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1
المؤلفون: Xin Chen, Shujaath Mehdi, Elaine Powers, Rachel Wang, Su-Fen Pu, Guyan Liang, Suzanne C. Aldous, Tianhui Xia
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2450-2455
مصطلحات موضوعية: Models, Molecular, Benzylamines, Protein Folding, Serine Proteinase Inhibitors, Molecular model, Stereochemistry, In silico, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Drug Discovery, Hydrolase, Humans, Computer Simulation, Molecular Biology, Serine protease, Virtual screening, Binding Sites, biology, Chemistry, Organic Chemistry, Kallikrein, Protein Structure, Tertiary, Folding (chemistry), Benzamides, biology.protein, Molecular Medicine, Kallikreins, Linker, Protein Binding
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2
المؤلفون: Xin Chen, Poli Gregory B, Joseph T. Tsay, Jiesheng Kang, Ying Zhang, Anne Minnich, Keith Sides, Qingping Wang, Yong Mi Choi-Sledeski, Patrick Wai-Kwok Shum, Guyan Liang, Vasant Kumar
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1606-1610
مصطلحات موضوعية: Models, Molecular, Benzylamines, ERG1 Potassium Channel, Scaffold, Molecular model, Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Thiophenes, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Benzylamine, Drug Stability, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, Serine protease, biology, Chemistry, Organic Chemistry, Cytochrome P450, Ether-A-Go-Go Potassium Channels, In vitro, Potassium channel, biology.protein, Molecular Medicine, Tryptases, Protein Binding
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3
المؤلفون: Keith Sides, James Pribish, Magali Mathieu, Sam Rebello, Gregory H. Merriman, Henry W. Pauls, Guyan Liang, Xin Chen, Julian Levell, Jennifer Cairns, Isabelle Morize, Brian Whitely, Joseph T. Tsay, Aldous Suzanne C, Sébastien Maignan
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1049-1054
مصطلحات موضوعية: Models, Molecular, Library design, Proteases, Molecular model, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Tryptase, Pharmacology, Crystallography, X-Ray, Biochemistry, Small Molecule Libraries, Serine, Structure-Activity Relationship, Drug Discovery, Hydrolase, medicine, Animals, Combinatorial Chemistry Techniques, Humans, Mast Cells, Enzyme Inhibitors, Molecular Biology, Serine protease, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Mast cell, Recombinant Proteins, Rats, medicine.anatomical_structure, biology.protein, Molecular Medicine, Tryptases
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4
المؤلفون: Yongyi Luo, David M. Fink, Sukhveen Sahni, Guyan Liang, Peter Crackett, Raymond John Boffey, Lee Lan, Magali Mathieu, Jean Merrill, Sam S. Rebello, Bryan Rees, Wei He, Melanie Wong, Thaddeus R. Nieduzak, Jackson Sharon, Yulin Chiang, Nicola Collar, Abdelazize Laoui, Jean-Pierre Guilloteau
المصدر: Bioorganic & Medicinal Chemistry. 13:2723-2739
مصطلحات موضوعية: Protein Conformation, Clinical Biochemistry, Nitric Oxide Synthase Type II, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Coumarins, Microsomes, Drug Discovery, Animals, Humans, Structure–activity relationship, Tissue Distribution, Enzyme Inhibitors, Molecular Biology, IC50, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Biological activity, Coumarin, Rats, Nitric oxide synthase, Kinetics, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Nitric Oxide Synthase, Protein Binding
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5
المؤلفون: Michael Gardyan, Mathew Rose M, Jane Davidson, Joseph Romano, Alain Dupuy, Aldous Suzanne C, Jennifer Kwong, Sam S. Rebello, Jennifer Cairns, Odessa Giardino, Yongyi Luo, Sébastien Maignan, Andrew David Morley, Clive Mccarthy, Joseph T. Tsay, Darren Engers, Guyan Liang, Houille Olivier, Julian Levell, Pribish James R, Jean-Pierre Guilloteau, Garry Fenton, Simon Watson, Trevor K.P. Harrison, Peter C. Astles, Liduo Shen, Mark Czekaj, Gregory H. Merriman, Keith Sides, Pauls Henry W, Keith Smith, Jie Wang, Heng-Keang Lim, Paul R. Eastwood, Brian Whiteley
المصدر: Bioorganic & Medicinal Chemistry. 13:2859-2872
