المؤلفون: Lawson H; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Holt-Martyn JP; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Dembitz V; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.; Department of Physiology and Immunology and Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia., Kabayama Y; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Wang LM; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Bellani A; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Atwal S; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Saffoon N; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Durko J; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., van de Lagemaat LN; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., De Pace AL; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Tumber A; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Corner T; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Salah E; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Arndt C; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Brewitz L; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Bowen M; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Dubusse L; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., George D; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Allen L; The Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Guitart AV; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.; Université de Bordeaux, Institut National de la Santé et de la Recherche Médicale INSERM U1035, Bordeaux, France., Fung TK; Leukemia and Stem Cell Biology Group, Comprehensive Cancer Centre, King's College London, London, UK.; Department of Haematological Medicine, King's College Hospital, King's College London, London, UK., So CWE; Leukemia and Stem Cell Biology Group, Comprehensive Cancer Centre, King's College London, London, UK.; Department of Haematological Medicine, King's College Hospital, King's College London, London, UK., Schwaller J; University Children's Hospital Basel (UKBB), Department of Biomedicine, University of Basel, Basel, Switzerland., Gallipoli P; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., O'Carroll D; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. christopher.schofield@chem.ox.ac.uk., Kranc KR; The Institute of Cancer Research, London, UK. kamil.kranc@icr.ac.uk.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK. kamil.kranc@icr.ac.uk.

المصدر: Nature cancer [Nat Cancer] 2024 Jun; Vol. 5 (6), pp. 916-937. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor-Proline Dioxygenases*/antagonists & inhibitors , Hypoxia-Inducible Factor-Proline Dioxygenases*/metabolism , Prolyl-Hydroxylase Inhibitors*/pharmacology , Prolyl-Hydroxylase Inhibitors*/therapeutic use , Disease Progression*, Humans ; Animals ; Mice ; Apoptosis/drug effects ; Proto-Oncogene Proteins/metabolism ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Cell Line, Tumor ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Protein Stability/drug effects ; Bridged Bicyclo Compounds, Heterocyclic

المؤلفون: Dupont M; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France., Huart M; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France., Lauvinerie C; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France., Bidet A; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France.; Service d'Hématologie Biologique, CHU Bordeaux, 33000 Bordeaux, France., Guitart AV; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France., Villacreces A; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France., Vigon I; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France., Desplat V; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France., El Habhab A; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France., Pigneux A; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France.; Service d'Hématologie Clinique et Thérapie Cellulaire, CHU Bordeaux, 33000 Bordeaux, France., Ivanovic Z; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France.; Etablissement Français du Sang Nouvelle Aquitaine, 33035 Bordeaux, France., Brunet De la Grange P; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France.; Etablissement Français du Sang Nouvelle Aquitaine, 33035 Bordeaux, France., Dumas PY; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France.; Service d'Hématologie Clinique et Thérapie Cellulaire, CHU Bordeaux, 33000 Bordeaux, France., Pasquet JM; Cellules Souches Hématopoïétiques Normales et Leucémiques, INSERM U1312 BRIC, Université de Bordeaux, Bat TP 4e étage, 146 rue Léo Saignat, 33076 Bordeaux, France.

المصدر: Cancers [Cancers (Basel)] 2022 Jan 17; Vol. 14 (2). Date of Electronic Publication: 2022 Jan 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Lawson H; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., van de Lagemaat LN; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Barile M; Department of Haematology, Wellcome and Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AW, UK., Tavosanis A; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Durko J; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Villacreces A; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Bellani A; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Mapperley C; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Georges E; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Martins-Costa C; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Sepulveda C; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Allen L; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Campos J; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Campbell KJ; CRUK Beatson Institute, Glasgow, UK., O'Carroll D; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Göttgens B; Department of Haematology, Wellcome and Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AW, UK., Cory S; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia., Rodrigues NP; European Cancer Stem Cell Research Institute, Cardiff University, School of Biosciences, Cardiff CF24 4HQ, UK., Guitart AV; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Université de Bordeaux, Institut National de la Santé et de la Recherche Médicale INSERM U1035, 33000 Bordeaux, France. Electronic address: amelie.guitart@u-bordeaux.fr., Kranc KR; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK. Electronic address: kamil.kranc@qmul.ac.uk.

