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المؤلفون: Graham M. A. Wells, Gert J. Ossenkoppele, Lindsay Bawden, Dimitri Breems, Norbert Vey, Phillip Debnam, Lindsey Ann Needham, Arjan A. van de Loosdrecht, Pierre Zachee, Martin Toal, Leon Hooftman, Alan H. Davidson, Bob Löwenberg
المساهمون: Hematology, Internal Medicine, CCA - Innovative therapy
المصدر: Ossenkoppele, G J, Lowenberg, B, Zachee, P, Vey, N, Breems, D, van de Loosdrecht, A A, Davidson, A H, Wells, G, Needham, L, Bawden, L, Toal, M, Hooftman, L & Debnam, P M 2013, ' A phase I first-in-human study with tefinostat-a monocyte/macrophage targeted histone deacetylase inhibitor-in patients with advanced haematological malignancies ', British Journal of Haematology, vol. 162, no. 2, pp. 191-201 . https://doi.org/10.1111/bjh.12359
British Journal of Haematology, 162(2), 191-201. Wiley-Blackwell Publishing Ltd
British Journal of Haematology, 162(2), 191-201. Wiley-Blackwellمصطلحات موضوعية: medicine.drug_class, Pharmacology, Hydroxamic Acids, Monocytes, Cohort Studies, Drug Delivery Systems, Pharmacokinetics, Humans, Medicine, Anilides, Adverse effect, Dose-Response Relationship, Drug, business.industry, Macrophages, Monocyte, Histone deacetylase inhibitor, Hematology, Rash, Histone Deacetylase Inhibitors, medicine.anatomical_structure, Tolerability, Hematologic Neoplasms, Toxicity, Bone marrow, medicine.symptom, business
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المؤلفون: Lindsay Bawden, Deborah Brotherton, Vanessa L. Clark, Richard Testar, Mcdermott Joanne, David Festus Charles Moffat, Yvonne McGovern, Stéphane Pintat, Graham M. A. Wells, Alan Hastings Drummond, Sanjay R. Patel, Alan H. Davidson, Jo Owen, Stephen Davies, Sam Bryant, David Krige, Andrew J. Belfield, Valérie Legris, Lindsey Ann Needham, Elisabeth A. Bone, Francesca Ann Day, Michael Hugh Charlton, A. Donald
المصدر: Journal of Pharmacology and Experimental Therapeutics. 339:132-142
مصطلحات موضوعية: Lipopolysaccharides, Drug, Cell type, Magnetic Resonance Spectroscopy, media_common.quotation_subject, Cell, Mice, Transgenic, Inflammation, Protein Serine-Threonine Kinases, Pharmacology, Biology, p38 Mitogen-Activated Protein Kinases, Monocytes, Carboxylesterase, Mice, Drug Delivery Systems, Cell Line, Tumor, medicine, Animals, Humans, HSP90 Heat-Shock Proteins, Amino Acids, Enzyme Inhibitors, Cell Proliferation, media_common, Tumor Necrosis Factor-alpha, Arthritis, Macrophages, Esterases, Intracellular Signaling Peptides and Proteins, Esters, Small molecule, Cell biology, medicine.anatomical_structure, Targeted drug delivery, Cell culture, Cytokines, Molecular Medicine, Histone deacetylase, medicine.symptom, Anisomycin, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99452f8f86d8124b12871827c8e5d797
https://doi.org/10.1124/jpet.111.183640 -
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المؤلفون: Graham M. A. Wells, Andrew J. H. Gearing, Michael Orth, Maria Demestre, Richard A. C. Hughes, Norman A. Gregson
المصدر: Neuropathology and Applied Neurobiology. 31:545-555
مصطلحات موضوعية: Male, medicine.medical_specialty, Histology, Nerve Crush, Biology, Matrix metalloproteinase, Neuromuscular junction, Pathology and Forensic Medicine, Physiology (medical), Internal medicine, medicine, Animals, Macrophage, RNA, Messenger, Muscle, Skeletal, Denervation, Reverse Transcriptase Polymerase Chain Reaction, Regeneration (biology), Anatomy, Immunohistochemistry, Sciatic Nerve, Matrix Metalloproteinases, Muscle Denervation, Nerve Regeneration, Rats, Staining, medicine.anatomical_structure, Endocrinology, Neurology, Rats, Inbred Lew, Nerve crush, Neurology (clinical), Reinnervation
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المؤلفون: John M. Clements, Graham M. A. Wells, M. C. Brown, Meirion Davies, P Hughes, K.M. Miller, E. J. Redford, Kenneth Smith, Andrew J. H. Gearing, R. A. C. Hughes
المصدر: Brain. 121:481-494
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Transcription, Genetic, medicine.medical_treatment, Inflammation, Matrix metalloproteinase, Polymerase Chain Reaction, Autoimmune Diseases, Schwann cell proliferation, Neuritis, Reference Values, medicine, Animals, Tissue Distribution, Matrilysin, Cellular localization, biology, Tumor Necrosis Factor-alpha, business.industry, Metalloendopeptidases, Immunohistochemistry, Sciatic Nerve, Rats, Myelin basic protein, Cytokine, Rats, Inbred Lew, biology.protein, Tumor necrosis factor alpha, Neurology (clinical), medicine.symptom, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fc0537131075e7583739b943674b76
https://doi.org/10.1093/brain/121.3.481 -
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المؤلفون: Graham M. A. Wells, Hans-Peter Hartung, Andrew J. H. Gearing, John M. Clements, Bernd C. Kieseier, Reinhard Kiefer, K.M. Miller, Tilmann Schweitzer