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, Arginine, Protein Conformation, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Tryptase, Crystallography, X-Ray, Biochemistry, Benzamidine, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Drug Discovery, medicine, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Serine protease, Molecular Structure, biology, Chemistry, Serine Endopeptidases, Organic Chemistry, Mast cell, Amides, Benzamidines, Recombinant Proteins, Rats, Enzyme, medicine.anatomical_structure, Liver, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Tryptases, Caco-2 Cells, Factor Xa Inhibitors
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6
المؤلفون: Magali Mathieu, Jackson Sharon, Guyan Liang, Henry Pauls, Sebastien Maignan, Nieduzak Thaddeus R, Kent W. Neuenschwander, Anthony C. Scotese, Corey R. Hopkins, Dona Cramer, Keith Sides, Jennifer Cairns
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:4819-4823
مصطلحات موضوعية: chemistry.chemical_classification, Serine Proteinase Inhibitors, biology, Serine Endopeptidases, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biological activity, Tryptase, Biochemistry, Chemical synthesis, Mast cell tryptase, Structure-Activity Relationship, Enzyme, chemistry, Enzyme inhibitor, Pyrazines, Drug Discovery, biology.protein, Molecular Medicine, Tryptases, Molecular Biology
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7
المؤلفون: Yong Mi Choi-Sledeski, Karen Brown, Robert J. Leadley, Gregory B. Poli, Vincent Mikol, Spada Alfred P, Yong Gong, Robert E. Kearney, Phillip Moxey, Charles J Kasiewski, Ross G. Bentley, Sébastien Maignan, Dennis Collussi, Pauls Henry W, Sam S. Rebello, Davis Roderick S, Valeria Chu, Gardner Charles J, Michael Becker, Jean-Pierre Guilloteau, Guyan Liang, Suzanne R Morgan
المصدر: Journal of Medicinal Chemistry. 46:681-684
مصطلحات موضوعية: Proteases, Indoles, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Stereochemistry, Factor Xa Inhibitor, Administration, Oral, Biological Availability, In Vitro Techniques, Crystallography, X-Ray, Ligands, Piperazines, Benzamidine, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Structure–activity relationship, chemistry.chemical_classification, Aza Compounds, Sulfonamides, biology, Chemistry, Benzamidines, Rats, Enzyme, Enzyme inhibitor, Microsomes, Liver, biology.protein, Molecular Medicine, Factor Xa Inhibitors
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8
المؤلفون: Guyan Liang, Jennifer B. Sorensen, J. Phillip Bowen, David Whitmire
المصدر: Journal of Computational Chemistry. 21:329-339
مصطلحات موضوعية: Bond length, Computational Mathematics, Dipole, Molecular geometry, Chemistry, Computational chemistry, Ab initio quantum chemistry methods, Oxocarbenium, General Chemistry, Moment of inertia, Molecular physics, Force field (chemistry), Ion
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7143846c7899b29b5fad16418f22d273
https://doi.org/10.1002/(sici)1096-987x(20000415)21:5<329::aid-jcc1>3.0.co;2-0 -
9
المؤلفون: Mason Helen J, Karen D. Brown, Valeria Chu, Guyan Liang, Daniel M. Green, Alfred P. Spada, Henry W. Pauls, Ross Bentley, Cuong Ly, Roderick S. Davis, Dennis J. Colussi, Daniel L. Cheney, Michael R. Becker, Y.M. Choi-Sledeski, Christopher T. Dunwiddie, Robert J. Leadley, Ewing William R, John H. Barton
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:2539-2544
مصطلحات موضوعية: Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Isostere, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Benzamidine, Amidine, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Structure–activity relationship, Molecular Biology, Binding Sites, Organic Chemistry, Isoquinolines, Benzamidines, chemistry, Molecular Medicine, Factor Xa Inhibitors
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10
المؤلفون: Xiannong Chen, J. Phillip Bowen, David Whitmire, Guyan Liang
المصدر: Journal of Physical Organic Chemistry. 11:378-386
مصطلحات موضوعية: chemistry.chemical_classification, Computational chemistry, Chemistry, Organic Chemistry, Ab initio, Physical and Theoretical Chemistry, Molecular mechanics, Alkyl
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ae3282b48029ba2e9ef420704342acf6
https://doi.org/10.1002/(sici)1099-1395(199806)11:6<378::aid-poc987>3.0.co;2-5