المصدر: Stem cell reports [Stem Cell Reports] 2021 Nov 09; Vol. 16 (11), pp. 2784-2797. Date of Electronic Publication: 2021 Oct 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation*, Hematopoiesis/*genetics , Hematopoietic Stem Cell Transplantation/*methods , Hematopoietic Stem Cells/*metabolism , Repressor Proteins/*genetics , Trans-Activators/*genetics, Animals ; Apoptosis/genetics ; Cell Proliferation/genetics ; Gene Regulatory Networks/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; RNA-Seq/methods ; Repressor Proteins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; Time Factors ; Trans-Activators/metabolism ; Mice

المؤلفون: Dumas PY; Service d'Hématologie et Thérapie Cellulaire, CHU Bordeaux, Bordeaux, France. vanessa.desplat@u-bordeaux.fr pierre-yves.dumas@u-bordeaux.fr.; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., Villacreces A; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., Guitart AV; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., El-Habhab A; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., Massara L; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., Mansier O; INSERM U1034, Institut National de la Santé et de la Recherche Médicale, University of Bordeaux, Bordeaux, France.; Service d'Hématologie Biologique, CHU Bordeaux, Bordeaux, France., Bidet A; Service d'Hématologie Biologique, CHU Bordeaux, Bordeaux, France., Martineau D; Service d'Hématologie et Thérapie Cellulaire, CHU Bordeaux, Bordeaux, France.; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., Fernandez S; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., Leguay T; Service d'Hématologie et Thérapie Cellulaire, CHU Bordeaux, Bordeaux, France., Pigneux A; Service d'Hématologie et Thérapie Cellulaire, CHU Bordeaux, Bordeaux, France.; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., Vigon I; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., Pasquet JM; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France., Desplat V; BMGIC, U1035 INSERM, University of Bordeaux, Bordeaux, France. vanessa.desplat@u-bordeaux.fr pierre-yves.dumas@u-bordeaux.fr.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Nov 01; Vol. 27 (21), pp. 6012-6025. Date of Electronic Publication: 2021 Aug 16.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Aniline Compounds/*pharmacology , Aniline Compounds/*therapeutic use , Benzothiazoles/*pharmacology , Benzothiazoles/*therapeutic use , Drug Resistance, Neoplasm/*drug effects , Leukemia, Myeloid, Acute/*drug therapy , Phenylurea Compounds/*pharmacology , Phenylurea Compounds/*therapeutic use , Proto-Oncogene Proteins/*antagonists & inhibitors , Pyrazines/*pharmacology , Pyrazines/*therapeutic use , Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors , fms-Like Tyrosine Kinase 3/*antagonists & inhibitors , fms-Like Tyrosine Kinase 3/*physiology, Cell Line, Tumor ; Hematopoiesis ; Humans ; Axl Receptor Tyrosine Kinase

المؤلفون: Rodriguez L; Etablissement Français du Sang Nouvelle Aquitaine, Place Amélie Raba Léon, CS22010, CEDEX, 33075 Bordeaux, France.; Inserm Bordeaux UMR 1035, 33000 Bordeaux, France.; Université de Bordeaux, 33000 Bordeaux, France., Duchez P; Etablissement Français du Sang Nouvelle Aquitaine, Place Amélie Raba Léon, CS22010, CEDEX, 33075 Bordeaux, France.; Inserm Bordeaux UMR 1035, 33000 Bordeaux, France.; Université de Bordeaux, 33000 Bordeaux, France., Touya N; Etablissement Français du Sang Nouvelle Aquitaine, Place Amélie Raba Léon, CS22010, CEDEX, 33075 Bordeaux, France.; Inserm Bordeaux UMR 1035, 33000 Bordeaux, France.; Université de Bordeaux, 33000 Bordeaux, France., Debeissat C; Inserm Bordeaux UMR 1035, 33000 Bordeaux, France.; Université de Bordeaux, 33000 Bordeaux, France., Guitart AV; Inserm Bordeaux UMR 1035, 33000 Bordeaux, France.; Université de Bordeaux, 33000 Bordeaux, France., Pasquet JM; Inserm Bordeaux UMR 1035, 33000 Bordeaux, France.; Université de Bordeaux, 33000 Bordeaux, France., Vlaski-Lafarge M; Etablissement Français du Sang Nouvelle Aquitaine, Place Amélie Raba Léon, CS22010, CEDEX, 33075 Bordeaux, France.; Inserm Bordeaux UMR 1035, 33000 Bordeaux, France.; Université de Bordeaux, 33000 Bordeaux, France., Brunet de la Grange P; Etablissement Français du Sang Nouvelle Aquitaine, Place Amélie Raba Léon, CS22010, CEDEX, 33075 Bordeaux, France.; Inserm Bordeaux UMR 1035, 33000 Bordeaux, France.; Université de Bordeaux, 33000 Bordeaux, France., Ivanovic Z; Etablissement Français du Sang Nouvelle Aquitaine, Place Amélie Raba Léon, CS22010, CEDEX, 33075 Bordeaux, France.; Inserm Bordeaux UMR 1035, 33000 Bordeaux, France.; Université de Bordeaux, 33000 Bordeaux, France.

