المؤلفون: Kobayashi-Kirschvink KJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. kkobayas@broadinstitute.org.; Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA. kkobayas@broadinstitute.org., Comiter CS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Gaddam S; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Joren T; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Grody EI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ounadjela JR; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhang K; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ge B; Department of Mechanical and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Kang JW; Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Xavier RJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA., So PTC; Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Mechanical and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Biancalani T; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. biancalt@gene.com.; Genentech, South San Francisco, CA, USA. biancalt@gene.com., Shu J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. jian.shu@mgh.harvard.edu.; Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. jian.shu@mgh.harvard.edu., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com.

المصدر: Nature biotechnology [Nat Biotechnol] 2024 Jan 10. Date of Electronic Publication: 2024 Jan 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

المؤلفون: Goyal Y; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. yogesh.goyal@northwestern.edu.; Center for Synthetic Biology, Northwestern University, Chicago, IL, USA. yogesh.goyal@northwestern.edu.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. yogesh.goyal@northwestern.edu.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA. yogesh.goyal@northwestern.edu., Busch GT; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Pillai M; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University, Chicago, IL, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Li J; Genetics and Epigenetics, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Boe RH; Genetics and Epigenetics, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Grody EI; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University, Chicago, IL, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Chelvanambi M; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dardani IP; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Emert B; Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bodkin N; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University, Chicago, IL, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Braun J; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University, Chicago, IL, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Fingerman D; The Wistar Institute, Philadelphia, PA, USA., Kaur A; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA., Jain N; Genetics and Epigenetics, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ravindran PT; Genetics and Epigenetics, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mellis IA; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.; Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kiani K; Genetics and Epigenetics, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Alicea GM; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD, USA.; Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Fane ME; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD, USA.; Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Ahmed SS; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University, Chicago, IL, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Li H; The Wistar Institute, Philadelphia, PA, USA., Chen Y; The Wistar Institute, Philadelphia, PA, USA., Chai C; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Center for Synthetic Biology, Northwestern University, Chicago, IL, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Reproductive Science, Northwestern University, Chicago, IL, USA., Kaster J; The Wistar Institute, Philadelphia, PA, USA., Witt RG; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lazcano R; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ingram DR; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Johnson SB; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wani K; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dunagin MC; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lazar AJ; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Weeraratna AT; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD, USA.; Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Wargo JA; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Herlyn M; The Wistar Institute, Philadelphia, PA, USA., Raj A; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA. arjunrajlab@gmail.com.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. arjunrajlab@gmail.com.

المصدر: Nature [Nature] 2023 Aug; Vol. 620 (7974), pp. 651-659. Date of Electronic Publication: 2023 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Clone Cells*/drug effects , Clone Cells*/metabolism , Clone Cells*/pathology , Drug Resistance, Neoplasm*/drug effects , Drug Resistance, Neoplasm*/genetics , Neoplasms*/drug therapy , Neoplasms*/genetics , Neoplasms*/pathology , Antineoplastic Agents*/pharmacology, Humans ; DNA Barcoding, Taxonomic ; RNA-Seq ; Single-Cell Gene Expression Analysis ; Tumor Cells, Cultured

المؤلفون: Martin-Rufino JD; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; PhD Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA., Castano N; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pang M; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA., Grody EI; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Joubran S; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology PhD Program, Harvard Medical School, Boston, MA 02115, USA., Caulier A; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wahlster L; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Li T; Department of Pharmacology and Yale Cancer Biology Institute, Yale University School of Medicine, New Haven, CT 06510, USA., Qiu X; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Riera-Escandell AM; Independent Researcher, now at Google, Zurich, Switzerland., Newby GA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Al'Khafaji A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Chaudhary S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Black S; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Weng C; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Munson G; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Liu DR; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Wlodarski MW; Department of Hematology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Sims K; St. Jude Affiliate Clinic at Our Lady of the Lake Children's Health, Baton Rouge, LA 70809, USA., Oakley JH; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA., Fasano RM; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, GA 30322, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Department of Molecular Biology, and Center for the Study of Inflammatory Bowel Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Klein DE; Department of Pharmacology and Yale Cancer Biology Institute, Yale University School of Medicine, New Haven, CT 06510, USA., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: sankaran@broadinstitute.org.

المصدر: Cell [Cell] 2023 May 25; Vol. 186 (11), pp. 2456-2474.e24. Date of Electronic Publication: 2023 May 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing* , Hematopoietic Stem Cells*/metabolism, Humans ; Cell Differentiation ; CRISPR-Cas Systems ; Genome ; Hematopoiesis ; Genetic Engineering ; Single-Cell Analysis

المؤلفون: Grody EI; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Synthetic Biology, Northwestern University, Chicago, IL 60208, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Abraham A; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.; Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Shukla V; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.; Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Goyal Y; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Synthetic Biology, Northwestern University, Chicago, IL 60208, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

المصدر: IScience [iScience] 2023 Apr 06; Vol. 26 (5), pp. 106574. Date of Electronic Publication: 2023 Apr 06 (Print Publication: 2023).

