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1دورية أكاديمية
المؤلفون: Guus J. J. E. Heynen, Kamil Lisek, Regina Vogel, Annika Wulf-Goldenberg, Joshua Alcaniz, Elodie Montaudon, Elisabetta Marangoni, Walter Birchmeier
المصدر: Breast Cancer Research, Vol 24, Iss 1, Pp 1-15 (2022)
مصطلحات موضوعية: Breast cancer, Drug resistance, Targeted therapy, PI3K and MAPK signaling, SHP2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1465-542X
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المؤلفون: Guus J. J. E. Heynen, Francis Baumgartner, Michael Heider, Upayan Patra, Maximilian Holz, Jan Braune, Melanie Kaiser, Isabell Schäffer, Stefanos A. Bamopoulos, Evelyn Ramberger, Arunima Murgai, Yuen Lam Dora Ng, Uta Margareta Demel, Dominik Laue, Sven Liebig, Josefine Krüger, Martin Janz, Axel Nogai, Markus Schick, Philipp Mertins, Stefan Müller, Florian Bassermann, Jan Krönke, Ulrich Keller, Matthias Wirth
المصدر: Blood Advances
مصطلحات موضوعية: Cancer Research, Hematology, Technology Platforms
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e3785fe11be986954c96a6487cb6c9
http://edoc.mdc-berlin.de/21976/2/21976suppl.zip -
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المؤلفون: Sander Palit, Cor Lieftink, René Bernards, Wilbert Zwart, Andreas Schlicker, Noorjahan Jagalur Basheer, Guus J. J. E. Heynen, Ekaterina Nevedomskaya, Prashanth Kumar Bajpe
المساهمون: Pediatrics
المصدر: Molecular Cancer Research, 14(5), 411-422. American Association for Cancer Research Inc.
Europe PubMed Centralمصطلحات موضوعية: 0301 basic medicine, Cancer Research, Cellular differentiation, Retinoic acid, Tretinoin, Receptor tyrosine kinase, Neuroblastoma, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Humans, Molecular Biology, Transcription factor, Protein kinase B, Cell Proliferation, Insulin-like growth factor 1 receptor, Regulation of gene expression, biology, Nuclear Proteins, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, chemistry, Drug Resistance, Neoplasm, Trans-Activators, biology.protein, Cancer research, Signal transduction, Signal Transduction, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaa03e25d7e5062df86e03bdcd60fba
https://doi.org/10.1158/1541-7786.mcr-15-0291-t -
4دورية أكاديمية
المؤلفون: Chong Sun, Liqin Wang, Sidong Huang, Guus J. J. E. Heynen, Anirudh Prahallad, Caroline Robert, John Haanen, Christian Blank, Jelle Wesseling, Stefan M. Willems, Davide Zecchin, Sebastijan H
المصدر: Nature, Nature. 508(7494):118-122
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المؤلفون: Guus J. J. E. Heynen, Wipawadee Grernrum, René Bernards, Roderick L. Beijersbergen, Iris de Rink, Sidong Huang, Prashanth Kumar Bajpe, Wouter Nijkamp, Lorenza Mittempergher
المصدر: Molecular and Cellular Biology. 33:3343-3353
مصطلحات موضوعية: Transcription, Genetic, Receptors, Retinoic Acid, Nerve Tissue Proteins, Tretinoin, Retinoid X receptor, Biology, Cell Line, Mice, Cell Line, Tumor, Animals, Humans, p300-CBP Transcription Factors, Promoter Regions, Genetic, Molecular Biology, Retinoid X receptor alpha, Cell Differentiation, Articles, Cell Biology, Phosphoproteins, Retinoid X receptor gamma, body regions, DNA-Binding Proteins, Alcohol Oxidoreductases, Retinoic acid receptor, Retinoid X Receptors, Gene Expression Regulation, Retinoic acid receptor alpha, embryonic structures, Nuclear receptor coactivator 3, Nuclear receptor coactivator 2, Cancer research, RNA Interference, Retinoid X receptor beta, Co-Repressor Proteins, Signal Transduction
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المؤلفون: Yulan Wang, Egbert F. Smit, Michael J. Seckl, Zhigang Liu, Emily Chater, Huiru Tang, Guus J. J. E. Heynen, Olivier E. Pardo, Hongde Li, William B. Stokes, Yili Hu, Julian Downward, Elza C. de Bruin, Rajat Roy
المساهمون: Pulmonary medicine, CCA - Cancer biology, Commission of the European Communities, Cancer Treatment & Research Trust, Cancer Research UK, National Institute for Health Research, Worldwide Cancer Research, Imperial College Healthcare NHS Trust- BRC Funding
المصدر: Cell discovery, 2. Nature Publishing Group
Cell Discovery
Li, H, Stokes, W, Chater, E, Roy, R, de Bruin, E, Hu, Y, Liu, Z, Smit, E F, Heynen, G J, Downward, J, Seckl, M J, Wang, Y, Tang, H & Pardo, O E 2016, ' Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer ', Cell discovery, vol. 2, pp. 16031 . https://doi.org/10.1038/celldisc.2016.31
Europe PubMed Centralمصطلحات موضوعية: 0301 basic medicine, Drug resistance, Pharmacology, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, T790M, Genetics, medicine, Epidermal growth factor receptor, glutathione, Lung cancer, Molecular Biology, chemistry.chemical_classification, drug resistance, biology, Cell Biology, Glutathione, medicine.disease, metabolomics, TKI, respiratory tract diseases, lung cancer, 030104 developmental biology, GCLC, Enzyme, chemistry, biology.protein, Erlotinib, medicine.drug
