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المؤلفون: Stacey M. Southall, Joydeep Banerjee, Jason Brown, Kristina Butkovic, Andrew D. Cansfield, Julie E. Cansfield, Miles S. Congreve, Gabriella Cseke, Francesca Deflorian, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Renata Rupcic, Gordon Saxty, Stephen P. Watson
المصدر: ACS Medicinal Chemistry Letters. 13:1776-1782
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry, GPCR, CGRP, CGRPR, Macrocycle, Macrocyclic, Antagonist
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المؤلفون: Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014876daf0ea3141cec8e46d4cd3afe8
https://doi.org/10.1158/1535-7163.22503741 -
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المؤلفون: Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707b5abacc5ec387fe47990836d03d73
https://doi.org/10.1158/1535-7163.22503738 -
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المؤلفون: Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60399ae060b7382e0f81605f3d51fc78
https://doi.org/10.1158/1535-7163.22503735 -
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المؤلفون: Matthew V. Lorenzi, Sylvie Laquerre, Patrick Angibaud, Christopher Moy, Jayaprakash D. Karkera, Suso J. Platero, Jennifer Yang, Liang Xie, Na Cheng, David R. Newell, Neil T. Thompson, George Ward, Ron Gilissen, Christopher W. Murray, Martin Page, Gordon Saxty, Matthew Squires, David C. Rees, Eddy Freyne, Peter King, Kelly Van De Ven, Caroline Paulussen, Tinne Verhulst, Desiree De Lange, Jorge Vialard, Laurence Mevellec, Eleonora Jovcheva, Timothy P.S. Perera
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bca756040d98715cf3d679230a312d
https://doi.org/10.1158/1535-7163.22503732.v1 -
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المؤلفون: Andrew D. Cansfield, Mark A. Ator, Joydeep Banerjee, Michael Bestwick, Andrea Bortolato, Giles A. Brown, Jason Brown, Kristina Butkovic, Julie E. Cansfield, John A. Christopher, Miles Congreve, Gabriella Cseke, Francesca Deflorian, Benjamin Dugan, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Goran Landek, Jonathan Mason, Alistair O’Brien, Gregory R. Ott, Renata Rupcic, Gordon Saxty, Stacey M. Southall, Rahela Zadravec, Stephen P. Watson
المصدر: ACS Chemical Neuroscience. 13:751-765
مصطلحات موضوعية: GPCR CGRP CGRPR macrocycle macrocyclic antagonist, Physiology, Cognitive Neuroscience, Calcitonin Receptor-Like Protein, Cell Biology, General Medicine, Crystallography, X-Ray, Ligands, Biochemistry, Receptors, Calcitonin Gene-Related Peptide, Receptors, G-Protein-Coupled
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المؤلفون: Ivaylo Jivkov Elenkov, Simon Feldbaek Nielsen, Kristina Butković, Sanja Koštrun, Dijana Pesic, Dack Kevin Neil, Tine Skak-Nielsen, Dinko Žiher, Martin Stahlhut, Adriana Petrinić Grba, Vlatka Bencetić Mihaljević, Ana Čikoš, Samra Kapić, Andrea Fajdetić, Renata Rupčić, Gordon Saxty, Maja Lambert, Jasna Padovan, Ivana Ozimec Landek, Karmen Brajša, Dubravko Jelić, Haakan Bladh, Ana Grgičević
المصدر: Journal of Medicinal Chemistry. 64:8354-8383
مصطلحات موضوعية: Male, Macrocyclic Compounds, THP-1 Cells, Anti-Inflammatory Agents, 01 natural sciences, Inflammatory bowel disease, Mice, Structure-Activity Relationship, 03 medical and health sciences, Immune system, In vivo, Psoriasis, Drug Discovery, medicine, Animals, Humans, 030304 developmental biology, ADME, 0303 health sciences, Receptors, Interleukin-17, Molecular Structure, Chemistry, Drug discovery, Interleukin-17, medicine.disease, 0104 chemical sciences, Molecular Docking Simulation, proteins, macrocycles, IL 17AM, Il 17RA, chemical structure inhibitors, 010404 medicinal & biomolecular chemistry, Rheumatoid arthritis, Immunology, Molecular Medicine, Interleukin 17, Protein Binding
