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1
المؤلفون: Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106516d185208367e68bb96ffc0bed07
https://doi.org/10.1158/1535-7163.22500843.v1 -
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المؤلفون: Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4ce3c68a5bf01dbc4b5578e36679e558
https://doi.org/10.1158/1535-7163.c.6536589.v1 -
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المؤلفون: Mark A. Nagy, Robert Hilgraf, Deborah S. Mortensen, Jan Elsner, Stephen Norris, Jayashree Tikhe, Won Yoon, David Paisner, Mercedes Delgado, Paul Erdman, Jason Haelewyn, Godrej Khambatta, Li Xu, William J. Romanow, Kevin Condroski, Sogole Bahmanyar, Meg McCarrick, Brent Benish, Kate Blease, Laurie LeBrun, Mehran F. Moghaddam, Julius Apuy, Stacie S. Canan, Brydon L. Bennett, Yoshitaka Satoh
المصدر: Journal of Medicinal Chemistry. 64:18193-18208
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Kate Blease, Garth Ringheim, Eduardo Torres, Jeffrey Muir, Laurie LeBrun, Veronique Plantevin-Krenitsky, Ashutosh Kulkarni, Maria Celeridad, Eun Mi Hur, Hegde Sayee Gajanan, Dehua Huang, Brian E. Cathers, John Sapienza, Henry Chan, Brydon Bennett, Katerina Leftheris, Correa Matthew D, Zheng Liu, Deborah S Mortensen, Brandon Whitefield, Mercedes Delgado, Dan Cashion, Sogole Bahmanyar, Lisa Morrison, Roli Khattri, Jason Parnes, Stephen Norris, Roy Harris, Kelven Burnett, Joshua Hansen, Godrej Khambatta, Patrick Papa
المصدر: Journal of Medicinal Chemistry. 64:11886-11903
مصطلحات موضوعية: Male, Gene isoform, T-Lymphocytes, T cell, Graft vs Host Disease, Lymphocyte Activation, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Immunologic Factors, Receptor, Protein Kinase Inhibitors, Protein kinase C, Cell Proliferation, Molecular Structure, Chemistry, Kinase, T-cell receptor, Cyclohexanols, Cell biology, Mice, Inbred C57BL, Molecular Docking Simulation, Protein Kinase C-delta, Pyrimidines, medicine.anatomical_structure, Protein Kinase C-theta, Molecular Medicine, Amine gas treating, Caco-2 Cells, Protein Binding
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المؤلفون: Yoshitaka Satoh, Gilles Carmel, Frans Baculi, Peter H. Schafer, Laurie LeBrun, Matt Hickman, Thomas O. Daniel, Brian E. Cathers, James Carmichael, Godrej Khambatta, Hon-Wah Man, Mary E Matyskiela, Philip P Chamberlain, Weihong Zhang, Mariko Riley, George W. Muller, Barbra Pagarigan, Gang Lu, Chin-Chun Lu
المصدر: Journal of Medicinal Chemistry. 61:535-542
مصطلحات موضوعية: 0301 basic medicine, Morpholines, Ubiquitin-Protein Ligases, Phthalimides, Crystallography, X-Ray, Heterocyclic Compounds, 4 or More Rings, Ikaros Transcription Factor, 03 medical and health sciences, DDB1, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, Fluorescence Resonance Energy Transfer, medicine, Humans, Binding site, Lenalidomide, Transcription factor, Piperidones, Adaptor Proteins, Signal Transducing, chemistry.chemical_classification, DNA ligase, biology, Cereblon, Protein Cereblon, Pomalidomide, Molecular biology, Ubiquitin ligase, Cell biology, DNA-Binding Proteins, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Proteolysis, biology.protein, Molecular Medicine, Multiple Myeloma, Peptide Hydrolases, Protein Binding, medicine.drug
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المؤلفون: Sogole Bahmanyar, Brian E. Cathers, Mehran F. Moghaddam, Peter Worland, Lida Tehrani, Brandon Wade Whitefield, Heather Raymon, James C. Gamez, Godrej Khambatta, Julius Apuy, Samantha J. Richardson, Rene R. Bisonette, Jingjing Zhao, Graziella I. Shevlin, Deborah Mortensen, Matt Hickman, Jan Elsner, Correa Matthew D, Roy L. Harris, Sophie Perrin-Ninkovic, Rama K. Narla, Jennifer Riggs, Kimberly Elizabeth Fultz, Sabita Sankar, Patrick Papa, John Sapienza, Stacie S. Canan, Sophie X. Peng, Jason Simon Parnes, Garrick Packard, Jim Leisten, Branden Lee
المصدر: Journal of Medicinal Chemistry. 58:5599-5608
