المؤلفون: Andrew J. Hayes, Jiulia Satiaputra, Louise M. Sternicki, Ashleigh S. Paparella, Zikai Feng, Kwang J. Lee, Beatriz Blanco-Rodriguez, William Tieu, Bart A. Eijkelkamp, Keith E. Shearwin, Tara L. Pukala, Andrew D. Abell, Grant W. Booker, Steven W. Polyak

المصدر: Antibiotics, Vol 9, Iss 4, p 165 (2020)

مصطلحات موضوعية: antimicrobial resistance, Gram-positive bacteria, Staphylococcus aureus, advanced resistance studies, biotin, biotin protein ligase, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-6382/9/4/165; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/03c962d4a73c448cad98240fb2c62993

المؤلفون: Jiage Feng, Ashleigh S. Paparella, Grant W. Booker, Steven W. Polyak, Andrew D. Abell

المصدر: Antibiotics, Vol 5, Iss 3, p 26 (2016)

مصطلحات موضوعية: antibiotic, biotin, biotin protein ligase, Staphylococcus aureus, inhibitor design, X-ray crystallography, in situ click chemistry, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.mdpi.com/2079-6382/5/3/26; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/f00fa77ec74a45e9923c4d0563782b60

المؤلفون: Jordan L. Pederick, Birgit I Gaiser, Nicholas C Schumann, Kate L. Wegener, Kwangjun Lee, James Hodgkinson-Bean, Steven W. Polyak, Thomas D. Avery, Grant W. Booker, John B. Bruning, Andrew D. Abell, Wanisa Salaemae, Andrew P. Thompson

المصدر: ACS Chemical Biology. 16:2339-2347

مصطلحات موضوعية: Tuberculosis, In silico, 01 natural sciences, Biochemistry, Dethiobiotin synthase, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Biotin, Biosynthesis, medicine, Tetrazole, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, 010405 organic chemistry, General Medicine, medicine.disease, biology.organism_classification, 0104 chemical sciences, 3. Good health, Enzyme, chemistry, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5ac2bc6435643604f3c068bed34da81f
https://doi.org/10.1021/acschembio.1c00491

المؤلفون: Kwangjun Lee, Andrew D. Abell, Steven W. Polyak, Beatriz Blanco-Rodriguez, John B. Bruning, Danielle Cini, Grant W. Booker, Robert W. Milne, Benjamin Noll, Andrew J. Hayes, Andrew C Marshall, Ashleigh S. Paparella, Jiage Feng, Matthew C.J. Wilce, Jingxian Yu, William Tieu

المساهمون: Lee, Kwang Jun, Tieu, William, Blanco-Rodriguez, Beatriz, Paparella, Ashleigh S, Yu, Jingxian, Hayes, Andrew, Feng, Jiage, Marshall, Andrew C, Noll, Benjamin, Milne, Robert, Cini, Danielle, Wilce, Matthew CJ, Booker, Grant W, Bruning, John B, Polyak, Steven W, Abell, Andrew D

المصدر: ACS Chemical Biology. 14:1990-1997

مصطلحات موضوعية: pharmacokinetic profile, 0301 basic medicine, Staphylococcus aureus, medicine.drug_class, Antibiotics, Microbial Sensitivity Tests, Molecular Dynamics Simulation, Crystallography, X-Ray, medicine.disease_cause, 01 natural sciences, Biochemistry, metabolic stability, Microbiology, Mice, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Drug Stability, Biotin, medicine, Animals, Carbon-Nitrogen Ligases, Enzyme Inhibitors, chemistry.chemical_classification, Sulfonamides, DNA ligase, 010405 organic chemistry, molecular dynamics simulations, General Medicine, Phosphate, Anti-Bacterial Agents, Rats, 0104 chemical sciences, Sulfonamide, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17972eb42541dd574d7fb900e1b5a4a3
https://doi.org/10.1021/acschembio.9b00463

المؤلفون: Nicholas C, Schumann, Kwang Jun, Lee, Andrew P, Thompson, Wanisa, Salaemae, Jordan L, Pederick, Thomas, Avery, Birgit I, Gaiser, James, Hodgkinson-Bean, Grant W, Booker, Steven W, Polyak, John B, Bruning, Kate L, Wegener, Andrew D, Abell

المصدر: ACS chemical biology. 16(11)

مصطلحات موضوعية: Drug Development, Molecular Structure, Antitubercular Agents, Carbon-Nitrogen Ligases, Mycobacterium tuberculosis, Enzyme Inhibitors, Crystallography, X-Ray, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::8a67d54aea5164bd70befc0f5c2bc214
https://pubmed.ncbi.nlm.nih.gov/34533923

المؤلفون: Tara L. Pukala, Andrew J. Hayes, Louise M. Sternicki, Keith E. Shearwin, Jiulia Satiaputra, Steven W. Polyak, Grant W. Booker

المساهمون: Satiaputra, Jiulia, Sternicki, Louise M, Hayes, Andrew J, Pukala, Tara L, Booker, Grant W, Shearwin, Keith E, Polyak, Steven W

