المؤلفون: Yi E; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Gujar AD; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Guthrie M; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Kim H; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut.; Department of Biopharmaceutical Convergence, Department of Pharmacy, Sungkyunkwan University, Suwon-si, Gyeong gi-do, Korea., Zhao D; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Johnson KC; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Amin SB; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Costa ML; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Yu Q; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Das S; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for SickKids, University of Toronto, Toronto, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.; Division of Neurosurgery, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada., Jillette N; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Clow PA; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut., Cheng AW; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut. roel.verhaak@jax.org albert.cheng@jax.org.; Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, Connecticut.; Institute for Systems Genomics, University of Connecticut Health Center, Farmington, Connecticut., Verhaak RGW; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut. roel.verhaak@jax.org albert.cheng@jax.org.; Department of Neurosurgery, Amsterdam UMC, Amsterdam, the Netherlands.

المصدر: Cancer discovery [Cancer Discov] 2022 Feb; Vol. 12 (2), pp. 468-483. Date of Electronic Publication: 2021 Nov 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Extrachromosomal Inheritance* , Gene Amplification* , Tumor Microenvironment*, DNA/*genetics , Neoplasms/*genetics, Humans

المؤلفون: Mahlokozera T; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Patel B; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Chen H; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Desouza P; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Qu X; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Mao DD; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Hafez D; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Yang W; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Taiwo R; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Paturu M; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Salehi A; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Gujar AD; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Dunn GP; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA., Mosammaparast N; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Petti AA; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Yano H; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA. yanoh@wustl.edu.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. yanoh@wustl.edu.; The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. yanoh@wustl.edu.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. yanoh@wustl.edu., Kim AH; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.; The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.

المصدر: Nature communications [Nat Commun] 2021 Nov 03; Vol. 12 (1), pp. 6321. Date of Electronic Publication: 2021 Nov 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Binding, Competitive/*physiology , Brain Neoplasms/*genetics , Glioblastoma/*genetics , SOXB1 Transcription Factors/*genetics , Tripartite Motif Proteins/*genetics , Ubiquitin-Protein Ligases/*genetics, Animals ; B30.2-SPRY Domain ; Binding, Competitive/genetics ; Female ; Gene Knockdown Techniques ; Glioblastoma/metabolism ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Proteomics ; SOXB1 Transcription Factors/metabolism ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination

المؤلفون: Johnson KC; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. kevin.c.johnson@jax.org., Anderson KJ; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Courtois ET; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Gujar AD; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Barthel FP; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Pathology, Brain Tumor Center Amsterdam, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Varn FS; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Luo D; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Seignon M; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Yi E; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Kim H; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Estecio MRH; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhao D; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Tang M; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Navin NE; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Maurya R; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Ngan CY; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Verburg N; Department of Neurosurgery, Brain Tumor Center Amsterdam, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., de Witt Hamer PC; Department of Neurosurgery, Brain Tumor Center Amsterdam, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Bulsara K; Division of Neurosurgery, The University of Connecticut Health Center, Farmington, CT, USA., Samuels ML; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Das S; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for SickKids, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Division of Neurosurgery, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Robson P; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA., Verhaak RGW; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. roel.verhaak@jax.org.

المصدر: Nature genetics [Nat Genet] 2021 Oct; Vol. 53 (10), pp. 1456-1468. Date of Electronic Publication: 2021 Sep 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Epigenesis, Genetic* , Single-Cell Analysis*, Brain Neoplasms/*genetics , Cell Plasticity/*genetics , Glioma/*genetics , Stress, Physiological/*genetics, Clonal Evolution ; DNA Copy Number Variations/genetics ; DNA Methylation/genetics ; Gene Expression Regulation, Neoplastic ; Genetic Heterogeneity ; Genome, Human ; Humans ; Mutation/genetics ; Phylogeny ; Promoter Regions, Genetic/genetics ; Tumor Microenvironment/genetics

المؤلفون: Zhu Y; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Gujar AD; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Wong CH; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Tjong H; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Ngan CY; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Gong L; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Chen YA; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Kim H; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Liu J; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Li M; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Mil-Homens A; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Maurya R; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Kuhlberg C; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Sun F; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Yi E; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., deCarvalho AC; Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA., Ruan Y; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA., Verhaak RGW; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Electronic address: roel.verhaak@jax.org., Wei CL; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Electronic address: chia-lin.wei@jax.org.

