المؤلفون: Abbott KL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ali A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Casalena D; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Do BT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA., Ferreira R; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Cheah JH; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Soule CK; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Deik A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kunchok T; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Schmidt DR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Renner S; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Honeder SE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria., Wu M; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chan SH; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Tseyang T; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Stoltzfus AT; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA., Michel SLJ; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA., Greaves D; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Hsu PP; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA., Ng CW; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Zhang CJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Farsidjani A; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Kent JR; Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA., Madariaga MLL; Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA., Gramatikov IMT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Matheson NJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Lewis CA; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Griner LM; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Muir A; Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, USA., Auld DS; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: mvh@mit.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2023 Sep 21; Vol. 30 (9), pp. 1156-1168.e7. Date of Electronic Publication: 2023 Sep 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Culture Techniques* , High-Throughput Screening Assays*, Humans ; Cell Line ; Small Molecule Libraries/pharmacology

المؤلفون: Abbott KL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ali A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Casalena D; Novartis Institute for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Do BT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA., Ferreira R; Department of Genetics, Harvard Medical School, Boston, MA, USA., Cheah JH; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Soule CK; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Deik A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kunchok T; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Schmidt DR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Renner S; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Honeder SE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria., Wu M; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chan SH; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Tseyang T; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Greaves D; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK.; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Hsu PP; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA., Ng CW; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Zhang CJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Farsidjani A; Novartis Institute for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Gramatikov IMT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Matheson NJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK.; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Lewis CA; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Griner LM; Novartis Institute for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Muir A; Ben May Department of Cancer Research, University of Chicago, Chicago, IL, USA., Auld DS; Novartis Institute for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA., Heiden MGV; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Dana-Farber Cancer Institute, Boston, MA 02115, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 27. Date of Electronic Publication: 2023 Feb 27.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Fontelonga TM; Department of Pharmacology, University of Nevada, Reno School of Medicine, , Reno, NV, USA., Jordan B; Department of Pharmacology, University of Nevada, Reno School of Medicine, , Reno, NV, USA., Nunes AM; Department of Pharmacology, University of Nevada, Reno School of Medicine, , Reno, NV, USA., Barraza-Flores P; Department of Pharmacology, University of Nevada, Reno School of Medicine, , Reno, NV, USA., Bolden N; Department of Pharmacology, University of Nevada, Reno School of Medicine, , Reno, NV, USA., Wuebbles RD; Department of Pharmacology, University of Nevada, Reno School of Medicine, , Reno, NV, USA., Griner LM; Division of Pre-clinical Innovation, NIH Center for Advancing Translational Sciences, Rockville, MD, USA., Hu X; Division of Pre-clinical Innovation, NIH Center for Advancing Translational Sciences, Rockville, MD, USA., Ferrer M; Division of Pre-clinical Innovation, NIH Center for Advancing Translational Sciences, Rockville, MD, USA., Marugan J; Division of Pre-clinical Innovation, NIH Center for Advancing Translational Sciences, Rockville, MD, USA., Southall N; Division of Pre-clinical Innovation, NIH Center for Advancing Translational Sciences, Rockville, MD, USA., Burkin DJ; Department of Pharmacology, University of Nevada, Reno School of Medicine, , Reno, NV, USA.

المصدر: Human molecular genetics [Hum Mol Genet] 2019 Jul 01; Vol. 28 (13), pp. 2120-2132.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Muscle, Skeletal/*drug effects , Muscular Dystrophy, Duchenne/*drug therapy , Myoblasts/*drug effects , Sunitinib/*therapeutic use, Animals ; Cell Line ; Disease Models, Animal ; Disease Progression ; Integrins/metabolism ; Male ; Mice ; Mice, Inbred mdx ; Muscle Development/drug effects ; Muscle, Skeletal/metabolism ; MyoD Protein/metabolism ; Myoblasts/cytology ; Myoblasts/metabolism ; Myogenin/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/drug effects ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism ; Regeneration ; STAT3 Transcription Factor/drug effects ; STAT3 Transcription Factor/metabolism ; Satellite Cells, Skeletal Muscle/drug effects ; Satellite Cells, Skeletal Muscle/metabolism ; Sunitinib/pharmacology

المؤلفون: Griner LM; Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research; lesley.griner@novartis.com., Gampa K; Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research., Do T; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research., Nguyen H; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research., Farley D; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research., Hogan CJ; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research., Auld DS; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research., Silver SJ; Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research.

المصدر: Journal of visualized experiments : JoVE [J Vis Exp] 2018 Sep 05 (139). Date of Electronic Publication: 2018 Sep 05.

