نتائج البحث - "Hélène M, Faessel"

1

Supplementary Tables 1-2, Supplementary Methods, Supplementary Figure Legend from Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors

المؤلفون: R. Donald Harvey, Bruce J. Dezube, George Mulligan, Kristine Burke, Allison J. Berger, Hélène M. Faessel, Michael D. Pickard, Devalingam Mahalingam, James M. Cleary, Glen J. Weiss, John S. Kauh, Jeffrey W. Clark, Roger B. Cohen, Geoffrey I. Shapiro, John Sarantopoulos

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75456e92ff982140d74cb102fe174526
https://doi.org/10.1158/1078-0432.22460184.v1

2

Data from Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors

المؤلفون: R. Donald Harvey, Bruce J. Dezube, George Mulligan, Kristine Burke, Allison J. Berger, Hélène M. Faessel, Michael D. Pickard, Devalingam Mahalingam, James M. Cleary, Glen J. Weiss, John S. Kauh, Jeffrey W. Clark, Roger B. Cohen, Geoffrey I. Shapiro, John Sarantopoulos

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f76b5b4dc66d7673263c84e4919004
https://doi.org/10.1158/1078-0432.c.6524421.v1

3

Supplementary Tables 1-6, Supplementary Figure Legend from Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma

المؤلفون: Sagar Lonial, Bruce J. Dezube, Stephen Tirrell, Hélène M. Faessel, George Mulligan, Allison J. Berger, Zhaowei Hua, Kevin Kelly, Catherine Diefenbach, Daniel Lebovic, Mitchell R. Smith, R. Donald Harvey, Robert Z. Orlowski, Owen A. O'Connor, Andrzej J. Jakubowiak, Jatin J. Shah

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69368895ec64270dc5b189b2471dc0b
https://doi.org/10.1158/1078-0432.22460607.v1

4

Supplementary Figure 1 from Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma

المؤلفون: Sagar Lonial, Bruce J. Dezube, Stephen Tirrell, Hélène M. Faessel, George Mulligan, Allison J. Berger, Zhaowei Hua, Kevin Kelly, Catherine Diefenbach, Daniel Lebovic, Mitchell R. Smith, R. Donald Harvey, Robert Z. Orlowski, Owen A. O'Connor, Andrzej J. Jakubowiak, Jatin J. Shah

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299333152221ebb4323036988d5d1870
https://doi.org/10.1158/1078-0432.22460610

5

Data from Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma

المؤلفون: Sagar Lonial, Bruce J. Dezube, Stephen Tirrell, Hélène M. Faessel, George Mulligan, Allison J. Berger, Zhaowei Hua, Kevin Kelly, Catherine Diefenbach, Daniel Lebovic, Mitchell R. Smith, R. Donald Harvey, Robert Z. Orlowski, Owen A. O'Connor, Andrzej J. Jakubowiak, Jatin J. Shah

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b46235f714a1c01fdecda341d414434
https://doi.org/10.1158/1078-0432.c.6524544

6

Supplemental Figure 1 from Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors

المؤلفون: R. Donald Harvey, Bruce J. Dezube, George Mulligan, Kristine Burke, Allison J. Berger, Hélène M. Faessel, Michael D. Pickard, Devalingam Mahalingam, James M. Cleary, Glen J. Weiss, John S. Kauh, Jeffrey W. Clark, Roger B. Cohen, Geoffrey I. Shapiro, John Sarantopoulos

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acef34629e04fb77315450ae17a00a1d
https://doi.org/10.1158/1078-0432.22460187

7

Safety, tolerability, pharmacokinetics, pharmacodynamics, bioavailability and food effect of single doses of soticlestat in healthy subjects

المؤلفون: Emilio Merlo Pich, Grace Chen, Michael Cwik, John Affinito, Hélène M. Faessel, Shining Wang

المصدر: British Journal of Clinical Pharmacology

مصطلحات موضوعية: Male, Pyridines, Cmax, Administration, Oral, Biological Availability, cholesterol 24‐hydroxylase inhibitor, Urine, Pharmacology, Placebo, 030226 pharmacology & pharmacy, Food-Drug Interactions, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Piperidines, Pharmacokinetics, Oral administration, Humans, Medicine, Pharmacology (medical), 030212 general & internal medicine, 24S‐hydroxycholesterol, Adverse effect, Cross-Over Studies, Dose-Response Relationship, Drug, business.industry, NMDA signalling, Original Articles, Healthy Volunteers, Bioavailability, Area Under Curve, Pharmacodynamics, epilepsy, Female, Original Article, business, pharmacokinetics, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a0db4de110188f9846d73125cfb3b9
https://doi.org/10.1111/bcp.14854

View record at Wiley

8

A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Single‐Dose and Multiple‐Rising‐Dose Study of the BTK Inhibitor TAK‐020 in Healthy Subjects

المؤلفون: Ehsanollah Esfandiari, Mary Chen, Glennda Smithson, Eric R. Fedyk, Derek Blair, Lachy McLean, John A. Wagner, Hélène M. Faessel

المصدر: Clinical and Translational Science, Vol 14, Iss 3, Pp 820-828 (2021)
Clinical and Translational Science

مصطلحات موضوعية: Adult, Male, 030213 general clinical medicine, Adolescent, Administration, Oral, RM1-950, Pharmacology, Placebo, 030226 pharmacology & pharmacy, General Biochemistry, Genetics and Molecular Biology, Article, Placebos, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, Myasthenia Gravis, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Adverse effect, Protein Kinase Inhibitors, Purpura, Thrombocytopenic, Idiopathic, biology, Dose-Response Relationship, Drug, business.industry, General Neuroscience, Research, General Medicine, Articles, Middle Aged, Healthy Volunteers, Basophils, Tolerability, Pharmacodynamics, biology.protein, Female, Therapeutics. Pharmacology, Public aspects of medicine, RA1-1270, business, Tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd630e46c30245008f690a915f3447de
https://doaj.org/article/f77399c561284afe8c1603a678c5045f

View record at Wiley

Find this article in full text from ProQuest

9

Phase I study assessing the mass balance, pharmacokinetics, and excretion of [14C]-pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors

المؤلفون: Jayaprakasam Bolleddula, Xiaofei Zhou, Douglas V. Faller, Yuexian Li, Swapan Chowdhury, Dan Zhao, Hélène M. Faessel, Farhad Sedarati, Karthik Venkatakrishnan, Zsuzsanna Papai

المصدر: Investigational New Drugs. 39:488-498

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8f10edb2e4e45379985451ac370d03a6
https://doi.org/10.1007/s10637-020-01017-x

Find this article in full text from Springer Verlag.

Find this article in full text from ProQuest

10

Pharmacokinetics, pharmacodynamics and safety assessment of multiple doses of soticlestat in healthy volunteers

المؤلفون: Shining Wang, Grace Chen, Emilio Merlo Pich, John Affinito, Michael Cwik, Hélène M. Faessel

المصدر: British journal of clinical pharmacology. 88(6)

مصطلحات موضوعية: Pharmacology, Adult, Dose-Response Relationship, Drug, Double-Blind Method, Piperidines, Pyridines, Humans, Pharmacology (medical), Healthy Volunteers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db15aebf61c18a95c38cbe6798a3886b
https://pubmed.ncbi.nlm.nih.gov/35001412

View record at Wiley

تنقيح النتائج