المؤلفون: Haifeng Tang, Zack Zhiqiang Guo, Lee-Yuh Pai, Adam B. Weinglass, Xin Gu, Shuzhi Dong, Alexander Pasternak, Yang Yu, Kathleen A. Sullivan, Mengwei Hu, Kelsey VanGelder, Gloria J. Zingaro, Sophie Roy, Jessica Liu, Qinghong Fu, Birgit T. Priest, Michael Margulis, Brande Thomas-Fowlkes, Pierre Morissette, Robin E. Haimbach, Zhicai Wu, Juliann Ehrhart, Karen Owens, Caryn Hampton, Zhi-Cai Shi, Jessica Frie, Ron Ferguson, Shiyao Xu, Vincent Tong

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2559-2566

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Scaffold, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Dogs, 0302 clinical medicine, Thiadiazoles, In vivo, Rats, Inbred SHR, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Structure–activity relationship, Spiro Compounds, Potassium Channels, Inwardly Rectifying, Molecular Biology, biology, Chemistry, Organic Chemistry, Potassium channel blocker, Rats, Disease Models, Animal, Pyrimidines, 030104 developmental biology, 030220 oncology & carcinogenesis, Hypertension, ROMK, biology.protein, Molecular Medicine, Pharmacophore, Half-Life, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2dc6104dc29c3168c501b413896773
https://doi.org/10.1016/j.bmcl.2017.03.086

المؤلفون: A. Galijatovic-Idrizbegovic, S. O'Sullivan, H. Schuck, K.A. Bustard, Alysia A. Chaves, Richard Briscoe, M.A. Yordy, C.M. Hoe, D.B. Christian, Gloria J. Zingaro

المصدر: Journal of Pharmacological and Toxicological Methods. 56:103-114

مصطلحات موضوعية: Male, Time Factors, Moxifloxacin, Administration, Oral, Guidelines as Topic, Torsades de pointes, Pharmacology, Toxicology, Sensitivity and Specificity, QT interval, Beagle, Electrocardiography, Dogs, Piperidines, Heart Rate, Telemetry, medicine, Haloperidol, Animals, Humans, Benzopyrans, Aza Compounds, Dose-Response Relationship, Drug, business.industry, Prolongation, Reproducibility of Results, medicine.disease, Ether-A-Go-Go Potassium Channels, Anti-Bacterial Agents, Highly sensitive, Disease Models, Animal, Long QT Syndrome, Area Under Curve, Quinolines, Female, business, Anti-Arrhythmia Agents, Antipsychotic Agents, Fluoroquinolones, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e294616ed6bfcec3f6fed7fbbf3ab4a
https://doi.org/10.1016/j.vascn.2007.04.007

المؤلفون: Jeffrey Travis, Chao-Min Hoe, Joseph J. Salata, Gloria J. Zingaro, Matthew M. Zrada, Pamela Gerenser, Armando Lagrutta, John Imredy, Elena Trepakova, Alysia A. Chaves, Greg Friedrichs, Masahiro Nishida, Kimberly M. Hoagland, Pierre Morissette

المصدر: Journal of pharmacological and toxicological methods. 68(1)

مصطلحات موضوعية: Male, hERG, Guinea Pigs, Torsades de pointes, Toxicology, QT interval, Sensitivity and Specificity, Ion Channels, QRS complex, Electrocardiography, In vivo, Predictive Value of Tests, Telemetry, Toxicity Tests, Medicine, Animals, Humans, Anesthesia, cardiovascular diseases, Lead (electronics), Pharmacology, biology, business.industry, Safety pharmacology, Reproducibility of Results, medicine.disease, Long QT Syndrome, Drug Design, Models, Animal, cardiovascular system, biology.protein, business, circulatory and respiratory physiology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7569c48d2bd153328a78b217dbd0f5d
https://pubmed.ncbi.nlm.nih.gov/23649000

المؤلفون: Theodore P. Broten, William J. Greenlee, Robert A. Gabel, Nathan B. Mantlo, Peter K. S. Siegl, Debra Ondeyka, Salah D. Kivlighn, Raymond S.L. Chang, Gloria J. Zingaro, Raymond E. Gibson

المصدر: European Journal of Pharmacology. 294:439-450

مصطلحات موضوعية: Pharmacology, Angiotensin receptor, medicine.medical_specialty, Angiotensin II receptor type 1, biology, business.industry, Bradykinin, Angiotensin-converting enzyme, Angiotensin II receptor antagonist, Angiotensin II, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Renin–angiotensin system, biology.protein, Medicine, Enalapril, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4bee47301c887cc474cb3e85ad342b77
https://doi.org/10.1016/0014-2999(95)00564-1