المصدر: Biomolecules [Biomolecules] 2021 Apr 10; Vol. 11 (4). Date of Electronic Publication: 2021 Apr 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

مواضيع طبية MeSH: Oxidative Phosphorylation* , Resting Phase, Cell Cycle*, Antioxidants/*pharmacology , Hematopoietic Stem Cells/*drug effects , Vitamins/*pharmacology , alpha-Tocopherol/*pharmacology, Animals ; Antigens, CD34/genetics ; Antigens, CD34/metabolism ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Self Renewal ; Cells, Cultured ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, SCID ; Reactive Oxygen Species/metabolism

المؤلفون: Lawson H; Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Sepulveda C; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom., van de Lagemaat LN; Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom., Durko J; Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Barile M; Department of Haematology, Wellcome and Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Tavosanis A; Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Georges E; Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Shmakova A; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom., Timms P; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom., Carter RN; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom., Allen L; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom., Campos J; Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Vukovic M; Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Guitart AV; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom., Giles P; Wales Gene Park and Wales Cancer Research Centre, Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom., O'Shea M; Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom., Vernimmen D; Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom., Morton NM; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom., Rodrigues NP; European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Göttgens B; Department of Haematology, Wellcome and Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom., Lengeling A; Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.; Administrative Headquarters, Max Planck Society, Munich, Germany; and., O'Carroll D; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.; Institute for Stem Cell Research and.; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom., Kranc KR; Laboratory of Haematopoietic Stem Cell and Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.

المصدر: Blood advances [Blood Adv] 2021 Feb 09; Vol. 5 (3), pp. 889-899.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

مواضيع طبية MeSH: Hematopoiesis* , Hematopoietic Stem Cells*, Bone Marrow ; Bone Marrow Transplantation ; Cell Differentiation

المؤلفون: Mansier O; Biology of Cardiovascular Diseases, University of Bordeaux, INSERM, UMR1034, Pessac, France.; Laboratoire d'Hématologie, CHU de Bordeaux, Pessac, France., Kilani B; Biology of Cardiovascular Diseases, University of Bordeaux, INSERM, UMR1034, Pessac, France., Guitart AV; Biothérapie des Maladies Génétiques Inflammatoires et Cancers, University of Bordeaux, INSERM, UMR1035, Bordeaux, France., Guy A; Biology of Cardiovascular Diseases, University of Bordeaux, INSERM, UMR1034, Pessac, France., Gourdou-Latyszenok V; Biology of Cardiovascular Diseases, University of Bordeaux, INSERM, UMR1034, Pessac, France., Marty C; University of Paris-Saclay, INSERM UMR1170, Gustave Roussy, Villejuif, France; and., Parrens M; Laboratoire d'Anatomopathologie, CHU de Bordeaux, Pessac, France., Plo I; University of Paris-Saclay, INSERM UMR1170, Gustave Roussy, Villejuif, France; and., Vainchenker W; University of Paris-Saclay, INSERM UMR1170, Gustave Roussy, Villejuif, France; and., James C; Biology of Cardiovascular Diseases, University of Bordeaux, INSERM, UMR1034, Pessac, France.; Laboratoire d'Hématologie, CHU de Bordeaux, Pessac, France.

المصدر: Blood [Blood] 2019 Dec 26; Vol. 134 (26), pp. 2383-2387.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Disease Models, Animal* , Mutation*, Hematopoietic Stem Cells/*pathology , Janus Kinase 2/*genetics , Megakaryocytes/*pathology , Myeloproliferative Disorders/*pathology , Polycythemia Vera/*pathology, Animals ; Cell Differentiation ; Gene Knock-In Techniques ; Humans ; Mice ; Mice, Transgenic ; Myeloproliferative Disorders/genetics ; Phenotype ; Polycythemia Vera/genetics