المصدر: Brain. 121:159-166
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Encephalomyelitis, Autoimmune, Experimental, Encephalomyelitis, Gelatinase A, Matrix metalloproteinase, Biology, Polymerase Chain Reaction, Pathogenesis, medicine, Animals, Gelatinase, Collagenases, RNA, Messenger, Matrilysin, Experimental autoimmune encephalomyelitis, Proteolytic enzymes, Metalloendopeptidases, medicine.disease, Immunohistochemistry, Rats, Matrix Metalloproteinase 9, Spinal Cord, Gelatinases, Rats, Inbred Lew, Matrix Metalloproteinase 7, Female, Neurology (clinical)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded50a5bc1d37076b704436a31586914
https://doi.org/10.1093/brain/121.1.159 -
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المؤلفون: Karen Helfrich, Dominic J. Corkill, Gary Stabler, George Ward, Judy Cossins, John M. Clements, K.M. Miller, Graham M. A. Wells, L.Mike Wood, Andrew J. H. Gearing, Rod Pigott
المصدر: Journal of Neuroimmunology. 74:85-94
مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Encephalomyelitis, Autoimmune, Experimental, Encephalomyelitis, medicine.medical_treatment, Immunology, Connective tissue, Matrix metalloproteinase, Biology, Polymerase Chain Reaction, Dexamethasone, Benzyl Compounds, medicine, Animals, Immunology and Allergy, Gelatinase, Protease Inhibitors, Pentoxifylline, Matrilysin, Tumor Necrosis Factor-alpha, Experimental autoimmune encephalomyelitis, Metalloendopeptidases, Succinates, medicine.disease, Immunohistochemistry, Extracellular Matrix, Rats, Drug Combinations, medicine.anatomical_structure, Cytokine, Spinal Cord, Neurology, Rats, Inbred Lew, Matrix Metalloproteinase 7, Cancer research, Tumor necrosis factor alpha, Neurology (clinical)
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المؤلفون: Judy Cossins, Graham Catlin, K.M. Miller, John M. Clements, George Ward, Matthew Mangan, Graham M. A. Wells
المصدر: Glia. 18:332-340
مصطلحات موضوعية: Connective tissue, Biology, Matrix metalloproteinase, Molecular biology, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Neurology, Cell culture, Complementary DNA, Gene expression, medicine, Gelatinase, Matrilysin, Astrocyte
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::88154cce8ba9d0137694b8990f2a6bd3
https://doi.org/10.1002/(sici)1098-1136(199612)18:4<332::aid-glia7>3.0.co;2-z -
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المؤلفون: Judy Cossins, Graham M. A. Wells, Stephen Chandler, Jon Lury
المصدر: Biochemical and Biophysical Research Communications. 228:421-429
مصطلحات موضوعية: Swine, Recombinant Fusion Proteins, Chondrosarcoma, Biophysics, Matrix metallopeptidase 12, Matrix metalloproteinase, Biochemistry, Cell Line, Substrate Specificity, Type IV collagen, Laminin, Matrix Metalloproteinase 12, Tumor Cells, Cultured, Animals, Humans, Point Mutation, Collagenases, Molecular Biology, biology, Tumor Necrosis Factor-alpha, Chemistry, Metalloendopeptidases, Myelin Basic Protein, Cell Biology, Fusion protein, Recombinant Proteins, Rats, Myelin basic protein, Fibronectin, Kinetics, Collagen, type I, alpha 1, Gelatinases, Mutagenesis, Site-Directed, biology.protein, Tetradecanoylphorbol Acetate, Collagen, Matrix Metalloproteinase 1
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المؤلفون: Stephen Chandler, Graham M. A. Wells, Elisabeth A. Bone, Andrew J. H. Gearing, Rachael E. Coates, Jon Lury
المصدر: Neuroscience Letters. 201:223-226
مصطلحات موضوعية: Basement membrane, General Neuroscience, Metalloendopeptidases, Myelin Basic Protein, CHO Cells, Biology, Matrix metalloproteinase, Myelin basic protein, Myelin, medicine.anatomical_structure, Biochemistry, Membrane protein, Cricetinae, medicine, biology.protein, Animals, Humans, Interstitial collagenase, Gelatinase, Matrilysin, Demyelinating Diseases
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المؤلفون: Daniel C. Anthony, Sandra J. Campbell, Graham M. A. Wells, John M. Clements, Malcolm Finlay, V. Hugh Perry, K.M. Miller
المصدر: Journal of neurochemistry. 89(6)
مصطلحات موضوعية: Kainic acid, Matrix metalloproteinase inhibitor, Plasmin, Neurotoxins, Excitotoxicity, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, medicine.disease_cause, Biochemistry, Tissue plasminogen activator, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Leukocytes, medicine, Animals, Fibrinolysin, RNA, Messenger, Enzyme Inhibitors, Rats, Wistar, Cells, Cultured, alpha-2-Antiplasmin, Kainic Acid, Cell Death, biology, Calpain, Reverse Transcriptase Polymerase Chain Reaction, T-plasminogen activator, Brain, Matrix Metalloproteinases, Rats, Up-Regulation, Cell biology, Animals, Newborn, Neutrophil Infiltration, chemistry, Immunology, biology.protein, Microglia, medicine.drug