مصطلحات موضوعية: Protein Conformation, Triazole, mTORC1, Pharmacology, mTORC2, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Dose-Response Relationship, Drug, Chemistry, Kinase, TOR Serine-Threonine Kinases, Triazoles, Xenograft Model Antitumor Assays, Rats, Molecular Docking Simulation, Biochemistry, Drug Design, Pyrazines, Molecular Medicine, Signal Transduction
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المؤلفون: Jason Simon Parnes, Rene R. Bisonette, Sophie Perrin-Ninkovic, Deborah Mortensen, Branden Lee, Peter Worland, James C. Gamez, Graziella I. Shevlin, Matt Hickman, Stacie S. Canan, Julius Apuy, Samantha J. Richardson, Jingjing Zhao, Godrej Khambatta, Sophie X. Peng, Jim Leisten, Garrick Packard, Correa Matthew D, Rama K. Narla, Lida Tehrani, Jennifer Riggs, Heather Raymon, Jan Elsner, Roy L. Harris, Kimberly Elizabeth Fultz, Patrick Papa, Sogole Bahmanyar, Brandon Wade Whitefield, Sabita Sankar, John Sapienza, Mehran F. Moghaddam, Brian E. Cathers
المصدر: Journal of Medicinal Chemistry. 58:5323-5333
مصطلحات موضوعية: Male, Models, Molecular, Antineoplastic Agents, Pharmacology, MTOR Kinase Inhibitor CC-223, Structure-Activity Relationship, In vivo, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Molecular Structure, Drug discovery, Chemistry, Kinase, TOR Serine-Threonine Kinases, RPTOR, Prostatic Neoplasms, Rats, Inhibitory potency, Pyrazines, Molecular Medicine, Signal Transduction
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المؤلفون: Jingjing Zhao, Sophie X. Peng, Brian E. Cathers, Sabita Sankar, Garrick Packard, Stacie S. Canan, Shuichan Xu, Heather Raymon, Godrej Khambatta, Rama K. Narla, Kimberly Elizabeth Fultz, Sophie Perrin-Ninkovic, Matt Hickman, Tam Tran, Samantha J. Richardson, Jim Leisten, Kamran Ghoreishi, Rene Bissonette, Mehran F. Moghaddam, Julius Apuy, Tao Shi, Deborah Mortensen, Wen Qing Yang, Weiming Xu, James C. Gamez, Peter Worland, Zeen Tong
المصدر: Molecular Cancer Therapeutics. 14:1295-1305
مصطلحات موضوعية: Cancer Research, Blotting, Western, Apoptosis, P70-S6 Kinase 1, Mechanistic Target of Rapamycin Complex 2, Mice, SCID, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biology, mTORC2, In vivo, Cell Line, Tumor, Neoplasms, Animals, Humans, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Neovascularization, Pathologic, Cell growth, Kinase, TOR Serine-Threonine Kinases, RPTOR, HCT116 Cells, Xenograft Model Antitumor Assays, Tumor Burden, HEK293 Cells, Oncology, Multiprotein Complexes, Pyrazines, Cancer research, Female
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50876b20cd6236c0e871976f53e0b444
https://doi.org/10.1158/1535-7163.mct-14-1052 -
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المؤلفون: Godrej Khambatta, Krzysztof Appelt, Shawn Misialek, Chris Pinko, Barbara Mroczkowski, Camran V. Parast
المصدر: Biochemistry. 37(47)
مصطلحات موضوعية: Time Factors, Angiogenesis, Neovascularization, Physiologic, Biochemistry, Binding, Competitive, Receptor tyrosine kinase, Catalysis, Substrate Specificity, chemistry.chemical_compound, Adenosine Triphosphate, Humans, Magnesium, Receptors, Growth Factor, Phosphorylation, Manganese, Binding Sites, biology, Receptor Protein-Tyrosine Kinases, Kinase insert domain receptor, Protein Structure, Tertiary, Vascular endothelial growth factor, Enzyme Activation, Vascular endothelial growth factor A, Kinetics, Receptors, Vascular Endothelial Growth Factor, chemistry, cardiovascular system, biology.protein, GRB2, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src, Cadmium
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10دورية أكاديمية
المؤلفون: Deborah S. Mortensen, SophieM. Perrin-Ninkovic, Graziella Shevlin, Jan Elsner, Jingjing Zhao, Brandon Whitefield, Lida Tehrani, John Sapienza, Jennifer R. Riggs, Jason S. Parnes, Patrick Papa, Garrick Packard, BrandenG.S. Lee, Roy Harris, Matthew Correa, Sogole Bahmanyar, Samantha J. Richardson, Sophie X. Peng, Jim Leisten, Godrej Khambatta
المصدر: Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 14, p5599-5608, 10p