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1دورية أكاديمية
المؤلفون: Khanh B. Tran, Sharada Kolekar, Anower Jabed, Patrick Jaynes, Jen-Hsing Shih, Qian Wang, Jack U. Flanagan, Gordon W. Rewcastle, Bruce C. Baguley, Peter R. Shepherd
المصدر: BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
مصطلحات موضوعية: mTOR, PI 3-kinase, PI3Kα, PI3Kδ, PIK3CA, PIK3CD, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1471-2407
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2دورية أكاديمية
المؤلفون: AlexanderJ. Trevarton, Yan Zhou, Dehua Yang, Gordon W. Rewcastle, Jack U. Flanagan, Antony Braithwaite, Peter R. Shepherd, Cristin G. Print, Ming-Wei Wang, Annette Lasham
المصدر: Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 997-1007 (2019)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Melanie eSweetlove, Emma eWrightson, Sharada eKolekar, Gordon W. Rewcastle, Bruce C. Baguley, Peter R. Shepherd, Stephen M. F. Jamieson
المصدر: Frontiers in Oncology, Vol 5 (2015)
مصطلحات موضوعية: Melanoma, PI3K, BRAF, mTOR, Vemurafenib, BEZ235, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
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4
المؤلفون: Gordon W. Rewcastle
المصدر: Arkivoc. 2020:214-227
مصطلحات موضوعية: Chemistry, Organic Chemistry, Organic chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::60ae0f66647fc043a698c30e5967ad49
https://doi.org/10.24820/ark.5550190.p011.337 -
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المؤلفون: James M. J. Dickson, Swarna A. Gamage, Julie Ann Spicer, Kit Yee Tsang, Woo-Jeong Lee, Gordon W. Rewcastle, William A. Denny, Patrick D. O'Connor, Peter R. Shepherd, Jack U. Flanagan
المصدر: Chemistry – An Asian Journal. 14:1249-1261
مصطلحات موضوعية: Benzimidazole, Pyridines, Stereochemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Heck reaction, Pyridine, Humans, Phosphatidylinositol, Enzyme Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Kinase, Hydrogen bond, Organic Chemistry, Biological activity, General Chemistry, 0104 chemical sciences, chemistry, Selectivity
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6
المؤلفون: William A. Denny, Kit Yee Tsang, Jackie D. Kendall, Weiping Han, Ripudaman Singh, Gordon W. Rewcastle, Christina M. Buchanan, David J. Matthews, Anna C. Giddens, Sharada Kolekar, Greg C. Smith, Peter R. Shepherd, Stephen M. F. Jamieson, Woo-Jeong Lee, Swarna A. Gamage
المصدر: Oncotarget
مصطلحات موضوعية: Male, 0301 basic medicine, Gerontology, SN32976, phosphatidylinositol 3-kinase, Buparlisib, Antineoplastic Agents, Pharmacology, law.invention, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, law, Cell Line, Tumor, Animals, Humans, Medicine, Phosphorylation, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Clinical pharmacology, business.industry, Kinase, pan PI3K inhibitor, TOR Serine-Threonine Kinases, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Molecular medicine, kinase selectivity, Rats, PI3Kα-preferential, Enzyme Activation, Disease Models, Animal, Glucose, 030104 developmental biology, Oncology, chemistry, Research centre, 030220 oncology & carcinogenesis, business, Research Paper, Biomedical sciences
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a50a46d521188d2591f550c8c62f66
https://doi.org/10.18632/oncotarget.17730 -
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المؤلفون: Anna C. Giddens, Swarna A. Gamage, Jackie D. Kendall, Woo-Jeong Lee, Bruce C. Baguley, Christina M. Buchanan, Stephen M.F. Jamieson, James M.J. Dickson, Peter R. Shepherd, William A. Denny, Gordon W. Rewcastle
المصدر: Bioorganicmedicinal chemistry. 27(8)
مصطلحات موضوعية: Sulfonamides, Triazines, Organic Chemistry, Clinical Biochemistry, Transplantation, Heterologous, Drug Evaluation, Preclinical, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Inhibitory Concentration 50, Mice, Phosphatidylinositol 3-Kinases, Protein Subunits, Structure-Activity Relationship, Cell Line, Tumor, Neoplasms, Drug Discovery, Molecular Medicine, Animals, Humans, Female, Molecular Biology, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors
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8
المؤلفون: Antony W. Braithwaite, Annette Lasham, Ming-Wei Wang, Alexander Trevarton, Jack U. Flanagan, Yan Zhou, Gordon W. Rewcastle, Dehua Yang, Cristin G. Print, Peter R. Shepherd
المصدر: Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 997-1007 (2019)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Original article, DMSO, dimethylsulfoxide, YBX1, Y-box binding protein gene 1, HTS, high-throughput screening, YB-1, cDNA, complementary DNA, 03 medical and health sciences, 0302 clinical medicine, AlphaScreen, EGR1, early growth response 1, ssDNA, single-stranded DNA, shRNA, short-hairpin RNA, YB-1, Y-box binding protein-1, E2F1, Luciferase, NTD, N-terminal domain, General Pharmacology, Toxicology and Pharmaceutics, E2F1, E2F transcription factor 1, Transcription factor, Cancer, 030304 developmental biology, siRNA, small-interfering RNA, 0303 health sciences, dsDNA, double-stranded DNA, Chemistry, Drug discovery, lcsh:RM1-950, Small molecule, CSD, cold shock domain, CTD, C-terminal domain, DNA binding site, lcsh:Therapeutics. Pharmacology, Targeted drug delivery, Biochemistry, 030220 oncology & carcinogenesis, Nucleic acid, Single-stranded DNA
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9
المؤلفون: Jackie D. Kendall, Gordon W. Rewcastle, Yan Zhou, James M. J. Dickson, William A. Denny, Grace Qun Gong, Ming-Wei Wang, Christina M. Buchanan, Peter R. Shepherd, Jia Wang, Woo-Jeong Lee, Dehua Yang, Jack U. Flanagan
المصدر: Acta pharmacologica Sinica. 39(11)
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, High-throughput screening, Plasma protein binding, Phosphatidylinositol 3-Kinases, medicine.disease_cause, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Pharmacology (medical), Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Pharmacology, Mutation, Cell growth, Kinase, Chemistry, Hydrogen Bonding, General Medicine, High-Throughput Screening Assays, Isoenzymes, Molecular Docking Simulation, 030104 developmental biology, Biochemistry, 030220 oncology & carcinogenesis, Protein Binding
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10
المؤلفون: Stephen M. F. Jamieson, Anna C. Giddens, Woo-Jeong Lee, Jackie D. Kendall, Swarna A. Gamage, Kit Yee Tsang, William A. Denny, Jack U. Flanagan, Bruce C. Baguley, Peter R. Shepherd, Gordon W. Rewcastle, Christina M. Buchanan
المصدر: Bioorganicmedicinal chemistry. 25(20)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Phosphatidylinositol 3-Kinases, P110α, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Enzyme activator, 0302 clinical medicine, In vivo, Morpholine, Cell Line, Tumor, Drug Discovery, Humans, Phosphatidylinositol, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Sulfonamides, Molecular Structure, Triazines, Organic Chemistry, Sulfonamide, Enzyme Activation, 030104 developmental biology, chemistry, Solubility, 030220 oncology & carcinogenesis, Molecular Medicine, Derivative (chemistry)