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Spectrometry, Mass, Electrospray Ionization, Staphylococcus aureus, Repressor, Biotin, lcsh:Medicine, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Bacterial Proteins, biotin, Nanotechnology, Carbon-Nitrogen Ligases, Amino Acid Sequence, lcsh:Science, chemistry.chemical_classification, DNA ligase, Multidisciplinary, biology, Escherichia coli Proteins, lcsh:R, DNA, Protein Structure, Tertiary, Repressor Proteins, Biotin transport, 030104 developmental biology, Biochemistry, chemistry, Biotinylation, biology.protein, Fatty acid elongation, lcsh:Q, Protein A, Dimerization, 030217 neurology & neurosurgery, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e872c44a140fdec1fb6afa9987e76fd7
http://link.springer.com/article/10.1038/s41598-019-39398-6

المؤلفون: Steven W. Polyak, Andrew P. Thompson, Kate L. Wegener, Grant W. Booker, John B. Bruning

المساهمون: Thompson, Andrew P, Wegener, Kate L, Booker, Grant W, Polyak, Steven W, Bruning, John B

المصدر: Acta Crystallographica Section D Structural Biology. 74:965-972

مصطلحات موضوعية: 0301 basic medicine, Biochemistry & Molecular Biology, Cytidine triphosphate, Protein Conformation, Cytidine Triphosphate, Biophysics, Plasma protein binding, ligand, Crystallography, X-Ray, Ligands, Binding, Competitive, Biochemical Research Methods, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, Structural Biology, Transferase, Carbon-Nitrogen Ligases, Binding site, Crystallography, Binding Sites, 030102 biochemistry & molecular biology, biology, Chemistry, exchange, biology.organism_classification, Combinatorial chemistry, Adenosine Diphosphate, Adenosine diphosphate, 030104 developmental biology, dethiobiotin synthetase, ADP binding, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba5c210bebd796d977d0ca3a84cf221
https://doi.org/10.1107/s2059798318010136

المؤلفون: Stephanie Nguyen, Nicole R. Pendini, Louise M. Sternicki, Grant W. Booker, Yoann Huet, Kate L. Wegener, Perdita E. Barran, Kamila J. Pacholarz, Tara L. Pukala, Steven W. Polyak, Rachel Baltz

المساهمون: Sternicki, Louise M, Nguyen, Stephanie, Pacholarz, Kamila J, Barran, Perdita, Pendini, Nicole R, Booker, Grant W, Huet, Yoanne, Baltz, Rachel, Wegener, Kate L, Pukala, Tara L, Polyak, Steven W

المصدر: Archives of biochemistry and biophysics. 691

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Saccharomyces cerevisiae, Biophysics, Biochemistry, Substrate Specificity, Fungal Proteins, 03 medical and health sciences, chemistry.chemical_compound, zymoseptoria tritici, Biotin, Ascomycota, biotin, saccharomyces cerevisiae, Carbon-Nitrogen Ligases, biotin protein ligase, Enzyme Inhibitors, Molecular Biology, Botrytis cinerea, Protein Unfolding, chemistry.chemical_classification, DNA ligase, 030102 biochemistry & molecular biology, biology, Protein Stability, biology.organism_classification, Yeast, 030104 developmental biology, Enzyme, chemistry, Biotinylation, fungal pathogens, Botrytis, botrytis cinerea, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c9737fc53e6c724a86114c45554024
https://pubmed.ncbi.nlm.nih.gov/32717225

المؤلفون: Wanida Phetsang, Mark A. T. Blaskovich, Zikai Feng, Ashleigh S. Paparella, Jiage Feng, Mark E. Cooper, Andrew D. Abell, Beatriz Blanco-Rodriguez, Grant W. Booker, Steven W. Polyak

المساهمون: Paparella, Ashleigh S, Feng, Jiage, Blanco-Rodriguez, Beatriz, Feng, Zikai, Phetsang, Wanida, Blaskovich, Mark AT, Cooper, Matthew A, Booker, Grant W, Polyak, Steven W, Abell, Andrew D

المصدر: Tetrahedron. 74:1175-1183

مصطلحات موضوعية: staphylococcus aureus, 0301 basic medicine, enzyme inhibitors, Mutant, medicine.disease_cause, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Biotin, antibiotic, Drug Discovery, medicine, Fluorescence microscope, biotin protein ligase, Escherichia coli, chemistry.chemical_classification, DNA ligase, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, biology.organism_classification, Molecular biology, 0104 chemical sciences, 030104 developmental biology, Staphylococcus aureus, azide-alkyne cycloaddition, Efflux, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3ee83d4c85812f14daf2c21ac1dd82
https://doi.org/10.1016/j.tet.2017.10.032

المؤلفون: Sarah Clark, Andrew J. Hayes, Ashleigh S. Paparella, Grant W. Booker, David Heim, Steven W. Polyak, William Tieu, Andrew D. Abell, Jiage Feng

المساهمون: Feng, Jiage, Paparella, Ashleigh S, Tieu, William, Heim, David, Clark, Sarah, Hayes, Andrew, Booker, Grant W, Polyak, Steven W, Abell, Andrew D

المصدر: ACS Medicinal Chemistry Letters. 7:1068-1072

مصطلحات موضوعية: inorganic chemicals, 0301 basic medicine, Staphylococcus aureus, enzyme inhibitors, Binding pocket, Biology, medicine.disease_cause, Biochemistry, antibiotics, 03 medical and health sciences, chemistry.chemical_compound, Biotin, Drug Discovery, Ribose, medicine, biotin protein ligase, Cytotoxicity, chemistry.chemical_classification, DNA ligase, Organic Chemistry, 030104 developmental biology, chemistry, Hepg2 cells, Benzyl group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e60b92eb571193cac10eeb87712df75
https://doi.org/10.1021/acsmedchemlett.6b00248