نتائج البحث - "Glucuronosyltransferase metabolism"

1

Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets

المؤلفون: Gregory Guthrie, Charlotte Lauridsen, Douglas G. Burrin, Shaji Chacko, Barbara Stoll, Jogchum Plat

المساهمون: Nutrition and Movement Sciences, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health

المصدر: American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(1), G41-G52. American Physiological Society
Guthrie, G, Stoll, B, Chacko, S, Lauridsen, C, Plat, J & Burrin, D G 2020, ' Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets ', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 318, no. 1, pp. G41-G52 . https://doi.org/10.1152/ajpgi.00193.2019
Am J Physiol Gastrointest Liver Physiol

مصطلحات موضوعية: 0301 basic medicine, Parenteral Nutrition, Physiology, medicine.medical_treatment, Sus scrofa, parenteral nutrition-associated liver disease, INFANTS, vitamin E, Pharmacology, Liver Diseases/etiology, rifampicin, Liver disease, chemistry.chemical_compound, ABC TRANSPORTERS, Liver/drug effects, Cytochrome P-450 CYP3A, Glucuronosyltransferase, Phospholipids, FISH-OIL, Hyperbilirubinemia, Pregnane X receptor, Liver Diseases, ALPHA-TOCOPHEROL, Gastroenterology, Pregnane X Receptor, Cytochrome P-450 CYP3A/metabolism, Fish oil, Liver, FAT OVERLOAD SYNDROME, ACID, alfa-tocopherol, Emulsions, Rifampin, medicine.drug, Research Article, Signal Transduction, EXPRESSION, Fat Emulsions, Intravenous, Bile Acids and Salts/biosynthesis, Hyperbilirubinemia/etiology, METABOLISM, Bile Acids and Salts, 03 medical and health sciences, Pregnane X Receptor/agonists, Cholestasis, Physiology (medical), medicine, Animals, Vitamin E/pharmacology, 030109 nutrition & dietetics, Hepatology, business.industry, Vitamin E, bile acid metabolism, Cholestasis/etiology, LIPID EMULSION, medicine.disease, Soybean Oil, Disease Models, Animal, 030104 developmental biology, Parenteral nutrition, chemistry, Animals, Newborn, Glucuronosyltransferase/metabolism, BILE, alpha-Tocopherol, business, Rifampin/pharmacology, cholestasis, Rifampicin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d93c23b8e62b533153371662603600
https://doi.org/10.1152/ajpgi.00193.2019

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2

رسالة جامعية

Size determination of hyaluronan and multivariate analysis of amyloid prone proteins

المؤلفون: Malm, Linus

مصطلحات موضوعية: Extracellular matrix -- metabolism, Glucuronosyltransferase -- metabolism, Hyaluronic acid -- metabolism, Myocytes, cardiac -- cytology, Platelet-derived growth factor -- metabolism, Amyloidogenic proteins -- metabolism, Multivariate analysis, Hyaluronan, Dynamic light scattering, GEMMA, Amyloid aggregation

URL الوصول: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46601

Degree: Diss. (sammanfattning) Umeå : Umeå universitet, 2011

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رسالة جامعية

Steroid metabolism in human reproductive organs

المؤلفون: Karypidis, Anna Helena

مصطلحات موضوعية: Steroids -- genetics, Steroids -- metabolism, Androgens -- genetics, Androgens -- metabolism, Estrogens -- genetics, Estrogens -- metabolism, Genitalia -- metabolism, Prostate -- metabolism, Prostatic Neoplasms -- genetics, Prostatic Neoplasms -- metabolism, Glucuronosyltransferase -- genetics, Glucuronosyltransferase -- metabolism, Gene Expression Regulation, Enzymologic, Abortion, Spontaneous -- genetics, Abortion, Spontaneous -- metabolism

URL الوصول: http://hdl.handle.net/10616/40435

Degree: Diss. (sammanfattning) Stockholm : Karolinska institutet, 2011

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New therapeutic targets in dermatoporosis

المؤلفون: Guerkan Kaya

المصدر: Journal of Nutrition, Health and Aging, Vol. 16, No 4 (2012) pp. 285-8

مصطلحات موضوعية: Keratinocytes, Male, Aging, Pathology, Down-Regulation/drug effects, Medicine (miscellaneous), Pathogenesis, Mice, Adrenal Cortex Hormones, Cell Movement, Epidermal growth factor, Medicine, Epidermis/metabolism/pathology, Pseudopodia, Glucuronosyltransferase, Hyaluronic Acid, Receptor, Skin, Aged, 80 and over, Nutrition and Dietetics, integumentary system, biology, Pseudopodia/metabolism, Drug Synergism, Middle Aged, Skin Diseases/drug therapy/physiopathology, medicine.anatomical_structure, Retinaldehyde, Intercellular Signaling Peptides and Proteins, Female, Keratinocytes/cytology/drug effects/metabolism, Keratinocyte, Filopodia, Heparin-binding EGF-like Growth Factor, medicine.medical_specialty, Down-Regulation, Skin Diseases, Atrophy, Downregulation and upregulation, Animals, Humans, Adrenal Cortex Hormones/adverse effects/antagonists & inhibitors, Aged, business.industry, Skin/drug effects/pathology, CD44, Intercellular Signaling Peptides and Proteins/metabolism, medicine.disease, ddc:616.8, Glucuronosyltransferase/metabolism, Cancer research, biology.protein, Retinaldehyde/pharmacology, Epidermis, Geriatrics and Gerontology, business, Hyaluronan Synthases, Hyaluronic Acid/metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8964e8434964182c8128153e5b902067
https://doi.org/10.1007/s12603-012-0041-0

