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1دورية أكاديمية
المؤلفون: Gopalakrishnan SM; Advanced Technology, Global Pharmaceutical Research & Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA. sujatha.m.gopalakrishnan@abbott.com, Philip BM, Gronlien JH, Malysz J, Anderson DJ, Gopalakrishnan M, Warrior U, Burns DJ
المصدر: Assay and drug development technologies [Assay Drug Dev Technol] 2011 Dec; Vol. 9 (6), pp. 635-45. Date of Electronic Publication: 2011 Feb 10.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101151468 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8127 (Electronic) Linking ISSN: 1540658X NLM ISO Abbreviation: Assay Drug Dev Technol Subsets: MEDLINE
مواضيع طبية MeSH: High-Throughput Screening Assays/*methods , Nicotinic Agonists/*chemistry , Nicotinic Agonists/*pharmacology , Nicotinic Antagonists/*chemistry , Nicotinic Antagonists/*pharmacology , Receptors, Nicotinic/*physiology, Allosteric Regulation/drug effects ; Allosteric Regulation/physiology ; Animals ; Animals, Newborn ; Cell Line, Tumor ; Cells, Cultured ; Dose-Response Relationship, Drug ; Female ; Humans ; Neuroblastoma ; Rats ; Xenopus laevis ; alpha7 Nicotinic Acetylcholine Receptor
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2دورية أكاديمية
المؤلفون: Mortell KH; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. kathleen.mortell@abbott.com, Schrimpf MR, Bunnelle WH, Anderson DJ, Gronlien JH, Hagene KT, Gopalakrishnan M
المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jan 01; Vol. 20 (1), pp. 104-7. Date of Electronic Publication: 2009 Nov 14.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
مواضيع طبية MeSH: Ligands*, Nicotinic Agonists/*chemistry , Pyridazines/*chemistry , Pyrroles/*chemistry , Receptors, Nicotinic/*chemistry, Animals ; Humans ; Nicotinic Agonists/chemical synthesis ; Nicotinic Agonists/pharmacology ; Oocytes/metabolism ; Pyridazines/chemical synthesis ; Pyridazines/pharmacology ; Pyrroles/chemical synthesis ; Pyrroles/pharmacology ; Receptors, Nicotinic/metabolism ; Structure-Activity Relationship ; Xenopus ; alpha7 Nicotinic Acetylcholine Receptor
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3دورية أكاديمية
المؤلفون: Faghih R; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA. ramin.faghih@abbott.com, Gopalakrishnan SM, Gronlien JH, Malysz J, Briggs CA, Wetterstrand C, Ween H, Curtis MP, Sarris KA, Gfesser GA, El-Kouhen R, Robb HM, Radek RJ, Marsh KC, Bunnelle WH, Gopalakrishnan M
المصدر: Journal of medicinal chemistry [J Med Chem] 2009 May 28; Vol. 52 (10), pp. 3377-84.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Allosteric Regulation*, Pyrroles/*pharmacology , Receptors, Nicotinic/*drug effects , Sensory Gating/*drug effects , Sulfonamides/*pharmacology, Animals ; Brain/metabolism ; Cells, Cultured ; Drug Discovery ; Mice ; Microsomes ; Oocytes ; Patch-Clamp Techniques ; Pharmacokinetics ; Xenopus laevis ; alpha7 Nicotinic Acetylcholine Receptor ; Benzenesulfonamides
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4دورية أكاديمية
المؤلفون: Tietje KR; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA., Anderson DJ, Bitner RS, Blomme EA, Brackemeyer PJ, Briggs CA, Browman KE, Bury D, Curzon P, Drescher KU, Frost JM, Fryer RM, Fox GB, Gronlien JH, Håkerud M, Gubbins EJ, Halm S, Harris R, Helfrich RJ, Kohlhaas KL, Law D, Malysz J, Marsh KC, Martin RL, Meyer MD, Molesky AL, Nikkel AL, Otte S, Pan L, Puttfarcken PS, Radek RJ, Robb HM, Spies E, Thorin-Hagene K, Waring JF, Ween H, Xu H, Gopalakrishnan M, Bunnelle WH
المصدر: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2008 Spring; Vol. 14 (1), pp. 65-82.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Print ISSN: 1755-5930 (Print) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
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5دورية أكاديمية
المؤلفون: Bitner RS; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA. robert.s.bitner@abbott.com, Bunnelle WH, Anderson DJ, Briggs CA, Buccafusco J, Curzon P, Decker MW, Frost JM, Gronlien JH, Gubbins E, Li J, Malysz J, Markosyan S, Marsh K, Meyer MD, Nikkel AL, Radek RJ, Robb HM, Timmermann D, Sullivan JP, Gopalakrishnan M
المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2007 Sep 26; Vol. 27 (39), pp. 10578-87.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
مواضيع طبية MeSH: Receptors, Nicotinic*, Central Nervous System Agents/*pharmacology , Cyclic AMP Response Element-Binding Protein/*metabolism , Extracellular Signal-Regulated MAP Kinases/*metabolism , Mental Processes/*drug effects, Aminoacetonitrile/analogs & derivatives ; Aminoacetonitrile/pharmacology ; Animals ; Cognition/drug effects ; Cognition/physiology ; Humans ; Learning/drug effects ; Learning/physiology ; Macaca mulatta ; Male ; Mental Processes/physiology ; Mice ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Phosphorylation ; Pyridazines/pharmacology ; Pyrroles/pharmacology ; Rats ; Signal Transduction ; Treatment Outcome ; Xenopus ; alpha7 Nicotinic Acetylcholine Receptor