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المؤلفون: Helen F. Sneddon, Rodolfo Cadilla, Young Do, Jeffrey Guss, Gordon Saxty, Paresh I. Masuria, Caterina Musetti, J. Darren Stuart, Beth Pietrak, Daniela Ennulat, Andrew G. King, Barry G. Shearer, Nicholas J. Kramer, Peckham Gregory, Chuck Poole, Alan R. Rendina, Daniel J. Price, H. Fritz Kramer, Tiahshun Xu, Girish Sati, Stephen A. Thomson, Patricia A. Elkins, Jason A. Holt, Alan V. McDougal, Joseph W. Wilson, Susan B. Laffan, Michael R. Jeune, Jan Klapwijk, Dean N. Thomas, Mark Youngman, Paris Ward, Paul N. Mortenson, Lisa M. Shewchuk, Eugene L. Stewart, David N. Deaton
المصدر: Bioorganicmedicinal chemistry. 28(23)
مصطلحات موضوعية: Male, Cell Survival, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Polar surface area, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Drug Stability, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Muscle, Skeletal, Molecular Biology, chemistry.chemical_classification, Aza Compounds, Binding Sites, 010405 organic chemistry, Drug discovery, Organic Chemistry, Quinoline, Brain, Cns toxicity, 0104 chemical sciences, Rats, Intramolecular Oxidoreductases, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Kinetics, Enzyme, Hematopoietic prostaglandin D synthase, chemistry, Quinolines, Molecular Medicine
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المؤلفون: Gianni Chessari, Ildiko Maria Buck, Edward J. Lewis, Elisabetta Chiarparin, Jong Sook Ahn, Gordon Saxty, Anna Hopkins, Nicola E. Wilsher, Michael Reader, George Ward, Torren M. Peakman, Steven Howard, Pamela A. Williams, Tomoko Smyth, Christopher N. Johnson, Neil T. Thompson, Vanessa Martins, Joanne M. Munck, Alessia Millemaggi, James Edward Harvey Day, Lee William Page, Sharna J. Rich
المصدر: Journal of Medicinal Chemistry. 61:7314-7329
مصطلحات موضوعية: 010405 organic chemistry, Peptidomimetic, Stereochemistry, Antagonist, Inhibitor of apoptosis, 01 natural sciences, 0104 chemical sciences, XIAP, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Apoptosis, 030220 oncology & carcinogenesis, Drug Discovery, Molecular Medicine, Hydroxymethyl, Selectivity, Antagonism
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المؤلفون: Young Do, Lisa A. Orband-Miller, Anthony Shillings, Joelle Le, Caterina Musetti, Gordon Saxty, Beth Pietrak, Simon Teanby Hodgson, Petrov Kimberly, Daniel J. Price, Stephen A. Thomson, Eugene L. Stewart, Christie Schulte, Ashley Paul Hancock, Terrence L. Smalley, Michael R. Jeune, H. Fritz Kramer, Chuck Poole, Heather Hobbs, Kirsten M. Kahler, J. Darren Stuart, Paul N. Mortenson, Robert T. Nolte, Jason A. Holt, David N. Deaton, Don O. Somers, Elsie Diaz, Jeffrey Guss, Robert T. Gampe, Peckham Gregory
المصدر: Bioorganic & Medicinal Chemistry Letters. 47:128113
مصطلحات موضوعية: Imidazopyridine, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyridine, Virtual screen, medicine, Humans, Enzyme Inhibitors, Molecular Biology, Class (computer programming), Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Intramolecular Oxidoreductases, 010404 medicinal & biomolecular chemistry, Orally active, chemistry, Molecular Medicine