المصدر: Cancer cell [Cancer Cell] 2021 May 10; Vol. 39 (5), pp. 694-707.e7. Date of Electronic Publication: 2021 Apr 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Chromosomes/*genetics , DNA, Neoplasm/*genetics , Glioblastoma/*genetics , Oncogenes/*genetics, Carcinogenesis/genetics ; Chromatin/genetics ; Humans

المؤلفون: Kim H; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Nguyen NP; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.; Boundless Bio, La Jolla, CA, USA., Turner K; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.; Boundless Bio, La Jolla, CA, USA., Wu S; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA., Gujar AD; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Luebeck J; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.; Bioinformatics & Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA, USA., Liu J; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Deshpande V; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA.; Illumina, San Diego, CA, USA., Rajkumar U; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA., Namburi S; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Amin SB; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Yi E; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Menghi F; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Schulte JH; Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany., Henssen AG; Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany., Chang HY; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA., Beck CR; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Genetics and Genome Sciences, Institute for Systems Genomics, University of Connecticut Health Center, Farmington, CT, USA., Mischel PS; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA. pmischel@health.ucsd.edu.; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. pmischel@health.ucsd.edu.; Department of Pathology, University of California, San Diego, San Diego, CA, USA. pmischel@health.ucsd.edu., Bafna V; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA. vbafna@cs.ucsd.edu., Verhaak RGW; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. roel.verhaak@jax.org.

المصدر: Nature genetics [Nat Genet] 2020 Sep; Vol. 52 (9), pp. 891-897. Date of Electronic Publication: 2020 Aug 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Chromosomes/*genetics , DNA/*genetics , Gene Amplification/*genetics , Neoplasms/*genetics , Oncogenes/*genetics, Cell Line, Tumor ; Chromatin/genetics ; Humans

المؤلفون: Huang J; Department of Radiation Oncology, Center for Advanced Medicine, Washington University School of Medicine, 4921 Parkview Place, Campus Box #8224, St. Louis, MO, 63110, USA. jiayi.huang@wustl.edu., Campian JL; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, USA., Gujar AD; Department of Neurosurgery, Washington University School of Medicine, St Louis, MO, 63110, USA., Tsien C; Department of Radiation Oncology, Center for Advanced Medicine, Washington University School of Medicine, 4921 Parkview Place, Campus Box #8224, St. Louis, MO, 63110, USA., Ansstas G; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, USA., Tran DD; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, USA., DeWees TA; Department of Radiation Oncology, Center for Advanced Medicine, Washington University School of Medicine, 4921 Parkview Place, Campus Box #8224, St. Louis, MO, 63110, USA., Lockhart AC; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, USA., Kim AH; Department of Neurosurgery, Washington University School of Medicine, St Louis, MO, 63110, USA.

المصدر: Journal of neuro-oncology [J Neurooncol] 2018 May; Vol. 138 (1), pp. 105-111. Date of Electronic Publication: 2018 Jan 27.

نوع المنشور: Clinical Trial, Phase I; Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*therapeutic use , Brain Neoplasms/*drug therapy , Copper/*therapeutic use , Disulfiram/*therapeutic use , Glioblastoma/*drug therapy , Trace Elements/*therapeutic use, Adjuvants, Immunologic ; Adult ; Aged ; Cohort Studies ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Maximum Tolerated Dose ; Middle Aged ; Survival Analysis ; Temozolomide/therapeutic use ; Young Adult

المؤلفون: Gujar AD; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Mao DD; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Finlay JB; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA., Kim AH; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. alberthkim@wustl.edu.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1741, pp. 53-62.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Glioblastoma/*metabolism , Glioblastoma/*pathology , Neoplastic Stem Cells/*metabolism , Neoplastic Stem Cells/*pathology, Biomarkers ; Cell Culture Techniques ; Gene Expression ; Genes, Reporter ; Humans ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Primary Cell Culture

