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المؤلفون: Simon J F, Macdonald, Geoffrey D E, Clarke, Michael D, Dowle, Lee A, Harrison, Simon T, Hodgson, Graham G A, Inglis, Martin R, Johnson, Prit, Shah, Richard J, Upton, Steven B, Walls
المصدر: The Journal of organic chemistry. 64(14)
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المؤلفون: Simon Peace, Gianpaolo Bravi, Máire A. Convery, Hannah Davies, Graham G. A. Inglis, Joanna M. Redmond, Sandeep Pal, Heather Hobbs, Declan Summers, Ian B. Campbell
المصدر: Journal of Medicinal Chemistry. 62:6972-6984
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Isostere, Morpholines, 01 natural sciences, mTORC2, Bridged Bicyclo Compounds, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, chemistry.chemical_compound, Morpholine, Drug Discovery, Humans, Cycloheptanes, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Hydrogen bond, TOR Serine-Threonine Kinases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, Pharmacophore, Selectivity, Proto-Oncogene Proteins c-akt, Signal Transduction
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المؤلفون: Paul Rowland, Anthony William James Cooper, Kenneth David Down, Nick Barton, James E. Rowedder, Máire A. Convery, Natalie Wellaway, J. Nicole Hamblin, Jonathan A. Taylor, Simon Peace, Graham G. A. Inglis
المصدر: Journal of medicinal chemistry. 61(24)
مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Stereochemistry, Drug Evaluation, Preclinical, Crystallography, X-Ray, Madin Darby Canine Kidney Cells, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Administration, Inhalation, Transferase, Structure–activity relationship, Animals, Enzyme Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Phosphoinositide 3-kinase, biology, Chemistry, Madin Darby canine kidney cell, Hydrogen Bonding, Isoquinolines, Rats, Class Ia Phosphatidylinositol 3-Kinase, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine
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المؤلفون: Sorif Uddin, Graham G. A. Inglis, Paul Rowland, Christopher J. Tame, Christopher N. Luscombe, Nick Barton, Natalie Wellaway, Anthony William James Cooper, Josie Morrell, Giovanni Vitulli, David Perez, Augustin Amour, Simon Peace, Craig Jamieson
المصدر: Journal of Medicinal Chemistry. 59:7239-7251
مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Respiratory Tract Diseases, Biological Availability, Pharmacology, Rats sprague dawley, RS, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, In vivo, Administration, Inhalation, Drug Discovery, medicine, Animals, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Respiratory disease, medicine.disease, Rats, Bioavailability, Class Ia Phosphatidylinositol 3-Kinase, 030104 developmental biology, Molecular Medicine, Biological availability
وصف الملف: application/pdf
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المؤلفون: Leanna E. Shuster, Graham G. A. Inglis, Abraham Nudelman, Yanqiu Qian, Grazyna Graczyk-Millbrandt, David Perez, Helen F. Sneddon, Richard J. Upton, Hugo E. Gottlieb
المصدر: Green Chemistry. 18:3867-3878
مصطلحات موضوعية: Green chemistry, NMR spectra database, 010405 organic chemistry, Chemistry, Chemical shift, Environmental Chemistry, Organic chemistry, 010402 general chemistry, 01 natural sciences, Pollution, 0104 chemical sciences
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::99844d5a19ff923eb629ded8c28d5ff3
https://doi.org/10.1039/c6gc00446f -
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المؤلفون: Philip Alan Skone, Iain Uings, Davina Humphreys, Diane M. Coe, George Hardy, Simon J. F. Macdonald, Doug J. Minick, Richard Loiseau, Haydn Terence Jones, Iain M. McLay, David House, Derek A. Demaine, Michael John Johnston, Graham G. A. Inglis, Margaret Clackers
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4737-4745
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, chemistry.chemical_compound, Receptors, Glucocorticoid, Glucocorticoid receptor, Drug Discovery, medicine, Moiety, Binding site, Glucocorticoids, Molecular Biology, Binding Sites, Bicyclic molecule, Chemistry, Aryl, Organic Chemistry, Stereoisomerism, Amides, Models, Chemical, Drug Design, Pyrazoles, Molecular Medicine, Steroids, Glucocorticoid, medicine.drug
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المؤلفون: Melanie Washington, Davina Humphreys, Lesley Nisbet, Philip Alan Skone, Royston C. B. Copley, Simon J. F. Macdonald, Graham G. A. Inglis, Richard J. Upton, Mike D. Barker, Margaret Clackers, Victoria Vinader, Haydn Terence Jones, Michael John Johnston, Iain M. McLay, Derek A. Demaine, Stephen E. Shanahan, David House, Richard Loiseau, Dan Tape, Michael V. Haase, Francois Pacquet, Iain Uings
المصدر: Journal of Medicinal Chemistry. 49:4216-4231
مصطلحات موضوعية: Models, Molecular, Transcriptional Activation, Agonist, medicine.medical_specialty, Tetrahydronaphthalenes, Transcription, Genetic, medicine.drug_class, Administration, Topical, Binding, Competitive, Partial agonist, Dexamethasone, Cell Line, Mice, Radioligand Assay, Structure-Activity Relationship, Transactivation, Receptors, Glucocorticoid, Glucocorticoid receptor, Internal medicine, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Hypersensitivity, Delayed, Receptor, Transrepression, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Stereoisomerism, Benzoxazines, Endocrinology, Docking (molecular), Molecular Medicine
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المصدر: Tetrahedron Letters. 43:5057-5060
مصطلحات موضوعية: chemistry.chemical_compound, Template, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, polycyclic compounds, Serine Protease Inhibitors, biochemical phenomena, metabolism, and nutrition, Biochemistry, Pyrrolidine
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المؤلفون: Lee Andrew Harrison, Michael Dennis Dowle, Harry Finch, Robin Andrew Smith, Pritom Shah, K.Abhhilash Kumar, Gill Fleetwood, Simon Teanby Hodgson, George W. Hardy, Graham Murkitt, Simon J. F. Macdonald, Graham G. A. Inglis, Christopher R Molloy, Geoffrey D. Clarke, Augustin Amour, Rosalind E Godward, Tony Padfield, Davina Humphreys, M. R. Johnson, Mary Dixon, Tadeusz Skarzynski, Onkar M. P. Singh
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:895-898
مصطلحات موضوعية: Lactams, Human neutrophil, Metabolic Clearance Rate, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Dogs, Drug Stability, Piperidines, Pharmacokinetics, Cricetinae, Drug Discovery, Animals, Molecular Biology, Short duration, Serpins, Bacteria, Pancreatic Elastase, Chemistry, Serine Endopeptidases, Organic Chemistry, Elastase, Bacterial Infections, Rats, Bioavailability, Orally active, Pharmacodynamics, Molecular Medicine, Crystallization, Leukocyte Elastase, Intracellular
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المصدر: Tetrahedron Letters. 51:382-384
مصطلحات موضوعية: chemistry.chemical_classification, Nucleophile, chemistry, Organic Chemistry, Drug Discovery, Iodide, Leaving group, Closure (topology), Ring (chemistry), Photochemistry, Biochemistry, Medicinal chemistry