المؤلفون: Lhousseine Touqui, Aarbiou J, Bob J. Scholte, Yongzheng Wu, Y. Kita, Pierre-Régis Burgel, Borot F, Michel Chignard, Ollero M, Clémence Martin, Fariel Dif, Ignacio Garcia-Verdugo, D. Israel-Biet, Dimitri Leduc

المساهمون: Défense innée et inflammation, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mucoviscidose et bronchopathies chroniques : biopathologie et phénotypes cliniques (EA 2511), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5), Centre de recherche Croissance et signalisation (UMR_S 845), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Cell Biology [Rotterdam, Pays-Bas], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Service de Pneumologie et soins intensifs respiratoires [Hôpital Européen Georges Pompidou, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Department of Biochemistry and Molecular Biology [Tokyo], Graduate School of Science [Tokyo], The University of Tokyo (UTokyo)-The University of Tokyo (UTokyo), This work was supported in part by a Contrat de Recherche with the French Associations 'Vaincre la Mucoviscidose' and DARRI, Institut Pasteur. F. Dif was supported by 'Vaincre la Mucoviscidose'. J. Aarbiou and R. Buijs-Offerman (Erasmus MC, Cell Biology Dept, Rotterdam, The Netherlands) were supported by grants STW 6565 and EU FP6IMPROVED PRECISION LSHB-CT-2004-005213., The authors would like to thank V. Balloy (Unite de Défense Innée et Inflammation/Unité INSERM U. 874, Institut Pasteur, Paris, France) for her helpful assistance for animal instillations. We are grateful to M. Huerre (Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur) for expert advice and criticisms and P. Ave and S. Bergère (Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur) for help on histological analyses. M. Wilke (Erasmus MC, Biochemistry Dept, Rotterdam, The Netherlands) and R. Buijs-Offerman (Erasmus MC, Cell Biology Dept) are acknowledged for assistance in preparing the lung tissues and BALF samples., Wu, Yongzheng, Cell biology, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: European Respiratory Journal
European Respiratory Journal, 2010, 36 (5), pp.1120-1130. ⟨10.1183/09031936.00183409⟩
European Respiratory Journal, 36(5), 1120-1130. European Respiratory Society
European Respiratory Journal, European Respiratory Society, 2010, 36 (5), pp.1120-1130. ⟨10.1183/09031936.00183409⟩

مصطلحات موضوعية: Lipopolysaccharides, Cystic Fibrosis Transmembrane Conductance Regulator, Phospholipase, Mucin 5AC, MESH: Lipopolysaccharides / pharmacology, Cystic fibrosis, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, cystic fibrosis, chemistry.chemical_compound, Mice, 0302 clinical medicine, Cytosol, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: RNA, Small Interfering, MESH: Bronchi / metabolism, MESH: Animals, MESH: Respiratory Mucosa / metabolism, RNA, Small Interfering, 0303 health sciences, MESH: Chlorides / metabolism, lipopolysaccharide, respiratory system, mucusphospholipase A2, Cystic fibrosis transmembrane conductance regulator, MESH: Group IV Phospholipases A2 / genetics, 3. Good health, Arachidonic acid, MESH: Cystic Fibrosis Transmembrane Conductance Regulator / metabolism, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Mice, Inbred CFTR, medicine.symptom, Pulmonary and Respiratory Medicine, medicine.medical_specialty, MESH: Bronchi / cytology, Bronchial mucus, Inflammation, Bronchi, MESH: Group IV Phospholipases A2 / metabolism, MESH: Mucin 5AC / genetics, Respiratory Mucosa, Biology, Cell Line, 03 medical and health sciences, Phospholipase A2, Chlorides, MESH: Mice, Inbred C57BL, Internal medicine, medicine, MESH: Arachidonic Acid / metabolism, MESH: Mucus / metabolism, Animals, Humans, Mice, Inbred CFTR, [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity, MESH: Mice, 030304 developmental biology, MESH: Humans, Group IV Phospholipases A2, MESH: Respiratory Mucosa / cytology, MESH: Mucin 5AC / metabolism, medicine.disease, MUC5AC, Mucus, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, respiratory tract diseases, MESH: Cell Line, Mice, Inbred C57BL, Disease Models, Animal, Endocrinology, 030228 respiratory system, chemistry, biology.protein, MESH: Cystic Fibrosis Transmembrane Conductance Regulator / genetics, MESH: Cytosol / metabolism, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Disease Models, Animal

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