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المؤلفون: Russo G; Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, B-9000 Ghent, Belgium., Barbato F; Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy., Grumetto L; Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy., Philippe L; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, United States., Lynen F; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, B-9000 Ghent, Belgium., Goetz GH; Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, United States. Electronic address: gilles.h.goetz@pfizer.com.

المصدر: International journal of pharmaceutics [Int J Pharm] 2019 Apr 05; Vol. 560, pp. 294-305. Date of Electronic Publication: 2019 Feb 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Models, Statistical*, Blood-Brain Barrier/*metabolism , Brain/*metabolism , Chromatography, Supercritical Fluid/*methods, Chemistry, Pharmaceutical/methods ; Computer Simulation ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Tissue Distribution

المؤلفون: Walker SWC; Department of Chemistry, University of Waterloo, Waterloo, N2L 3G1, ON, Canada., Anwar A; Department of Chemistry, University of Waterloo, Waterloo, N2L 3G1, ON, Canada., Psutka JM; Department of Chemistry, University of Waterloo, Waterloo, N2L 3G1, ON, Canada., Crouse J; Department of Chemistry, University of Waterloo, Waterloo, N2L 3G1, ON, Canada., Liu C; SCIEX, 71 Four Valley Drive, Concord, L4V 4V8, ON, Canada., Le Blanc JCY; SCIEX, 71 Four Valley Drive, Concord, L4V 4V8, ON, Canada., Montgomery J; Pfizer Global Research and Development, Eastern Point Road, Groton, 06340, CT, USA., Goetz GH; Pfizer Global Research and Development, Eastern Point Road, Groton, 06340, CT, USA., Janiszewski JS; Pfizer Global Research and Development, Eastern Point Road, Groton, 06340, CT, USA., Campbell JL; Department of Chemistry, University of Waterloo, Waterloo, N2L 3G1, ON, Canada. Larry.Campbell@sciex.com.; SCIEX, 71 Four Valley Drive, Concord, L4V 4V8, ON, Canada. Larry.Campbell@sciex.com., Hopkins WS; Department of Chemistry, University of Waterloo, Waterloo, N2L 3G1, ON, Canada. Scott.Hopkins@uwaterloo.ca.

المصدر: Nature communications [Nat Commun] 2018 Nov 30; Vol. 9 (1), pp. 5096. Date of Electronic Publication: 2018 Nov 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE

المؤلفون: Boehm M; Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States., Beaumont K; Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States., Jones R; Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States., Kalgutkar AS; Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States., Zhang L; Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States., Atkinson K; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Bai G; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Brown JA; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Eng H; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Goetz GH; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Holder BR; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Khunte B; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Lazzaro S; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Limberakis C; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Ryu S; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Shapiro MJ; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Tylaska L; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Yan J; Pfizer Worldwide Research & Development , Groton, Connecticut 06340, United States., Turner R; Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States., Leung SSF; Department of Pharmaceutical Chemistry, University of California , San Francisco, California 94158, United States.; Circle Pharma , South San Francisco, California 94080, United States., Ramaseshan M; Circle Pharma , South San Francisco, California 94080, United States., Price DA; Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States., Liras S; Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States., Jacobson MP; Department of Pharmaceutical Chemistry, University of California , San Francisco, California 94158, United States., Earp DJ; Circle Pharma , South San Francisco, California 94080, United States., Lokey RS; Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States., Mathiowetz AM; Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States., Menhaji-Klotz E; Pfizer Worldwide Research & Development , Cambridge, Massachusetts 02139, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2017 Dec 14; Vol. 60 (23), pp. 9653-9663. Date of Electronic Publication: 2017 Oct 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Peptides/*chemistry , Peptides/*pharmacology , Peptoids/*chemistry , Peptoids/*pharmacology , Receptors, CXCR/*agonists , Receptors, CXCR/*metabolism, Administration, Oral ; Animals ; Biological Availability ; Dogs ; Humans ; Macrocyclic Compounds/administration & dosage ; Macrocyclic Compounds/chemistry ; Macrocyclic Compounds/pharmacokinetics ; Macrocyclic Compounds/pharmacology ; Madin Darby Canine Kidney Cells ; Male ; Molecular Docking Simulation ; Peptides/administration & dosage ; Peptides/pharmacokinetics ; Peptoids/administration & dosage ; Peptoids/pharmacokinetics ; Rats ; Rats, Wistar

المؤلفون: Price DA; Pfizer Inc. Medicine Design, 610 Main Street, Cambridge, Massachusetts, 02155 USA. david.a.price@pfizer.com., Eng H, Farley KA, Goetz GH, Huang Y, Jiao Z, Kalgutkar AS, Kablaoui NM, Khunte B, Liras S, Limberakis C, Mathiowetz AM, Ruggeri RB, Quan JM, Yang Z

المصدر: Organic & biomolecular chemistry [Org Biomol Chem] 2017 Mar 28; Vol. 15 (12), pp. 2501-2506. Date of Electronic Publication: 2017 Mar 07.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cyclosporine/*pharmacokinetics , Oligopeptides/*pharmacokinetics, Animals ; Cyclosporine/administration & dosage ; Cyclosporine/chemistry ; Male ; Molecular Conformation ; Oligopeptides/administration & dosage ; Oligopeptides/chemistry ; Rats ; Rats, Wistar ; Stereoisomerism

المؤلفون: Goetz GH; Worldwide Medicinal Chemistry, Pfizer Worldwide Research & Development, Pfizer Inc. , Groton, Connecticut 06340, United States., Shalaeva M; Worldwide Medicinal Chemistry, Pfizer Worldwide Research & Development, Pfizer Inc. , Groton, Connecticut 06340, United States., Caron G; Molecular Biotechnology and Health Sciences Department, University of Torino , via Quarello 15, 10135 Torino, Italy., Ermondi G; Molecular Biotechnology and Health Sciences Department, University of Torino , via Quarello 15, 10135 Torino, Italy., Philippe L; Worldwide Medicinal Chemistry, Pfizer Worldwide Research & Development, Pfizer Inc. , Groton, Connecticut 06340, United States.

المصدر: Molecular pharmaceutics [Mol Pharm] 2017 Feb 06; Vol. 14 (2), pp. 386-393. Date of Electronic Publication: 2017 Jan 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Pharmaceutical Preparations/*metabolism, Animals ; Biological Transport ; Caco-2 Cells ; Cell Line ; Cell Line, Tumor ; Dogs ; Humans ; Hydrophobic and Hydrophilic Interactions ; Madin Darby Canine Kidney Cells ; Permeability