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE

المؤلفون: Gupta A; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115., Martin-Rufino JD; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115.; Dana-Farber Cancer Institute, Boston, MA 02215., Jones TR; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Subramanian V; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Qiu X; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; HHMI, Massachusetts Institute of Technology, Cambridge, MA 02139., Grody EI; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Bloemendal A; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Weng C; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115.; Dana-Farber Cancer Institute, Boston, MA 02215.; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Niu SY; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Min KH; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139., Mehta A; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Dana-Farber Cancer Institute, Boston, MA 02215.; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114., Zhang K; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Siraj L; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Al' Khafaji A; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Sankaran VG; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115.; Dana-Farber Cancer Institute, Boston, MA 02215., Raychaudhuri S; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115.; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115., Cleary B; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Grossman S; Broad Institute of MIT and Harvard, Cambridge, MA 02142., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.; Department of Systems Biology, Harvard Medical School, Boston, MA 02115.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 23; Vol. 119 (34), pp. e2207392119. Date of Electronic Publication: 2022 Aug 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation* , Models, Biological* , Transcription Factors*/genetics , Transcription Factors*/metabolism, Computer Simulation ; Gene Regulatory Networks

المؤلفون: Qiu X; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: xqiu@wi.mit.edu., Zhang Y; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA; Joint CMU-Pitt Ph.D. Program in Computational Biology, University of Pittsburgh, Pittsburgh, PA, USA., Martin-Rufino JD; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Weng C; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Hosseinzadeh S; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Yang D; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Pogson AN; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Hein MY; Chan Zuckerberg Biohub, 499 Illinois St, San Francisco, CA 94158, USA., Hoi Joseph Min K; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Wang L; Department of Mathematics, University of Texas at Arlington, Arlington, TX, USA., Grody EI; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shurtleff MJ; Lycia Therapeutics, South San Francisco, San Francisco, CA, USA., Yuan R; California Institute for Quantitative Biosciences, University of California, Berkeley, CA, USA., Xu S; Microsoft, Redmond, WA, USA., Ma Y; Halıcıoğlu Data Science Institute, University of California San Diego, San Diego, CA, USA., Replogle JM; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA; Medical Scientist Training Program, University of California, San Francisco, CA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Systems Biology Harvard Medical School, Boston, MA 02125, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Darmanis S; Genentech Inc., South San Francisco, CA, USA., Bahar I; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA; Joint CMU-Pitt Ph.D. Program in Computational Biology, University of Pittsburgh, Pittsburgh, PA, USA., Sankaran VG; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Xing J; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA; Joint CMU-Pitt Ph.D. Program in Computational Biology, University of Pittsburgh, Pittsburgh, PA, USA; UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: xing1@pitt.edu., Weissman JS; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA; Koch Institute For Integrative Cancer Research at MIT, MIT, Cambridge, MA, USA. Electronic address: weissman@wi.mit.edu.

المصدر: Cell [Cell] 2022 Feb 17; Vol. 185 (4), pp. 690-711.e45. Date of Electronic Publication: 2022 Feb 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Single-Cell Analysis*, Transcriptome/*genetics, Algorithms ; Female ; Gene Expression Regulation ; HL-60 Cells ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/metabolism ; Humans ; Kinetics ; Models, Biological ; RNA, Messenger/metabolism ; Staining and Labeling

المؤلفون: He Y; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tang X; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huang J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ren J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhou H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chen K; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Liu A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Shi H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Lin Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Li Q; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Aditham A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Ounadjela J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Grody EI; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Shu J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Liu J; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. jia_liu@seas.harvard.edu., Wang X; Broad Institute of MIT and Harvard, Cambridge, MA, USA. wangxiao@broadinstitute.org.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. wangxiao@broadinstitute.org.

المصدر: Nature communications [Nat Commun] 2021 Oct 08; Vol. 12 (1), pp. 5909. Date of Electronic Publication: 2021 Oct 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Cluster Analysis* , Gene Expression* , Transcriptome*, Animals ; Brain ; Female ; Gene Expression Profiling ; Genetic Techniques ; Humans ; Image Processing, Computer-Assisted ; Mice ; Mice, Inbred C57BL ; Organoids ; Placenta ; Pregnancy ; Single-Cell Analysis