المؤلفون: Lei Chen, Ling Tong, Joseph A. Kozlowski, Sony Agrawal, Christian L. Holst, Bin Zhong, Yueheng Jiang, Oleg Selyutin, Craig A. Coburn, A. Samuel Vellekoop, Frederick C. Lahser, James I. Fells, Bin Hu, Patricia McMonagle, Donna Carr, Ernest Asante-Appiah, Laura Rokosz, Rong Liu, Gregory Scott Martin, Anilkumar G. Nair, Michael P. Dwyer, Stuart B. Rosenblum, Paul Ingravallo, Michael Wong, Tao Ji, Wensheng Yu, Bancha Vibulbhan, Stephanie Curry, Qingbei Zeng

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3793-3799

مصطلحات موضوعية: 0301 basic medicine, Macrocyclic Compounds, Stereochemistry, Hepacivirus, 030106 microbiology, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, NS5A, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Organic Chemistry, virus diseases, Hepatitis C, medicine.disease, biology.organism_classification, Virology, digestive system diseases, In vitro, Titer, Regimen, 030104 developmental biology, Viral replication, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0f63a0987e007812c5ee3e770f1ad2
https://doi.org/10.1016/j.bmcl.2016.05.042

المؤلفون: Janet Dell-John, John D. Dimarco, Cheryl A. Rizzo, Mark E. Salvati, Steven H. Spergel, Gregory Scott Martin, Weifang Shan, Aaron Balog, Georgia Cornelius, Richard Rampulla, Marco M. Gottardis, Andrew Nation, Christian L. Holst, Liang Schweizer, Gregory D. Vite, Lana M. Rossiter, Ricardo M. Attar, David J. Fairfax, Thomas E. Spires, Stanley R. Krystek, George L. Trainor, Jack Z. Gougoutas

المصدر: ACS Medicinal Chemistry Letters. 6:908-912

مصطلحات موضوعية: Nonsteroidal, Bicalutamide, business.industry, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, Cancer, Pharmacology, medicine.disease, Biochemistry, In vitro, Androgen receptor, stomatognathic diseases, Prostate cancer, chemistry.chemical_compound, chemistry, Drug Discovery, Medicine, Androgen receptor antagonist, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade3699fe30010f468bf3970ddbfb7bd
https://doi.org/10.1021/acsmedchemlett.5b00173

المؤلفون: Ying Zhai, Ellen Xia, Lei Chen, Bandarpalle B. Shankar, Qingbei Zeng, Anilkumar G. Nair, Sony Agrawal, Ronald N. Buckle, Guowei Zhou, Kannan P. Naicker, John P. Caldwell, Ling Tong, Yueheng Jiang, Stuart B. Rosenblum, Wensheng Yu, Kerry Keertikar, Haiqun Tang, Seong Heon Kim, Rong Liu, De-Yi Yang, Paul Ingravallo, Gregory Scott Martin, Samuel A. Vellekoop, Melissa L. Allard, Christian L. Holst, Michael P. Dwyer, Amin A. Nomeir, Robert Mazzola, Polivina Jolicia F Gauuan, Joseph A. Kozlowski, Oleg Selyutin, Rong Kong

المصدر: Bioorganicmedicinal chemistry letters. 26(5)

مصطلحات موضوعية: 0301 basic medicine, Silylation, Genotype, Proline, viruses, Hepacivirus, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Pharmacology, Viral Nonstructural Proteins, Virus Replication, 01 natural sciences, Biochemistry, Antiviral Agents, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Potency, Structure–activity relationship, NS5A, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, virus diseases, biochemical phenomena, metabolism, and nutrition, Silanes, biology.organism_classification, digestive system diseases, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85586f1ce259c9e4c3146d6078489ecd
https://pubmed.ncbi.nlm.nih.gov/26850003

المؤلفون: Hai-Yun Xiao, Jieping Geng, David J. Fairfax, Thomas E. Spires, Wen-Ching Han, Marco M. Gottardis, Mark E. Salvati, Andrew Nation, Weifang Shan, Mary-Ellen Cvjic, Jing Chen, Liang Schweizer, Mary T. Obermeier, Gregory Scott Martin, Ricardo M. Attar, Gregory D. Vite, Aaron Balog, Ashvinikumar V. Gavai, Janet Dell-John, Cheryl A. Rizzo, Lana M. Rossiter, Linda B. Fleming, Christian L. Holst