المؤلفون: Stephen E. de Laszlo, Raymond S. Chang, Tsing-Bau Chen, Kristie A. Faust, William J. Greenlee, Salah D. Kivlighn, Victor J. Lotti, Stacey S. O'Malley, Terry W. Schorn, Peter K. Siegl, Jennifer Tran, Gloria J. Zingaro

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:1359-1364

مصطلحات موضوعية: chemistry.chemical_classification, Angiotensin II receptor type 1, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Bioavailability, Drug Discovery, Aqueous solubility, Molecular Medicine, Receptor, Molecular Biology, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e0a634555cb07627e9316d3c58e22ecc
https://doi.org/10.1016/0960-894x(95)00224-h

المؤلفون: Peter K. S. Siegl, Salah D. Kivlighn, Gloria J. Zingaro, Tsing-Bau Chen, Kristie A. Faust, Victor J. Lotti, William J. Greenlee, Arthur A. Patchett, Thomas F. Walsh, Kenneth J. Fitch, Raymond S.L. Chang

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:1151-1154

مصطلحات موضوعية: Angiotensin II receptor type 1, Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Angiotensin II, Receptor subtype, Drug Discovery, Molecular Medicine, Potency, Receptor, Molecular Biology, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2ac6208c532d72a61e408771fa3545d7
https://doi.org/10.1016/0960-894x(95)00185-v

المؤلفون: Salah D. Kivlighn, Kenneth J. Fitch, W.J. Greenlee, T. F. Walsh, Peter K. S. Siegl, R. S. L. Chang, Kristie A. Faust, Arthur A. Patchett, Tsing-Bau Chen, Victor J. Lotti, Gloria J. Zingaro

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:155-158

مصطلحات موضوعية: Biphenyl, Angiotensin II receptor type 1, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Angiotensin II, Blockade, chemistry.chemical_compound, Pressor response, In vivo, Drug Discovery, cardiovascular system, Molecular Medicine, Tetrazole, Molecular Biology, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology, Binding affinities

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7fdc507efde0eace8587fa3c1b7d5d9e
https://doi.org/10.1016/0960-894x(94)00476-v

المؤلفون: Robert A. Gabel, Theodore P. Broten, Gloria J. Zingaro, Linda W. Schaffer, Peter K. S. Siegl, Arthur A. Patchett, Terry W. Schorn, William J. Greenlee, Prasun K. Chakravarty, Elizabeth M. Naylor, Salah D. Kivlighn

المصدر: American Journal of Hypertension. 8:58-66

مصطلحات موضوعية: medicine.medical_specialty, Angiotensin II receptor type 1, biology, medicine.drug_class, business.industry, Antagonist, Angiotensin-converting enzyme, Angiotensin II receptor antagonist, Pharmacology, Receptor antagonist, Angiotensin II, Endocrinology, Losartan, Internal medicine, Internal Medicine, medicine, biology.protein, Enalapril, business, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9f55083766855f91ccf77204abbefbc5
https://doi.org/10.1016/0895-7061(94)00169-c

المؤلفون: Ralph A. Rivero, Peter K. S. Siegl, K. L. Flanagan, Salah D. Kivlighn, Wallace T. Ashton, Gloria J. Zingaro, Tsing-Bau Chen, Victor J. Lotti, R. S. L. Chang, S. S. O'malley, W.J. Greenlee, Linda L. Chang

المصدر: Bioorganic & Medicinal Chemistry Letters. 4:2787-2792

مصطلحات موضوعية: endocrine system, Angiotensin receptor, Angiotensin II receptor type 1, Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Drug Discovery, cardiovascular system, Molecular Medicine, Moiety, Molecular Biology, IC50, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7833c612680e51d2bc1ae919ba3ffd73
https://doi.org/10.1016/s0960-894x(01)80595-3

المؤلفون: William J. Greenlee, Terry S. Schorn, Kristie A. Faust, Peter K. S. Siegl, Salah D. Kivlighn, Tsing-Bau Chen, Stephen E. de Laszlo, Gloria J. Zingaro, Victor J. Lotti, Tomasz W. Glinka, Raymond S.L. Chang

المصدر: Bioorganic & Medicinal Chemistry Letters. 4:2337-2342

مصطلحات موضوعية: medicine.medical_specialty, Angiotensin receptor, Angiotensin II receptor type 1, Chemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Pharmacology, Biochemistry, Angiotensin II, Blockade, chemistry.chemical_compound, Endocrinology, Oral administration, Internal medicine, Drug Discovery, medicine, Quinazoline, Molecular Medicine, Receptor, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::96faf37f446e5b44223383aee9e35010
https://doi.org/10.1016/0960-894x(94)85036-4