نتائج البحث - "Grahame J. McKenzie"

1

دورية أكاديمية

Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1

المؤلفون: David J. Huggins, Bryn S. Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J. Narvaez, Meredith Roberts-Thomson, Alex T. Crooks, Robert G. Boyle, Richard Boyce, David W. Walker, Natalia Mateu, Grahame J. McKenzie, David R. Spring, Ashok R. Venkitaraman

المصدر: ACS Omega, Vol 5, Iss 1, Pp 822-831 (2019)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/3fe07deb35644870ad3f7fc29a93ca5e

Find this issue from the American Chemical Society

Full Text Finder

2

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

المساهمون: Scott, Duncan [0000-0003-1917-9576], Coyne, Anthony [0000-0003-0205-5630], Esposito, Alessandro [0000-0002-5051-091X], Pellegrini, Luca [0000-0002-9300-497X], Blundell, Tom [0000-0002-2708-8992], Skidmore, John [0000-0001-9108-7858], Abell, Chris [0000-0001-9174-1987], Apollo - University of Cambridge Repository

المصدر: Cell Chemical Biology
'Cell Chemical Biology ', vol: 28, pages: 835-847 (2021)

مصطلحات موضوعية: Models, Molecular, DNA repair, DNA damage, Poly ADP ribose polymerase, Clinical Biochemistry, genetic processes, RAD51, Molecular Conformation, homologous recombination, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Article, law.invention, Small Molecule Libraries, chemistry.chemical_compound, law, Drug Discovery, Tumor Cells, Cultured, Humans, structure-guided drug discovery, Molecular Biology, Polymerase, Pharmacology, BRCA2 Protein, radiosensitizer, biology, Cell Death, 010405 organic chemistry, BRCA2, protein-protein interaction inhibition, 0104 chemical sciences, Cell biology, enzymes and coenzymes (carbohydrates), chemistry, biology.protein, Recombinant DNA, health occupations, Molecular Medicine, cancer therapy, Rad51 Recombinase, biological phenomena, cell phenomena, and immunity, Homologous recombination, RAD51 inhibitor, DNA, DNA Damage, Protein Binding

وصف الملف: 835 - 847 (+ e1 - e5); Print-Electronic; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e8b51ead91fb6e0441f1e51a013c4f

3

Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library

المصدر: Cell Chemical Biology

مصطلحات موضوعية: Phenotypic screening, Systems biology, Clinical Biochemistry, Peptide, Computational biology, Biology, medicine.disease_cause, 01 natural sciences, Biochemistry, Article, Protein–protein interaction, law.invention, Small Molecule Libraries, protein-protein interaction, Peptide Library, target identification, law, Drug Discovery, medicine, Humans, Genes, Tumor Suppressor, Phosphorylation, FOXO3a, lead discovery, Peptide library, Molecular Biology, Cells, Cultured, 14-3-3, Pharmacology, chemistry.chemical_classification, Mutation, 010405 organic chemistry, Forkhead Box Protein O3, phenotypic screening, Small molecule, 0104 chemical sciences, prokaryal genomes, target validation, chemistry, bioactive peptide, Molecular Medicine, Suppressor, Female, protein interference

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82261f81e78bea18e12f385b6c100941
https://doi.org/10.1016/j.chembiol.2021.05.009

4

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

مصطلحات موضوعية: Programmed cell death, biology, DNA damage, Poly ADP ribose polymerase, genetic processes, RAD51, Cell biology, law.invention, enzymes and coenzymes (carbohydrates), chemistry.chemical_compound, chemistry, law, Ribose, Recombinant DNA, biology.protein, Polymerase, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::13c1c19577aace398628cc240fb87a89
https://doi.org/10.1101/2020.07.15.200709

5

The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis

المؤلفون: Bryn Hardwick, Juan A. Bernal, Dirk Gewert, Joaquin A. Palma, Cristina Sánchez-Ramos, Francisco Cruz, David Sanz-Rosa, Andrés González-Guerra, Borja Ibanez, Grahame J. McKenzie, Vicente Andrés, Marta Roche-Molina

المساهمون: Ministerio de Ciencia, Innovación y Universidades (España), Fundación ProCNIC, Apollo - University of Cambridge Repository

المصدر: Repisalud
Instituto de Salud Carlos III (ISCIII)
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)

مصطلحات موضوعية: 0301 basic medicine, Mice, Knockout, ApoE, Enfermedad cardiovascular, Anti-Inflammatory Agents, lcsh:Medicine, Apoptosis, 030204 cardiovascular system & hematology, Monocytes, Small hairpin RNA, Mice, 0302 clinical medicine, 631/337/572, RNA, Small Interfering, lcsh:Science, Drug safety, Aorta, Aterosclerosis, Multidisciplinary, Medicamento, Cell adhesion molecule, Chemistry, 631/154/1438, Pyrrolidinones, KLF2, Medicamentos, Tumor necrosis factor alpha, medicine.symptom, Transcription, DNA, Complementary, Kruppel-Like Transcription Factors, Inflammation, Article, Cell Line, 03 medical and health sciences, In vivo, medicine, Cell Adhesion, Human Umbilical Vein Endothelial Cells, Animals, Humans, Cell adhesion, Transcription factor, Gene Library, Tumor Necrosis Factor-alpha, Gene Expression Profiling, lcsh:R, 692/4019/592/75/593/2100, Endothelial Cells, Atherosclerosis, 030104 developmental biology, 631/250/256, Cancer research, Solvents, lcsh:Q

وصف الملف: application/zip; application/pdf; text/xml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b2dd2b20515f3a57a82e5c67ad9bce
https://hdl.handle.net/20.500.12105/11097

6

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation

المؤلفون: Pooja Sharma, Marko Hyvönen, Robert Mahen, Bryn Hardwick, David J. Huggins, David R. Spring, Ashok R. Venkitaraman, M. Rossmann, Jamie E. Stokes, Amy Emery, D.L. Kunciw, Grahame J. McKenzie

المساهمون: Apollo - University of Cambridge Repository, Rossmann, Maxim [0000-0001-8811-3277], Huggins, David [0000-0003-1579-2496], Spring, David [0000-0001-7355-2824]

المصدر: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: 0301 basic medicine, 82/29, NEDD1, lcsh:Medicine, Cell Cycle Proteins, Polo-like kinase, 01 natural sciences, Substrate Specificity, Chromosome segregation, Histones, Chromosome Segregation, RNA, Small Interfering, 14/19, lcsh:Science, Kinetochores, 3' Untranslated Regions, 13/89, 45/70, Multidisciplinary, Kinetochore, Chemistry, Small molecules, article, 45/77, Cell biology, Chromatin, 3. Good health, 631/92/275, RNA Interference, 631/92/612/1246, Protein Binding, Cell Survival, 631/80/103/1966, 145, Mitosis, Kinases, 13/106, 13/109, Protein Serine-Threonine Kinases, PLK1, 631/92/613, 03 medical and health sciences, Protein Domains, Proto-Oncogene Proteins, Humans, Protein Kinase Inhibitors, 14/35, 010405 organic chemistry, 631/80/641/1655, lcsh:R, Phosphoproteins, 0104 chemical sciences, Protein Structure, Tertiary, 030104 developmental biology, Mutagenesis, Phosphoprotein, 14/63, lcsh:Q, 82/51, HeLa Cells