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4491-4495

مصطلحات موضوعية: Male, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Antiandrogen, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Nitriles, Drug Discovery, medicine, Humans, Androgen Receptor Antagonists, Imide, Molecular Biology, Trifluoromethyl, Chemistry, Organic Chemistry, Prostatic Neoplasms, In vitro, Androgen receptor, Receptors, Androgen, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa7ea427f1d25e9dcfd82444931e7e2
https://doi.org/10.1016/j.bmcl.2010.06.034

المؤلفون: Michael Ellis, Robert K. Suto, Ming Min Hsia, Bryan Cordell Duffy, Cheng Guo, Karen Norek, He Zhao, Henrik C. Hansen, Damodharan Lakshminarasimhan, Shuang Liu, Peter Young, Ruifang Wang, Gregory S. Wagner, Douglas B. Kitchen, Andre White, John Frederick Quinn, Kevin G. McLure, Emily M. Gesner, Gregory Scott Martin, Olesya A. Kharenko

المصدر: Bioorganicmedicinal chemistry letters. 25(14)

مصطلحات موضوعية: BRD4, Clinical Biochemistry, Druggability, Drug Evaluation, Preclinical, Pharmaceutical Science, Cell Cycle Proteins, Plasma protein binding, Crystallography, X-Ray, Ligands, Biochemistry, Structure-Activity Relationship, Quinoxalines, Drug Discovery, Humans, Molecular Biology, Virtual screening, Binding Sites, Chemistry, Organic Chemistry, Nuclear Proteins, Combinatorial chemistry, Bromodomain, Protein Structure, Tertiary, Molecular Docking Simulation, Förster resonance energy transfer, Protein–ligand docking, Docking (molecular), Drug Design, Molecular Medicine, Protein Binding, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0775dfb16744dbd530a75977aed3bcfd
https://pubmed.ncbi.nlm.nih.gov/26022843

المؤلفون: Gregory Scott Martin, David J. Fairfax, Lisa H. Bourdon, Casey J. N. Mathison, Pavel Zhichkin

المصدر: Tetrahedron: Asymmetry. 15:3485-3487

مصطلحات موضوعية: Inorganic Chemistry, chemistry, Yield (chemistry), Organic Chemistry, Enantioselective synthesis, chemistry.chemical_element, Organic chemistry, Physical and Theoretical Chemistry, Dynamic resolution, Enantiomeric excess, Nitrogen, Catalysis, Rhodium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::19f30914100a7f92211ee89da2bd13e1
https://doi.org/10.1016/j.tetasy.2004.10.005

المؤلفون: Bharat P. Patel, Gregory D. Vite, Gregory Scott Martin, Kenneth J. Leavitt, Lana M. Rossiter, Hongjian Zhang, Francis Y. Lee, Chiang Yu, Arvind Mathur, Simone Oppenheimer, Shankar Swaminathan, John S. Tokarski, Ashvinikumar V. Gavai, Derek J. Norris, Christian L. Holst, Tai W. Wong, Punit Marathe, Wen-Ching Han, Dolatrai M. Vyas, Soong-Hoon Kim, David J. Fairfax, Harold Mastalerz, Joseph Fargnoli, Brian E. Fink, Bindu Goyal

المصدر: Journal of medicinal chemistry. 52(21)

مصطلحات موضوعية: Stereochemistry, Receptor, ErbB-2, Transplantation, Heterologous, Administration, Oral, Biological Availability, Antineoplastic Agents, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Carbamic acid, Dogs, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Epidermal growth factor receptor, BMS-599626, biology, Kinase, Triazines, Stereoisomerism, In vitro, ErbB Receptors, Macaca fascicularis, chemistry, biology.protein, Molecular Medicine, Carbamates, Signal transduction, Drug Screening Assays, Antitumor, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25d642f72ade19941b80c3a648395cc
https://pubmed.ncbi.nlm.nih.gov/19821562