المؤلفون: Gujar AD; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110., Le S; Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32605., Mao DD; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110., Dadey DY; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110.; Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110., Turski A; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110., Sasaki Y; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110., Aum D; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110., Luo J; Division of Biostatistics, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110., Dahiya S; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110., Yuan L; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110., Rich KM; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110., Milbrandt J; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110., Hallahan DE; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110., Yano H; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110.; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Tran DD; Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32605., Kim AH; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110; kima@wudosis.wustl.edu.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Dec 20; Vol. 113 (51), pp. E8247-E8256. Date of Electronic Publication: 2016 Dec 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Radiation Tolerance* , Transcription, Genetic*, Brain Neoplasms/*metabolism , Cytokines/*genetics , Glioblastoma/*metabolism , NAD/*biosynthesis , Nicotinamide Phosphoribosyltransferase/*genetics, Animals ; Antineoplastic Agents/pharmacology ; Brain/pathology ; Brain Neoplasms/radiotherapy ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Glioblastoma/radiotherapy ; Humans ; Mice ; Mutation ; Neoplasm Transplantation ; RNA Interference ; Signal Transduction/drug effects ; Stem Cells/cytology

المؤلفون: Huang J; Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, 63110, USA. jhuang@radonc.wustl.edu.; Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, USA. jhuang@radonc.wustl.edu., Campian JL; Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, USA.; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, 63110, USA., Gujar AD; Department of Neurosurgery, Washington University School of Medicine, St Louis, MO, 63110, USA., Tran DD; Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, 63110, USA.; Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, USA.; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, 63110, USA., Lockhart AC; Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, USA.; Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, 63110, USA., DeWees TA; Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, 63110, USA., Tsien CI; Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, 63110, USA.; Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, USA., Kim AH; Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, USA.; Department of Neurosurgery, Washington University School of Medicine, St Louis, MO, 63110, USA.

المصدر: Journal of neuro-oncology [J Neurooncol] 2016 Jun; Vol. 128 (2), pp. 259-66. Date of Electronic Publication: 2016 Mar 10.

نوع المنشور: Clinical Trial, Phase I; Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*therapeutic use , Dacarbazine/*analogs & derivatives , Disulfiram/*therapeutic use , Glioblastoma/*therapy , Supratentorial Neoplasms/*therapy, Administration, Oral ; Adult ; Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacokinetics ; Chemoradiotherapy ; Dacarbazine/therapeutic use ; Disulfiram/adverse effects ; Disulfiram/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Repositioning ; Drug Therapy, Combination ; Female ; Glioblastoma/blood ; Humans ; Male ; Middle Aged ; Proteasome Endopeptidase Complex/blood ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Inhibitors/adverse effects ; Proteasome Inhibitors/pharmacokinetics ; Proteasome Inhibitors/therapeutic use ; Supratentorial Neoplasms/blood ; Temozolomide ; Treatment Outcome ; Young Adult

المؤلفون: Kang SK; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Murphy RK; Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA., Hwang SW; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-701, Republic of Korea., Lee SM; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Harburg DV; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Krueger NA; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Shin J; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Gamble P; Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA., Cheng H; Department of Engineering Science and Mechanics, Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA., Yu S; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Liu Z; Institute of High Performance Computing, Singapore 138632, Singapore., McCall JG; Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA., Stephen M; Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA., Ying H; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Kim J; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Park G; Department of Biomicrosystem Technology, Korea University, Seoul 136-701, South Korea.; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136-713, South Korea., Webb RC; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Lee CH; Weldon School of Biomedical Engineering, School of Mechanical Engineering, The Center for Implantable Devices, Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA., Chung S; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Wie DS; School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, USA., Gujar AD; Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA., Vemulapalli B; Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA., Kim AH; Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA., Lee KM; Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136-713, South Korea., Cheng J; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Huang Y; Department of Mechanical Engineering, Civil and Environmental Engineering, Materials Science and Engineering, and Skin Disease Research Center, Northwestern University, Evanston, Illinois 60208, USA., Lee SH; Department of Biomedical Engineering, College of Health Science, Korea University, Seoul 136-703, South Korea., Braun PV; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Ray WZ; Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA., Rogers JA; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

المصدر: Nature [Nature] 2016 Feb 04; Vol. 530 (7588), pp. 71-6. Date of Electronic Publication: 2016 Jan 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Absorbable Implants*/adverse effects , Prostheses and Implants*/adverse effects , Silicon*, Brain/*metabolism , Electronics/*instrumentation , Monitoring, Physiologic/*instrumentation, Administration, Cutaneous ; Animals ; Body Temperature ; Brain/surgery ; Equipment Design ; Hydrolysis ; Male ; Monitoring, Physiologic/adverse effects ; Organ Specificity ; Pressure ; Rats ; Rats, Inbred Lew ; Telemetry/instrumentation ; Wireless Technology/instrumentation