نوع المنشور: Journal Article; Video-Audio Media

بيانات الدورية: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

مواضيع طبية MeSH: Drug Evaluation, Preclinical/*methods , High-Throughput Screening Assays/*methods , Spheroids, Cellular/*drug effects, Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Fibronectins/metabolism ; Humans

المؤلفون: Frankowski KJ; Specialized Chemistry Center, The University of Kansas, Lawrence, KS 66047, USA., Wang C; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Patnaik S; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA., Schoenen FJ; Specialized Chemistry Center, The University of Kansas, Lawrence, KS 66047, USA., Southall N; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA., Li D; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Teper Y; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Sun W; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA., Kandela I; Center for Developmental Therapeutics, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60208, USA., Hu D; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Dextras C; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA., Knotts Z; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Bian Y; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Norton J; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Titus S; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA., Lewandowska MA; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Wen Y; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Farley KI; Departments of Molecular Biophysics and Biochemistry, Genetics, and Therapeutic Radiology, Yale University and Yale School of Medicine, New Haven, CT 06520, USA., Griner LM; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA., Sultan J; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA., Meng Z; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA., Zhou M; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA., Vilimas T; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Fort Detrick, Frederick, MD 21702, USA., Powers AS; Laboratory of Pathology, Center for Cancer Research, NIH, Bethesda, MD 20892, USA., Kozlov S; Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Fort Detrick, Frederick, MD 21702, USA., Nagashima K; Electron Microscope Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Quadri HS; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Fang M; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA., Long C; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Khanolkar O; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Chen W; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Kang J; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Huang H; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Chow E; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Goldberg E; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Feldman C; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Xi R; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA., Kim HR; Department of Human Genetics, Cancer Biology Graduate Program, Emory University School of Medicine, Atlanta, GA 30322, USA., Sahagian G; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA., Baserga SJ; Departments of Molecular Biophysics and Biochemistry, Genetics, and Therapeutic Radiology, Yale University and Yale School of Medicine, New Haven, CT 06520, USA., Mazar A; Center for Developmental Therapeutics, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60208, USA., Ferrer M; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA., Zheng W; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA., Shilatifard A; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Aubé J; Specialized Chemistry Center, The University of Kansas, Lawrence, KS 66047, USA., Rudloff U; Thoracic and Gastrointestinal Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. s-huang2@northwestern.edu maruganj@mail.nih.gov rudloffu@mail.nih.gov., Marugan JJ; NIH (National Institutes of Health) Chemical Genomics Center, National Center for Advancing Translational Sciences, NIH, Rockville, MD, 20850, USA. s-huang2@northwestern.edu maruganj@mail.nih.gov rudloffu@mail.nih.gov., Huang S; Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA. s-huang2@northwestern.edu maruganj@mail.nih.gov rudloffu@mail.nih.gov.

المصدر: Science translational medicine [Sci Transl Med] 2018 May 16; Vol. 10 (441).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Cell Nucleolus/*pathology , Neoplasm Metastasis/*drug therapy , Pyrimidines/*therapeutic use , Pyrroles/*therapeutic use, Animals ; Cell Line, Tumor ; Cell Nucleolus/drug effects ; Cell Nucleolus/metabolism ; Cell Nucleolus/ultrastructure ; Cell Proliferation/drug effects ; Chromatin/metabolism ; DNA, Ribosomal/genetics ; Humans ; Male ; Mice ; Neoplasm Invasiveness ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Peptide Elongation Factor 1/metabolism ; Promoter Regions, Genetic/genetics ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Pyrroles/chemistry ; Pyrroles/pharmacology ; RNA Polymerase I/metabolism ; RNA Precursors/biosynthesis ; Survival Analysis ; Transcription, Genetic/drug effects ; Xenograft Model Antitumor Assays

المؤلفون: Hamilton DH; Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland., Griner LM; National Center for Advancing Translational Sciences, NIH, Rockville, Maryland., Keller JM; National Center for Advancing Translational Sciences, NIH, Rockville, Maryland., Hu X; National Center for Advancing Translational Sciences, NIH, Rockville, Maryland., Southall N; National Center for Advancing Translational Sciences, NIH, Rockville, Maryland., Marugan J; National Center for Advancing Translational Sciences, NIH, Rockville, Maryland., David JM; Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland., Ferrer M; National Center for Advancing Translational Sciences, NIH, Rockville, Maryland., Palena C; Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. palenac@mail.nih.gov.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2016 Dec 15; Vol. 22 (24), pp. 6204-6216. Date of Electronic Publication: 2016 Jun 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Estradiol/*analogs & derivatives , Estrogen Receptor alpha/*metabolism , Lung Neoplasms/*drug therapy , Lung Neoplasms/*immunology , Signal Transduction/*drug effects, Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/immunology ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/immunology ; Estradiol/pharmacology ; Fulvestrant ; Humans ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Lung Neoplasms/metabolism ; Signal Transduction/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology

المؤلفون: Blevins MA; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA., Kouznetsova J; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA., Krueger AB; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA., King R; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA., Griner LM; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA., Hu X; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA., Southall N; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA., Marugan JJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA., Zhang Q; Department of Dermatology, University of Colorado School of Medicine, Aurora, CO, USA., Ferrer M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA., Zhao R; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA qinghong.zhang@ucdenver.edu marc.ferrer@nih.gov rui.zhao@ucdenver.edu.

المصدر: Journal of biomolecular screening [J Biomol Screen] 2015 Jun; Vol. 20 (5), pp. 663-72. Date of Electronic Publication: 2014 Dec 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays*/methods, Alcohol Oxidoreductases/*metabolism , Carrier Proteins/*metabolism , DNA-Binding Proteins/*metabolism , Gene Expression Regulation/*drug effects , Naphthoquinones/*pharmacology , Transcription, Genetic/*drug effects, Dose-Response Relationship, Drug ; Drug Discovery/methods ; Humans ; Protein Binding/drug effects ; Reproducibility of Results ; Small Molecule Libraries ; Substrate Specificity