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المؤلفون: Guus J. J. E. Heynen, Cor Lieftink, René Bernards, Valentina Gambino, Roderick L. Beijersbergen, Loredana Vecchione, Stefan M. Willems, Giovanni Germano, Anirudh Prahallad, Bastiaan Evers, Federica Di Nicolantonio, Alberto Bardelli
المصدر: Cell Reports, Vol 12, Iss 12, Pp 1978-1985 (2015)
Cell Reports [E], 12(12), 1978. Cell Pressمصطلحات موضوعية: Genetics and Molecular Biology (all), Indoles, Colorectal cancer, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Biochemistry, Receptor tyrosine kinase, Mice, Mice, Inbred NOD, Transduction, Genetic, RNA, Small Interfering, Vemurafenib, skin and connective tissue diseases, Non-U.S. Gov't, Melanoma, lcsh:QH301-705.5, Genomic Library, Sulfonamides, Research Support, Non-U.S. Gov't, High-Throughput Nucleotide Sequencing, 3. Good health, ErbB Receptors, Gene Expression Regulation, Neoplastic, Colonic Neoplasms, medicine.drug, Proto-Oncogene Proteins B-raf, MAP Kinase Signaling System, Genetic Vectors, Antineoplastic Agents, Biology, Research Support, General Biochemistry, Genetics and Molecular Biology, Cell Line, Tumor, medicine, Journal Article, Animals, Humans, neoplasms, Biochemistry, Genetics and Molecular Biology (all), Lentivirus, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, PTPN11, lcsh:Biology (General), Drug Resistance, Neoplasm, ras Proteins, biology.protein, Cancer research, V600E, Genetic screen
وصف الملف: image/pdf
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المؤلفون: René Bernards, Guus J. J. E. Heynen, Aldona Fonfara
مصطلحات موضوعية: Lung Neoplasms, Proto-Oncogene Proteins c-akt, Antineoplastic Agents, Drug resistance, Biology, medicine, Humans, Molecular Biology, Protein Kinase Inhibitors, Kinase, Hepatocyte Growth Factor, Extra View, Cancer, Cell Biology, Proto-Oncogene Proteins c-met, medicine.disease, Cell biology, ErbB Receptors, Drug Resistance, Neoplasm, Cancer cell, Cancer research, Hepatocyte growth factor, Signal transduction, Mitogen-Activated Protein Kinases, Developmental Biology, medicine.drug, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141db04efe790fe218ad6a25b8502748
https://europepmc.org/articles/PMC4615055/ -
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المؤلفون: Christian U. Blank, René Bernards, Wipawadee Grernrum, Jelle Wesseling, Federica Di Nicolantonio, Andreas Schlicker, Chong Sun, Prashanth Kumar Bajpe, Stefan M. Willems, Alberto Bardelli, Sebastijan Hobor, Stéphan Vagner, Ingrid Hofland, Guus J. J. E. Heynen, Liqin Wang, Christina Mateus, John B. A. G. Haanen, Lodewyk F. A. Wessels, Davide Zecchin, Cor Lieftink, Roderick L. Beijersbergen, Alexander M.M. Eggermont, Caroline Robert, Sidong Huang, Anirudh Prahallad
مصطلحات موضوعية: Multidisciplinary, Melanoma, PDGFRB, Drug resistance, Biology, medicine.disease, Small hairpin RNA, Growth factor receptor, medicine, Cancer research, biology.protein, Epidermal growth factor receptor, Vemurafenib, neoplasms, V600E, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b63cfde6924d5a39c6b040a57884b4
http://hdl.handle.net/2318/152041 -
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المؤلفون: Leticia G. Leon, Guus J. J. E. Heynen, René Bernards, Kwangho Lee, Elisa Giovannetti, Ravi S. Narayan, Elena Galvani, Rocco Sciarrillo, Robert Tjin Tham Sjin, Godefridus J. Peters, Kadoaki Ohashi, Jing Sun, William Pao, Roberta Alfieri, Daniëlle A.M. Heideman, Egbert F. Smit
المساهمون: Medical oncology laboratory, Hematology laboratory, Radiation Oncology, Pathology, Pulmonary medicine, CCA - Innovative therapy
المصدر: Galvani, E, Sun, J, Leon, L G, Sciarrillo, R, Narayan, R S, Tjin Tham Sjin, R, Lee, K, Ohashi, K, Heideman, D A M, Alfieri, R R, Heynen, G J, Bernards, R, Smit, E F, Pao, W, Peters, G J & Giovannetti, E 2015, ' NF-kappaB drives acquired resistance to a novel mutant-selective EGFR inhibitor ', Oncotarget, vol. 6, no. 40, pp. 42717-42732 . https://doi.org/10.18632/oncotarget.3956
Oncotarget, 6(40), 42717. Impact Journals
Oncotarget
Oncotarget, 6(40), 42717-42732. Impact Journalsمصطلحات موضوعية: Oncology, medicine.medical_specialty, Lung Neoplasms, Context (language use), Antineoplastic Agents, Enzyme-Linked Immunosorbent Assay, Drug resistance, Pharmacology, Biology, Transfection, NSCLC, NF-κB, T790M, chemistry.chemical_compound, Mice, Acquired resistance, drug-resistance, Internal medicine, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, Journal Article, Animals, Humans, RNA, Small Interfering, Protein Kinase Inhibitors, EGFR inhibitors, Acrylamides, Hematology, NF-kappa B, EMT, Cancer, EGFR-T790M, medicine.disease, Xenograft Model Antitumor Assays, 3. Good health, respiratory tract diseases, ErbB Receptors, Pyrimidines, chemistry, Drug Resistance, Neoplasm, Azetidines, Research Paper
وصف الملف: image/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca03e38bf1aa4123d08fb445791f2a20
https://hdl.handle.net/1874/333267
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