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1
المؤلفون: Sergei Timofeevski, Lars D. Engstrom, Mingying He, Michael R. Collins, Martin Paul Edwards, Phuong Le, Graham L. Smith, John Charles Kath, Helen Y. Zou, Deal Judith G, Ya-Li Deng, Robert Steven Kania, Benjamin J. Burke, Cynthia Louise Palmer, Huichun Zhu, A.E. Stewart, Hieu Lam, Dac M. Dinh, Simon Bailey, Jacqui Elizabeth Hoffman, Neal W. Sach, Robert Louis Hoffman, Qinhua Huang, J. Jean Cui, Alexei Brooun, Wei Liu, Laura Lingardo, Tod Smeal, Ted William Johnson, Michele McTigue, Justine L. Lam, Jinjiang Zhu, Paul F. Richardson
المصدر: Journal of Medicinal Chemistry. 57:4720-4744
مصطلحات موضوعية: Models, Molecular, Lactams, Brigatinib, Lactams, Macrocyclic, Aminopyridines, Antineoplastic Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Proto-Oncogene Proteins, hemic and lymphatic diseases, Drug Discovery, medicine, ROS1, Animals, Humans, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, ADME, Crizotinib, Chemistry, Drug discovery, Brain, Receptor Protein-Tyrosine Kinases, Stereoisomerism, Protein-Tyrosine Kinases, Lorlatinib, Rats, Drug Resistance, Neoplasm, Lipophilic efficiency, Mutation, Microsomes, Liver, NIH 3T3 Cells, Cancer research, Pyrazoles, Molecular Medicine, medicine.drug
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2
المؤلفون: Tod Smeal, Wei Liu, Huichun Zhu, Simon Bailey, Michael R. Collins, A.E. Stewart, Jacqui Elizabeth Hoffman, Lars D. Engstrom, Graham L. Smith, J. Jean Cui, Ya-Li Deng, Benjamin J. Burke, Laura Lingardo, Phuong Le, Andrew Simon Cook, Konstantinos Tsaparikos, Hieu Lam, Jinjiang Zhu, Ted William Johnson, Neal W. Sach, Dac M. Dinh, Robert Louis Hoffman, Mingying He, Hui Wang, Alexei Brooun, Dack Kevin Neil, Qinhua Huang, Sergei Timofeevski, Deal Judith G, Justine L. Lam, Qiuhua Li, Hong Shen, Melissa West Lu, Michele McTigue, Paul F. Richardson, Kevin D. Bunker, Robert Steven Kania, Martin Paul Edwards, Helen Y. Zou, Cynthia Louise Palmer, Patrick S. Johnson
المصدر: Journal of Medicinal Chemistry. 57:1170-1187
مصطلحات موضوعية: Drug, Pyridines, media_common.quotation_subject, Drug resistance, Pharmacology, Crizotinib, hemic and lymphatic diseases, Drug Discovery, medicine, Humans, Point Mutation, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Protein Kinase Inhibitors, media_common, Chemistry, Point mutation, Receptor Protein-Tyrosine Kinases, medicine.disease, Protein kinase domain, Drug Resistance, Neoplasm, Cell culture, Cancer research, Pyrazoles, Molecular Medicine, Progressive disease, medicine.drug
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3
المؤلفون: Michael A. Tones, Paul A. Bradley, Graham L. Smith, Lee R. Roberts, Geoff E. Gymer, Katherine S. England, Fox David Nathan Abraham, Steven E. Heasley, Michelle Schmidt, Mark E. Bunnage, Yvette M. Fobian, Jerome Molette, David Fairman, Dack Kevin Neil
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6515-6518
مصطلحات موضوعية: chemistry.chemical_classification, GUCY1B3, Organic Chemistry, Clinical Biochemistry, GUCY1A3, Triazole, Guanylate Cyclase Stimulators, Enzyme Activators, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, Triazoles, Biochemistry, chemistry.chemical_compound, Soluble Guanylyl Cyclase, Enzyme, chemistry, Guanylate Cyclase, Drug Discovery, Molecular Medicine, Organic chemistry, Molecule, Acids, Molecular Biology
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4
المؤلفون: Tran Khanh Tuan, Qiyue Hu, Zhang Junhu, Scott L. Butler, Atsuo Kuki, Qinghai Peng, Erik Jon Flahive, Graham L. Smith, Huichun Zhu, Deepak Dalvie, Plewe Michael Bruno, Jim Solowiej, Dorothy Delisle, Ted William Johnson, Wen Liu, Steven P. Tanis, Klaus Ruprecht Dress, Jon E. Kuehler, Guy A. McClellan, Xiaoming Yu, Hai Wang, Paul F. Richardson
المصدر: Journal of Medicinal Chemistry. 54:3393-3417
مصطلحات موضوعية: Cell Membrane Permeability, Molecular Conformation, Administration, Oral, Biological Availability, Integrase inhibitor, Pharmacology, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Humans, HIV Integrase Inhibitors, Naphthyridines, Cells, Cultured, chemistry.chemical_classification, biology, Chemistry, virus diseases, Ligand (biochemistry), Integrase, Bioavailability, Enzyme, Liver, Viral replication, Drug Design, HIV-1, Hepatocytes, biology.protein, Hiv 1 integrase, Molecular Medicine, Heterocyclic Compounds, 3-Ring, Tricyclic
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5