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The Hepatic Glucuronate Pathway in the Rat after Treatment with 3,3′,5-Triiodothyronine and Phenobarbital

المؤلفون: Marios Marselos, Tapio Rantanen, Eino Puhakainen

المصدر: Acta Pharmacologica et Toxicologica. 38:273-280

مصطلحات موضوعية: Glucuronates/*metabolism, Male, endocrine system, medicine.medical_specialty, Glucuronosyltransferase, endocrine system diseases, Glucuronate, Glucuronates, Urine, Uridine Diphosphate Glucose Dehydrogenase, Toxicology, Hyperthyroidism, Excretion, Internal medicine, medicine, Animals, Euthyroid, Glucuronidase, Pharmacology, Hyperthyroidism/enzymology, Triiodothyronine, biology, Chemistry, Rats, Inbred Strains, Metabolism, Microsomes, Liver/enzymology/*metabolism, Rats, Endocrinology, Phenobarbital/*pharmacology, Phenobarbital, Uridine Diphosphate Glucose Dehydrogenase/metabolism, Glucuronosyltransferase/metabolism, Microsomes, Liver, Glucuronidase/metabolism, biology.protein, hormones, hormone substitutes, and hormone antagonists, Triiodothyronine/*pharmacology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff7a8109178699f2dfa6841de3ba543
https://doi.org/10.1111/j.1600-0773.1976.tb03120.x

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Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

المؤلفون: Aleksandra Galetin, Ruedi Aebersold, Aleksanteri Petsalo, Mariette Matondo, Oliver Hatley, Aki T. Heikkinen, Neil Parrott, Jens Lamerz, Paul Cutler, Amin Rostami-Hodjegan, Arno Friedlein, Risto O. Juvonen, Tom Dunkley

المساهمون: School of Medicine - Itä-Suomen yliopiston apteekki [Kuipo, Finland], Faculty of Health Sciences [UEF, Kuopio, Finland], University of Eastern Finland-University of Eastern Finland, Roche Innovation Center [Basel, Switzerland], Institute of Molecular Systems Biology [Zurich], Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Centre for Applied Pharmacokinetic Research [Manchester, UK] (CAPKR), Manchester Pharmacy School [Manchester, UK], University of Manchester [Manchester]-University of Manchester [Manchester], Simcyp Division [UK], Certara UK Limited, This work was funded by Roche Postdoc Fellowship (RPF) program., The authors gratefully acknowledge: Zheng Yang (Bristol-Myers Squibb) for kind offering of labs and organisation of placement for intestinal microsome preparation, Mary Obermeier (Bristol-Myers Squibb) for assistance in the lab during intestinal microsome preparation, Laura Singer, Heather Martin, David Wellington and Claudia Suenderhauf (all Roche) for contributions on dog tissue collection and shipment, Martin Ebeling and Marco Berrera (Roche) for compiling the dog protein database, Peter Jakob (Roche) for sample preparation for MS experiments, Hannele Jaatinen, Pirjo Hänninen and Virpi Koponen (all University of Eastern Finland) for support in liver sample processing and characterization.

المصدر: Pharmaceutical Research
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2015, 32 (1), pp.74-90. ⟨10.1007/s11095-014-1446-8⟩

مصطلحات موضوعية: Male, Proteomics, Glucuronosyltransferase, [SDV]Life Sciences [q-bio], Pharmaceutical Science, MESH: Colon/enzymology, Beagle, Mass Spectrometry, Canine, Protein quantitation, MESH: Dogs, chemistry.chemical_compound, MESH: Cytochrome P-450 Enzyme System/metabolism, Cytochrome P-450 Enzyme System, In vitro-in vivo extrapolation, Intestine, Small, Pharmacology (medical), MESH: Animals, MESH: Glucuronosyltransferase/metabolism, ADME, chemistry.chemical_classification, MESH: Glucuronosyltransferase/analysis, 3. Good health, Biochemistry, Liver, Molecular Medicine, Female, Biotechnology, Colon, Biology, Interspecies differences, MESH: Intestine, Small/enzymology, Models, Biological, digestive system, Dogs, Pharmacokinetics, Species Specificity, MESH: Liver/enzymology, Microsomes, Animals, Humans, MESH: Species Specificity, MESH: Proteomics/methods, Pharmacology, MESH: Mass Spectrometry, Drug metabolism, MESH: Humans, Organic Chemistry, MESH: Models, Biological, Cytochrome P450, MESH: Male, MESH: Cytochrome P-450 Enzyme System/analysis, Uridine diphosphate, Enzyme, chemistry, biology.protein, MESH: Microsomes/enzymology, MESH: Female