المؤلفون: Mayers JR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Varon J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA., Zhou RR; Department of Statistics, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA., Daniel-Ivad M; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Beaulieu C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Bhosle A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Glasser NR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Lichtenauer FM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Ng J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA., Vera MP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Perrella MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zhao SD; Department of Statistics, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA., Baron RM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: rbaron@bwh.harvard.edu., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: balskus@chemistry.harvard.edu.

المصدر: Cell [Cell] 2024 Jul 25; Vol. 187 (15), pp. 4095-4112.e21. Date of Electronic Publication: 2024 Jun 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Metabolomics* , Polyamines*/metabolism, Humans ; Animals ; Mice ; Bacteremia/microbiology ; Bacteremia/metabolism ; Bacteremia/drug therapy ; Anti-Bacterial Agents/pharmacology ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/metabolism ; Female

المؤلفون: Glasser NR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Cui D; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Risser DD; Department of Biology, University of the Pacific, Stockton, CA, USA., Okafor CD; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA, USA., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. balskus@chemistry.harvard.edu.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. balskus@chemistry.harvard.edu.

المصدر: Nature chemistry [Nat Chem] 2024 Feb; Vol. 16 (2), pp. 173-182. Date of Electronic Publication: 2024 Jan 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE

مواضيع طبية MeSH: Biological Products*, Halogenation

المؤلفون: Mayers JR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA 02115.; Harvard Medical School, Boston, MA, USA 02115.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA 02138., Varon J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA 02115.; Harvard Medical School, Boston, MA, USA 02115., Zhou RR; Department of Statistics, University of Illinois at Urbana Champaign, Champaign, IL, USA 61820., Daniel-Ivad M; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA 02138.; Broad Institute of MIT and Harvard, Cambridge, MA, USA 02142., Beaulieu C; Broad Institute of MIT and Harvard, Cambridge, MA, USA 02142., Bholse A; Broad Institute of MIT and Harvard, Cambridge, MA, USA 02142.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA 02115., Glasser NR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA 02138., Lichtenauer FM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA 02138., Ng J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA 02115.; Harvard Medical School, Boston, MA, USA 02115., Vera MP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA 02115., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA, USA 02142.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA 02115.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Perrella MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA 02115.; Harvard Medical School, Boston, MA, USA 02115., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA 02142., Zhao SD; Department of Statistics, University of Illinois at Urbana Champaign, Champaign, IL, USA 61820.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana Champaign, Champaign, IL, USA 61820., Baron RM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA 02115.; Harvard Medical School, Boston, MA, USA 02115., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA 02138.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA 02138.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 21. Date of Electronic Publication: 2023 Sep 21.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Mehta RS; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Mayers JR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Zhang Y; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Harvard Chan Microbiome in Public Health Center, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Bhosle A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Harvard Chan Microbiome in Public Health Center, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Glasser NR; Resnick Sustainability Institute, California Institute of Technology, Pasadena, CA, USA., Nguyen LH; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ma W; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Bae S; Department of Immunology & Infectious Disease, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Branck T; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Song K; Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Sebastian L; Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Pacheco JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Seo HS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Clish C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Ananthakrishnan AN; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Franzosa EA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Balskus EP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Chan AT; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Immunology & Infectious Disease, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA, USA. chuttenh@hsph.harvard.edu.; Department of Biostatistics, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA. chuttenh@hsph.harvard.edu.; Harvard Chan Microbiome in Public Health Center, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA. chuttenh@hsph.harvard.edu.; Department of Immunology & Infectious Disease, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA. chuttenh@hsph.harvard.edu.

المصدر: Nature medicine [Nat Med] 2023 Mar; Vol. 29 (3), pp. 700-709. Date of Electronic Publication: 2023 Feb 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Gastrointestinal Microbiome*/genetics , Inflammatory Bowel Diseases*/drug therapy, Humans ; Mesalamine/therapeutic use ; Cross-Sectional Studies ; Treatment Outcome

المؤلفون: Dong X; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA., Guthrie BGH; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, 94143, USA., Alexander M; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, 94143, USA., Noecker C; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, 94143, USA., Ramirez L; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, 94143, USA., Glasser NR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA., Turnbaugh PJ; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, 94143, USA.; Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA. balskus@chemistry.harvard.edu.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, 02138, USA. balskus@chemistry.harvard.edu.