المؤلفون: Kevin K.-C. Liu, Qinhua Huang, Paul F. Richardson, Jinjiang Zhu, Graham L. Smith, Daniel Merritt Bowles, Neal W. Sach
المصدر: Organic Process Research & Development. 15:556-564
مصطلحات موضوعية: chemistry.chemical_compound, Column chromatography, Suzuki reaction, Chemistry, Organic Chemistry, Scalability, Triazole, Organic chemistry, Physical and Theoretical Chemistry, Combinatorial chemistry
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6
المؤلفون: Qinghai Peng, Tran Khanh Tuan, Atsuo Kuki, Steven P. Tanis, Zhang Junhu, Deepak Dalvie, Yang Anle, Xiaoming Yu, Jim Solowiej, Ted William Johnson, Hai Wang, Wen Liu, Plewe Michael Bruno, Buwen Huang, Graham L. Smith, Jon E. Kuehler, Klaus Ruprecht Dress, Chunfeng Yin, Qiyue Hu, Dorothy Delisle, Huichun Zhu, Scott L. Butler
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7429-7434
مصطلحات موضوعية: Indoles, Stereochemistry, Clinical Biochemistry, Glucuronidation, Administration, Oral, Pharmaceutical Science, Integrase inhibitor, HIV Integrase, Hydroxamic Acids, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Structure–activity relationship, HIV Integrase Inhibitors, Molecular Biology, ADME, chemistry.chemical_classification, Hydroxamic acid, biology, Organic Chemistry, Integrase, Enzyme, chemistry, Enzyme inhibitor, HIV-1, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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7Correction to Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity
المؤلفون: Peter A. Wells, Matthew A. Marx, Qiyue Hu, Jinjiang Zhu, Marlena Walls, Graham L. Smith, Simon Bailey, Neal W. Sach, Min-Jean Yin, Qing J. Li, Paderes Genevieve Deguzman, Kevin K.-C. Liu, Chunze Li, Paul F. Richardson, Aihua Zou, Jeffrey H. Chen, Qinhua Huang, Sangita M. Baxi
مصطلحات موضوعية: Antitumor activity, business.industry, Organic Chemistry, Drug Discovery, Medicine, Pharmacology, Highly selective, business, Biochemistry, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226ec5f732f92fd7798adb5241a85dd7
https://europepmc.org/articles/PMC4030792/ -
8
المؤلفون: Sangita M. Baxi, Marlena Walls, Paderes Genevieve Deguzman, Neal W. Sach, Kevin K.-C. Liu, Jeffrey H. Chen, Qinhua Huang, Matthew A. Marx, Aihua Zou, Min-Jean Yin, Qiyue Hu, Graham L. Smith, Simon Bailey, Qing J. Li, Jinjiang Zhu, Paul F. Richardson, Peter A. Wells, Chunze Li
مصطلحات موضوعية: Kinase, Organic Chemistry, Triazole, Pharmacology, Biology, Biochemistry, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Potency, Moiety, Selectivity, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0586b273c58f27e3a33cf986e91a06d4
https://europepmc.org/articles/PMC4018126/ -
9
المؤلفون: Zhengyu Liu, Haitao Wang, Bernadette Pascual, Jing Yuan, Dan Knighton, Shubha Bagrodia, Simon Bailey, Graham L. Smith, Caroline Rodgers, Lisa Gao, Yang Anle, Cheng Hengmiao, Kevin K.-C. Liu, Jacqui Elizabeth Hoffman, Kristina Rafidi, Shaoxian Sun, Samantha Elizabeth Greasley, Aihua Zou, Sacha Ninkovic, Hui Chen, Nambu Mitchell David, Matthew A. Marx, Qiyue Hu, Theodore O. Johnson
المصدر: Bioorganicmedicinal chemistry letters. 20(20)
مصطلحات موضوعية: Models, Molecular, Molecular model, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, In vivo, Oral administration, Cell Line, Tumor, Neoplasms, Drug Discovery, Potency, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, biology, Kinase, Chemistry, Pteridines, TOR Serine-Threonine Kinases, Organic Chemistry, Pteridinones, Glioma, Solubility, Enzyme inhibitor, biology.protein, Molecular Medicine
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10
المؤلفون: Michael R. Collins, Cynthia Louise Palmer, Robert Steven Kania, Neal W. Sach, Mingying He, Phuong Le, Jacqui Elizabeth Hoffman, Ted William Johnson, Helen Y. Zou, Judy G. Deal, Michele McTigue, Benjamin J. Burke, Tod Smeal, Robert Louis Hoffman, Qinhua Huang, Graham L. Smith, J. Jean Cui, Paul F. Richardson, Justine L. Lam, Martin Paul Edwards, Lars D. Engstrom, Ya-Li Deng, Wenyue Hu, Simon Bailey, Hieu Lam
المصدر: Molecular Cancer Therapeutics. 12:PR10-PR10
مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Crizotinib, business.industry, Kinase, medicine.drug_class, Drug discovery, Pharmacology, medicine.disease, ALK inhibitor, Protein kinase domain, hemic and lymphatic diseases, Internal medicine, medicine, ROS1, Adenocarcinoma, Anaplastic lymphoma kinase, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::511357869a2bcdf7e598428280b2df6f
https://doi.org/10.1158/1535-7163.targ-13-pr10