المؤلفون: Fernandez S; Institut National de la Santé et de la Recherche Médicale, U1035 Bordeaux, France.; Université de Bordeaux, 33076 Bordeaux, France., Desplat V; Institut National de la Santé et de la Recherche Médicale, U1035 Bordeaux, France.; Université de Bordeaux, 33076 Bordeaux, France., Villacreces A; Institut National de la Santé et de la Recherche Médicale, U1035 Bordeaux, France.; Université de Bordeaux, 33076 Bordeaux, France., Guitart AV; Institut National de la Santé et de la Recherche Médicale, U1035 Bordeaux, France.; Université de Bordeaux, 33076 Bordeaux, France., Milpied N; Institut National de la Santé et de la Recherche Médicale, U1035 Bordeaux, France.; Université de Bordeaux, 33076 Bordeaux, France.; CHU Bordeaux, Service d'Hématologie Clinique et Thérapie Cellulaire, F-33000 Bordeaux, France., Pigneux A; Institut National de la Santé et de la Recherche Médicale, U1035 Bordeaux, France.; Université de Bordeaux, 33076 Bordeaux, France.; CHU Bordeaux, Service d'Hématologie Clinique et Thérapie Cellulaire, F-33000 Bordeaux, France., Vigon I; Institut National de la Santé et de la Recherche Médicale, U1035 Bordeaux, France.; Université de Bordeaux, 33076 Bordeaux, France., Pasquet JM; Institut National de la Santé et de la Recherche Médicale, U1035 Bordeaux, France.; Université de Bordeaux, 33076 Bordeaux, France., Dumas PY; Institut National de la Santé et de la Recherche Médicale, U1035 Bordeaux, France. pierre-yves.dumas@u-bordeaux.fr.; Université de Bordeaux, 33076 Bordeaux, France. pierre-yves.dumas@u-bordeaux.fr.; CHU Bordeaux, Service d'Hématologie Clinique et Thérapie Cellulaire, F-33000 Bordeaux, France. pierre-yves.dumas@u-bordeaux.fr.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2019 Jul 12; Vol. 20 (14). Date of Electronic Publication: 2019 Jul 12.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers, Tumor* , Molecular Targeted Therapy*, Antineoplastic Agents/*therapeutic use , Leukemia, Myeloid, Acute/*drug therapy , Leukemia, Myeloid, Acute/*metabolism , Protein Kinase Inhibitors/*therapeutic use , Protein-Tyrosine Kinases/*antagonists & inhibitors, Animals ; Antineoplastic Agents/pharmacology ; Clinical Trials as Topic ; Gene Expression Regulation, Leukemic ; Humans ; Leukemia, Myeloid, Acute/etiology ; Leukemia, Myeloid, Acute/pathology ; Protein Kinase Inhibitors/pharmacology ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Proteome ; Signal Transduction ; Transcriptome ; Treatment Outcome

المؤلفون: Paris J; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Morgan M; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK., Campos J; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Spencer GJ; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4GJ, UK., Shmakova A; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Ivanova I; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK., Mapperley C; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Lawson H; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Wotherspoon DA; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Sepulveda C; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Vukovic M; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Allen L; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Sarapuu A; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Tavosanis A; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Guitart AV; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Villacreces A; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK., Much C; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK., Choe J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Azar A; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., van de Lagemaat LN; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK., Vernimmen D; Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK., Nehme A; Université de Tours, CNRS, LNOx ERL 7001, Tours, France., Mazurier F; Université de Tours, CNRS, LNOx ERL 7001, Tours, France., Somervaille TCP; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4GJ, UK., Gregory RI; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., O'Carroll D; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK. Electronic address: donal.ocarroll@ed.ac.uk., Kranc KR; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK. Electronic address: kamil.kranc@qmul.ac.uk.

المصدر: Cell stem cell [Cell Stem Cell] 2019 Jul 03; Vol. 25 (1), pp. 137-148.e6. Date of Electronic Publication: 2019 Apr 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute/*therapy , Neoplastic Stem Cells/*physiology , RNA-Binding Proteins/*metabolism, Animals ; Cell Self Renewal ; Hematopoiesis ; Hematopoietic Stem Cells ; Humans ; Leukemia, Myeloid, Acute/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RNA, Small Interfering/genetics ; RNA-Binding Proteins/genetics ; THP-1 Cells

المؤلفون: Guitart AV; MRC Centre for Regenerative Medicine, University of Edinburgh, UK.; INSERM U1035, Université Bordeaux, Bordeaux, France., Finch AJ; Cancer Research UK Edinburgh Centre, University of Edinburgh, UK., Kranc KR; MRC Centre for Regenerative Medicine, University of Edinburgh, UK Kamil.Kranc@ed.ac.uk.; Cancer Research UK Edinburgh Centre, University of Edinburgh, UK.

المصدر: The Journal of experimental medicine [J Exp Med] 2018 Aug 06; Vol. 215 (8), pp. 1971-1973. Date of Electronic Publication: 2018 Jul 12.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

مواضيع طبية MeSH: Calcium* , Hematopoietic Stem Cells*, Cell Division ; Mitochondria