المصدر: Nature communications [Nat Commun] 2022 Dec 09; Vol. 13 (1), pp. 7624. Date of Electronic Publication: 2022 Dec 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Actinobacteria*/metabolism, Animals ; Humans ; Bacteria/metabolism ; Eubacterium/metabolism ; Transcription Factors/metabolism ; CRISPR-Cas Systems/genetics ; Mammals/metabolism

SCR Organism: Eggerthella lenta

المؤلفون: Martins TP; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal.; ICBAS - Institute of Biomedical Sciences Abel Salazar, University of Porto, 4050-313 Porto, Portugal., Glasser NR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States., Kountz DJ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States., Oliveira P; i3S - Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal.; IBMC - Institute of Molecular and Cell Biology, University of Porto, 4200-135 Porto, Portugal.; Department of Biology, Faculty of Sciences, University of Porto, 4169-00 Porto, Portugal., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States., Leão PN; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal.

المصدر: ACS chemical biology [ACS Chem Biol] 2022 Aug 31. Date of Electronic Publication: 2022 Aug 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

المؤلفون: Braffman NR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States., Ruskoski TB; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, United States., Davis KM; Department of Chemistry, The Pennsylvania State University, University Park, United States., Glasser NR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States., Johnson C; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States., Okafor CD; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, United States.; Department of Chemistry, The Pennsylvania State University, University Park, United States., Boal AK; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, United States.; Department of Chemistry, The Pennsylvania State University, University Park, United States., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States.; Howard Hughes Medical Institute, Harvard University, Cambridge, United States.

المصدر: ELife [Elife] 2022 Feb 25; Vol. 11. Date of Electronic Publication: 2022 Feb 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Cyanobacteria*/genetics , Cyanobacteria*/metabolism, Alkylation ; Carbon/metabolism ; Catalysis ; Catalytic Domain ; Crystallography, X-Ray

المؤلفون: Eusebio N; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal., Rego A; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal., Glasser NR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Castelo-Branco R; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. balskus@chemistry.harvard.edu., Leão PN; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal. pleao@ciimar.up.pt.

المصدر: BMC genomics [BMC Genomics] 2021 Aug 31; Vol. 22 (1), pp. 633. Date of Electronic Publication: 2021 Aug 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Cyanobacteria*/genetics , Cyanobacteria*/metabolism, Halogenation ; Humans ; Multigene Family ; Neoplasm Recurrence, Local

المؤلفون: Glasser NR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America., Hunter RC; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America., Liou TG; The Center for Quantitative Biology and The Adult Cystic Fibrosis Center, Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States of America., Newman DK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America.

مؤلفون مشاركون: Mountain West CF Consortium Investigators

المصدر: PloS one [PLoS One] 2019 Dec 18; Vol. 14 (12), pp. e0226578. Date of Electronic Publication: 2019 Dec 18 (Print Publication: 2019).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Cystic Fibrosis/*metabolism , Heme/*metabolism , Lung/*physiopathology , Sputum/*metabolism, Adult ; Female ; Humans ; Male

المؤلفون: Martins TP; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal. pleao@ciimar.up.pt., Rouger C, Glasser NR, Freitas S, de Fraissinette NB, Balskus EP, Tasdemir D, Leão PN

المصدر: Natural product reports [Nat Prod Rep] 2019 Oct 16; Vol. 36 (10), pp. 1437-1461.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 8502408 Publication Model: Print Cited Medium: Internet ISSN: 1460-4752 (Electronic) Linking ISSN: 02650568 NLM ISO Abbreviation: Nat Prod Rep Subsets: MEDLINE

مواضيع طبية MeSH: Cyanobacteria/*metabolism , Resorcinols/*chemistry , Resorcinols/*pharmacology, Cyanobacteria/genetics ; Molecular Structure ; Multigene Family ; Resorcinols/metabolism