المؤلفون: Kelly MR; Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California.; Program in Cancer Biology, Stanford University School of Medicine, Stanford, California., Kostyrko K; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, California., Han K; Department of Genetics, Stanford University School of Medicine, Stanford, California., Mooney NA; Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California., Jeng EE; Department of Genetics, Stanford University School of Medicine, Stanford, California., Spees K; Department of Genetics, Stanford University School of Medicine, Stanford, California., Dinh PT; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, California., Abbott KL; Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California., Gwinn DM; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, California., Sweet-Cordero EA; Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, California. pjackson@stanford.edu bassik@stanford.edu Alejandro.Sweet-Cordero@ucsf.edu., Bassik MC; Department of Genetics, Stanford University School of Medicine, Stanford, California. pjackson@stanford.edu bassik@stanford.edu Alejandro.Sweet-Cordero@ucsf.edu.; Chemistry, Engineering, and Medicine for Human Health (ChEM-H), Stanford University, Stanford, California., Jackson PK; Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California. pjackson@stanford.edu bassik@stanford.edu Alejandro.Sweet-Cordero@ucsf.edu.; Chemistry, Engineering, and Medicine for Human Health (ChEM-H), Stanford University, Stanford, California.; Department of Pathology, Stanford University School of Medicine, Stanford, California.

المصدر: Cancer discovery [Cancer Discov] 2020 Dec; Vol. 10 (12), pp. 1950-1967. Date of Electronic Publication: 2020 Jul 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms/*genetics , Proteomics/*methods , ras Proteins/*genetics, Humans

المؤلفون: Gwinn DM; Division of Hematology and Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Hematology and Oncology, Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA., Lee AG; Division of Hematology and Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Hematology and Oncology, Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA., Briones-Martin-Del-Campo M; Division of Hematology and Oncology, Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA., Conn CS; School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Simpson DR; Division of Hematology and Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Hematology and Oncology, Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA., Scott AI; Stanford University, Department of Pathology, Stanford, CA 94305, USA., Le A; Stanford University, Department of Pathology, Stanford, CA 94305, USA., Cowan TM; Stanford University, Department of Pathology, Stanford, CA 94305, USA., Ruggero D; School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Sweet-Cordero EA; Division of Hematology and Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Hematology and Oncology, Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: alejandro.sweet-cordero@ucsf.edu.

المصدر: Cancer cell [Cancer Cell] 2018 Jan 08; Vol. 33 (1), pp. 91-107.e6.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Activating Transcription Factor 4/*metabolism , Asparaginase/*pharmacology , Aspartate-Ammonia Ligase/*metabolism , Proto-Oncogene Proteins p21(ras)/*metabolism, Animals ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Homeostasis/drug effects ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Mice

المؤلفون: Egan DF; Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ

المصدر: Science (New York, N.Y.) [Science] 2011 Jan 28; Vol. 331 (6016), pp. 456-61. Date of Electronic Publication: 2010 Dec 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Autophagy*, AMP-Activated Protein Kinases/*metabolism , Intracellular Signaling Peptides and Proteins/*metabolism , Protein Serine-Threonine Kinases/*metabolism, Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Autophagy-Related Protein-1 Homolog ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Survival ; Energy Metabolism ; Hepatocytes/metabolism ; Humans ; Insulin/metabolism ; Intracellular Signaling Peptides and Proteins/chemistry ; Intracellular Signaling Peptides and Proteins/genetics ; Liver/metabolism ; Metformin/pharmacology ; Mice ; Mitochondria, Liver/metabolism ; Mitochondria, Liver/ultrastructure ; Phenformin/pharmacology ; Phosphorylation ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/genetics ; Sequestosome-1 Protein ; Signal Transduction ; Transcription Factor TFIIH ; Transcription Factors/metabolism

المؤلفون: Gwinn DM; Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, La Jolla, California, United States of America., Asara JM, Shaw RJ

المصدر: PloS one [PLoS One] 2010 Feb 12; Vol. 5 (2), pp. e9197. Date of Electronic Publication: 2010 Feb 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Mitosis*, Adaptor Proteins, Signal Transducing/*metabolism , CDC2 Protein Kinase/*metabolism, Adaptor Proteins, Signal Transducing/genetics ; Amino Acid Sequence ; Binding Sites/genetics ; CDC2 Protein Kinase/genetics ; Cell Line ; Cell Line, Tumor ; Cyclin B/genetics ; Cyclin B/metabolism ; Cyclin-Dependent Kinases ; HeLa Cells ; Humans ; Immunoblotting ; Immunoprecipitation ; Mass Spectrometry ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Phosphorylation ; Protein Binding ; Regulatory-Associated Protein of mTOR ; Sequence Homology, Amino Acid ; Serine/metabolism ; Threonine/metabolism ; Transcription Factors/metabolism ; Transfection

المؤلفون: Gwinn DM; Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ

المصدر: Molecular cell [Mol Cell] 2008 Apr 25; Vol. 30 (2), pp. 214-26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Multienzyme Complexes/*metabolism , Protein Serine-Threonine Kinases/*metabolism , Proteins/*metabolism , Transcription Factors/*metabolism, AMP-Activated Protein Kinases ; Adaptor Proteins, Signal Transducing ; Amino Acid Motifs ; Animals ; Apoptosis ; Cell Cycle ; Cell Line ; Humans ; Male ; Mechanistic Target of Rapamycin Complex 1 ; Mice ; Mice, Inbred Strains ; Multienzyme Complexes/genetics ; Multiprotein Complexes ; Peptide Library ; Phosphorylation ; Protein Serine-Threonine Kinases/genetics ; Proteomics ; Regulatory-Associated Protein of mTOR ; Serine/metabolism ; Substrate Specificity ; TOR Serine-Threonine Kinases ; Transcription Factors/antagonists & inhibitors