4113
مصطلحات موضوعية: Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, NAV1.7 Voltage-Gated Sodium Channel, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Nav1.5, Pharmacology, Biochemistry, Combinatorial chemistry, Structure-Activity Relationship, Sodium channel blocker, Pharmacokinetics, Quinoxalines, Drug Discovery, biology.protein, Humans, Molecular Medicine, Spiro Compounds, Dosing, Selectivity, Molecular Biology, Sodium Channel Blockers
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3
المؤلفون: Jennifer Smotryski, Shu-Wei Yang, William J. Greenlee, Mario Guzzi, Robert A. Hodgson, Kallol Basu, Zheng Tan, Deen Tulshian, Xiaoping Zhang, William T. McElroy, Carina J. Bleickardt, Ginny D. Ho, Deborra Mullins
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1335-1339
مصطلحات موضوعية: Molecular Structure, Phosphoric Diester Hydrolases, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Quinoline, Pharmaceutical Science, Haplorhini, Biochemistry, Rats, Enzyme Activation, Inhibitory Concentration 50, chemistry.chemical_compound, In vivo, Drug Discovery, Hepatocytes, Quinolines, Animals, Molecular Medicine, PDE10A, Enzyme Inhibitors, Pyrazolones, Molecular Biology
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4
المؤلفون: Mario Guzzi, William J. Greenlee, Xiaoping Zhang, Ginny D. Ho, Shu-Wei Yang, Deen Tulshian, William T. McElroy, Alan Hruza, Jennifer Smotryski, Li Xiao, Tze-Ming Chan, Robert A. Hodgson, Zheng Tan, Diane Rindgen, Deborra Mullins, Carina J. Bleickardt
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:235-239
مصطلحات موضوعية: Phosphodiesterase Inhibitors, Chemistry, Pharmaceutical, medicine.medical_treatment, Clinical Biochemistry, Rat model, Molecular Conformation, Administration, Oral, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Management of schizophrenia, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Antipsychotic, Molecular Biology, Phosphoric Diester Hydrolases, Chemistry, Organic Chemistry, Rats, Disease Models, Animal, Orally active, Models, Chemical, Dizocilpine maleate, Drug Design, Quinolines, Schizophrenia, Excitatory Amino Acid Antagonists, Pyrazoles, Molecular Medicine, Dizocilpine Maleate, Antipsychotic Agents
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5
المؤلفون: Deen Tulshian, Xiomara Fernandez, William J. Greenlee, Ginny D. Ho, Robbie L. McLeod, Xiaoying Xu, John A. Hey, Shu-Wei Yang, John C. Anthes
المصدر: Journal of Medicinal Chemistry. 52:5323-5329
مصطلحات موضوعية: Agonist, Receptors, Steroid, Pyridines, medicine.drug_class, Stereochemistry, Guinea Pigs, Administration, Oral, Nociceptin Receptor, Guinea pig, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Transcriptional Regulator ERG, Oral administration, Drug Discovery, medicine, Animals, Humans, Chemistry, Alkaloid, Pregnane X Receptor, Tropane, In vitro, Rats, Antitussive Agents, Nociceptin receptor, Cough, Antitussive Agent, Receptors, Opioid, Trans-Activators, Molecular Medicine, Vocalization, Animal, Tropanes
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6
المؤلفون: Geoffrey B. Varty, Shu-Wei Yang, Zheng Tan, Ahmad Fawzi, Sherry Lu, John C. Anthes, William J. Greenlee, Ginny D. Ho, Deen Tulshian, April Smith-Torhan, Hongtao Zhang, John A. Hey, Xiomara Fernandez, Robbie L. McLeod
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:2482-2486
مصطلحات موضوعية: Nortropanes, Stereochemistry, medicine.drug_class, Chemistry, Pharmaceutical, Guinea Pigs, Clinical Biochemistry, NOP, Administration, Oral, Pharmaceutical Science, Carboxamide, Peptide, Anxiety, Ligands, Biochemistry, Chemical synthesis, Anxiolytic, Nociceptin Receptor, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Chemistry, Ligand, Organic Chemistry, Antitussive Agents, Kinetics, Nociceptin receptor, Anti-Anxiety Agents, Cough, Antitussive Agent, Drug Design, Receptors, Opioid, Molecular Medicine
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7
المؤلفون: Robbie L. McLeod, Deen Tulshian, Leonard E. Parra, Ahmad Fawzi, Xiomara Fernandez, Donald C. Bolser, Jennifer C. Zimmer, Craig Lehr, Jason Erskine, Huchappa Jayappa, April Smith-Torhan, Christine H. Erickson, Hongtao Zhang, Ginny D. Ho, John A. Hey
المصدر: Pharmacology. 84:153-161
مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, Time Factors, medicine.drug_class, Guinea Pigs, NOP, Endogeny, CHO Cells, Pharmacology, Bordetella bronchiseptica, Nociceptin Receptor, Guinea pig, chemistry.chemical_compound, Cricetulus, Dogs, Species Specificity, Tracheobronchitis, Cricetinae, Internal medicine, medicine, Animals, Humans, Receptor, Bordetella Infections, Dose-Response Relationship, Drug, business.industry, General Medicine, Antitussive Agents, Disease Models, Animal, Nociceptin receptor, Endocrinology, Cough, chemistry, Capsaicin, Receptors, Opioid, Cats, Female, business, Tropanes
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8
المؤلفون: Ginny D. Ho, Deen Tulshian, Ahmad Fawzi, William J. Greenlee, Hongtao Zhang, April Smith Torhan, Ana Bercovici
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3023-3027
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Neuropeptide, Peptide, CHO Cells, Ligands, Biochemistry, Chemical synthesis, Nociceptin Receptor, Structure-Activity Relationship, Cricetulus, Piperidines, Cricetinae, Drug Discovery, Animals, Humans, Molecular Biology, G protein-coupled receptor, chemistry.chemical_classification, Molecular Structure, Chemistry, Ligand, Organic Chemistry, In vitro, Nociceptin receptor, Receptors, Opioid, Molecular Medicine
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9
المؤلفون: Deen Tulshian, Guoqing Li, Thierry O. Fischmann, James R. Tata, James Fossetta, Ginny D. Ho, Xiaoda Niu, Sunil Paliwal, James Jackson, W. Michael Seganish, William T. McElroy, Charles G. Garlisi, Kristine Devito, Christopher Sondey, Hong Bian, Loretta Bober, Daniel Lundell, Zheng Tan
مصطلحات موضوعية: biology, Kinase, Organic Chemistry, Arthritis, Pyrazole, Pharmacology, medicine.disease, IRAK4, Biochemistry, Compound 32, Proinflammatory cytokine, chemistry.chemical_compound, chemistry, In vivo, Enzyme inhibitor, Drug Discovery, medicine, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eec17ea3324013fccf2930366388de0
https://europepmc.org/articles/PMC4468401/ -
10
المؤلفون: Ana Bercovici, Hubert Jan Jozef Loozen, Timmers Cornelis Marius, Ginny D. Ho, W. Michael Seganish, Deen Tulshian
المصدر: Tetrahedron Letters. 53:903-905
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Organic Chemistry, Drug Discovery, Imidazole, Sequence (biology), Isoquinoline, Bischler–Napieralski reaction, Biochemistry, Combinatorial chemistry